{"id":16661,"date":"2020-08-24T15:29:47","date_gmt":"2020-08-24T19:29:47","guid":{"rendered":"https:\/\/www.bu.edu\/urop\/?post_type=profile&#038;p=16661"},"modified":"2020-08-24T15:29:47","modified_gmt":"2020-08-24T19:29:47","slug":"gerald-denis","status":"publish","type":"profile","link":"https:\/\/www.bu.edu\/urop\/profile\/gerald-denis\/","title":{"rendered":"Gerald Denis"},"content":{"rendered":"<p><span>I am a molecular oncologist with experience in chromatin control of transcription in cancer. I pioneered studies of the BET bromodomains proteins, a family comprised of BRD2 (originally named RING3), BRD3 and BRD4 in somatic cells, which are important as transcriptional co-regulators. I was the first to report a function for a BET protein, and to link these co-regulators to human cancer. The BET protein field has grown from sixteen papers, when I first published my work, to over 1,300 to date; they have since been implicated in several cancer types. Our recent data have established that BET bromodomain proteins provide a functional link between abnormal metabolism, inflammation and breast cancer progression in post-menopausal African American women. We are now realizing that BET proteins regulate cytokine\/chemokine production in the immune cells that infiltrate the breast cancer microenvironment, which are important for immune exhaustion, chemoresistance and metastasis.<\/span><\/p>\n","protected":false},"author":11707,"template":"","_links":{"self":[{"href":"https:\/\/www.bu.edu\/urop\/wp-json\/wp\/v2\/profile\/16661"}],"collection":[{"href":"https:\/\/www.bu.edu\/urop\/wp-json\/wp\/v2\/profile"}],"about":[{"href":"https:\/\/www.bu.edu\/urop\/wp-json\/wp\/v2\/types\/profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/urop\/wp-json\/wp\/v2\/users\/11707"}],"version-history":[{"count":1,"href":"https:\/\/www.bu.edu\/urop\/wp-json\/wp\/v2\/profile\/16661\/revisions"}],"predecessor-version":[{"id":16663,"href":"https:\/\/www.bu.edu\/urop\/wp-json\/wp\/v2\/profile\/16661\/revisions\/16663"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/urop\/wp-json\/wp\/v2\/media?parent=16661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}