Relevant publications (since 1995)


Ju S-T, Panka DJ, Cui H, Ettinger R, El-Khatib M, Sherr DH, Stanger BZ, and Marshak-Rothstein, A. 1995. The molecular mechanism of programmed cell death following T cell activation requires Fas/FasL interactions. Nature. 373:444.

Cui H, Sherr DH, El-Khatib M, Matsui K, Panka DJ, Marshak-Rothstein A, Ju S-T. 1996. Regulation of T-cell death genes: Selective inhibition of FasL- but not Fas-mediated function. Cell. Immunol. 167:276

Cui H, El-Khatib M, Sherr DH, Ettinger R, Sy M-S, Marshak-Rothstein A, Ju S-T. 1996. Characterization of LPR-derived T cell hybridomas:Fas-death deficient hybridomas are deathless, growth-arrested, and cytotoxic upon activation. Cell Immunol. 167:302. PMID: 8603440

Yamaguchi K, Near R, Shneider A, Cui, H., Ju S-T, and Sherr DH. 1996. Fluoranthene mediated apoptosis in murine T cell hybridomas is aryl hydrocarbon receptor independent. Toxicol. and Appl. Pharmacol. 139:144. PMID: 8685897 DOI: 10.1006/taap.1996.0153

Wu M, Lee H, Bellas RB, Schauer SL, Arsura M, Katz D, Fitzgerald MJ, Rothstein TL, Sherr DH, Sonenshein GE. 1996. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO. J. 15:101. PMID: 8887559 PMCID: PMC452200

Wu M, Arsura M, Bellas RE, FitzGerald MJ, Lee H, Schauer SL, Sherr DH and Sonenshein GE. 1996. Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells. Mol. Cell. Biol. 16:5015. PMID: 8756660 PMCID: PMC231503

Cui H, Ju S-T, and Sherr DH, 1996. Functional expression of Fas (CD95) protein in autoimmune lpr mice. Cell. Immunol. 174:35-41. PMID: 8929452 DOI: 10.1006/cimm.1996.0291

Vaziri C, Shneider A, Sherr DH, and Faller D. 1996. Expression of the aryl hydrocarbon receptor is regulated by serum and mitogenic growth factors in murine 3T3 fibroblasts. J. Biochem. 271:25921. PMID: 8824226

Yamaguchi K, Near R, Matulka R, Shneider A, Toselli P, Trombino AF, and Sherr DH. 1997. Activation of the aryl hydrocarbon receptor/transcription factor and bone marrow stromal cell-dependent preB cell apoptosis. J. Immunol. 158: 2165. PMID: 9036962

Yamaguchi K, Matulka RA, Shneider A, Toselli P, Trombino AF, Yang S, Hafer LJ, Mann KK, Tao X-J, Tilly JL, Near R, Sherr DH, 1997. Induction of preB cell apoptosis by 7,12 dimethylbenz[a]anthracene in long term primary bone marrow cultures. Toxicology and Applied Pharmacology. 147: 190. PMID: 9439715 DOI: 10.1006/taap.1997.8263

Near RI, Matulka RA, Mann KK, Shneider AM, Gogate SU, Trombino AF, and Sherr DH. 1999. Regulation of PreB Cell Apoptosis by Aryl Hydrocarbon Receptor/Transcription Factor-Expressing Stromal/Adherent Cells. Proceedings of the Society for Experimental Biology and Medicine. 221:242-252. PMID: 10404042

Mann K, Matulka R, Lawrence BP, Kerkvliet, N, Trombino AF, Hahn M, and Sherr DH. 1999. The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis. Toxicol. Appl. Pharmacol. 161:10-22. PMID: 10558919 DOI: 10.1006/taap.1999.8778

Robles R, Morita Y, Mann KK, Perez GI, Yang S, Matikainen T, Sherr DH, Tilly JL. 2000. The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse. Endocrinology. 141:450-453. PMID: 10614669 DOI: 10.1210/endo.141.1.7374

Trombino AF, Near RI, Matulka RA, Yang S, Hafer LJ, Toselli PA, Kim D, Sovak M, Rogers A, Sonenshein G, Sherr DH. 2000. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis. Breast Cancer Research and Treatment, 62:117-131. PMID: 11097088

Quadri S, Qadri A, Hahn ME, Mann KK, Sherr DH. 2000. The bioflavonoid galangin blocks aryl hydrocarbon receptor (AhR) activation and polycyclic aromatic hydrocarbon-induced pre-B cell apoptosis. Molec. Pharmacol. 58:515-525. PMID: 10953044

Kim DW, Gazourian L, Quadri SA, Sherr DH, Sonenshein GE. 2000. The aryl hydrocarbon receptor/transcription factor (AhR) and the Rel A nuclear factor-κB subunit cooperate to transactivate the c-myc promoter. Oncogene. 19:5498-5506.

