Research from Neural Systems Lab Featured on Cover of The Journal of Neuroscience
In a new article published in the Journal of Neuroscience and featured on the October cover, Serial Prefrontal Pathways Are Positioned to Balance Cognition and Emotion in Primates, BU Neural Systems Lab researchers
Navigating through life requires balancing emotion and reason, a feat accomplished by the brain region “area 32”of the anterior cingulate cortex. The area maintains emotional equilibrium by relaying information between cognitive and emotional brain regions, according to new research in monkeys published in The Journal of Neuroscience.
Emotional balance goes haywire in mood disorders like depression, leading to unchecked negative emotions and an inability to break out of rumination. In fact, people with depression often have an overactive area 25, a region involved in emotional expression. Healthy emotional regulation requires communication between cognitive regions, like the dorsolateral prefrontal cortex (DLPFC), and emotion regions, like area 25, the subgenual cortex. But because these two areas are weakly connected, there must be a middle man involved.
Researchers used bidirectional neuron tracers to visualize the connections between the DLPFC, area 25, and area 32, a potential middleman, in rhesus monkeys. The DLPFC connects to the deepest layers of area 32, where the strongest inhibitory neurons reside. Area 32 connects to every layer of area 25, positioning it as a powerful regulator of area 25 activity. In healthy brains, the DLPFC signals to area 32 to balance area 25 activity, allowing emotional equilibrium. But in depression, silence from the DLPFC results in too much area 25 activity and out–of–control emotional processing.