{"id":13954,"date":"2018-04-18T15:08:08","date_gmt":"2018-04-18T19:08:08","guid":{"rendered":"https:\/\/www.bu.edu\/research\/?page_id=13954"},"modified":"2024-06-13T10:49:56","modified_gmt":"2024-06-13T14:49:56","slug":"sindbis-virus-sinv-agent-information-sheet","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/research\/ethics-compliance\/safety\/rohp\/agent-information-sheets\/sindbis-virus-sinv-agent-information-sheet\/","title":{"rendered":"Sindbis virus (SINV) Agent Information Sheet"},"content":{"rendered":"

Research Occupational Health Program (ROHP)
\nBoston University
\n617-358-7647<\/p>\n

Agent<\/h2>\n

Sindbis fever is a self-limiting, mild, febrile disease with vesicular exanthema and arthralgia.\u00a0 Many infections cause no symptoms. Acutely symptoms consist of headache, fever, arthralgias (small joints).\u00a0 An M-P rash, fatigue, and muscle pain may develop.\u00a0 Rash including vesicular rash can affect trunk, limbs, palms, and sides.\u00a0 Recovery occurs in 14 days.\u00a0 Fifty percent of patients may have joint symptoms for up to 12 months to 2 years.<\/p>\n

    \n
  1. Disease\/Infection<\/strong>
    \nSINV causes a rash-small joint arthritis syndrome characterized by fever, M-P rash, headache, and arthralgia in humans.<\/li>\n
  2. Pathogenicity<\/strong>
    \nSINV usually causes a self-limited febrile illness that resolves in 1-2 weeks; however, arthralgia may persist in 50% of infected people for months to years. Asymptomatic infections occur. Fatal infections have not been reported.<\/li>\n
  3. Biosafety Information<\/strong>\n
      \n
    1. Risk Group\/BSL
      \nRisk Group 2
      \nBiosafety level: BSL2\/ABSL2<\/li>\n
    2. Modes of Transmission<\/strong>
      \nBite from various mosquitoes (Anopheles,\u00a0 Mansonia, Aedes, Culiseta, Culex species).\u00a0 \u00a0Virus has been isolated in ticks.<\/p>\n
      \n\n\n\n\n\n\n
      <\/td>\nTransmission<\/strong><\/td>\n<\/tr>\n
      Skin Exposure (Needlestick, animal bite, or scratch):<\/td>\nNeedlestick<\/td>\n<\/tr>\n
      Mucous Membrane Exposure Splash to Eye(s), Nose or Mouth:<\/td>\nDirect or indirect contact with mucous membranes<\/td>\n<\/tr>\n
      Inhalation:<\/td>\nUnlikely unless aerosolized<\/td>\n<\/tr>\n
      Ingestion:<\/td>\nUnlikely in laboratory setting<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<\/li>\n<\/ol>\n<\/li>\n
    3. Host Range\/Reservoir (Asymptomatic)<\/strong>
      \nWild birds are the natural reservoir.\u00a0 Migratory birds may contribute to transmission.<\/li>\n
    4. Symptoms<\/strong>
      \nLow grade fever, arthralgia, headache, itchy rash, and myalgia<\/li>\n
    5. Incubation Period<\/strong>
      \nUp to 10 days.\u00a0 No person-to-person transmission.<\/li>\n
    6. Viability<\/strong>
      \nSindbis virus can infect and survive outside in cell culture.\u00a0 Also, can survive in biological materials for an extended period.<\/li>\n
    7. Survival Outside Host<\/strong>
      \nCan survive in biologic materials for an extended period.<\/li>\n<\/ol>\n

