{"id":5968,"date":"2025-02-24T12:01:18","date_gmt":"2025-02-24T17:01:18","guid":{"rendered":"https:\/\/www.bu.edu\/photonics-programs\/?p=5968"},"modified":"2025-02-25T13:09:02","modified_gmt":"2025-02-25T18:09:02","slug":"test-5","status":"publish","type":"post","link":"https:\/\/www.bu.edu\/photonics-programs\/2025\/02\/24\/test-5\/","title":{"rendered":"Multi-Participant Template"},"content":{"rendered":"<h3>Mentors<\/h3>\n<table width=\"357\" height=\"42\" style=\"border: 2px solid white; margin-bottom: 0;\">\n<tbody>\n<tr>\n<td style=\"border: 2px solid white;\">\n\t<ul class=\"profile-listing profile-format-basic\">\n\t\t\t\t\t\n<li class=\"profile-item profile-item-basic has-title post-4511 profile type-profile status-publish hentry departments-bme departments-mse-dept affiliation-faculty program-year-yr-2018 program-year-yr-2021 program-year-yr-2022 program-year-yr-2023\">\n\t<a href=\"https:\/\/www.bu.edu\/photonics-programs\/profile\/christopher-chen\/\" class=\"profile-link profile-link-basic\">\n\t\t\t\t\t<figure class=\"profile-photo profile-photo-basic\"><img width=\"150\" height=\"150\" src=\"\/photonics-programs\/files\/2023\/01\/Chen-Chris-112017-21336-1-600x600-1.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<h6 class=\"profile-name profile-name-basic\">Christopher Chen**<\/h6>\n\t\t<p class=\"profile-title profile-title-basic\">Professor (BME, MSE)<\/p>\t<\/a>\n\n\t\n<\/li>\n\t\t\t<\/ul>\n\t<\/td>\n<td style=\"border: 2px solid white;\">\n\t<ul class=\"profile-listing profile-format-basic\">\n\t\t\t\t\t\n<li class=\"profile-item profile-item-basic has-title post-5762 profile type-profile status-publish hentry departments-bme affiliation-postdoctoral program-year-yr-2024\">\n\t<a href=\"https:\/\/www.bu.edu\/photonics-programs\/profile\/claudia-varela\/\" class=\"profile-link profile-link-basic\">\n\t\t\t\t\t<figure class=\"profile-photo profile-photo-basic\"><img width=\"150\" height=\"150\" src=\"\/photonics-programs\/files\/2025\/01\/Claudia-300x300.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<h6 class=\"profile-name profile-name-basic\">Claudia Varela<\/h6>\n\t\t<p class=\"profile-title profile-title-basic\">Postdoctoral Fellow<\/p>\t<\/a>\n\n\t\n<\/li>\n\t\t\t<\/ul>\n\t<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 style=\"margin-top: 0;\">Project Description<\/h3>\n<p><span>The severity of a heart attack is determined by the area of heart muscle affected by the occluded vessel, but also by a \u2018border zone\u2019 (BZ) that separates the infarct region from the unaffected heart muscle. The BZ has been implicated in adverse remodeling that occurs after a heart attack, but because the region is difficult to isolate and study using animal models, how BZ biology contributes to disease progression remains largely unknown. <\/span><\/p>\n<p><span>To study BZ biology, the Chen lab is engineering a cardiac microtissue model that recapitulates BZ biology and biomechanics. Together with Claudia Varela, a postdoctoral researcher in the Chen lab, the REU student will help with the design and manufacturing of prototypes of the culture system and conduct experiments to assess BZ induction into the cardiac microtissues. This model will enable studies that elucidate how the region evolves and provide key design criteria for interventions that need to interface with that region, such as the cardiac patches being engineered in CELL-MET.<\/span><\/p>\n<div class=\" bu-callout alignright\"><\/p>\n<h3>Research Participants<\/h3>\n<p><span style=\"color: #808080;\"><em>Program: CELL-MET\u00a0<\/em><\/span><\/p>\n<p><img loading=\"lazy\" src=\"\/photonics-programs\/files\/2025\/01\/20240801_REU-Lab-Headshots-Lea-001-636x424.jpg\" alt=\"\" width=\"636\" height=\"424\" class=\"size-medium wp-image-5958 alignnone\" srcset=\"https:\/\/www.bu.edu\/photonics-programs\/files\/2025\/01\/20240801_REU-Lab-Headshots-Lea-001-636x424.jpg 636w, https:\/\/www.bu.edu\/photonics-programs\/files\/2025\/01\/20240801_REU-Lab-Headshots-Lea-001-1024x683.jpg 1024w, https:\/\/www.bu.edu\/photonics-programs\/files\/2025\/01\/20240801_REU-Lab-Headshots-Lea-001-768x512.jpg 768w, https:\/\/www.bu.edu\/photonics-programs\/files\/2025\/01\/20240801_REU-Lab-Headshots-Lea-001-1536x1024.jpg 1536w, https:\/\/www.bu.edu\/photonics-programs\/files\/2025\/01\/20240801_REU-Lab-Headshots-Lea-001-2048x1365.jpg 2048w\" sizes=\"(max-width: 636px) 100vw, 636px\" \/><\/p>\n<p>Lea Herbert, Research Experiences for Undergraduates.