Lab Director: Helen Barbas, Ph.D.
Our research centers on the organization of the prefrontal cortex and its role in central executive functions in primates. The goal is to investigate prefrontal pathways that interface with both excitatory and inhibitory neurons in cortical and subcortical structures that may provide the basis for the selection of relevant information and suppression of irrelevant information in behavior. Research involves investigation of bidirectional pathways between prefrontal cortices and structures associated with sensory, cognitive, mnemonic and emotional processes in the cortex, the thalamus, and the amygdala.
Experimental approaches include the use of neural tracers to label pathways, combined with histochemical, immunocytochemical and molecular procedures to characterize the postsynaptic site of prefrontal pathways. We use quantitative approaches and imaging to reconstruct in 3D neural circuits at the level of systems and at the synaptic level, and employ multidimensional analyses to reveal patterns and principles of connections.
We are part of the Boston University Interdepartmental Program in Neuroscience