{"id":13908,"date":"2018-04-11T16:57:59","date_gmt":"2018-04-11T20:57:59","guid":{"rendered":"https:\/\/www.bu.edu\/research\/?page_id=13908"},"modified":"2019-05-01T12:21:06","modified_gmt":"2019-05-01T16:21:06","slug":"mayaro-virus-mayv","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/research\/ethics-compliance\/safety\/rohp\/agent-information-sheets\/mayaro-virus-mayv\/","title":{"rendered":"Mayaro virus (MAYV) Agent Information Sheet"},"content":{"rendered":"

Research Occupational Health Program (ROHP)
\nBoston University
\n617-358-7647<\/p>\n

Agent<\/h2>\n

Mayaro virus (MAYV) is a single-strand positive RNA virus belonging to the Togaviridae family and genus alphavirus. Since its isolation in Trinidad in 1954, sporadic outbreaks due to MAYV have occurred in Brazil and Bolivia. The virus or antibodies against the virus have also been detected in Brazil, Colombia, Ecuador, Peru, Surinam, Bolivia, French Guiana, Trinidad and Venezuela. MAYV causes an acute febrile illness in humans that is difficult to distinguish clinically from other mosquito-borne infections, such as dengue, chikungunya, and Zika virus.<\/p>\n

    \n
  1. Disease\/Infection<\/strong>
    \nMAYV virus causes acute febrile illness with fever, chills, severe arthralgia, headache, myalgia, and rash.<\/li>\n
  2. Pathogenicity<\/strong>
    \nThe illness is usually self-limited, lasting 3\u20135 days, with uneventful recover, although prolonged arthralgia may occur. A fatal infection with hemorrhagic fever has been reported.<\/li>\n
  3. Biosafety Information<\/strong>\n
      \n
    1. Risk Group\/BSL
      \nRisk Group 2
      \nBiosafety level: BSL2\/ABSL2<\/li>\n
    2. Modes of Transmission<\/strong>
      \nTransmission is thought to occur mainly through mosquito vectors, especially Haemagogus spp., but Aedes spp. mosquitoes may also be competent vectors.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n
      \n\n\n\n\n\n\n
      <\/td>\nTransmission<\/strong><\/td>\n<\/tr>\n
      Skin Exposure (Needlestick, animal bite, or scratch):<\/td>\nAccidental parenteral inoculation or exposure to non-intact skin<\/td>\n<\/tr>\n
      Mucous Membrane Exposure Splash to Eye(s), Nose or Mouth:<\/td>\nDirect or indirect contact with mucous membranes<\/td>\n<\/tr>\n
      Inhalation:<\/td>\nUnlikely unless aerosolized<\/td>\n<\/tr>\n
      Ingestion:<\/td>\nUnlikely in laboratory setting<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n
        \n
      • Host Range\/Reservoir<\/strong>
        \nMosquitoes and vertebrates. Natural reservoirs of MAYV are sylvatic vertebrates, mainly nonhuman primates, birds and reptiles.<\/li>\n
      • Symptoms<\/strong>
        \nFever, severe arthralgia, rash, eye pain, headache, myalgia, and occasionally nausea and vomiting, photophobia, abdominal pain, cough, diarrhea, and sore throat. A fatal infection with hemorrhagic fever has been reported.<\/li>\n
      • Incubation Period<\/strong>
        \nUnknown<\/li>\n
      • Viability<\/strong>
        \nSusceptible to 70% alcohol, 1% sodium hypochlorite, and 2% glutaraldehyde<\/li>\n
      • Survival Outside Host<\/strong>
        \nUnknown<\/li>\n<\/ul>\n

