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![\"\"](\"\/photonics-programs\/files\/2023\/01\/Chen-Chris-112017-21336-1-600x600-1.jpg\")
<\/figure>\t\t\t\tChristopher Chen**<\/h6>\n\t\t
Professor (BME, MSE)<\/p>\t<\/a>\n\n\t\n<\/li>\n\t\t\t\t\t\n
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![\"\"](\"\/photonics-programs\/files\/2025\/04\/mustafa_cagatay_karakan-copy.jpg\")
<\/figure>\t\t\t\tMustafa Cagatay Karakan<\/h6>\n\t\t
Postdoctoral Research Associate<\/p>\t<\/a>\n\n\t\n<\/li>\n\t\t\t<\/ul>\n\t<\/span><\/p>\n
Project Description<\/h3>\n
The field of tissue engineering commonly employs post-like 3D mechanical boundaries as a useful way to give cues to the cells for compacting and remodeling the extracellular matrix. These boundaries and anchoring play a key role since they define the shape of the tissue and report forces tissues generate through their deformations. However, these tissues tend to fail over time due to a lack of adhesion of the tissues to the boundaries, extreme levels of intratissue tension, or high tissue contractility. The overall goal of the project is to develop a scalable anchoring method to generate durable freestanding 3Dengineered tissues, increasing the throughput and longevity.<\/p>\n
Research Goals<\/h3>
\n- \n
- Design, model, and fabricate potentially well-plate compatible tissue culture wells and 3D anchors for tissue generation, using 3D printing and PDMS molding techniques<\/li>\n
- Perform basic cell culture<\/li>\n
- Monitor and analyze tissue remodeling and potential failures over time<\/li>\n
- Understand which parameters (e.g. anchoring design, tissue size\/shape, boundary stiffness) are the most successful.<\/div>\n<\/div>\n<\/li>\n<\/ul>\n
Learning Goals<\/h3>
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- Learning the basics of computer-aided design, and finite element modeling<\/li>\n
- Learning 3D printing and PDMS microfabrication techniques<\/li>\n
- Learning mammalian cell culture<\/li>\n
- Learning how to do data analysis through ImageJ and MATLAB-Develop effective scientific communication skills through written reports, research presentations, and discussions.<\/div>\n<\/div>\n<\/li>\n<\/ul>\n
Timeline<\/h3>\n
Week 1-2: Lab and lab safety training, software setup and training, literature review<\/strong><\/span><\/p>\n
Week 2-5: Working on the designs, learning 3D printing, PDMS microfabrication and cell culture basics<\/strong><\/span><\/p>\n
Week 6-8: Start testing tissue generation and monitoring tissue remodeling\/failure over time, adjust modify the designs if needed,<\/strong><\/span><\/p>\n
Week 9-10: Finalize experiments, data analysis\/visualization, poster preparation\/presentation.<\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"
Mentors Project Description The field of tissue engineering commonly employs post-like 3D mechanical boundaries as a useful way to give cues to the cells for compacting and remodeling the extracellular matrix. These boundaries and anchoring play a key role since they define the shape of the tissue and report forces tissues generate through their deformations. […]<\/p>\n","protected":false},"author":19768,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[118],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts\/8242"}],"collection":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/users\/19768"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/comments?post=8242"}],"version-history":[{"count":7,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts\/8242\/revisions"}],"predecessor-version":[{"id":10439,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts\/8242\/revisions\/10439"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/media?parent=8242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/categories?post=8242"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/tags?post=8242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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