{"id":1150,"date":"2023-05-31T16:18:10","date_gmt":"2023-05-31T21:18:10","guid":{"rendered":"https:\/\/www.bu.edu\/research\/?post_type=forms-policies&#038;p=1150"},"modified":"2024-04-02T15:28:07","modified_gmt":"2024-04-02T19:28:07","slug":"containment-levels-for-chemical-administration-in-animals","status":"publish","type":"forms-policies","link":"https:\/\/www.bu.edu\/research\/forms-policies\/containment-levels-for-chemical-administration-in-animals\/","title":{"rendered":"Chemical Containment Levels (CCL) for Animal Administration"},"content":{"rendered":"<p><strong>To Print or Save:<\/strong> Download the guidance below as a <a href=\"\/research\/files\/2017\/07\/Chemical-Containment-Levels-for-Animal-Administration-May-2023-Final.docx.pdf\">PDF<\/a><\/p>\n<h2 id=\"introduction-background\">Introduction\/Background<\/h2>\n<p>This program is intended to provide a standardized, risk-assessment based approach to engineering controls, PPE, and husbandry in BU\u2019s animal spaces for work with rodents. Other animals (i.e., birds, aquatic species, sheep, pigs, non-human primates) will require additional risk assessment to determine an appropriate CCL.<\/p>\n<p>This guide focuses on mitigating health hazards associated with the use of chemicals (including biological toxins) and drugs in animal research from the time the material is brought into the animal space until the animal and the material leave the space.&nbsp; Transportation of these materials shall follow the normal recommended safe use and transport guidelines based on the hazards.&nbsp; Chemical and hazardous drug preparation will generally be completed in the research laboratory or animal procedure room <em>not<\/em> the animal housing room.<\/p>\n<p>Chemicals and hazardous drugs are classified into four risk-based categories (CCL1-4, with 4 reserved for the most hazardous) in order to protect researchers, animal care staff, and the environment.&nbsp; The majority of chemicals\/ hazardous drugs with <em>known<\/em> toxicological data will fall within CCL-2.&nbsp; When determining a CCL, it is primarily the researcher\u2019s responsibility to provide data showing the material is non-hazardous, that a hazardous material is contained during and after dosing, or that a hazardous material is contained during dosing and all metabolites are non-hazardous.&nbsp; Researchers planning to euthanize the animal within two hours or less of dosing may apply for an exception to work at a lower CCL.<\/p>\n<h2 id=\"definitions\">Definitions<\/h2>\n<h3 id=\"chemical-containment-level-one-ccl-1\">Chemical Containment Level One (CCL-1)<\/h3>\n<p>CCL-1 is the lowest containment level for <strong>very low risk<\/strong> materials that pose little-to-no potential risk to researchers, Animal Science Center (ASC) staff, or the environment during or post- administration to animals.&nbsp; There are no additional controls beyond what is required by the ASC to work at the approved Animal Biosafety Level (ABSL).<\/p>\n<p><strong>CCL-1 materials include the following:<\/strong><\/p>\n<ul>\n<li>foods used in research,<\/li>\n<li>biodegradable, commercial nanoparticles,<\/li>\n<li>chemicals whose safety data sheet (SDS) states \u201cnot a hazardous substance or mixture\u201d or without an assigned GHS pictogram,<\/li>\n<li>SDS signal word is usually none\/not applicable or warning.<\/li>\n<\/ul>\n<p>Examples include condensed milk, cereals, sugar, phosphate buffered saline (PBS), sodium chloride (NaCl), citric acid.<\/p>\n<h3 id=\"chemical-containment-level-two-ccl-2\">Chemical Containment Level Two (CCL-2)<\/h3>\n<p>CCL-2 are materials that pose <strong>low risk<\/strong> to researchers, ASC staff, or the environment <strong>during<\/strong> administration to animals, <em>but do not present a hazard <strong>post-<\/strong>administration.<\/em>*<\/p>\n<p><strong>Routes of exposure during administration include accidental:<\/strong><\/p>\n<ul>\n<li>inhalation,<\/li>\n<li>direct inoculation,<\/li>\n<li>splatter to mucous membranes or exposed skin, and\/or<\/li>\n<li>ingestion<\/li>\n<\/ul>\n<p>Because of these risks, workers require additional control measures while dosing the animal, see <em>Table 2: CCL PPE and Hazard Control Measures<\/em> below.<\/p>\n<p>Post-administration, no additional controls are needed beyond what is required by ASC to work at the approved ABSL as there is no significant risk of excretion or shedding from the animal and\/or all known metabolites are characterized as non-hazardous.<\/p>\n<p>*<em>Note oral, topical, or rectal dosing on cage card <\/em>as chemical\/hazardous drug can fall off or be spit out and contaminate the inside the cage in the native (hazardous) form.<\/p>\n<p><strong>CCL-2 materials include the following:<\/strong><\/p>\n<ul>\n<li>SDS signal word often warning but can be danger,<\/li>\n<li>Many classes of irritants<\/li>\n<\/ul>\n<p>Examples include acetonitrile, 37% hydrochloric acid, Cefazolin<span>, dimethyl sulfoxide (DMSO).<\/span><\/p>\n<h3 id=\"chemical-containment-level-three-ccl-3\">Chemical Containment Level Three (CCL-3)<\/h3>\n<p>CCL-3 materials pose a <strong>moderate risk<\/strong> to researchers, ASC staff, or the environment during and post-administration to animals.