Jodo S, Hohlbaum A, Xiao S, Chan D, Strehlow D, Sherr DH, Marshak-Rothstein, M and Ju S-T. 2000. CD 95 ligand (FasL)-expressing vesicles display antibody-mediated, FcR-dependent enhancement of cytotoxicity. J. Immunol. 165:5487-5494. PMID: 11067901

Mann KK, Doerre S, Sherr DH, Quadri S. 2001. The role of NF- κB as a survival factor in environmental chemical-induced preB cell apoptosis. Mol. Pharmacol. 59:302-309. PMID: 11160867

Kavanagh KT, Hafer LJ, Kim DW, Mann KK, Sherr DH, Rogers AE, Sonenshein GE. 2001. Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture. J. Cell. Biol. 82:387-398. PMID: 11500915

Matikainen T, Perez, GI, Jurisicova A, Mann KK, Schlezinger JJ, Ryu H-Y, Sakai T, Korsmeyer SJ, Casper RF, Sherr DH, Tilly JT. 2001, Dioxin receptor-dependent bax gene transcription is required for ovarian failure caused by biohazardous environmental chemicals. Nature Genetics. 28:355-360. PMID: 11455387 DOI: 10.1038/ng575

Matikainen TM, Moriyama T, Morita Y, Perez GI, Korsmeyer SJ, Sherr DH, Tilly JL. 2001. Ligand activation of the aromatic hydrocarbon receptor (AHR)-transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells. Endocrinology. 143:615-620. PMID: 11796517 DOI: 10.1210/endo.143.2.8624

Schlezinger JJ, Jensen BA, Mann KK, Ryu H-Y , Sherr DH. 2002. Peroxisome proliferator-activated receptor g-mediated NF- k B activation and apoptosis in pre-B cells. J.Immunol. 169:6831. PMID: 12471115

Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr, DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, and Tilly JL. 2003. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo . Endocrinology 144:69-74. PMID: 12488331 DOI: 10.1210/en.2002-220814

Maecker B, Sherr DH, Vonderheide RH, von Bergwelt-Baildon M, Hirano N, Anderson KS, Xia Z, Butler MO, Wucherpfennif KW, O’Hara C, Cole G, Ramstedt U, Tomlinson AJ, Chicz RM, Nadler LM, and Schultze JL. 2003. The shared tumor associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Blood. 102:3287. PMID: 12869499 DOI: 10.1182/blood-2003-05-1374

Ryu-K-Y, Mann KK, Schlezinger JJ, Jensen B, Sherr DH. 2003. Environmental chemical-induced pre-B cell apoptosis: analysis of c-Myc, p27 Kip1, and p21 WAF1 reveals a death pathway distinct from clonal deletion. J. Immunol. 170:4897-4904. PMID: 12734332

Allan LL, Mann KK, Schlezinger JL, Sherr DH. 2003. Bone marrow interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis. Toxicol. Sci. 76:357. PMID: 14514961 DOI: 10.1093/toxsci/kfg239

Jensen BA, Leeman RJ, Schlezinger JJ, Sherr DH. 2003. Aryl hydrocarbon receptor (AhR) agonists suppress interleukin-6 expression by bone marrow stromal cells. Env. Health. J. 2:16. PMID: 14678569 PMCID: PMC317352

Tiwari S, Felekkis K, Moon E, Flies A, Sherr DH, Lerner A. 2003. Among circulating hematopoeitic cells, B-CLL uniquely expresses functional EPAC1 but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis. Blood. 103(7):2661-7. PMID: 14615375 DOI: 10.1182/blood-2003-06-2154

Webster T and Sherr DH. 2003. Types of AhREs and their implications. Organohalogen Compounds 65:106.

