{"id":3180,"date":"2023-02-21T16:00:53","date_gmt":"2023-02-21T21:00:53","guid":{"rendered":"https:\/\/www.bu.edu\/reinhardlab\/?page_id=3180"},"modified":"2023-03-10T13:57:53","modified_gmt":"2023-03-10T18:57:53","slug":"artificial-virus-nanoparticles","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/reinhardlab\/research\/artificial-virus-nanoparticles\/","title":{"rendered":""},"content":{"rendered":"<h1 style=\"text-align: center;\">Artificial Virus Nanoparticles<\/h1>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" src=\"\/reinhardlab\/files\/2023\/03\/Scheme.png\" alt=\"\" width=\"386\" height=\"304\" class=\"size-full wp-image-3257 aligncenter\" srcset=\"https:\/\/www.bu.edu\/reinhardlab\/files\/2023\/03\/Scheme.png 386w, https:\/\/www.bu.edu\/reinhardlab\/files\/2023\/03\/Scheme-381x300.png 381w\" sizes=\"(max-width: 386px) 100vw, 386px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>We developed artificial virus nanoparticles (AVNs) to track the infectious pathways of viruses through conventional optical methods. AVNs features a metal nanoparticle core, which is detected using scattering microscopy, and a lipid outer layer, which can be composed of any stable lipid membrane structure. Variation of the lipid composition during synthesis offers a unique opportunity to structure the lipid membrane for distinct purposes.<\/p>\n<p>Ganglioside (GM3)-functionalized LPNs can be sequestrated in nonlysosomal compartments through GM3-CD169 binding and recapitulate key aspects of HIV-1 uptake and trafficking in macrophages. GM3-functionalized LPNs are assembled with polylactic acid (PLA) core and lipid membrane containing 1,2-dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), cholesterol, and GM3, which captures all the main properties of HIV-1 membrane.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Artificial Virus Nanoparticles &nbsp; &nbsp; We developed artificial virus nanoparticles (AVNs) to track the infectious pathways of viruses through conventional optical methods. AVNs features a metal nanoparticle core, which is detected using scattering microscopy, and a lipid outer layer, which can be composed of any stable lipid membrane structure. Variation of the lipid composition during [&hellip;]<\/p>\n","protected":false},"author":20667,"featured_media":0,"parent":15,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/reinhardlab\/wp-json\/wp\/v2\/pages\/3180"}],"collection":[{"href":"https:\/\/www.bu.edu\/reinhardlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/reinhardlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/reinhardlab\/wp-json\/wp\/v2\/users\/20667"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/reinhardlab\/wp-json\/wp\/v2\/comments?post=3180"}],"version-history":[{"count":5,"href":"https:\/\/www.bu.edu\/reinhardlab\/wp-json\/wp\/v2\/pages\/3180\/revisions"}],"predecessor-version":[{"id":3256,"href":"https:\/\/www.bu.edu\/reinhardlab\/wp-json\/wp\/v2\/pages\/3180\/revisions\/3256"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/reinhardlab\/wp-json\/wp\/v2\/pages\/15"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/reinhardlab\/wp-json\/wp\/v2\/media?parent=3180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}