&nbsp; This can be due to the type of chemical and\/or the type of administration (e.g., in drinking water or food).*<\/p>\n<p><strong>Routes of exposure during administration include accidental:<\/strong><\/p>\n<ul>\n<li>inhalation,<\/li>\n<li>direct inoculation,<\/li>\n<li>splatter to mucous membranes or exposed skin, and\/or<\/li>\n<li>ingestion<\/li>\n<\/ul>\n<p>and workers require additional control measures while dosing the animal, see <em>Table 2: CCL PPE and Hazard Control<\/em> Measures below.<\/p>\n<p><strong>Post-administration risks include:<\/strong><\/p>\n<ul>\n<li>chemical excretion or shedding by the animal,<\/li>\n<li>metabolites are known to be hazardous and present in detectable quantities,<\/li>\n<li>metabolites and\/or their amounts and routes of excretion are unknown.<\/li>\n<\/ul>\n<p>Additional controls are required beyond what is typically used to work at the approved ABSL when performing animal husbandry after dosing, see <em>Table 2: CCL PPE and Hazard Control Measures<\/em> below.<\/p>\n<p>Animals dosed with chemicals and\/or hazardous drugs classified as CCL-3 with known short metabolic half-lives, may be moved to CCL-2 housing and care after five (5) metabolic half-lives have passed and 97% of the hazardous material should have cleared.&nbsp; Researchers looking to have animals dosed with CCL-3 materials moved to CCL-2 housing after five half-lives have passed must provide documentation of the biological half-life of the chemical in the species being exposed.*<\/p>\n<p>*<em>Note oral, topical, or rectal dosing on cage card <\/em>as chemical\/hazardous drug can fall off or be spit out and contaminate the inside the cage in the native (hazardous) form.<\/p>\n<p><strong>CCL-3 materials include the following:<\/strong><\/p>\n<ul>\n<li>Many toxic, mutagenic, carcinogenic, and\/or reproductive toxicant materials,<\/li>\n<li>BU HHCs that have not been classified as CCL-4<\/li>\n<\/ul>\n<p>Examples include methanol, Beta-aminopropionitrile (BAPN), isoflurane<span>, cyclophosphamide, streptozotocin, tamoxifen, bleomycin<\/span><\/p>\n<h3 id=\"chemical-containment-level-four-ccl-4\">Chemical Containment Level Four (CCL-4)<\/h3>\n<p>CCL-4 materials pose <strong>high<\/strong> <strong>risk<\/strong> to researchers, ASC staff, or the environment during and post-administration to animals. &nbsp;These materials require special risk assessment from EHS and ASC prior to use and additional containment measures may be necessary.&nbsp; Therefore, CCL-4 materials may not be approved within the standard five (5)-day approval window.<\/p>\n<p><strong>Routes of exposure during administration include accidental:<\/strong><\/p>\n<ul>\n<li>inhalation,<\/li>\n<li>direct inoculation,<\/li>\n<li>splatter to mucous membranes or exposed skin, and\/or<\/li>\n<li>ingestion<\/li>\n<\/ul>\n<p><strong>Post administration risks include:<\/strong><\/p>\n<ul>\n<li>chemical excretion or shedding by the animal,<\/li>\n<li>metabolites are known to be hazardous,<\/li>\n<li>metabolites and\/or their amounts and routes of excretion are unknown.<\/li>\n<\/ul>\n<p>Additional controls are required beyond what is typically used to work at the approved ABSL during administration and when performing animal husbandry after dosing <em>and may include specific PPE, administrative controls (SOP), and\/or engineering controls not typically used in a laboratory setting, <\/em>see <em>Table 2: CCL PPE and Hazard Control Measures<\/em> below.<\/p>\n<p>Animals dosed with chemicals and\/or hazardous drugs classified as CCL-4 generally remain in quarantine housing until they are euthanized. &nbsp;They may be downgraded to a lower CCL after five half-lives have passed based on risk assessment. &nbsp;Documentation of the half-life of the chemical in the species being exposed must be provided.<\/p>\n<p><strong>CCL-4 materials include the following:<\/strong><\/p>\n<ul>\n<li>Any chemical with GHS code H300, H310, and\/or H330 and hazard statement begins \u201cFatal if\u2026\u201d<\/li>\n<li>Chemicals that, in the event of an exposure, require immediate medical intervention and\/or antidote, including:\n<ul>\n<li>Hydrofluoric acid (HF)<\/li>\n<li>Cyanides<\/li>\n<\/ul>\n<\/li>\n<li>Chemicals that require specific PPE to handle safely in the research laboratory including:\n<ul>\n<li>HF<\/li>\n<li>Dimethylmercury<\/li>\n<\/ul>\n<\/li>\n<li>Chemicals that require specific storage (i.e., gas cabinet) or handling procedures to use safely in a research laboratory including:\n<ul>\n<li>Hazardous gases (with an NFPA rating of 3 or 4 in any hazard class (flammable, health, reactivity)) \u2013 i.e., chlorine.