{"id":610,"date":"2016-03-23T15:33:57","date_gmt":"2016-03-23T19:33:57","guid":{"rendered":"https:\/\/www.bu.edu\/photonics-ret\/?page_id=610"},"modified":"2021-09-28T12:13:45","modified_gmt":"2021-09-28T16:13:45","slug":"irving-bigio","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/photonics-ret\/research-projects\/projects-2025\/2016-summer-projects\/irving-bigio\/","title":{"rendered":"Irving Bigio"},"content":{"rendered":"<h3>Monitoring Response of Tumor Cells to Treatment Using Optical Spectroscopy<\/h3>\n<figure id=\"attachment611\" aria-describedby=\"caption-attachment611\" style=\"width: 199px\" class=\"wp-caption alignright\"><img loading=\"lazy\" src=\"\/photonics-ret\/files\/2016\/03\/bigio.jpg\" alt=\"Prof. Irving Bigio, BME and ECE\" class=\"wp-image-611\" height=\"252\" width=\"189\" \/><figcaption id=\"caption-attachment611\" class=\"wp-caption-text\">Prof. Irving Bigio, BME and ECE<\/figcaption><\/figure>\n<p><strong>PROJECT DESCRIPTION<\/strong><br \/>\n<span>By measuring the spectrum of light scattered back from tumor cells, changes in the nano-scale structures in the cells can provide early indications of response to chemotherapy agents. In this project, the student will develop 3-dimensional cultures of tumor cells, and then use an optical scattering spectroscopy system to measure the changes in the backscattered spectrum from the cell cultures. By analyzing changes in the optical spectrum at a series of time point following administration of chemotherapy agents, the rate of spectral changes can be used to monitor the effectiveness of treatment for various drugs and dosages.<\/span><span style=\"color: black; font-family: Calibri,sans-serif; font-size: small;\" face=\"Calibri,sans-serif\" color=\"black\" size=\"2\"><span><span style=\"font-family: sans-serif; font-size: xx-small;\" face=\"sans-serif\" size=\"1\"><\/span><\/span><\/span><\/p>\n<p><strong>LEARNING GOALS<\/strong><br \/>\n<span>\u2022 <\/span>Understanding some of the hallmarks of cancer at the cellular and sub-cellular levels.<br \/>\n<span>\u2022 <\/span>Understanding how backscattered light can provide spectral information about the sub-cellular structures, and their changes as a result of cancer, and treatment for cancer.<br \/>\n<span><span>\u2022 Optical instrumentation for spectroscopy and optical measurements on tissue-mimicking phantoms.<br \/>\n<\/span><\/span>\u2022 Statistical analysis of experimental data.<\/p>\n<p><strong>Learn more about <a href=\"https:\/\/www.bu.edu\/eng\/profile\/irving-bigio\/\">Professor Bigio&#8217;s<\/a> work at his <a href=\"http:\/\/www.bu.edu\/bmo\/\" target=\"_blank\" rel=\"noopener noreferrer\">lab website<\/a>.<\/strong><\/p>\n<div class=\"mceTemp\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Monitoring Response of Tumor Cells to Treatment Using Optical Spectroscopy PROJECT DESCRIPTION By measuring the spectrum of light scattered back from tumor cells, changes in the nano-scale structures in the cells can provide early indications of response to chemotherapy agents. In this project, the student will develop 3-dimensional cultures of tumor cells, and then use [&hellip;]<\/p>\n","protected":false},"author":11551,"featured_media":0,"parent":780,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/610"}],"collection":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/users\/11551"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/comments?post=610"}],"version-history":[{"count":7,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/610\/revisions"}],"predecessor-version":[{"id":1711,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/610\/revisions\/1711"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/780"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/media?parent=610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}