        Information for Lab Workers<\/h2>\n
          \n
        1. Laboratory PPE<\/strong>
          \nBSL-2 precautions \u2013 lab coat, gown, and gloves. Wear eye protection if splash risk.<\/li>\n
        2. Containment<\/strong>
          \nBSL-2 and ABSL-2 practices<\/li>\n
        3. In Case of Exposure\/Disease<\/strong>\n
            \n
          1. For injuries in the lab which are major medical emergencies (heart attacks, seizures, etc\u2026):\n
              \n
            1. Medical Campus: call or have a coworker call the Control Center at 617-414\u20134144.<\/strong><\/li>\n
            2. Charles River Campus: call or have a coworker call campus security at 617-353-2121.<\/strong> You will be referred to or transported to the appropriate health care location by the emergency response team.<\/li>\n<\/ol>\n<\/li>\n
            3. For lab exposures (needle sticks, bite, cut, scratch, splash, etc\u2026) involving animals or infectious agents, or for unexplained symptoms or illness call the ROHP 24\/7 hour number (1-617-358-ROHP (7647); or, 8-ROHP (7647) if calling from an on-campus location)<\/strong> to be connected with the BU Research Occupational Health Program (ROHP) medical officer. ROHP will refer you to the appropriate health care location.<\/li>\n
            4. Under any of these scenarios, always inform the physician of your work in the laboratory and the agent(s) that you work with.<\/li>\n
            5. Provide the wallet-size agent ID card to the physician.<\/li>\n<\/ol>\n<\/li>\n
            6. Vaccination<\/strong>
              \nNone available.<\/li>\n<\/ol>\n

              Information for First Responders\/Medical Personnel<\/h2>\n
                \n
              1. Public Health Issues<\/strong>
                \nNo risk as not transmitted human to human<\/li>\n
              2. Diagnosis\/Surveillance<\/strong>
                \nDiagnosed by PCR or 4 times rise in acute and convalescent serum specimens on blood serology \u2013 IgM and IgG response<\/li>\n
              3. First Aid\/Post Exposure Prophylaxis<\/strong>
                \nPerform one of the following actions:<\/p>\n
                \n\n\n\n\n
                Skin Exposure (Needlestick or scratch):<\/td>\nImmediately go to the sink and thoroughly wash the wound with soap and water for 15 minutes. Decontaminate any exposed skin surfaces with an antiseptic scrub solution.<\/td>\n<\/tr>\n
                Mucous Membrane Splash to Eye(s), Nose or Mouth:<\/td>\nExposure should be irrigated vigorously.<\/td>\n<\/tr>\n
                Splash Affecting Garments:<\/td>\nRemove garments that may have become soiled or contaminated and place them in a double red plastic bag.<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<\/li>\n
              4. Treatment<\/strong>
                \nThere is no treatment other than supportive care.<\/li>\n
              5. References<\/strong>
                \nAuguste AJ, Liria J, Forrester NL, et al. Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010. Emerging Infectious Diseases. 2015;21(10):1742-1750. doi:10.3201\/eid2110.141660.Halsey ES, Siles C, Guevara C, et al. Mayaro Virus Infection, Amazon Basin Region, Peru, 2010\u20132013. Emerging Infectious Diseases. 2013;19(11):1839-1842. doi:10.3201\/eid1911.130777.<\/p>\n

                Lednicky J, De Rochars V, Elbadry M, et al. Mayaro Virus in Child with Acute Febrile Illness, Haiti, 2015. Emerging Infectious Diseases. 2016;22(11):2000-2002. doi:10.3201\/eid2211.161015.<\/p>\n

                Mackay IM, Arden KE. Mayaro virus: a forest virus primed for a trip to the city? Microbes Infect. 2016 Dec;18(12):724-734.<\/p>\n

                Terzian AC, Auguste AJ, Vedovello D, Ferreira MU, da Silva-Nunes M, Speran\u00e7a MA, et al. Isolation and characterization of Mayaro virus from a human in Acre, Brazil.
                \nAm J Trop Med Hyg. 2015 Feb;92(2):401-4.<\/li>\n<\/ol>\n

                <\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

                Research Occupational Health Program (ROHP) Boston University 617-358-7647 Agent Mayaro virus (MAYV) is a single-strand positive RNA virus belonging to the Togaviridae family and genus alphavirus. Since its isolation in Trinidad in 1954, sporadic outbreaks due to MAYV have occurred in Brazil and Bolivia. The virus or antibodies against the virus have also been detected […]<\/p>\n","protected":false},"author":13717,"featured_media":0,"parent":5281,"menu_order":31,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/pages\/13908"}],"collection":[{"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/users\/13717"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/comments?post=13908"}],"version-history":[{"count":5,"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/pages\/13908\/revisions"}],"predecessor-version":[{"id":17211,"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/pages\/13908\/revisions\/17211"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/pages\/5281"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/research\/wp-json\/wp\/v2\/media?parent=13908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}