{"id":2320,"date":"2023-06-21T15:25:47","date_gmt":"2023-06-21T19:25:47","guid":{"rendered":"https:\/\/www.bu.edu\/photonics-ret\/?page_id=2320"},"modified":"2023-06-21T15:42:14","modified_gmt":"2023-06-21T19:42:14","slug":"alice-white-2023","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/photonics-ret\/alice-white-2023\/","title":{"rendered":"Characterizing Flow Through Cylindrical Constriction Devices"},"content":{"rendered":"<h4><strong><span style=\"color: #000000;\">Project Description<\/span><\/strong><\/h4>\n<p><span>When blood flows through a constriction, red blood cells within the whole blood can become damaged (hemolysis). This project involves the study of fluid dynamics through cylindrical constriction devices. A glycerol-water mixture, designed to mimic the behavior of human blood, will be driven by a syringe pump through the constriction device. A high precision load cell, adapted for use with the pump, is employed to measure the force, and thereby the pressure inside the syringe. The project further encompasses the use of computational fluid dynamics (COMSOL) to model the flow within the constriction device, comparing these simulations with experimental results. The project will then proceed to computationally simulate human blood as the working fluid. This will offer insights into the experiences of red blood cells traversing the device, thereby contributing to the larger goal of accurately modeling hemolysis in fluid flows.<\/span><\/p>\n<h4><span style=\"color: #000000;\"><strong>Mentors<\/strong><\/span><\/h4>\n<p>Alice White &amp; <span>Oliver McRae<\/span><\/p>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h4 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Research Goals<\/h4><div class=\"bu_collapsible_section\" style=\"display: none;\">\u2022 Experimentally characterize the pressure required to drive a glycerol-water mixture through various cylindrical constriction devices using a syringe pump and high precision load cell<br \/>\n\u2022 Use computational fluid dynamics (COMSOL) to model flow inside the constriction device and compare these simulations with the experimental results<br \/>\n\u2022 Simulate the flow of human blood within the device to better understand what the red blood cells undergo as they traverse the device<\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h4 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Learning Goals<\/h4><div class=\"bu_collapsible_section\" style=\"display: none;\">\u2022 Gain familiarity with preparing glycerol-water mixtures that mimic the behavior of human blood, and the operation of a syringe pump.<br \/>\n\u2022 Learn how to use a high precision load cell in conjunction with a syringe pump to measure pressure.<br \/>\n\u2022 Learn to use computational fluid dynamics software (COMSOL) to model fluid flow within cylindrical constriction devices.<br \/>\n\u2022 Compare simulation results with experimental data, and learn the nuances of interpreting and reconciling the two.<br \/>\n\u2022 Gain exposure to applying computational simulations to biological systems, specifically modeling the flow of human blood.<br \/>\n\u2022 Continue to develop effective scientific communication skills.<\/div>\n<\/div>\n\n<h4><span style=\"color: #000000;\"><strong>Project Timeline<\/strong><\/span><\/h4>\n<p><span>Weeks 1-2: Lab orientation, learn to operate syringe pump and load cell, prepare glycerol-water mixtures, start experiments with cylindrical constriction devices, and basic training in COMSOL for fluid dynamics.<\/span><br \/>\n<span>Weeks 3-4: Continue experiments and simulations, compare experimental data with simulations. Plan for human blood simulations.<\/span><br \/>\n<span>Weeks 5-6: Implement and interpret human blood simulations, complete data analysis, write report, and prepare final presentation.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Project Description When blood flows through a constriction, red blood cells within the whole blood can become damaged (hemolysis). This project involves the study of fluid dynamics through cylindrical constriction devices. A glycerol-water mixture, designed to mimic the behavior of human blood, will be driven by a syringe pump through the constriction device. A high [&hellip;]<\/p>\n","protected":false},"author":19768,"featured_media":0,"parent":0,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/2320"}],"collection":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/users\/19768"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/comments?post=2320"}],"version-history":[{"count":3,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/2320\/revisions"}],"predecessor-version":[{"id":2332,"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/pages\/2320\/revisions\/2332"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/photonics-ret\/wp-json\/wp\/v2\/media?parent=2320"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}