{"id":10381,"date":"2026-01-27T10:33:23","date_gmt":"2026-01-27T15:33:23","guid":{"rendered":"https:\/\/www.bu.edu\/photonics-programs\/?p=10381"},"modified":"2026-02-20T14:45:18","modified_gmt":"2026-02-20T19:45:18","slug":"cheng","status":"publish","type":"post","link":"https:\/\/www.bu.edu\/photonics-programs\/2026\/01\/27\/cheng\/","title":{"rendered":"Imaging tumor spheroid by SWIR CARS"},"content":{"rendered":"<h3>Mentors<\/h3>\n\n\t<ul class=\"profile-listing profile-format-advanced\">\n\t\t\t\t\t\n<li class=\"profile-item profile-item-advanced has-title post-4513 profile type-profile status-publish hentry departments-bme departments-ece departments-mse-dept affiliation-faculty program-year-yr-2019 program-year-yr-2021 program-year-yr-2022\">\n\t<a href=\"https:\/\/www.bu.edu\/photonics-programs\/profile\/ji-xin-cheng\/\" class=\"profile-link profile-link-advanced\">\n\t\t\t\t\t<figure class=\"profile-photo profile-photo-advanced\"><img width=\"150\" height=\"150\" src=\"\/photonics-programs\/files\/2025\/04\/ji-xin_cheng-300x300.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<h6 class=\"profile-name profile-name-advanced\">Ji-Xin Cheng<\/h6>\n\t\t<p class=\"profile-title profile-title-advanced\">Professor, BME, ECE, MSE<\/p>\t<\/a>\n\n\t\n<\/li>\n\t\t\t\t\t\n<li class=\"profile-item profile-item-advanced post-10691 profile type-profile status-publish hentry\">\n\t<a href=\"https:\/\/www.bu.edu\/photonics-programs\/profile\/shun-takahashi\/\" class=\"profile-link profile-link-advanced\">\n\t\t\t\t\t\t\t\t\t<h6 class=\"profile-name profile-name-advanced\">Shun Takahashi<\/h6>\n\t\t\t<\/a>\n\n\t\n<\/li>\n\t\t\t<\/ul>\n\t\n<h3><span data-preserver-spaces=\"true\">Project Description<\/span><\/h3>\n<p><span>Spheroid and organoid as non-animal models offer a valuable platform for basic biology and drug screen. Yet, probing cellular metabolic activity inside the spheroid remain a grand challenge due to limited penetration depth of optical microscopy and fluorescent labels. In the REU project, we tackle this challenge through developing shortwave infrared (SWIR) coherent anti-Stokes Raman scattering (CARS) microscopy, a label-free imaging platform with large imaging depth.<\/span><\/p>\n<p><span data-preserver-spaces=\"true\"><div class=\"bu_collapsible_container  bu_collapsible_open\" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Research Goals<\/h3><div class=\"bu_collapsible_section\" ><\/span><\/p>\n<p><span data-preserver-spaces=\"true\">This REU project will use phantom and spheroid models to show the capacity of this new technology, including imaging depth, spatial resolution and spectroscopic detection of biomolecules.<\/span><span data-preserver-spaces=\"true\"><\/div>\n<\/div>\n<\/span><span data-preserver-spaces=\"true\"><div class=\"bu_collapsible_container  bu_collapsible_open\" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Learning Goals<\/h3><div class=\"bu_collapsible_section\" ><\/span><\/p>\n<div>\n<ul>\n<li>Project formulation<\/li>\n<li>Instrumentation<\/li>\n<li>Label-free imaging<\/li>\n<li>Research presentation<\/li>\n<li>Team work <\/div>\n<\/div>\n<\/li>\n<\/ul>\n<\/div>\n<h3><span data-preserver-spaces=\"true\">Timeline<\/span><\/h3>\n<p><span style=\"color: #003366;\"><strong>Week 1:<\/strong><\/span><span data-preserver-spaces=\"true\"> Project formulation.<br \/>\n<\/span><span style=\"color: #003366;\"><strong>Weeks 2-3:<\/strong><\/span><span data-preserver-spaces=\"true\"> Learning CARS.<br \/>\n<\/span><span style=\"color: #003366;\"><strong>Weeks 4-5:<\/strong><\/span><span data-preserver-spaces=\"true\"> CARS imaging of 2D samples.<br \/>\n<\/span><span style=\"color: #003366;\"><strong>Weeks 6-7:<\/strong><\/span><span data-preserver-spaces=\"true\"> CARS imaging of 3D samples.<br \/>\n<\/span><span style=\"color: #003366;\"><strong>Weeks 8-9:<\/strong><\/span><span data-preserver-spaces=\"true\"> CARS imaging of tumor spheroid.<br \/>\n<\/span><span style=\"color: #003366;\"><strong>Week 10:<\/strong><\/span><span data-preserver-spaces=\"true\"> Research presentation.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mentors Project Description Spheroid and organoid as non-animal models offer a valuable platform for basic biology and drug screen. Yet, probing cellular metabolic activity inside the spheroid remain a grand challenge due to limited penetration depth of optical microscopy and fluorescent labels. In the REU project, we tackle this challenge through developing shortwave infrared (SWIR) [&hellip;]<\/p>\n","protected":false},"author":19768,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[118],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts\/10381"}],"collection":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/users\/19768"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/comments?post=10381"}],"version-history":[{"count":9,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts\/10381\/revisions"}],"predecessor-version":[{"id":10720,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/posts\/10381\/revisions\/10720"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/media?parent=10381"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/categories?post=10381"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bu.edu\/photonics-programs\/wp-json\/wp\/v2\/tags?post=10381"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}