An Assessment of Whether Aspirin and/or Vitamin D Improves Breast Cancer Outcomes in Black Women and the Modifying Effect of Genetic Variants

The effects of the use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) or of vitamin D status on breast cancer recurrence and mortality are unknown. Such research is critical because breast cancer mortality is disproportionately high in Black women, Black Americans are more likely to be vitamin D deficient, and evidence from White populations suggest that aspirin/NSAID use and higher vitamin D levels may improve prognosis. If aspirin/NSAID use and vitamin D status affect breast cancer recurrence and mortality in Black women, they would provide feasible and cost-effective points of intervention. Additional data on genetic variation would help to identify those individuals most likely to benefit from intervention.