{"id":92,"date":"2011-02-03T13:37:41","date_gmt":"2011-02-03T18:37:41","guid":{"rendered":"https:\/\/www.bu.edu\/nf-kb\/?page_id=92"},"modified":"2012-08-05T14:02:43","modified_gmt":"2012-08-05T18:02:43","slug":"table-2b","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/nf-kb\/table-2b\/","title":{"rendered":"Table 2b"},"content":{"rendered":"

Table 2b IkBa phosphorylation and\/or degradation inhibitors<\/em><\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Molecule<\/strong><\/td>\nPoint of Inhibition<\/strong><\/td>\nReferences<\/strong><\/td>\n<\/tr>\n
Desloratadine; diphenhydramine<\/td>\nHistamine H1 receptor<\/td>\nWu<\/a> et al, 2004; Scadding<\/a>, 2005; Roumestan<\/a> et al, 2008<\/td>\n<\/tr>\n
Bikunin<\/td>\nLPS receptor agonists<\/td>\nKobayashi<\/a>, 2006; Kanayama<\/a> et al, 2007<\/td>\n<\/tr>\n
Ron Tyrosine kinase receptor<\/td>\nSuppresses TNF production<\/td>\nLentsch<\/a> et al, 2007<\/td>\n<\/tr>\n
TAK-242<\/td>\nTLR4 intracellular domain<\/td>\nKawamoto<\/a> et al, 2008<\/td>\n<\/tr>\n
Salmeterol, fluticasone propionate<\/td>\nbeta2 agonists<\/td>\nBaouz<\/a> et al, 2005<\/td>\n<\/tr>\n
CPU0213<\/td>\nEndothelin receptor antagonist<\/td>\nHe<\/a> et al, 2006<\/td>\n<\/tr>\n
Doxazosin<\/td>\nalpha1-adrenergic receptor antagonist<\/td>\nHui<\/a> et al, 2007<\/td>\n<\/tr>\n
Erbin overexpression<\/td>\nNOD2 inhibitor<\/td>\nMcDonald<\/a> et al, 2005<\/td>\n<\/tr>\n
Protein-bound polysaccharide from basidiomycetes<\/td>\nLPS-CD14 interaction<\/td>\nAsai<\/a> et al, 2005<\/td>\n<\/tr>\n
Anti-CD146 antibody AA98<\/td>\nupstream of IKK<\/td>\nBu<\/a> et al, 2006<\/td>\n<\/tr>\n
Calagualine (fern derivative)<\/td>\nupstream of IKK (TRAF2-NIK)<\/td>\nManna<\/a> et al, 2003<\/td>\n<\/tr>\n
NS3\/4A (HCV protease)<\/td>\nupstream of IKK<\/td>\nKarayiannis<\/a>, 2005<\/td>\n<\/tr>\n
golli BG21 (product of myelin basic protein)<\/td>\nupstream of IKK (PKC)<\/td>\nFeng<\/a> et al, 2004<\/td>\n<\/tr>\n
NPM-ALK oncoprotein<\/td>\nTraf2 inhibition<\/td>\nHorie<\/a> et al, 2004<\/td>\n<\/tr>\n
NS5A (Hepatitis C virus)<\/td>\nTraf2 inhibition<\/td>\nPark<\/a> et al, 2002<\/td>\n<\/tr>\n
LY29 and LY30<\/td>\nPI3 Kinase inhibitors<\/td>\nChoi<\/a> et al, 2004<\/td>\n<\/tr>\n
Shiga toxin (Enterohemorrhagic E coli)<\/td>\nPI3 Kinase inhibitor<\/td>\nGobert<\/a> et al, 2007<\/td>\n<\/tr>\n
Evodiamine (Evodiae Fructus component)<\/td>\nAKT-IKK interaction<\/td>\nTakada<\/a> et al, 2005<\/td>\n<\/tr>\n
Rituximab (anti-CD20 antibody)<\/td>\nup-regulates Raf-1 kinase inhibitor<\/td>\nJazirehi<\/a> et al, 2005<\/td>\n<\/tr>\n
Kinase suppressor of ras (KSR2)<\/td>\nMEKK3 inhibitor<\/td>\nChannavajhala<\/a> et al, 2005<\/td>\n<\/tr>\n
Cholecystokinin ocatpeptide (CCK-8)<\/td>\np38 kinase<\/td>\nLi<\/a> et al, 2007<\/td>\n<\/tr>\n
M2L (Vaccinia virus)<\/td>\nERK2 inhibitor<\/td>\nGedey<\/a> et al, 2006; Hinthong<\/a> et al, 2008<\/td>\n<\/tr>\n
Pefabloc (serine protease inhibitor)<\/td>\nupstream of IKK<\/td>\nTando<\/a> et al, 2002<\/td>\n<\/tr>\n
Rocaglamides (Aglaia derivatives)<\/td>\nupstream of IKK<\/td>\nBaumann<\/a> et al, 2002<\/td>\n<\/tr>\n
Ymer<\/td>\nBinds to Ub-RIP<\/td>\nBohgaki<\/a> et al, 2007<\/td>\n<\/tr>\n
Epoxyquinol B<\/td>\nTAK1 crosslinker<\/td>\nKamiyama<\/a> et al, 2008<\/td>\n<\/tr>\n
Betaine<\/td>\nNIK\/IKK<\/td>\nGo<\/a> et al, 2004, 2007<\/a><\/td>\n<\/tr>\n
TNAP<\/td>\nNIK<\/td>\nHu<\/a> et al, 2005<\/td>\n<\/tr>\n
Selected peptides<\/td>\nNEMO binding to Ub<\/td>\nWyler<\/a> et al, 2007<\/td>\n<\/tr>\n
Biochanin<\/td>\nupstream of IKK\/ phosphorylates of I\u03baB\u03b1<\/td>\nManna<\/a> et al, 2012<\/td>\n<\/tr>\n
Desflurane<\/td>\nIKK complex formation with TNF-R1<\/td>\nLi<\/a> et al, 2008<\/td>\n<\/tr>\n
Geldanamycin<\/td>\nIKK complex formation<\/td>\nChen<\/a> et al, 2002<\/td>\n<\/tr>\n
Grape seed proanthocyanidins<\/td>\nIKKa activity<\/td>\nMantena<\/a> & Katiyar, 2006; Sharma<\/a> et al, 2007; Cheng<\/a> et al, 2007; Xu<\/a> et al, 2008<\/td>\n<\/tr>\n
Laretia acaulis azorellane diterpenoids<\/td>\nIKKa activity<\/td>\nBorquez<\/a> et al, 2007<\/td>\n<\/tr>\n
MC160 (Molluscum contagiosum virus)<\/td>\nIKKa activity<\/td>\nNichols<\/a> & Shisler , 2006<\/td>\n<\/tr>\n
NS5B (Hepatitis C protein)<\/td>\nIKKa activity<\/td>\nChoi<\/a> et al, 2006<\/td>\n<\/tr>\n
Pomegranate fruit extract<\/td>\nIKKa activity<\/td>\nAfaq<\/a> et al, 2004; Khan <\/a>et al, 2006<\/td>\n<\/tr>\n
Tetrandine (plant alkaloid)<\/td>\nIKKa activity<\/td>\nHo<\/a> et al, 2004; Xue<\/a> et al, 2008; Lin <\/a>et al, 2008<\/td>\n<\/tr>\n
BMS-345541 (4(2′-Aminoethyl)amino-1,8-dimethylimidazo(1,2-a) <\/p>\n

