{"id":377,"date":"2019-11-21T12:27:02","date_gmt":"2019-11-21T17:27:02","guid":{"rendered":"https:\/\/www.bu.edu\/physics\/?post_type=profile&p=377"},"modified":"2023-07-11T13:10:52","modified_gmt":"2023-07-11T17:10:52","slug":"kenneth-rothschild","status":"publish","type":"profile","link":"https:\/\/www.bu.edu\/physics\/profile\/kenneth-rothschild\/","title":{"rendered":"Kenneth Rothschild"},"content":{"rendered":"

Research Interests:<\/h3>\n

Molecular Biophysics<\/strong><\/p>\n

We, The Molecular Biophysics Laboratory, are developing advanced biophysical methods in vibrational spectroscopy combined with advanced techniques in biomolecular engineering to understand the molecular mechanisms of membrane protein function. The group focuses primarily on rhodopsins, a large family of integral membrane proteins involved in animal vision and photo-sensing and ion transport in bacteria and algae. One important application of this work is the development of optogenetic proteins for use in neuroscience research, such as elucidating the functioning of complex neural circuits and understanding the basis for neurodegenerative diseases.<\/p>\n

Selected Publications:<\/h3>\n

\u201cStructural Changes in an Anion Channelrhodopsin: Formation of the K and L Intermediates at 80 K.\u201d Yi, A., Li, H., Mamaeva, N., Fernandez De Cordoba, R. E., Lugtenburg, J., DeGrip, W. J., Spudich, J. L., and Rothschild, K. J. (2017)\u00a0<\/span>Biochemistry<\/em>\u00a0<\/span>56<\/strong>, 2197-2208<\/p>\n

\u201cThe early development and application of FTIR difference spectroscopy to membrane proteins: A personal perspective.\u201d Rothschild, K. J. (2016)\u00a0<\/span>Biomedical Spectroscopy and Imaging<\/em>\u00a0<\/span>5<\/strong>, 231-267<\/p>\n

\u201cProton transfers in a channelrhodopsin-1 studied by Fourier transform infrared (FTIR) difference spectroscopy and site-directed mutagenesis.\u201d Ogren, J. I., Yi, A., Mamaev, S., Li, H., Spudich, J. L., and Rothschild, K. J. (2015)\u00a0<\/span>J Biol Chem<\/em>\u00a0<\/span>290<\/strong>, 12719-12730<\/p>\n

\u201cVibrational spectroscopy of bacteriorhodopsin mutants: light-driven proton transport involves protonation changes of aspartic acid residues 85, 96, and 212.\u201d Braiman, M. S., Mogi, T., Marti, T., Stern, L. J., Khorana, H. G., and Rothschild, K. J. (1988)\u00a0<\/span>Biochemistry<\/em>\u00a0<\/span>27<\/strong>, 8516-8520<\/p>\n

\u201cNanometer molecular lithography\u201d Douglas, K., Clark, N. A., and Rothschild, K. J. (1986).\u00a0<\/span>Appl. Phys. Lett.<\/em>\u00a0<\/span>48<\/strong>, 676-678<\/p>\n

For a full list of publications, please see the attached CV<\/a>.<\/p>\n

Honors\/Awards:<\/h3>\n
    \n
  • Fellow of the National Academy of Inventors<\/li>\n
  • Fellow of the American Physical Society<\/li>\n
  • Fellow of the Sloan Research Foundation<\/li>\n<\/ul>\n","protected":false},"author":15235,"template":"","_links":{"self":[{"href":"https:\/\/www.bu.edu\/physics\/wp-json\/wp\/v2\/profile\/377"}],"collection":[{"href":"https:\/\/www.bu.edu\/physics\/wp-json\/wp\/v2\/profile"}],"about":[{"href":"https:\/\/www.bu.edu\/physics\/wp-json\/wp\/v2\/types\/profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/physics\/wp-json\/wp\/v2\/users\/15235"}],"version-history":[{"count":2,"href":"https:\/\/www.bu.edu\/physics\/wp-json\/wp\/v2\/profile\/377\/revisions"}],"predecessor-version":[{"id":1835,"href":"https:\/\/www.bu.edu\/physics\/wp-json\/wp\/v2\/profile\/377\/revisions\/1835"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/physics\/wp-json\/wp\/v2\/media?parent=377"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}