BU Researchers ID Possible Biomarker for Diagnosing CTE during Life

MED’s Ann McKee calls findings a hopeful step

Ann McKee (left), director of BU’s CTE Center, and Jonathan Cherry, a BU School of Medicine postdoctoral fellow, have written a study, published September 26, 2017, reporting that a new chronic traumatic encephalopathy biomarker has been discovered that could potentially allow diagnosis of the disease during life. Photo by Cydney Scott

Chronic traumatic encephalopathy (CTE), a progressive degenerative brain disease found in people with a history of repeated head trauma, can currently be detected only after death, through an autopsy. Absent being able to diagnose the disease in living patients, researchers cannot develop treatments for CTE.

In the past several years, scientists have taken small steps forward in identifying possible biomarkers for the disease, and now researchers from the Boston University School of Medicine (MED) and the VA Boston Healthcare System (VABHS) have discovered a new biomarker that may potentially allow the disease to be diagnosed in the living.

In a study published on September 26, 2017, in the journal PLOS ONE, the researchers found that the biomarker, the protein CCL11, might also help distinguish CTE from Alzheimer’s disease, which often presents with symptoms similar to CTE and also can be definitively diagnosed only postmortem. The ability to diagnose CTE in the living would allow not only for the development of possible therapies to treat the disease but also for research into prevention.

“This is a step forward from our knowledge gained in understanding CTE from brain donations,” says study senior author Ann McKee, a MED professor of neurology and pathology, director of BU’s CTE Center, and chief of neuropathology at VABHS. “It’s a hopeful step. The whole point is to understand as much as we can from the individuals who’ve fallen, so we can apply it to our future veterans and athletes.”

The new research “offers a possible mechanism for distinguishing between CTE and other diseases,” says study first author Jonathan Cherry, a MED postdoctoral fellow in neurology. “By making it possible to distinguish between normal individuals and individuals with Alzheimer’s disease, CTE therapies can become more targeted and hopefully more effective.”

Microscopic images of tau, stained red, embedded in samples of normal, mild CTE, and severe CTE brain tissue
A sample of normal brain tissue (top, left), alongside samples showing mild and severe CTE. The brown stain indicates tangles of tau protein. Defective tau is associated with CTE, Alzheimer’s disease, and Parkinson’s disease. The bottom row shows microscopic images of tau, stained red, embedded in brain tissue. Photo by Ann McKee

Cherry and the other researchers studied the brains of 23 former college and professional football players. They compared them to the brains of 50 nonathletes with Alzheimer’s disease and 18 nonathlete controls.

They found baseline levels of CCL11 in the brains of the nonathlete controls and the nonathletes with Alzheimer’s disease, but the CCL11 levels were significantly elevated in the brains of people with CTE. They then compared the degree of elevation of CCL11 to the number of years those people played football and found that there was a positive correlation between the CCL11 levels and the number of years played.

The researchers were able to take postmortem samples of the cerebrospinal fluid (CSF) from four of the control individuals, seven of the people with CTE, and four of the people with Alzheimer’s. They found that CCL11 levels in the CSF were similarly normal in the control individuals and people with Alzheimer’s, but elevated in those people with CTE. Cherry says that this suggests that the presence of CCL11 might one day be able to assist in the detection of CTE in the living.

Additional studies are needed, the study authors say, to determine whether increased levels of CCL11 occur early or late in the CTE disease process, and whether CCL11 levels might be able to predict the severity of a person’s disease.

“What’s most likely going to happen is that we’ll end up with a panel of biomarkers—maybe three or four—that will let us diagnose CTE reliably,” Cherry says.

A version of this article was originally published in BU Today.

2 comments

  1. Sara, thank you for the article. This is an interesting discovery. I was surprised to see that CCL11 levels appeared normal in all non-athletes. I am curious to know the age of the control group. I only mention this because a separate 2011 study showed that CCL11 levels increased naturally as part of the aging process (https://www.ncbi.nlm.nih.gov/pubmed/21886162).

    “We identify chemokines–including CCL11 (also known as eotaxin)–the plasma levels of which correlate with reduced neurogenesis in heterochronic parabionts and aged mice, and the levels of which are increased in the plasma and cerebrospinal fluid of healthy ageing humans.”

  2. Can you comment about the relationship between this study and the DETECT-CTE (completed) and DIAGNOSE-CTE (in progress) also at Boston U? DETECT-CTE showed a “tau” blood biomarker (Exosome Science’s TauSome) was 9 times higher in NFL players than in controls. DIAGNOSE-CTE is using both that biomarker and a PET scan using AVID Radiopharmaceutical’s AV-1451 contrast agent (I think that’s the right number). Does Boston now have an opinion about whether CCL11 is a better route than TauSome? When is more DIAGNOSE-CTE data expected?

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