<br \/>\n<a href='#' class='button button'>Learn More<\/a><\/p>\n<p><img loading=\"lazy\" src=\"\/photonics-programs\/files\/2025\/01\/20240801_REU-Lab-Headshots-Lea-001-636x424.jpg\" alt=\"\" width=\"636\" height=\"424\" class=\"alignnone size-medium wp-image-5958\" srcset=\"https:\/\/www.bu.edu\/photonics-programs\/files\/2025\/01\/20240801_REU-Lab-Headshots-Lea-001-636x424.jpg 636w, https:\/\/www.bu.edu\/photonics-programs\/files\/2025\/01\/20240801_REU-Lab-Headshots-Lea-001-1024x683.jpg 1024w, https:\/\/www.bu.edu\/photonics-programs\/files\/2025\/01\/20240801_REU-Lab-Headshots-Lea-001-768x512.jpg 768w, https:\/\/www.bu.edu\/photonics-programs\/files\/2025\/01\/20240801_REU-Lab-Headshots-Lea-001-1536x1024.jpg 1536w, https:\/\/www.bu.edu\/photonics-programs\/files\/2025\/01\/20240801_REU-Lab-Headshots-Lea-001-2048x1365.jpg 2048w\" sizes=\"(max-width: 636px) 100vw, 636px\" \/><\/p>\n<p>Teacher name, Research Experiences for Teachers.<br \/>\n<a href='#' class='button button'>Learn More<\/a><\/div>\n<div class=\"bu_collapsible_container  bu_collapsible_open\" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Research Goals<\/h3><div class=\"bu_collapsible_section\" >\n<ul>\n<li>Gain technical expertise in device engineering and cardiac biology.<\/li>\n<li>Wet lab skills such as induced pluripotent stem cell differentiations into cardiomyocytes and cell maintenance, immunofluorescence, PCR, as well as manufacturing of cardiac microtissue culture devices.<\/li>\n<li>Gain experience in experimental design and data analysis.<\/div>\n<\/div>\n<\/li>\n<\/ul>\n<div class=\"bu_collapsible_container  bu_collapsible_open\" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Learning Goals<\/h3><div class=\"bu_collapsible_section\" >\n<ul>\n<li>Manufacture devices, learn cardiac tissue seeding and produce a focal injury to induce a BZ-like phenotype.<\/li>\n<li>Quantifying biomechanical BZ features: visualize and quantitatively evaluate tissue force as well as perform biological assays to quantify markers of BZ biology.<\/div>\n<\/div>\n<\/li>\n<\/ul>\n<h3>Timeline<\/h3>\n<p><span style=\"color: #003366;\"><strong>Week 1:<\/strong><\/span> Orientation in the lab, manufacturing cardiac microtissue devices, learning iPSCs culture.<br \/>\n<span style=\"color: #003366;\"><strong>Weeks 2-5:<\/strong><\/span> Conduct first round of iPSCs differentiation, microtissue seeding, BZ induction protocol and quantification. Optimize induction protocol as needed.<br \/>\n<span style=\"color: #003366;\"><strong>Weeks 6-9:<\/strong><\/span> Conduct first round of iPSCs differentiation, microtissue seeding, BZ induction protocol and quantification.<br \/>\n<span style=\"color: #003366;\"><strong>Week 10:<\/strong><\/span> Finish data analysis and synthesize final presentation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mentors Project Description The severity of a heart attack is determined by the area of heart muscle affected by the occluded vessel, but also by a \u2018border zone\u2019 (BZ) that separates the infarct region from the unaffected heart muscle. The BZ has been implicated in adverse remodeling that occurs after a heart attack, but because [&hellip;]<\/p>\n","protected":false},"author":19768,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts\/5968"}],"collection":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/users\/19768"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/comments?post=5968"}],"version-history":[{"count":10,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts\/5968\/revisions"}],"predecessor-version":[{"id":6017,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts\/5968\/revisions\/6017"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/media?parent=5968"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/categories?post=5968"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/tags?post=5968"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}