quinoxaline) and 4-amino derivatives<\/td>\n

IKKa and IKKb kinase activity<\/td>\nBurke<\/a> et al, 2002; Yang<\/a> et al, 2006; Beaulieu<\/a> et al, 2006<\/td>\n<\/tr>\n
1-O-acetylbritannilactone<\/td>\nIKKb activity<\/td>\nLiu<\/a> et al, 2007<\/td>\n<\/tr>\n
2-amino-3-cyano-4-aryl-6-(2-hydroxy-phenyl)pyridine derivatives<\/td>\nIKKb activity<\/td>\nMurata<\/a> et al, 2003, 2004<\/a>, 2004<\/a><\/td>\n<\/tr>\n
Acrolein<\/td>\nIKKb activity\/p50 DNA binding<\/td>\nVallacchi<\/a> et al, 2005; Lambert<\/a> et al, 2007<\/td>\n<\/tr>\n
Anandamide<\/td>\nIKKb activity<\/td>\nSancho<\/a> et al, 2003<\/td>\n<\/tr>\n
AS602868<\/td>\nIKKb activity<\/td>\nFrelin<\/a> et al, 2003: Griessinger<\/a> et al, 2007<\/td>\n<\/tr>\n
benzoxathiole(6,6-dimethyl-2-(phenylimino)-6,7-dihydro-5H<\/em>-benzo-[1,3]oxathiol-4-one (and its analogs)<\/td>\nIKKb activity<\/td>\nVenkateswararao<\/a> et al, 2012<\/td>\n<\/tr>\n
Cobrotoxin<\/td>\nIKKb activity\/p50 DNA binding<\/td>\nPark<\/a> et al, 2005<\/td>\n<\/tr>\n
Core protein (Hepatitis C)<\/td>\nIKKb activity<\/td>\nJoo<\/a> et al, 2005; Shrivastava<\/a> et al, 1998<\/td>\n<\/tr>\n
1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl] <\/p>\n