<\/li>\n<li>Osmium tetroxide<\/li>\n<\/ul>\n<\/li>\n<li>Certain BU HHCs including organomercury compounds and dioxins<\/li>\n<li>Certain neurotoxins including:\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK27974\/\">MTPT\/MPP+<\/a> (penetrates the blood\u2014brain barrier and enters the brain cells causing Parkinson&#8217;s disease like symptoms)<\/li>\n<li>6-OHDA<\/li>\n<\/ul>\n<\/li>\n<li><span> <\/span>Default for chemicals listed in <a href=\"https:\/\/www.ecfr.gov\/current\/title-40\/chapter-I\/subchapter-I\/part-261\/subpart-C\">40 CFR 261.24 Subpart C- Characteristics of Hazardous Waste<\/a> including their derivatives, salts, compounds, and mixtures;\n<ul>\n<li><a href=\"https:\/\/www.sigmaaldrich.com\/US\/en\/sds\/mm\/1.12067\">powdered lead<\/a><\/li>\n<\/ul>\n<\/li>\n<li><a href=\"https:\/\/www.ecfr.gov\/current\/title-40\/chapter-I\/subchapter-I\/part-261\/subpart-D\/section-261.33\">40 CFR section 261.33 P-listed and U-listed chemicals<\/a>;<\/li>\n<li>Brand new chemicals without SDS or known metabolite data<\/li>\n<\/ul>\n<h2 id=\"roles-responsibilities\">Roles &amp; Responsibilities<\/h2>\n<h3 id=\"iacuc\">IACUC<\/h3>\n<ul>\n<li>Notify EHS Research Safety when protocols for treating animals with potentially hazardous chemicals have been submitted.<\/li>\n<\/ul>\n<h3 id=\"bu-animal-science-center-asc-staff\">BU Animal Science Center (ASC) Staff<\/h3>\n<ul>\n<li>Ensure that appropriate facilities, equipment, and PPE are available for the assigned chemical containment level in BUASC spaces;<\/li>\n<li>Ensure that researchers are following the appropriate procedures defined in the chemical containment level in BUASC spaces. Notify the principal investigator and Environmental Health and Safety if non-compliance is noted;<\/li>\n<li>Ensure that BUASC staff are appropriately trained and follow appropriate cage change procedures, that appropriate cages and bedding are used, and appropriate waste containers are available as required by chemical containment level;<\/li>\n<li>Supply cage cards and signage to the researchers in order to identify rooms and animals involved in procedures using chemicals as dictated by the chemical containment level;<\/li>\n<li>Ensure the appropriate signage was posted by the researcher on the door of the room when animals are being or have been treated with a chemical, as required by the chemical containment level;<\/li>\n<li>Assist in the determination of the CCL based on the individual risk of each project\u2019s chemicals, doses, animal metabolism and other factors and communicate the requirements for that level to the PI and EHS in a timely manner.<\/li>\n<\/ul>\n<h3 id=\"buasc-trainer\">BUASC Trainer<\/h3>\n<ul>\n<li>Provide BUASC-specific training to all researchers and PI\u2019s working in BUASC.<\/li>\n<\/ul>\n<h3 id=\"ehs-research-safety\">EHS Research Safety<\/h3>\n<ul>\n<li>Assist in the determination of the CCL based on the individual risk of each project\u2019s chemicals, doses, animal metabolism and other factors and communicate the requirements for that level to the PI and BUASC in a timely manner;<\/li>\n<li>Update requirements outlined in the chemical containment levels as needed;<\/li>\n<li>Provide assistance to BUASC and PIs in training staff and researchers as requested;<\/li>\n<li>Coordinate review of IACUC protocols within EHS as needed.<\/li>\n<\/ul>\n<h3 id=\"ehs-environmental-management\">EHS Environmental Management<\/h3>\n<ul>\n<li>Make waste determination of bedding, carcasses, cage wash effluent, etc.<\/li>\n<\/ul>\n<h3 id=\"principal-investigators\">Principal Investigators<\/h3>\n<ul>\n<li>Assign a preliminary CCL upon submission of an IACUC protocol;<\/li>\n<li>Provide information to allow EHS Research Safety Staff to perform an appropriate risk assessment for the chemical exposure in animals;<\/li>\n<li>Ensure that research staff are appropriately trained;<\/li>\n<li>Ensure that research staff follows the procedures prescribed by the chemical containment level for the project as specified by EHS;<\/li>\n<li>Notify Research Occupational Health (ROHP) of any suspected exposure to a potentially hazardous chemical.<\/li>\n<\/ul>\n<h3 id=\"research-staff\">Research Staff<\/h3>\n<ul>\n<li>Follow the procedures prescribed by the chemical containment level for the project as specified by EHS. Notify Environmental Health and Safety and BUASC staff if the procedures require modification;<\/li>\n<li>Notify Research Occupational Health (ROHP) of any suspected exposure to a potentially hazardous chemical;<\/li>\n<li>Obtain and post the appropriate signage on the door to the room when animals are being or have been treated with a chemical, as required by the chemical containment level;<\/li>\n<li>Use the appropriate cage card to identify animals that are involved in a project using chemicals, as required by the chemical containment level.<\/li>\n<\/ul>\n<h3 id=\"laboratory-safety-committee\">Laboratory Safety Committee<\/h3>\n<ul>\n<li>Ensure that all work at Boston University and Boston Medical Center is completed per the requirements outlined in the Chemical Hygiene Plan;<\/li>\n<li>Provide enforcement actions against laboratories that are not in compliance with this procedure.<\/li>\n<\/ul>\n<h3 id=\"research-occupational-health-program-rohp\">Research Occupational Health Program (ROHP)<\/h3>\n<ul>\n<li>Provide medical surveillance for hazardous agents in compliance with relevant OSHA standards as indicated by EHS exposure assessment<\/li>\n<li>Provide confidential reproductive counseling for laboratory workers;<\/li>\n<li>Provide immediate first aid care; post exposure risk assessment and guidance;<\/li>\n<li>Review research-related exposure to potentially hazardous chemicals.