Sherr DH. 2004. 2,3,7,8-Tetrachloro-p-dioxin (TCDD) and long-term immunologic memory. Toxicol. Sci. 79:211. PMID: 15185717

Xiao S, Zhang X, Mann KK, Jodo S, Li L, Jarjour WN, Marshak-Rothstein A, Sherr DH, Ju ST. 2004. Changes in sensitivity of peripheral lymphocytes of autoimmune gld mice to FasL-mediated apoptosis reveal a mechanism for the preferential deletion of CD4-CD8-B220+ T cells. Int. Immuno. 16(5):759-66. PMID: 15096479 DOI: 10.1093/intimm/dxh078

Schlezinger, JJ, Hurst CH, Waxman DJ, Sherr DH. 2004. Mono-2-ethylhexylphthalate, an environmental PPARγ agonist, induces growth arrest and apoptosis in pro/pre-B cells. J. Immunol. 173:3165. PMID: 15322177

Maecker B, von Bergwelt-Baildon MS, Sherr DH, Nadler LM, Schultze JL. Identification of a new HLA-A*0201 restricted cryptic epitope from CYP1B1. 2005. International Journal of Cancer. 115:333. PMID: 15688394

Murray SA, Yang S, Demicco E, Ying H, Sherr DH, Hafer LJ, Rogers AE, Sonenshein GE, and Xiao Z-X J. 2005. Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors. J. Cell Biochem. 95:875. PMID: 15844214 DOI: 10.1002/jcb.20414

Schaefer KL, Senevich S, Ma C, Cooley SR, Nakajima A, Wada, K, Schlezinger JJ, Sherr DH, and Saubermann LJ. 2005. Intestinal anti-inflammatory effects of thiazolidenedione PPARγ ligands on Th1 chemokine regulation include non-transcriptional control mechanisms. Inflammatory Bowel Diseases. 11:244. PMID: 15735430

Allan L and Sherr DH. 2005. Constitutive activation and environmental chemical induction of the aryl hydrocarbon receptor/transcription factor (AhR) in activated human B lymphocytes. Mol. Pharmacol. 67:1740. PMID: 15681594 DOI: 10.1124/mol.104.009100

Yang X, Murray TJ, Liu D, Mitchell GC, Hesterman EV, Karchner SI, Hahn ME and Sherr DH. 2005. The aryl hydrocarbon receptor/transcription factor constitutively represses c-myc transcription in human mammary tumor cells. Oncogene. 24:7869. PMID: 16091746 DOI: 10.1038/sj.onc.1208938

Ryu H-Y, Emberley J, Schlezinger J, Allan LL, Na S, and Sherr DH. 2005. Environmental chemical-induced bone marrow B cell apoptosis: Death receptor-independent activation of a caspase-3 to caspase-8 pathway. Molecular Pharmacology. 68:1087. PMID: 16014577 DOI: 10.1124/mol.105.014712

Currier N, Solomon S, Demicco E, Chang D, Farago M, Ying H, Dominguez I, Sonenshein GE, Cardiff R, Xiao J, Sherr DH, and Seldin DC. 2005. Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors. Toxicologic Pathology.33:726. PMID: 16263698 DOI: 10.1080/01926230500352226

Shin SR, Sanchez-Velar N, Sherr DH, and Sonenshein GE. 2006. 7,12-Dimethylbenz[a]Anthracene treatment of a c-rel mouse mammary tumor cell line induces epithelial to mesenchymal transition via activation of NF-κB. Cancer Research. 66:2570. PMID: 16510574 DOI: 10.1158/0008-5472.CAN-05-3056

Allan LL, Schlezinger J, Shansab M, and Sherr DH. 2006. CYP1A1 in polycyclic aromatic hydrocarbon-induced B lymphocyte growth suppression. Biochem. Biophys. Res. Commun. 342:227. PMID: 16472762 DOI: 10.1016/j.bbrc.2006.01.131

Murray TJ, Yang X, and Sherr DH. 2006. Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A. Breast Cancer Res. 8:R17. PMID: 16569260 PMCID: PMC1557718

Schlezinger JJ, Emberley J, and Sherr DH. 2006. Activation of multiple MAP Kinases in pro/pre-B cells by GW7845, a PPARγ agonist, and their contribution to GW7845-induced apoptosis. Toxicological Sciences. 92:433. PMID: 16672323 DOI: 10.1093/toxsci/kfl003

Schlezinger JJ, Liu D, Farago M, Seldin DC, Belguise K, Sonenshein G, and Sherr DH. 2006. A role for the aryl hydrocarbon receptor in mammary gland tumorigenesis. Biological Chemistry. 387:1175-87. PMID: 16972784 DOI: 10.1515/BC.2006.145

Schlezinger JJ, Emberley J, Bissonette S, and Sherr DH. 2007. An l-tyrosine derivative and PPARγ agonist, GW7845, activates a multi-faceted caspase cascade in bone marrow B cells. Toxicological Sciences. 98:125-136 PMID: 17400580 DOI: 10.1093/toxsci/kfm071

Yang X, Solomon S, Fraser LR, Trombino AF, Liu D, Sonenshein GE, Hestermann EV, and Sherr DH. 2007. Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue. J. Cell. Biochem. 104:402-417. PMID: 18059014 DOI: 10.1002/jcb.21630