imidazole<\/td>\n

IKKb activity<\/td>\nYore<\/a> et al, 2006<\/td>\n<\/tr>\n
Dihydroxyphenylethanol<\/td>\nIKKb activity<\/td>\nGuichard<\/a> et al, 2006<\/td>\n<\/tr>\n
Herbimycin A<\/td>\nIKKb activity<\/td>\nIwasaki<\/a> et al, 1992; Mahon<\/a> & O\u2019Neill, 1995; Ogino<\/a> et al, 2004<\/td>\n<\/tr>\n
Inhibitor 22<\/td>\nIKKb activity<\/td>\nBaxter<\/a> et al, 2004<\/td>\n<\/tr>\n
Isorhapontigenin<\/td>\nIKKb activity<\/td>\nLi<\/a> et al, 2005<\/td>\n<\/tr>\n
Manumycin A<\/td>\nIKKb activity<\/td>\nBernier<\/a> et al, 2005; Frassanito<\/a> et al, 2005<\/td>\n<\/tr>\n
6-methyl-2-propolyimino-6,7-dihydro-5H- <\/p>\n

benzo[1,3]oxathiol-4-one<\/td>\n

IKKb<\/td>\nKim<\/a> et al, 2008<\/td>\n<\/tr>\n
MLB120 (small molecule)<\/td>\nIKKb activity<\/td>\nNagashima<\/a> et al, 2006<\/td>\n<\/tr>\n
Naphthopyrones (6-methoxycomaparvin and 6-methooxycomaparvin 5-methyl ether)<\/td>\nIKKb activity<\/td>\nFulmer<\/a> et al, 2008<\/td>\n<\/tr>\n
Novel Inhibitor<\/td>\nIKKb activity<\/td>\nKamon<\/a> et al, 2004<\/td>\n<\/tr>\n
vIRF3 (KSHV)<\/td>\nIKKb activity<\/td>\nSeo<\/a> et al, 2004<\/td>\n<\/tr>\n
Nitric oxide<\/td>\nIKKb activity\/IkB phosphorylation<\/td>\nKatsuyama<\/a> et al, 1998; Matthews<\/a> et al, 1996; Spieker<\/a> & Liao, 1999; Reynaert<\/a> et al, 2004<\/td>\n<\/tr>\n
SC-514 (small molecule)<\/td>\nIKKb activity<\/td>\nKishore<\/a> et al, 2003<\/td>\n<\/tr>\n
Thienopyridine<\/td>\nIKKb activity<\/td>\nMorwick<\/a> et al, 2006<\/td>\n<\/tr>\n
Acetyl-boswellic acids<\/td>\nIKK activity<\/td>\nSyrovets<\/a> et al, 2004, 2005<\/a><\/td>\n<\/tr>\n
Amino-pyrimidine derivative<\/td>\nIKK activity<\/td>\nKarin<\/a> et al, 2004<\/td>\n<\/tr>\n
Benzoimidazole derivative<\/td>\nIKK activity<\/td>\nKarin<\/a> et al, 2004<\/td>\n<\/tr>\n
BMS-345541<\/td>\nIKK activity<\/td>\nBurke<\/a> et al, 2003<\/td>\n<\/tr>\n
Butein<\/td>\nIKKb activity<\/td>\nPandey<\/a> et al, 2007<\/td>\n<\/tr>\n
Beta-carboline<\/td>\nIKK activity<\/td>\nYoon<\/a> et al, 2005<\/td>\n<\/tr>\n
CYL-19s and CYL-26z, two synthetic alpha-methylene-gamma-butyrolactone derivatives<\/td>\nIKK activity<\/td>\nHuang<\/a> et al, 2004<\/td>\n<\/tr>\n
ACHP (2-amino-6-[2-(cyclopropylmethoxy)-6- <\/p>\n