<\/li>\n<\/ul>\n<h2 id=\"special-requirements\">Special Requirements<\/h2>\n<h3 id=\"training\">Training<\/h3>\n<ul>\n<li>All researchers performing research with animals must attend BUASC\u2019s New Researcher Orientation and Environmental Health and Safety\u2019s Laboratory Safety Training.<\/li>\n<li>Researchers must also be trained on the requirements set forth by the assigned CCL.\n<ul>\n<li>For all CCL\u2019s, the principal investigator must assure that the researchers are informed of the hazards associated with the chemical being used.<\/li>\n<li>For CCL 2, BUASC will communicate the requirements beyond the standard BUASC requirements for non-chemical work to the researcher.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<hr>\n<h2 id=\"table-1-ccl-classification-scheme-by-ghs-hazard-code\">Table 1: CCL Classification Scheme by GHS Hazard Code<\/h2>\n<div class=\"responsive-table\">\n<div class=\"responsive-table\"><table class=\"table table-striped table-bordered\">\n<thead>\n<tr>\n<th style=\"text-align: center;\"><\/th>\n<th style=\"text-align: center;\">Signal Word<\/th>\n<th style=\"text-align: center;\">Pictogram<\/th>\n<th style=\"text-align: center;\">Hazard Code<\/th>\n<th style=\"text-align: center;\">Hazard Statement<\/th>\n<th>\n<p style=\"text-align: center;\">Category<\/p>\n<p style=\"text-align: center;\">29 CFR 1910.1200<\/p>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td rowspan=\"9\" style=\"text-align: center;\"><b>CCL-1<\/b><\/td>\n<td rowspan=\"9\" style=\"text-align: center;\"><span style=\"font-weight: 400;\">None<\/span><\/p>\n<p><span style=\"font-weight: 400;\">or<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Warning<\/span><\/td>\n<td rowspan=\"9\">\n<p style=\"text-align: center;\"><span style=\"font-weight: 400;\">None<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-weight: 400;\">or<\/span><\/p>\n<p><img loading=\"lazy\" src=\"\/research\/files\/2017\/07\/Screen-Shot-2023-06-01-at-9.46.35-AM.png\" alt=\"!\" width=\"61\" height=\"54\" class=\"wp-image-46912 aligncenter\"><\/td>\n<td><span style=\"font-weight: 400;\">H303<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May be harmful if swallowed<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 5<\/span><\/td>\n<\/tr>\n<tr class=\"table-bordered\" scope=\"row\">\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H313<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May be harmful in contact with skin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 5<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H333<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May be harmful if inhaled<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 5<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H315<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Causes skin irritation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 2<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H316<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Causes mild skin irritation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 3<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H319<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Causes serious eye irritation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 2A<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H320<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Causes eye irritation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 2B<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H335<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May cause respiratory irritation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 3<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H336<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May cause drowsiness or dizziness<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 3<\/span><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"8\" style=\"text-align: center;\"><b>CCL-2<\/b><\/td>\n<td rowspan=\"8\" style=\"text-align: center;\"><span style=\"font-weight: 400;\">Warning or<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Danger<\/span><\/td>\n<td rowspan=\"8\"><img loading=\"lazy\" src=\"\/research\/files\/2017\/07\/Screen-Shot-2023-06-01-at-9.46.35-AM.png\" alt=\"!\" width=\"61\" height=\"54\" class=\" wp-image-46912 aligncenter\"><\/p>\n<p style=\"text-align: center;\"><span style=\"font-weight: 400;\">and\/or<\/span><\/p>\n<p><img loading=\"lazy\" src=\"\/research\/files\/2017\/07\/Screen-Shot-2023-06-01-at-9.46.40-AM.png\" alt=\"\" width=\"62\" height=\"50\" class=\" wp-image-46911 aligncenter\"><\/td>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H302<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Harmful if swallowed<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 4<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H312<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Harmful in contact with skin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 4<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H332<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Harmful