Belguise K, Guo S, Yang S, Rogers AE, Seldin DC, Sherr DH, and Sonenshein GE. 2007. Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype. Cancer Res. 67:11742-11750. PMID: 18089804 DOI: 10.1158/0008-5472.CAN-07-2730

Ahmadi T, Efebera Y, and Sherr DH. 2007: CD40 ligand-activated, antigen-specific B Cells are comparable to mature dendritic cells in presenting protein antigens and MHC class I- and class II-binding peptides. Immunology. 124:129-140. PMID: 18067555 PMCID: PMC2434387

Min C, Eddy SF, Sherr DH, and Sonenshein GE. 2008. NF-κB and epithelial mesenchymal transition of cancer. J. Cell. Biochem. 104: 733-744. PMID: 18253935 DOI: 10.1002/jcb.21695

Evans BR, Karchner SI, Allan LL, Pollenz RS, Tanguay RL, Jenny MJ, Sherr DH, and Hahn ME. 2008. Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator. Mol. Pharmacol. 73:387-398. PMID: 18000031 PMCID: PMC3263532

Bissonnette S, Emberley J, Sherr DH, and Schlezinger JJ. 2008. Overlapping but distinct apoptosis signaling pathways induced by an environmental (MEHP) and an endogenous (15d-PGJ2) PPARγ agonist. J. Immunol. 181:1728-36 PMID: 18641309 PMCID: PMC2494875

Hahn ME, Allan LL, Sherr DH. 2009. Regulation of constitutive and inducible AhR signaling: Complex interactions involving the AhR repressor. Biochem. Pharmacol. 77:485-497. PMID: 18848529 PMCID: PMC2701375

Karchner S, Jenny M, Franks D, Evans B, Tarrant A, Kang A, Bae I, Sherr DH, and Hahn ME. 2009. The active form of human aryl hydrocarbon receptor repressor lacks exon 8 and its Pro185 and Ala185 variants repress both AHR and HIF. Molec. Cell. Biol. 13:3465. PMID: 19380484 PMCID: PMC2698758

Teague J, Ryu H-Y, Kirber M, Sherr DH and Schlezinger J. 2010. Proximal events in 7,12-dimethylbenz[a]anthracene-induced, stromal cell-dependent bone marrow B cell apoptosis: Stromal cell-B cell communication, p53 induction and mitochondrial permeabilization. J. Immunol. 185:3369-3378 (Featured on J.I. cover). PMID: 20720205 PMCID: PMC2933279

Schlezinger JJ, Bernard P, Haas A, Grandjean P, and Sherr DH. 2010. Direct assessment of cumulative aryl hydrocarbon receptor agonist activity in sera from experimentally exposed mice and environmentally exposed humans. Environmental Health Perspectives. 118:693-698. PMID: 20435556 PMCID: PMC2866687

Allan LL and Sherr DH. 2010. Disruption of human plasma cell differentiation by an environmental polycyclic aromatic hydrocarbon: a mechanistic immunotoxicological study. Environmental Health. 9:15. PMID: 20334656 PMCID: PMC2851679

Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, Burns EJ, Sherr DH, Weiner HL, and Kuchroo VK. 2010. The aryl hydrocarbon receptor (AhR) interacts with c-Maf to promote the differentiation of IL-27-induced regulatory type 1 (Tr1) cells. Nature Immunology. 11: 854-861. PMID: 20676095 PMCID: PMC2940320

Ehrlich DJ, McKenna BK, Evans JG, Kina A, Denis GV, Sherr DH, and Cheung MC. 2010. Parallel imaging microfluidic cytometry. Methods in Cell Biology102:49-75. PMID: 21704835 PMCID: PMC3139515

Flies A , Ahmadi T, Parks AJ, Prokaeva T, Weng L, Rolfe SS, Seldin DC, and Sherr DH. 2012. Immunoglobulin light chain, Blimp-1 and cytochrome P4501B1 peptides as potential vaccines for AL amyloidosis. Immunol. Cell Biol. 90:528-539. PMID: 21894172 DOI: 10.1038/icb.2011.73

Selmi C LP, Sherr DH, Dias M, Nyland J, Rose N and Gershwin ME. 2012. The role of the environment in the development of autoimmune disease: an NIEHS Expert Panel Workshop. J. Autoimmunity. 39:272. PMID: 22749494 DOI: 10.1016/j.jaut.2012.05.007