hydroxyphenyl]-4-piperidin-4-yl nicotinonitrile<\/td>\n

IKKb activity (ATP analog)<\/td>\nSanda<\/a> et al, 2006<\/td>\n<\/tr>\n
Berberine<\/td>\nIKKb activity<\/td>\nHu<\/a> et al, 2007; Yi<\/a> et al, 2008; Pandey<\/a> et al, 2008<\/td>\n<\/tr>\n
Compound A<\/td>\nIKKb activity (ATP analog)<\/td>\nZiegelbauer<\/a> et al, 2005<\/td>\n<\/tr>\n
Flavopiridol<\/td>\nIKK activity and RelA phosphor.<\/td>\nTakada<\/a> & Aggarwal, 2003<\/td>\n<\/tr>\n
Cyclopentones<\/td>\nIKKb activity<\/td>\nBickley<\/a> et al, 2004<\/td>\n<\/tr>\n
Dehydroascorbic acid (Vitamin C)<\/td>\nIKKb activity<\/td>\nCarcamo<\/a> et al, 2004<\/td>\n<\/tr>\n
Gossypyin or Gossypium extracts<\/td>\nIKKb activity<\/td>\nKunnumakkara<\/a> et al, 2007; Ji<\/a> et al, 2008<\/td>\n<\/tr>\n
M protein (SARS-Cornonavirus protein)<\/td>\nIKKb activity<\/td>\nFang<\/a> et al, 2007<\/td>\n<\/tr>\n
IMD-0354<\/td>\nIKKb activity<\/td>\nTanaka<\/a> et al, 2004, 2006<\/a>; Inayama<\/a> et al, 2006<\/td>\n<\/tr>\n
Jesterone dimer<\/td>\nIKKb activity; DNA binding<\/td>\nLiang<\/a> et al, 2003, 2006<\/td>\n<\/tr>\n
KINK-1<\/td>\nIKKb activity<\/td>\nSchon<\/a> et al, 2008<\/td>\n<\/tr>\n
LCY-2-CHO<\/td>\nIKKb activity<\/td>\nHo<\/a> et al, 2007<\/td>\n<\/tr>\n
Prolyl hydroxylase-1<\/td>\nIKKb activity<\/td>\nCummins<\/a> et al, 2006<\/td>\n<\/tr>\n
Naphthopyrones (Echinoderm Comanthus parvicirrus)<\/td>\nIKKb activity<\/td>\nFolmer<\/a> et al, 2007<\/td>\n<\/tr>\n
Neuropeptides CGRP, PACAP and VIP<\/td>\nIKKb activity<\/td>\nDing<\/a> et al, 2007<\/td>\n<\/tr>\n
PS-1145 (MLN1145)<\/td>\nIKKb activity<\/td>\nHideshima<\/a> et al, 2002<\/td>\n<\/tr>\n
2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3- <\/p>\n

