Neuroendocrinology

Options

Volunteer Basis, Potential for UROP Funding, Potential for Academic Credit

Overview

Thyroid hormone (TH) signaling and action play a critical role in human development and adult life. Even mild deficiencies can lead to significant morbidity including metabolic abnormalities, cardiac disease, and obesity. One focus of our Laboratory is to investigate the neurocircuitry regulating TH levels, as well as the central actions of TH.

We are opening an opportunity for one student to participate in a project on the role of thyroid hormone receptors in regulating neurons of the arcuate and paraventricular hypothalamic nuclei. In this project, we use a multitude of mouse models and adeno-associated viruses (AAVs) to test specific experimental paradigms. This work will be conducted under the direct supervision of Dr. Ricardo Sousa, in Dr. Anthony Hollenberg’s Lab at the Medical Campus.

The successful candidate will practice the scientific method, learn to develop a hypothesis, and apply proper experimental design to test it. Laboratory work will include molecular biology techniques, central nervous system histology/immunofluorescence, mouse handling, and dissection, with the potential to learn rodent stereotaxic surgery.

The expected time commitment is 8-10 hours per week.

Back to On-Campus Opportunities