Smith BW, Rozelle SS, Leung A, Ubellacker J, Parks A, Nah SK, French D, Gadue P, Monti S, Shui DHK, Steinberg MH, Frelinger AL, Michelson AD, Theberge R, McComb ME, Costello CE, Kotton, DN, Mostoslavsky G, Sherr DH, and Murphy GJ. 2013. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood. 122:376-385. PMID: 23723449 PMCID: PMC3716202

Quintana F and Sherr DH. 2013. Endogeous AhR ligands and their role in autoimmunity. Pharmacological Reviews. 65:1148-1161. PMID: 23908379 PMCID: PMC3799235

Monti S and Sherr DH. 2013. The role of the aryl hydrocarbon receptor in normal and malignant B cell development. Seminars in Immunopathology. 35:705-716. PMID: 23942720 PMCID: PMC3824572

Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Franks DG, Schlezinger JJ, Sherr DH, Silverstone AE, Hahn ME, and McCune JM. 2013. Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives Th22 DifferentiationIL-22 Production. PLOS One. 9:e87877. PMID: 24498387 PMCID: PMC3912126

Parks A, Pollastri M, Franks D, Haigh-Molina S, Ashton T, Ubellacker J, Stanford E, Schlezinger JJ, and Sherr DH. 2013. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol. Pharmacol. 86:593-608. PMID: 25159092 PMCID: PMC4201140

Gusenleitner D, Auerbach S, Tice R, Sherr DH, and Monti S. 2014. Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity. PLOS One. 9:e102579. PMID: 25058030 PMCID: PMC4109923

Grandjean P, Barouki R, Bellinger D, Casteleyn L, Chadwick L, Cordier S, Etzel R, Gray K, Ha E-H, Junien D, Karagas M, Kawamoto T, Lawrence BP, Perera F, Prins GS, Puga A, Rosenfeld C, Sherr DH, Sly P, Suk W, Sun Q, Toppari J, van den Hazel P, Walker C, and Heindel J. 2015. Life-long implications of developmental exposure to stressors and the research perspective. Endocrinology. 156(10):3408-15. PMID: 26241067 PMCID: PMC4588822

Shivanna S, Kolandaivelu K, Moshe S, Novikov O, Balcells M, Zheng A, Weinberg J, Francis J, Edelman ER, Sherr DH, and VC. Chitalia. 2016. The aryl hydrocarbon receptor is a critical regulator of tissue factor stability and is a novel anti-thrombotic target in uremia. J.Am.Soc. Neph. 27:189-201. PMID: 26019318 PMCID: PMC4696580

Stanford E, Wang Z, Novikov O, Mulas F, Landesman-Bolag E, Monti S, Smith B, Muprhy GJ, and Sherr DH. 2016. The role of the aryl hydrocarbon receptor in the development of cells with molecular and functional characteristics of breast cancer stem cells. BMC Biology. 14:20. PMID: 26984638 PMCID: PMC4794823

Smith BW, Stanford EA, Sherr DH, Murphy GJ. 2016. Genome editing of the Cyp1a1 locus in iPSCs as a platform to map AHR expression throughout human development. Stem Cell International. 2016:2574152. PMID: 27148368 PMCID: PMC4842384

Stanford EA, Ramirez-Cardenas A, Wang Z, Novikov O, Alamoud K, Koutrakis P, Mizgerd JP, Genco CA, Kukuruzinska MA, Monti S, Bais MV, and Sherr DH. 2016. The role of the aryl hydrocarbon receptor and its diverse ligands in oral cancer cell migration and tumorigenesis. Mol. Cancer Res. 14(8):696-706. PMID: 27130942 PMCID: PMC4987205

Novikov O, Wang Z, Stanford EA, Parks AJ, Ramirez-Cardenas A, Gusenleitner D, Li A, Monti S, Manteiga S, Lee K, and Sherr DH. 2016. An aryl hydrocarbon receptor-mediated positive feedback loop that enforces cell migration in ER-/PR-/Her2-human breast cancer cells. Mol. Pharm. In Press.

Chen H-R, Sherr DH, Hu Z, DeLisi C. 2016. A network based approach to drug repositioning identifies plausible candidates for breast cancer and prostate cancer. BMC Medical Genomics9(1):51. PMID: 27475327 PMCID: PMC4967295

Mulas F, Li A, Sherr DH, Monti S. 2016. Network-based analysis of transcriptional profiles from chemical perturbation experiments. BMC Bioinformatics. In Press.

Narasimhan S, Gusenleitner D, Monti S, Rolfe S, Schlezinger JJ, and Sherr DH. 2016. The aryl hydrocarbon receptor regulates human mammary tumor cell invasion. Manuscript in preparation.