if inhaled<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 4<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H305<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May be fatal if swallowed and enters airways<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 2<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H314<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Causes severe skin burns and eye damage<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1A, 1B, 1C<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H317<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May cause an allergic skin reaction<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1, 1A, 1B<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H318<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Causes serious eye damage<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H334<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May cause allergy or asthma symptoms or breathing difficulties if inhaled<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1, 1A, 1B<\/span><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"14\" style=\"text-align: center;\"><b>CCL-3<\/b><\/td>\n<td rowspan=\"14\" style=\"text-align: center;\"><span style=\"font-weight: 400;\">Danger<\/span><\/td>\n<td rowspan=\"14\"><img loading=\"lazy\" src=\"\/research\/files\/2017\/07\/Screen-Shot-2023-06-01-at-9.46.58-AM.png\" alt=\"\" width=\"61\" height=\"58\" class=\"wp-image-46909 aligncenter\"><\/p>\n<p style=\"text-align: center;\"><span style=\"font-weight: 400;\">and\/or<\/span><\/p>\n<p><img loading=\"lazy\" src=\"\/research\/files\/2017\/07\/Screen-Shot-2023-06-01-at-9.47.10-AM.png\" alt=\"\" width=\"56\" height=\"51\" class=\"wp-image-46907 aligncenter\"><\/td>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H301<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Toxic if swallowed<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 3<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H311<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Toxic in contact with skin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 3<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H331<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Toxic if inhaled<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 3<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H304<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May be fatal if swallowed and enters airways<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H340<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May cause genetic defects<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1A, 1B<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H341<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Suspected of causing genetic defects<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 2<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H350<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May cause cancer<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1A, 1B<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H351<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Suspected of causing cancer<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 2<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H360<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May damage fertility or the unborn child<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1A, 1B<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H361<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Suspected of damaging fertility or the unborn child<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 2<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H370<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Causes damage to organs<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H371<\/span><\/td>\n<td><span style=\"font-weight: 400;\">May cause damage to organs<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 2<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H372<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Causes damage to organs through prolonged or repeated exposure<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H373<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Causes damage to organs through prolonged or repeated exposure<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 2<\/span><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\">\n<p style=\"text-align: center;\"><b>CCL-4<\/b><\/p>\n<\/td>\n<td rowspan=\"3\">\n<p style=\"text-align: center;\"><span style=\"font-weight: 400;\">Danger<\/span><\/p>\n<\/td>\n<td rowspan=\"3\"><img loading=\"lazy\" src=\"\/research\/files\/2017\/07\/Screen-Shot-2023-06-01-at-9.46.58-AM.png\" alt=\"\" width=\"61\" height=\"58\" class=\" wp-image-46909 aligncenter\"><\/td>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H300<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Fatal if swallowed<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1, 2<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H310<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Fatal