{"id":8204,"date":"2025-09-18T11:10:35","date_gmt":"2025-09-18T15:10:35","guid":{"rendered":"https:\/\/www.bu.edu\/photonics-programs\/?p=8204"},"modified":"2026-01-29T15:22:40","modified_gmt":"2026-01-29T20:22:40","slug":"statadx","status":"publish","type":"post","link":"https:\/\/www.bu.edu\/photonics-programs\/2025\/09\/18\/statadx\/","title":{"rendered":"Advancing Early Alzheimer\u2019s Detection with Biosensing"},"content":{"rendered":"<h3>Mentors<\/h3>\n\n\t<ul class=\"profile-listing profile-format-advanced\">\n\t\t\t\t\t\n<li class=\"profile-item profile-item-advanced has-title post-4523 profile type-profile status-publish hentry departments-bme departments-me affiliation-business-innovation-center program-year-yr-2021 program-year-yr-2022 program-year-yr-2023 program-year-186\">\n\t<a href=\"https:\/\/www.bu.edu\/photonics-programs\/profile\/daniel-lookadoo\/\" class=\"profile-link profile-link-advanced\">\n\t\t\t\t\t<figure class=\"profile-photo profile-photo-advanced\"><img width=\"150\" height=\"150\" src=\"\/photonics-programs\/files\/2025\/04\/daniel_lookadoo-300x300.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<h6 class=\"profile-name profile-name-advanced\">Daniel Lookadoo<\/h6>\n\t\t<p class=\"profile-title profile-title-advanced\">Chief Scientific Officer, StataDX<\/p>\t<\/a>\n\n\t\n<\/li>\n\t\t\t\t\t\n<li class=\"profile-item profile-item-advanced post-8217 profile type-profile status-publish hentry affiliation-graduate-student program-year-186 profile-field-mentor\">\n\t<a href=\"https:\/\/www.bu.edu\/photonics-programs\/profile\/hilena-frew-2\/\" class=\"profile-link profile-link-advanced\">\n\t\t\t\t\t<figure class=\"profile-photo profile-photo-advanced\"><img width=\"150\" height=\"150\" src=\"\/photonics-programs\/files\/2025\/09\/IMG_20180921_162131_1-225x300-1.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<h6 class=\"profile-name profile-name-advanced\">Hilena Frew<\/h6>\n\t\t\t<\/a>\n\n\t\n<\/li>\n\t\t\t<\/ul>\n\t\n<h3><span data-preserver-spaces=\"true\">Project Description<\/span><\/h3>\n<p class=\"p1\">Our research lab, in Boston University Photonics Center\u2019s Business Innovation Center, is focused on the development of new diagnostic tests to support personalized therapeutic strategies for patients suffering from neurological conditions. Given the increasingly decentralized nature of healthcare and clinical trials, there is a need for easy-to-use, cost-effective remote monitoring tools in near-patient settings. To address this unmet need, we are focused on developing an electrochemical-based microfluidic platform to bridge the gap between multiple-biomarker strategies\u2014that are more optimistic with complex, multifactorial diseases\/conditions\u2014and their implementation as a part of routine clinical care\/trials. Our platform\u2014based on novel electrochemical sensing technology developed at Harvard University\u2019s Wyss Institute\u2014selectively detects protein biomarkers captured by antibodies that are coupled to a nanocomposite coating on the electrode surface. The goal of this project will be to develop an electrode chip to improve the early detection of Alzheimer\u2019s Disease. Researchers working on this project will learn about the application of protein biomarkers for neurological conditions and some of the interdisciplinary challenges associated with developing near patient diagnostics.<\/p>\n<div class=\"bu_collapsible_container  bu_collapsible_open\" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Research Goals<\/h3><div class=\"bu_collapsible_section\" >\n<ul>\n<li class=\"p1\">Design prototype and characterize an electrode chip.<\/li>\n<li class=\"p1\">Optimize the design for the electrochemical detection of protein biomarkers.<\/li>\n<li class=\"p1\">Develop methods for characterizing the prototype<\/div>\n<\/div>\n<\/li>\n<\/ul>\n<div class=\"bu_collapsible_container  bu_collapsible_open\" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Learning Goals<\/h3><div class=\"bu_collapsible_section\" >\n<ul>\n<li>Learn about the design and fabrication of electrode chips.<\/li>\n<li>Learn about the design and chemistry of electrochemical biosensors.<\/li>\n<li>Learn about surface characterization techniques and tools for data analysis.<\/div>\n<\/div>\n<\/li>\n<\/ul>\n<h3>Timeline<\/h3>\n<p><span style=\"color: #003366;\"><strong>Week 1: I<\/strong>ntroduction and general lab training<\/span><\/p>\n<p><span style=\"color: #003366;\"><strong>Week 2: <\/strong><\/span><span style=\"color: #003366;\">Review the literature and ideate design <\/span><\/p>\n<p><span style=\"color: #003366;\"><strong>Week 3: <\/strong>Develop electrode chip <\/span><\/p>\n<p><span style=\"color: #003366;\"><strong>Week 4: <\/strong>Prototype electrode chip <\/span><\/p>\n<p><span style=\"color: #003366;\"><strong>Week 5:<\/strong>\u00a0Characterize electrode chip <\/span><\/p>\n<p><span style=\"color: #003366;\"><strong>Week 6:<\/strong>\u00a0Functionalize electrode surface <\/span><\/p>\n<p><span style=\"color: #003366;\"><strong>Week 7:<\/strong>\u00a0Characterize and optimize functionalized surface <\/span><\/p>\n<p><span style=\"color: #003366;\"><strong>Week 8: <\/strong>Evaluate the prototype <\/span><\/p>\n<p><span style=\"color: #003366;\"><strong>Week 9: <\/strong>Make conclusions and report results <\/span><\/p>\n<p><span style=\"color: #003366;\"><strong>Week 10: <\/strong>Prepare and present findings<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mentors Project Description Our research lab, in Boston University Photonics Center\u2019s Business Innovation Center, is focused on the development of new diagnostic tests to support personalized therapeutic strategies for patients suffering from neurological conditions. Given the increasingly decentralized nature of healthcare and clinical trials, there is a need for easy-to-use, cost-effective remote monitoring tools in [&hellip;]<\/p>\n","protected":false},"author":19768,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[118],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts\/8204"}],"collection":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/users\/19768"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/comments?post=8204"}],"version-history":[{"count":5,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts\/8204\/revisions"}],"predecessor-version":[{"id":10407,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts\/8204\/revisions\/10407"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/media?parent=8204"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/categories?post=8204"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/tags?post=8204"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}