thiophenecarboxamides (TPCA-1)<\/td>\n

IKKb activity<\/td>\nBonafoux<\/a> et al, 2005; Podolin<\/a> et al, 2005<\/td>\n<\/tr>\n
1′-Acetoxychavicol acetate (Languas galanga)<\/td>\nIKK activity<\/td>\nIchikawa<\/a> et al, 2005; Ito<\/a> et al, 2005<\/td>\n<\/tr>\n
17-Acetoxyjolkinolide B<\/td>\nIKK activity<\/td>\nYan<\/a> et al, 2008<\/td>\n<\/tr>\n
Acute alcohol exposure<\/td>\nIKK activity<\/td>\nMandrekar<\/a> et al, 2007<\/td>\n<\/tr>\n
Anacardic acid (6-nonadecyl-salicylic acid)<\/td>\nIKK activity<\/td>\nSung<\/a> et al, 2008<\/td>\n<\/tr>\n
Apigenin (plant flavinoid)<\/td>\nIKK activity<\/td>\nShukla<\/a> & Gupta, 2004; Yoon<\/a> et al, 2006<\/td>\n<\/tr>\n
Asiatic acid<\/td>\nIKK activity<\/td>\nYun<\/a> et al, 2008<\/td>\n<\/tr>\n
Cardamomin<\/td>\nIKK activity<\/td>\nLee<\/a> et al, 2005<\/td>\n<\/tr>\n
CDDO-Me (synthetic triterpenoid)<\/td>\nIKK activity<\/td>\nShishodia<\/a> et al, 2006<\/td>\n<\/tr>\n
CHS 828 (anticancer drug)<\/td>\nIKK activity<\/td>\nOlsen<\/a> et al, 2004<\/td>\n<\/tr>\n
CML-1<\/td>\nIKK activity<\/td>\nMo<\/a> et al, 2006<\/td>\n<\/tr>\n
Compound 5 (Uredio-thiophenecarboxamide derivative)<\/td>\nIKK activity<\/td>\nRoshak<\/a> et al, 2002<\/td>\n<\/tr>\n
CT20126<\/td>\nIKK activity\/NIK<\/td>\nLee<\/a> et al, 2008<\/td>\n<\/tr>\n
Diaylpyridine derivative<\/td>\nIKK activity<\/td>\nMurata<\/a> et al, 2003<\/td>\n<\/tr>\n
3,4-dihydroxybenzalacetone (from Chaga)<\/td>\nIKK activity<\/td>\nSung<\/a> et al, 2008<\/td>\n<\/tr>\n
Diosgenin<\/td>\nIKK activity<\/td>\nShishodia<\/a> & Aggarwal, 2005; Liagre<\/a> et al, 2005<\/td>\n<\/tr>\n
E3-14.7K (Adenovirus)<\/td>\nIKK activity<\/td>\nLi<\/a> et al, 1999<\/td>\n<\/tr>\n
E3-10.4K\/14.5K (Adenovirus)<\/td>\nIKK activity<\/td>\nFriedman<\/a> & Horwitz, 2002<\/td>\n<\/tr>\n
E7 (human papillomavirus)<\/td>\nIKK activity<\/td>\nSpitkovsky<\/a> et al, 2002<\/td>\n<\/tr>\n
Furonaphthoquinone<\/td>\nIKK activity<\/td>\nShin <\/a>et al, 2006<\/td>\n<\/tr>\n
3-Formylchromone<\/td>\nIKKb activity\/p65 DNA binding<\/td>\nYadav<\/a> et al, 2011<\/td>\n<\/tr>\n
Guggulsterone<\/td>\nIKK activity<\/td>\nIchikawa<\/a> & Aggarwal, 2006; Deng<\/a>, 2007; Lv<\/a> et al, 2008; Lee<\/a> et al, 2008<\/td>\n<\/tr>\n
HB-EGF (Heparin-binding epidermal growth factor-like growth factor)<\/td>\nIKK activity<\/td>\nMehta<\/a> & Besner, 2003<\/td>\n<\/tr>\n
Falcarindol<\/td>\nIKK activity<\/td>\nShiao<\/a> et al, 2005<\/td>\n<\/tr>\n
Hammerhead ribozyme to IKKa\/b<\/td>\nIKK activity<\/td>\nYang<\/a> et al, 2007<\/td>\n<\/tr>\n
Hepatocyte growth factor<\/td>\nIKK activity<\/td>\nMin<\/a> et al, 2005; Gong<\/a> et al, 2006<\/td>\n<\/tr>\n
Honokiol<\/td>\nIKK activity<\/td>\nTse<\/a> et al, 2005; Munroe<\/a> et al, 2007<\/td>\n<\/tr>\n
Humulone<\/td>\nIKK activity<\/td>\nLee<\/a> et al, 2007<\/td>\n<\/tr>\n
Hypoestoxide<\/td>\nIKK activity<\/td>\nOjo-Amaize<\/a> et al, 2001<\/td>\n<\/tr>\n
Indolecarboxamide derivative<\/td>\nIKK activity<\/td>\nKarin<\/a> et al, 2004<\/td>\n<\/tr>\n