in contact with skin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1, 2<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border-left: #CED3D7 solid 1px;\"><span style=\"font-weight: 400;\">H330<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Fatal if inhaled<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Category 1, 2<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2 id=\"table-2-ccl-ppe-and-hazard-control-measures\">Table 2: CCL PPE and Hazard Control Measures<\/h2>\n<div class=\"table-responsive\">\n<div class=\"responsive-table\"><table class=\"table table-bordered table-striped\">\n<thead>\n<tr>\n<th><\/th>\n<th style=\"background: #92D050;\">CCL-1<\/p>\n<p>Very Low Risk<\/th>\n<th style=\"background: #FFFF04;\">CCL-2<\/p>\n<p>Low Risk<\/th>\n<th style=\"background: #FFC001;\">CCL-3<\/p>\n<p>Moderate Risk<\/th>\n<th style=\"background: #FF0000;\">CCL-4<\/p>\n<p>High Risk<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Researcher PPE&nbsp;<\/b><\/p>\n<p><b>(administration)<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li><span style=\"font-weight: 400; padding-left: 0;\">Normal for ABSL with<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye protection<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL with<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye protection<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL with<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye protection&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Additional PPE as needed after risk assessment<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>Researcher PPE&nbsp;<\/b><\/p>\n<p><b>(post-administration)<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL&nbsp;<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL with&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye protection<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL with<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye protection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Additional PPE as needed after risk assessment<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>ASC PPE<\/b><\/p>\n<p><b>(post-administration)<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"3\"><span style=\"font-weight: 400;\">Respiratory protection for dirty cage wash<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL with&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye protection<\/span><\/li>\n<\/ul>\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"3\"><span style=\"font-weight: 400;\">(Respiratory protection for dirty cage wash)<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Not applicable \u2013 researchers will do all animal and cage handling<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>Engineering Controls (administration)<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Preparing stock solutions and\/ or neat substances require chemical fume hood or Type II hard ducted biosafety cabinet, otherwise normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">All administration requires chemical fume hood or Type II hard ducted biosafety cabinet&nbsp;<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">All administration requires chemical fume hood or Type II hard ducted biosafety cabinet<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Additional engineering controls after risk assessment&nbsp;<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>Engineering Controls (post-administration)<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chemical fume hood or Type II hard ducted biosafety cabinet<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Environmental monitoring for cage dump as needed<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chemical fume hood or Type II hard ducted biosafety cabinet<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Additional engineering controls after risk assessment<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>Additional Practices &amp; Procedures<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use appropriate engineering controls<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sharps precautions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Spill\/emergency response supplies<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cages are packaged and transported according to ASC guidelines<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Highly hazardous chemicals (HHC) require SOP<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use appropriate engineering controls<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sharps precautions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Spill\/emergency response supplies<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use appropriate engineering controls<\/span><\/li>\n<\/ul>\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agent \/ HHC specific SOP&nbsp;<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Sharps precautions<\/span><\/p>\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Spill\/emergency response