{"id":798,"date":"2017-03-03T12:05:54","date_gmt":"2017-03-03T17:05:54","guid":{"rendered":"https:\/\/www.bu.edu\/photonics-ret\/?page_id=798"},"modified":"2021-09-28T12:20:03","modified_gmt":"2021-09-28T16:20:03","slug":"keith-brown","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/photonics-ret\/research-projects\/projects-2025\/2017-summer-projects\/keith-brown\/","title":{"rendered":"Keith Brown"},"content":{"rendered":"<h3><span>Patterned Enzymatic Growth of Materials<\/span><\/h3>\n<p><strong>PROJECT DESCRIPTION<br \/>\n<\/strong><strong><img loading=\"lazy\" src=\"https:\/\/www.bu.edu\/eng\/files\/2015\/12\/ME.Faculty.KeithABrown_June2015.jpg\" alt=\"ME.Faculty.KeithABrown_June2015\" width=\"192\" height=\"289\" class=\"alignright\" \/><\/strong>The goal of this project is to combine aspects of top down patterning and bottom-up bioassembly to create new hierarchical materials. Specifically, we have recently developed a method for patterning hydrogel films loaded with active enzymes. The REU and RET will combine this protocol and procedures for directing enzymes to grow functional materials as a means of growing materials with spatially patterned structural, conductive, and optical elements. Ultimately, this is a basic science project and the researchers will seek to understand the limitations and opportunities inherent to templated enzymatic growth of materials in porous environments.<\/p>\n<p><strong>LABORATORY MENTOR<\/strong><br \/>\n<a href=\"mailto:leli1990@bu.edu\" target=\"_blank\" rel=\"noopener noreferrer\">Le Li<\/a><\/p>\n<p><strong>RESEARCH GOALS<\/strong><br \/>\n<span>\u2022<\/span> Develop a method for quantifying the location and concentration of enzymes in photopatterned hydrogel films.<br \/>\n<span>\u2022<\/span>\u00a0Observe the growth of conductive nanowires, structural nanocrystals, and optical elements with high spatial resolution.<br \/>\n<span>\u2022<\/span>\u00a0Understand the constraints of materials growth in terms of resolution.<\/p>\n<p><strong>LEARNING GOALS<\/strong><br \/>\n<span>\u2022<\/span>\u00a0The REU and RET students will learn cleanroom microfabrication techniques as well as biomolecular growth and materials characterization.<br \/>\n<span>\u2022<\/span>\u00a0Learn how to design robust experiments and interpret results in systems where characterization is incomplete.<br \/>\n<span>\u2022<\/span>\u00a0There is a creative element of this project in designing novel hierarchical materials.<\/p>\n<p><strong>TIMELINE<\/strong><br \/>\n<span style=\"text-decoration: underline;\">Weeks 1-3<\/span>: develop a series of protocols for immobilizing different enzymes in hydrogel films and measuring their concentration.<br \/>\n<span style=\"text-decoration: underline;\">Weeks 3-6<\/span>: Observe the enzyme-mediated growth of materials originating from these immobilized enzymes<br \/>\n<span style=\"text-decoration: underline;\">Weeks 6-9<\/span>: Explore novel hierarchical structures and parameterize emergent mechanical, electrical, and optical properties.<\/p>\n<p><strong>Learn more about Professor Brown on his <a href=\"https:\/\/www.bu.edu\/eng\/profile\/keith-brown\/\" target=\"_blank\" rel=\"noopener noreferrer\">faculty page<\/a>.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Patterned Enzymatic Growth of Materials PROJECT DESCRIPTION The goal of this project is to combine aspects of top down patterning and bottom-up bioassembly to create new hierarchical materials. Specifically, we have recently developed a method for patterning hydrogel films loaded with active enzymes. The REU and RET will combine this protocol and procedures for directing [&hellip;]<\/p>\n","protected":false},"author":12283,"featured_media":0,"parent":1201,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/798"}],"collection":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/users\/12283"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/comments?post=798"}],"version-history":[{"count":10,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/798\/revisions"}],"predecessor-version":[{"id":1728,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/798\/revisions\/1728"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/1201"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/media?parent=798"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}