Lawrence Mwananyanda
Profiles

Lawrence Mwananyanda, MD

Adjunct Research Assistant Professor, Global Health - Boston University School of Public Health

Biography

Dr.Lawrence Mwananyanda is a clinician/scientist with a wealth of experience in conducting medical and public health research. He has been Principal Investigator or Co-PI on multiple research project. His portfolio includes being the Director of the HIV Vaccines Trials Unit at the Botswana Harvard Partnership where he and colleagues worked on the first Phase 1 HIV vaccine trials to be conducted in Africa. His interest with HIV vaccines research continued with his stint at the Emory University under the Zambia HIV Research Project where they studied conformational changes of the HIV at infection in a cohort of discordant couples to aid in design of next generation HIV trial vaccines.
With colleagues at Boston University, Dr.Mwananyanda’s focus has been research on child survival. Ongoing research include the Zambia Pertussis RSV Infant Mortality Estimation Study (ZPRIME) Southern Africa Mother Infant Pertussis Study – Nasopharyngeal Carriage (SAMIPS-NPC), Zambia Infant Cohort Study (ZICS) whose overall goal is to determine if HIV-exposed but uninfected infants (HEU) infants born to HIV-infected mothers on antiretroviral therapy have increased morbidity and mortality, and to correlate maternal Immune Activation ( with infant clinical outcome, and immune dysregulation as a potential mechanism for the poor HEU outcome. All these studies are based in Lusaka, Zambia. Dr. Mwananyanda is also the Zambia Site Director for the Harvard-Boston University-Northwestern University-New Mexico Fogarty Global Health program.

Education

  • Jagiellonian University, MD Field of Study: Medicine
  • University of Alabama at Birmingham, MPH Field of Study: Epidemiology
  • Jagiellonian University, BSc Field of Study: Biology

Publications

  • Published on 9/2/2021

    Forman LS, Macleod W, Mwananyanda L, Kwenda G, Pieciak R, Mupila Z, Murphy C, Thea D, Chikoti C, Yankonde B, Ngoma B, Chimoga C, Gill CJ. Association of Respiratory Syncytial Virus Infection and Underlying Risk Factors for Death Among Young Infants Who Died at University Teaching Hospital, Lusaka Zambia. Clin Infect Dis. 2021 09 02; 73(Suppl_3):S180-S186. PMID: 34472569.

    Read At: PubMed
  • Published on 9/2/2021

    Murphy C, MacLeod WB, Forman LS, Mwananyanda L, Kwenda G, Pieciak RC, Mupila Z, Thea D, Chikoti C, Yankonde B, Ngoma B, Chimoga C, Gill CJ. Risk Factors for Respiratory Syncytial Virus-Associated Community Deaths in Zambian Infants. Clin Infect Dis. 2021 09 02; 73(Suppl_3):S187-S192. PMID: 34472570.

    Read At: PubMed
  • Published on 9/2/2021

    Mazur NI, Löwensteyn YN, Willemsen JE, Gill CJ, Forman L, Mwananyanda LM, Blau DM, Breiman RF, Madhi SA, Mahtab S, Gurley ES, El Arifeen S, Assefa N, Scott JAG, Onyango D, Tippet Barr BA, Kotloff KL, Sow SO, Mandomando I, Ogbuanu I, Jambai A, Bassat Q, Caballero MT, Polack FP, Omer S, Kazi AM, Simões EAF, Satav A, Bont LJ. Global Respiratory Syncytial Virus-Related Infant Community Deaths. Clin Infect Dis. 2021 09 02; 73(Suppl_3):S229-S237. PMID: 34472576.

    Read At: PubMed
  • Published on 9/1/2021

    Mwananyanda L, Thea DM, Chipeta J, Kwenda G, Mulindwa JM, Mwenechanya M, Prosperi C, Higdon MM, Haddix M, Hammitt LL, Feikin DR, Murdoch DR, O'Brien KL, Deloria Knoll M, Mwansa J, Wa Somwe S, Seidenberg P. The Etiology of Pneumonia in Zambian Children: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study. Pediatr Infect Dis J. 2021 Sep 01; 40(9S):S40-S49. PMID: 34448743.

    Read At: PubMed
  • Published on 9/1/2021

    Seidenberg P, Mwananyanda L, Chipeta J, Kwenda G, Mulindwa JM, Mwansa J, Mwenechanya M, Wa Somwe S, Feikin DR, Haddix M, Hammitt LL, Higdon MM, Murdoch DR, Prosperi C, O'Brien KL, Deloria Knoll M, Thea DM. The Etiology of Pneumonia in HIV-infected Zambian Children: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study. Pediatr Infect Dis J. 2021 Sep 01; 40(9S):S50-S58. PMID: 34448744.

    Read At: PubMed
  • Published on 7/31/2021

    Baillie VL, Moore DP, Mathunjwa A, Park DE, Thea DM, Kwenda G, Mwananyanda L, Madhi SA. Epidemiology and Seasonality of Endemic Human Coronaviruses in South African and Zambian Children: A Case-Control Pneumonia Study. Viruses. 2021 07 31; 13(8). PMID: 34452378.

    Read At: PubMed
  • Published on 6/7/2021

    Gill CJ, Gunning CE, MacLeod WB, Mwananyanda L, Thea DM, Pieciak RC, Kwenda G, Mupila Z, Rohani P. Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers. Elife. 2021 06 07; 10. PMID: 34097599.

    Read At: PubMed
  • Published on 6/1/2021

    Park DE, Higdon MM, Prosperi C, Baggett HC, Brooks WA, Feikin DR, Hammitt LL, Howie SRC, Kotloff KL, Levine OS, Madhi SA, Murdoch DR, O'Brien KL, Scott JAG, Thea DM, Antonio M, Awori JO, Baillie VL, Bunthi C, Kwenda G, Mackenzie GA, Moore DP, Morpeth SC, Mwananyanda L, Paveenkittiporn W, Ziaur Rahman M, Rahman M, Rhodes J, Sow SO, Tapia MD, Deloria Knoll M. Upper Respiratory Tract Co-detection of Human Endemic Coronaviruses and High-density Pneumococcus Associated With Increased Severity Among HIV-Uninfected Children Under 5 Years Old in the PERCH Study. Pediatr Infect Dis J. 2021 06 01; 40(6):503-512. PMID: 33883479.

    Read At: PubMed
  • Published on 3/29/2021

    Lohman-Payne B, Koster J, Gabriel B, Chilengi R, Forman LS, Heeren T, Duffy CR, Herlihy J, Crimaldi S, Gill C, Chavuma R, Mwananyanda L, Thea DM. Persistent Immune activation in HIV-Infected Pregnant Women Initiating cART Post Conception. J Infect Dis. 2021 Mar 29. PMID: 33780543.

    Read At: PubMed
  • Published on 3/15/2021

    Camelo IY, Mwananyanda LM, Thea DM, Seidenberg P, Gill CJ, Weinstein JR. A Tale of 2 Pneumos: The Impact of Human Immunodeficiency Virus Exposure or Infection Status on Pediatric Nasopharyngeal Carriage of Streptococcus pneumoniae and Pneumocystis jiroveci: A Nested Case Control Analysis From the Pneumonia Etiology Research In Child Health Study. Clin Infect Dis. 2021 03 15; 72(6):1033-1041. PMID: 32342105.

    Read At: PubMed

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