supplies<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>Cages<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Micro-isolator<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Micro-isolator&nbsp;<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Micro-isolator&nbsp;<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><i><span style=\"font-weight: 400;\">Disposable<\/span><\/i><span style=\"font-weight: 400;\"> cage<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>Bedding<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low dust bedding<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low dust bedding<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>Housing<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Quarantine room<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">(May move to CCL-2 housing after 5 metabolic half-lives)<\/span><\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Quarantine room<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>Signage &amp; labeling<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">CCL-2 cage &amp; door card<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">CCL-3 cage &amp; door card<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">CCL-4 cage &amp; door card<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>ASC Post-Admin. Animal Husbandry &amp; Cage Cleaning<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">ASC Staff&nbsp;<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">ASC Staff<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">ASC Staff<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Researchers&nbsp;<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>Waste Management<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Residual chemicals- dispose per hazardous waste guidelines<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sharps- dispose per sharps guidance<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Residual chemicals- dispose per hazardous waste guidelines in SAA<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sharps- dispose per sharps guidance<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Residual chemicals- dispose per hazardous waste guidelines in SAA<\/span><\/li>\n<\/ul>\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sharps- dispose per sharps guidance<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>Bedding Waste<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">EHS to make hazardous waste determination if characteristically hazardous reagents or HHCs are present in the bedding waste.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.ecfr.gov\/current\/title-40\/chapter-I\/subchapter-I\/part-261\/subpart-C\"><span style=\"font-weight: 400;\">40 CFR 261.24 Subpart C- Characteristics of Hazardous Waste<\/span><\/a><\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">EHS to make hazardous waste determination if characteristically hazardous reagents or HHCs are present in the bedding waste.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.ecfr.gov\/current\/title-40\/chapter-I\/subchapter-I\/part-261\/subpart-C\"><span style=\"font-weight: 400;\">40 CFR 261.24 Subpart C- Characteristics of Hazardous Waste<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><b>Carcass Waste<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal for ABSL<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">EHS to make hazardous waste determination if characteristically hazardous reagents or HHCs are present in the carcass waste.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.ecfr.gov\/current\/title-40\/chapter-I\/subchapter-I\/part-261\/subpart-C\"><span style=\"font-weight: 400;\">40 CFR 261.24 Subpart C- Characteristics of Hazardous Waste<\/span><\/a><\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">EHS to make hazardous waste determination if characteristically hazardous reagents or HHCs are present in the carcass waste.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.ecfr.gov\/current\/title-40\/chapter-I\/subchapter-I\/part-261\/subpart-C\"><span style=\"font-weight: 400;\">40 CFR 261.24 Subpart C- Characteristics of Hazardous Waste<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><b>ROHP<\/b><\/td>\n<td style=\"background: #E2EFD9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal&nbsp;<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFFFC9;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Standard agent specific<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFE38B;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Standard agent specific<\/span><\/li>\n<\/ul>\n<\/td>\n<td style=\"background: #FFC1C2;\">\n<ul style=\"padding-left: 0.5em;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agent specific.&nbsp; Additional monitoring may be required.<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<\/div>\n","protected":false},"template":"page-templates\/chapter-navigation.php","form_policy_kind":[147],"classes":"post-1150 forms-policies type-forms-policies status-publish hentry stage-conducting-research form_policy_kind-policy","modified_text":"April 2, 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