Hasselmo laboratory

Center for Memory and Brain
Department of Psychology and
Program in Neuroscience
Boston University

Computational modeling in my laboratory addresses the role of hippocampus, prefrontal cortex and theta rhythm oscillations in memory-guided behavior. This page provides links to some of the modeling scripts used in recent publications. These are scripts created with the MATLAB package from Mathworks. You must have MATLAB 6.5 or later installed on your computer in order to run them. They are MATLAB "m" files.

MATLAB scripts:

Retrieve overlapping trajectory
MATLAB script generating Figure 8C from Hasselmo M.E. (2009) A model of episodic memory: Mental time travel along encoded trajectories using grid cells. Neurobiol Learn Mem. 92(4):559-73.

Replay on circular track
MATLAB script generating figures of simulation of replay in Hasselmo, M.E. (2008) Temporally structured replay of neural activity in a model of entorhinal cortex, hippocampus and postsubiculum. Eur. J. Neurosci. 28:1301-1315.

Simplified Prefrontal cortex
MATLAB script demonstrating a highly simplified version of the model presented in Hasselmo (2005) J. Cogn. Neurosci.

Goal-directed behavior with SARSA
MATLAB script demonstrating the actor-critic and SARSA algorithms from Reinforcement Learning Theory.

Prefrontal cortex model
MATLAB script demonstrating the function of the model presented in:
Hasselmo, M.E. (2005) A model of prefrontal cortical mechanisms for goal directed behavior. J. Cogn. Neurosci. 17:1115-1129.

Hippocampal context-dependent retrieval
MATLAB script demonstrating the function of the model presented in:
Hasselmo, M.E. and Eichenbaum H.B. (2005) Hippocampal mechanisms for the context-dependent retrieval of episodes. Neural Networks, 18(9): 1172-1190.

Fixed point attractor
MATLAB script demonstrating the model of fixed point attractors mediated by excitatory feedback with subtractive inhibition in a continuous firing rate model, as presented in:
Hasselmo, M.E., Schnell, E., Barkai, E. (1995) Dynamics of learning and recall at excitatory recurrent synapses and cholinergic modulation in hippocampal region CA3. J. Neurosci. 15(7): 5249-5262.

Center for Memory and Brain
Department of Psychology,
2 Cummington St., Boston, MA, 02215.
hasselmo@bu.edu, (617) 353-1397, FAX: 358-3296