Project 1

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Impact of Early Life Exposure to Environmental and Social Stressors on Substance Use

Project Leader, Ann Aschengrau
Boston University School of Public Health

Studying the impact of early life exposure to PCE and social stressors on unhealthy alcoholic beverage consumption and illicit drug use.


Project 2

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Assessing the Relation of Chemical and Non-Chemical Stressors with Risk-Taking Behavior and Related Outcomes among Adolescents Living near the New Bedford Harbor Superfund Site

Project Leader, Jon Levy
Boston University School of Public Health
Co-Leader, Susan Korrick
Brigham and Women’s Hospital, Harvard T.H. Chan School of Public Health

Our main focus is investigating the relation of prenatal exposure to chemical and non-chemical stressors with adolescents’ risk-taking and related behaviors and characterizing current exposure among reproductive aged women in communities surrounding the New Bedford Harbor.


Project 3

Emberley et al; Figure 5BEnvironmental PPARγ Pathway Activators: Multifaceted Metabolic Disruptors Impacting Adipose and Bone Homeostasis

Project Leader, Jennifer Schlezinger
Boston University School of Public Health

Determining the molecular mechanism by which individual and complex mixtures of environmental chemicals impact adipose and bone homeostasis.


New Project 3

Resiliency of Sediment Capping Approaches for Containment of PCB Contaminated Sediments in Aquatic Environments

Project Leader, Matt Charette
Woods Hole Oceanographic Institution
Co-Leader, Duncan FitzGerald
Boston University, Earth & Environmental Science

The main purpose of this new project is to address SRP Mandate 4 by determining the fate of heavily contaminated sediment in Combined Aquatic Disposal (CAD) cells in New Bedford Harbor. While dredging and deposition of PCB- and heavy metal-contaminated sediment in wells dug in the floor of the Harbor (and other marine Superfund sites) is ongoing, the ultimate fate of these contaminants has not been well studied. Furthermore, little is known of the likely effects of extreme weather on these cells and capped, heavily contaminated sediment, some of which is just a few feet below the water surface.

Project 4

Mechanisms and Impacts of PCB Resistance in Fish

Project Leader, Mark E. Hahn
Woods Hole Oceanographic Institution
Co-Leader, Sibel I. Karchner
Woods Hole Oceanographic Institution

Project 4 seeks to understand the population-level impacts of long-term exposure to Superfund chemicals by elucidating the molecular mechanisms of evolved resistance of fish to halogenated aromatic hydrocarbons (HAHs, including polychlorinated biphenyls (PCBs)) and polynuclear aromatic hydrocarbons (PAHs).


Project 5

A Novel Mechanism of Ortho-PCB-induced Toxicity: Targeting Nuclear Receptors in Brain of Fish

Project Leader, John J. Stegeman
Woods Hole Oceanographic Institution
Co-Leader, Jared V. Goldstone
Woods Hole Oceanographic Institution

A comprehensive study of ortho-PCB effects on development, and possible mechanisms using fish models.

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