{"id":790,"date":"2017-03-03T11:38:03","date_gmt":"2017-03-03T16:38:03","guid":{"rendered":"https:\/\/www.bu.edu\/photonics-ret\/?page_id=790"},"modified":"2021-09-28T12:19:43","modified_gmt":"2021-09-28T16:19:43","slug":"douglas-densmore","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/photonics-ret\/research-projects\/projects-2025\/2017-summer-projects\/douglas-densmore\/","title":{"rendered":"Douglas Densmore"},"content":{"rendered":"

Microfabrication of Lab on a Chip Devices<\/h3>\n

PROJECT DESCRIPTION<\/strong>
\n\"DougMicrofluidics has the potential to address numerous challenges in the field of synthetic biology [1-3]. However, the cost barrier of the common microfluidic design (lack of automation) and fabrication method (photolithography), has slowed down the contribution of microfluidics in the field of biology. CIDAR lab has developed a low cost rapid manufacturing platform based on micromachining that allows researchers to specify, design, build, and test microfluidic chips in an automated manner.<\/p>\n

[1] Ferry, M. S., I. A. Razinkov, and J. Hasty. “Microfluidics for synthetic biology: from design to execution.” Methods in enzymology 497 (2011): 295.
\n[2] H. Huang, \u201cFluigi: An end-to-end Software Workflow for Microfluidic Design,\u201d Boston University, 2015.
\n[3] Gulati, Shelly, et al. “Opportunities for microfluidic technologies in synthetic biology.” Journal of The Royal Society Interface (2009): rsif20090083.<\/p>\n

ABOUT THE LAB<\/strong>
\nCross-Disciplinary Integration of Design Automation Research (CIDAR) focuses on the development of tools that help accelerate research in synthetic biology. These tools range from computational, physical, biological and incorporate ideas from different fields into synthetic biology.<\/p>\n

LABORATORY MENTOR<\/strong>
\nAli Lashkaripour<\/a><\/p>\n

RESEARCH GOALS<\/strong>
\n\u2022<\/span>\u00a0Build microfluidic systems and will also help contribute to the verification of Neptune, a software platform for microfluidic chip design automation, fabrication and control developed in CIDAR lab.
\n\u2022<\/span>\u00a0Researcher will have to fabricate and test the proposed designs by Neptune and verify the design automation process.
\n\u2022<\/span>\u00a0The design output of Neptune will be fabricated on polycarbonate stock using a desktop micro-CNC mill.
\n\u2022<\/span>\u00a0Ultimately, this will lead to automated design of lab on a chip devices that could play a major role in advancing the field of synthetic biology.<\/p>\n

LEARNING GOALS<\/strong>
\n\u2022 Microfluidics:<\/span> The researcher will have the opportunity to shadow and learn about the fundamental concepts of designing microfluidic systems and understanding the fluid dynamics seen in these systems.
\n\u2022 Manufacturing:<\/span> The researcher will master microfabrication and microfluidic chip assembly protocols developed at CIDAR [transposer ref].
\n\u2022 CAD\/CAM Tools:<\/span> The researcher will have the opportunity to use CAD\/CAM tools like Solidworks and Autodesk Fusion 360 during the design process.
\n\u2022 Embedded Systems:<\/span>\u00a0The researcher will also get familiarized with using microfluidic peripheral devices including syringe pumps, microscopes and Arduinos.<\/p>\n

TIMELINE OF PROJECT<\/strong>
\nWeeks 1-2:<\/span> Learning the CIDAR tools and manufacturing protocols
\nWeeks 2-4:<\/span> Literature research on microfluidics applications in Synthetic biology
\nWeek 5:<\/span> Initial design and prototyping and design. Establishment of performance metrics
\nWeeks 6-8:<\/span> Iteration and Verification of design
\nWeek 9:<\/span> Documentation of work and poster preparation<\/p>\n

Learn more about Professor Denmore\u00a0on his faculty page<\/a>.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Microfabrication of Lab on a Chip Devices PROJECT DESCRIPTION Microfluidics has the potential to address numerous challenges in the field of synthetic biology [1-3]. However, the cost barrier of the common microfluidic design (lack of automation) and fabrication method (photolithography), has slowed down the contribution of microfluidics in the field of biology. CIDAR lab has […]<\/p>\n","protected":false},"author":12283,"featured_media":0,"parent":1201,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/790"}],"collection":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/users\/12283"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/comments?post=790"}],"version-history":[{"count":13,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/790\/revisions"}],"predecessor-version":[{"id":1689,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/790\/revisions\/1689"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/1201"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/media?parent=790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}