{"id":426,"date":"2012-11-26T12:16:28","date_gmt":"2012-11-26T17:16:28","guid":{"rendered":"https:\/\/www.bu.edu\/slone\/?page_id=426"},"modified":"2013-01-24T12:53:51","modified_gmt":"2013-01-24T17:53:51","slug":"hfm","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/slone\/research\/studies\/hfm\/","title":{"rendered":"Case-Control Study of Hemifacial Microsomia (HFM) and Drug Use"},"content":{"rendered":"<h3>Objectives<\/h3>\n<ul>\n<li>To test the hypothesis that hemifacial  microsomia (HFM) risk is increased by maternal use of vasoconstrictive  decongestants while controlling for the effects of frequency, dose, type  and indication;<\/li>\n<li>To test the hypothesis that HFM risk is  increased by maternal use of other vasoactive exposures, including  aspirin, ibuprofen, caffeinated coffee, alcohol, and smoking;<\/li>\n<li>To examine the relation between HFM risk  and maternal exposure to other medications, illnesses, or specific  nutrient deficiencies or excesses; and<\/li>\n<li>To collect and store buccal cell samples  for future analyses of the relation between HFM risk and possible  genetic marker\/exposure interactions.<\/li>\n<\/ul>\n<h3>Methods<\/h3>\n<p>Cases less 12 months of age are identified  from craniofacial centers in over twenty cities across the U.S. and  Canada . Controls are identified by case infant\u2019s primary physician and  will comprise the next three infants born after the case. Mothers of  cases and controls will be interviewed by telephone within 15 months  after the infant\u2019s date of birth. The standardized questionnaire asks in  detail about demographic factors; reproductive, medical and pregnancy  illness histories; medication use; behaviors (smoking, alcohol, coffee);  and nutrition. Buccal cell samples are collected from cases, controls,  and their parents and sent to Slone for storage. Standardized  photographs are taken and the medical record of each case infant will be  reviewed for HFM classification by Dr. John Mulliken, Children\u2019s  Hospital, Boston.<\/p>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Investigators and Study Staff<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p>Martha M. Werler, Sc.D., Principal Investigator<br \/>\nCatherine Hayes, D.M.D., D.M.Sc., Co-Investigator<br \/>\nAllen A. Mitchell, M.D., Co-Investigator<\/p>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Study Details<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p><b>Source of Funding:<\/b><\/p>\n<p style=\"padding-left: 30px;\">National Institutes of Dental Research and Child Health and Human Development<\/p>\n<p><b>Study Period:<\/b><\/p>\n<p style=\"padding-left: 30px;\">July 1997 to June 2001<\/p>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Associated Studies<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<ul>\n<li><a href=\"https:\/\/www.bu.edu\/slone\/research\/studies\/calls\/\">The Child and Adolescent Learning and Living Study (CALLS)<\/a><\/li>\n<li><a href=\"https:\/\/www.bu.edu\/slone\/research\/studies\/hfm-psos\/\">Hemifacial Microsomia: Psychosocial and Other Sequelae<\/a><\/li>\n<\/ul>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Presentations<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<ul>\n<li>Werler MM, Sheehan JE, Mitchell AA. <a target=\"_blank\" href=\"https:\/\/www.bu.edu\/slone\/files\/2012\/11\/Anotia_Microtia_PPT.pdf\">Diabetes, body mass index, vitamin supplementation and anotia\/microtia<\/a>. Presented at Teratology Society Annual Meeting. Vancouver, BC, June 30, 2004.<\/li>\n<\/ul>\n<ul>\n<li>Werler MM. <a target=\"_blank\" href=\"https:\/\/www.bu.edu\/slone\/files\/2012\/11\/ACPA0304_PPT.pdf\">Do vasoactive exposures and vascular events affect the development of hemifacial microsomia?<\/a>. Presented at the American Cleft Palate Craniofacial Association Meeting. Chicago, IL, March 17, 2004.<\/li>\n<\/ul>\n<ul>\n<li>Werler MM, Hayes C, Sheehan JE, Mitchell AA. <a target=\"_blank\" href=\"https:\/\/www.bu.edu\/slone\/files\/2012\/11\/Gulf_War_PPT.pdf\">Military service, Gulf War service, and hemifacial microsomia<\/a>. Presented at Teratology Society Annual Meeting. Philadelphia, PA, June 25, 2003.<\/li>\n<\/ul>\n<ul>\n<li>Werler MM, Sheehan JE, Hayes C, Mulliken JB, Mitchell AA. <a target=\"_blank\" href=\"https:\/\/www.bu.edu\/slone\/files\/2012\/11\/ACPA0501_PPT.pdf\">Case-control study of hemifacial microsomia: preliminary findings<\/a>. Presented at American Cleft Palate Craniofacial Association Meeting. Seattle, WA, May 3, 2002.<\/li>\n<\/ul>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Publications<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<ul>\n<li>Cloonan  YK, Kifle Y, Davis S, Speltz ML, Werler MM, Starr JR. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19651569\" target=\"_blank\">Sleep outcomes in  children with hemifacial microsomia and controls: a follow-up study<\/a>.  Pediatrics 2009;124(2):e313-21. doi: 10.1542\/peds.2008-3488. PMCID:  PMC2739665.<\/li>\n<\/ul>\n<ul>\n<li>Werler  MM, Sheehan JE, Mitchell AA. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15602762\" target=\"_blank\">Gulf war veterans and hemifacial  microsomia<\/a>. Birth Defects Res A Clin Mol Teratol 2005;73:50-2.<\/li>\n<\/ul>\n<ul>\n<li>Werler  MM, Sheehan JE, Hayes C, Padwa BL, Mitchell AA, Mulliken JB.  <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15352870\" target=\"_blank\">Demographic and reproductive factors associated with hemifacial  microsomia<\/a>. Cleft Palate Craniofac J 2004;41:494-500.<\/li>\n<\/ul>\n<ul>\n<li>Werler  MM, Sheehan JE, Hayes C, Mitchell AA, Mulliken JB. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15211707\" target=\"_blank\">Vasoactive  exposures, vascular events, and hemifacial microsomia<\/a>. Birth Defects Res  A Clin Mol Teratol 2004;70(6):389-95.<\/li>\n<\/ul>\n<p><\/div>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Objectives To test the hypothesis that hemifacial microsomia (HFM) risk is increased by maternal use of vasoconstrictive decongestants while controlling for the effects of frequency, dose, type and indication; To test the hypothesis that HFM risk is increased by maternal use of other vasoactive exposures, including aspirin, ibuprofen, caffeinated coffee, alcohol, and smoking; To examine [&hellip;]<\/p>\n","protected":false},"author":4351,"featured_media":0,"parent":37,"menu_order":99,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/slone\/wp-json\/wp\/v2\/pages\/426"}],"collection":[{"href":"https:\/\/www.bu.edu\/slone\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/slone\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/slone\/wp-json\/wp\/v2\/users\/4351"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/slone\/wp-json\/wp\/v2\/comments?post=426"}],"version-history":[{"count":9,"href":"https:\/\/www.bu.edu\/slone\/wp-json\/wp\/v2\/pages\/426\/revisions"}],"predecessor-version":[{"id":435,"href":"https:\/\/www.bu.edu\/slone\/wp-json\/wp\/v2\/pages\/426\/revisions\/435"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/slone\/wp-json\/wp\/v2\/pages\/37"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/slone\/wp-json\/wp\/v2\/media?parent=426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}