      Information for Lab Workers<\/h2>\n
        \n
      1. Laboratory PPE<\/strong>
        \nBSL-2 precautions \u2013 lab coat, gown, and gloves. Wear eye protection if splash risk.\u00a0 No lab acquired infections have been reported.<\/li>\n
      2. Containment<\/strong>
        \nBSL-2 and ABSL-2 practices<\/li>\n
      3. In Case of Exposure\/Disease<\/strong>\n
          \n
        1. For injuries in the lab which are major medical emergencies (heart attacks, seizures, etc\u2026):\n
            \n
          1. Medical Campus: call or have a coworker call the Control Center at 617-358-4144<\/strong><\/li>\n
          2. Charles River Campus: call or have a coworker call campus security at 617-353-2121.<\/strong> You will be referred to or transported to the appropriate health care location by the emergency response team.<\/li>\n<\/ol>\n<\/li>\n
          3. For lab exposures (needle sticks, bite, cut, scratch, splash, etc\u2026) involving animals or infectious agents, or for unexplained symptoms or illness call the ROHP 24\/7-hour number (1-617-358-ROHP (7647); or 8-ROHP (7647) if calling from an on-campus location)<\/strong> to be connected with the BU Research Occupational Health Program (ROHP) medical officer. ROHP will refer you to the appropriate health care location.<\/li>\n
          4. Under any of these scenarios, always inform the physician of your work in the laboratory and the agent(s) that you work with.<\/li>\n
          5. Provide the wallet-size agent ID card to the physician.<\/li>\n<\/ol>\n<\/li>\n
          6. Vaccination<\/strong>
            \nNone available<\/li>\n<\/ol>\n

            Information for First Responders\/Medical Personnel<\/h2>\n
              \n
            1. Public Health Issues<\/strong>
              \nAfter exposure: No human-to-human transmission.
              \nIn case of illness: Standard precautions
              \nPPE: Standard precautions<\/li>\n
            2. Diagnosis\/Surveillance<\/strong>
              \nDiagnosed by PCR or 4-fold rise in acute and convalescent serum specimens on blood serology \u2013 IgM and IgG response (ELISA)<\/li>\n
            3. First Aid\/Post Exposure Prophylaxis<\/strong>
              \nPerform one of the following actions:<\/p>\n
              \n\n\n\n\n
              Skin Exposure (Needlestick or scratch):<\/td>\nImmediately go to the sink and thoroughly wash the wound with soap and water for 15 minutes. Decontaminate any exposed skin surfaces with an antiseptic scrub solution.<\/td>\n<\/tr>\n
              Mucous Membrane Splash to Eye(s), Nose or Mouth:<\/td>\nExposure should be irrigated vigorously for 15 minutes.<\/td>\n<\/tr>\n
              Splash Affecting Garments:<\/td>\nRemove garments that may have become soiled or contaminated and place them in a double red plastic bag.<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<\/li>\n
            4. Treatment<\/strong>
              \nThere is no treatment other than supportive care.<\/li>\n
            5. References<\/strong>
              \nEuropean Centre for Disease Prevention and Control. Facts about Sindbis fever. Available at: https:\/\/ecdc.europa.eu\/en\/sindbis-fever\/facts. (Accessed 7\/27\/2017)Kurkela S, R\u00e4tti O, Huhtamo E, et al. Sindbis Virus Infection in Resident Birds, Migratory Birds, and Humans, Finland. Emerging Infectious Diseases. 2008;14(1):41-47. Taylor RM, Hurlbut HS, Work TH, Kingston JR, Frothingham TE. Sindbis virus: a newly recognized arthropod-transmitted virus. Am J Trop Med Hyg. 1955 Sep;4(5):844-62.<\/li>\n
            6. Pathogen Safety Data Sheets:\u00a0 Infectious Substances – Sindbis Virus (SINV)- Government of Canada<\/li>\n<\/ol>\n

              Revised 4\/22\/24<\/p>\n","protected":false},"excerpt":{"rendered":"

              Research Occupational Health Program (ROHP) Boston University 617-358-7647 Agent Sindbis fever is a self-limiting, mild, febrile disease with vesicular exanthema and arthralgia.\u00a0 Many infections cause no symptoms. Acutely symptoms consist of headache, fever, arthralgias (small joints).\u00a0 An M-P rash, fatigue, and muscle pain may develop.\u00a0 Rash including vesicular rash can affect trunk, limbs, palms, and […]<\/p>\n","protected":false},"author":13717,"featured_media":0,"parent":5281,"menu_order":51,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/pages\/13954"}],"collection":[{"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/users\/13717"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/comments?post=13954"}],"version-history":[{"count":8,"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/pages\/13954\/revisions"}],"predecessor-version":[{"id":52733,"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/pages\/13954\/revisions\/52733"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/pages\/5281"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/media?parent=13954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}