Labdane diterpenoids<\/td>\nIKK activity<\/td>\nGiron<\/a> et al, 2008<\/td>\n<\/tr>\n
LF15-0195 (analog of 15-deoxyspergualine)<\/td>\nIKK activity<\/td>\nYang<\/a> et al, 2003<\/td>\n<\/tr>\n
gamma-mangostin (from Garcinia mangostana)<\/td>\nIKK activity<\/td>\nNakatani<\/a> et al, 2004<\/td>\n<\/tr>\n
Garcinone B<\/td>\nIKK activity<\/td>\nYamakuni<\/a> et al, 2005<\/td>\n<\/tr>\n
(Amino)imidazolylcarboxaldehyde derivative<\/td>\nIKK activity<\/td>\nKarin<\/a> et al, 2004<\/td>\n<\/tr>\n
Imidazolylquinoline-carboxaldehyde derivative<\/td>\nIKK activity<\/td>\nKarin<\/a> et al, 2004<\/td>\n<\/tr>\n
Kahweol<\/td>\nIKK activity<\/td>\nKim<\/a> et al, 2004<\/td>\n<\/tr>\n
Kava (Piper methysticum) derivatives<\/td>\nIKK activity<\/td>\nFolmer<\/a> et al, 2006<\/td>\n<\/tr>\n
Lead<\/td>\nIKK activity<\/td>\nXu<\/a> et al, 2006<\/td>\n<\/tr>\n
Marasmius oreades liquid extract<\/td>\nIKK activity<\/td>\nPetrova<\/a> et al, 2008<\/td>\n<\/tr>\n
Menatetrenone (vitamin K2 analogue)<\/td>\nIKK activity<\/td>\nOzaki<\/a> et al, 2007<\/td>\n<\/tr>\n
Metformin<\/td>\nIKK activity<\/td>\nHuang<\/a> et al, 2008<\/td>\n<\/tr>\n
Mild hypothermia<\/td>\nIKK activity<\/td>\nHan<\/a> et al, 2003<\/td>\n<\/tr>\n
ML120B<\/td>\nIKK activity<\/td>\nCatley<\/a> et al, 2006<\/td>\n<\/tr>\n
Morin (3,5,7,2′,4′-Pentahydroxyflavone)<\/td>\nIKK activity<\/td>\nManna<\/a> et al, 2007<\/td>\n<\/tr>\n
Morusin<\/td>\nIKK activity<\/td>\nLee<\/a> et al, 2008<\/td>\n<\/tr>\n
MX781 (retinoid antagonist)<\/td>\nIKK activity<\/td>\nBayon <\/a>et al, 2003<\/td>\n<\/tr>\n
N-acetylcysteine<\/td>\nIKK activity<\/td>\nOka<\/a> et al, 2000<\/td>\n<\/tr>\n
Nitrosylcobalamin (vitamin B12 analog)<\/td>\nIKK activity<\/td>\nChawla-Sarkar<\/a> et al, 2003<\/td>\n<\/tr>\n
NSAIDs<\/td>\nIKK activity<\/td>\nTakada<\/a> et al, 2004<\/td>\n<\/tr>\n
Hepatits C virus NS5B<\/td>\nIKK activity<\/td>\nChoi <\/a>et al, 2006<\/td>\n<\/tr>\n
PAN1 (aka NALP2 or PYPAF2)<\/td>\nIKK activity<\/td>\nBruey<\/a> et al, 2004<\/td>\n<\/tr>\n
Pectin (citrus)<\/td>\nIKK activity<\/td>\nChen<\/a> et al, 2006<\/td>\n<\/tr>\n
Pinitol<\/td>\nIKK activity<\/td>\nSethi<\/a> et al, 2008<\/td>\n<\/tr>\n
PMX464<\/td>\nIKK activity<\/td>\nCallister<\/a> et al, 2008<\/td>\n<\/tr>\n
Pyrazolo[4,3-c]quinoline derivative<\/td>\nIKK activity<\/td>\nKarin<\/a> et al, 2004<\/td>\n<\/tr>\n
Pyridooxazinone derivative<\/td>\nIKK activity<\/td>\nKarin<\/a> et al, 2004<\/td>\n<\/tr>\n
N-(4-hydroxyphenyl) retinamide<\/td>\nIKK activity<\/td>\nShishodia<\/a> et al, 2005; Kuefer<\/a> et al, 2007<\/td>\n<\/tr>\n
Scytonemin<\/td>\nIKK activity<\/td>\nStevenson<\/a> et al, 2002<\/td>\n<\/tr>\n
Semecarpus anacardiu extract<\/td>\nIKK activity<\/td>\nSingh<\/a> et al, 2006<\/td>\n<\/tr>\n
SPC-839<\/td>\nIKK activity<\/td>\nPalanki<\/a> et al, 2002<\/td>\n<\/tr>\n
Sulforaphane and phenylisothiocyanate<\/td>\nIKK activity<\/td>\nXu<\/a> et al, 2005; Murakami<\/a> et al, 2007; Liu<\/a> et al, 2008: Hayes<\/a> et al, 2008<\/td>\n<\/tr>\n
Survanta (Surfactant product)<\/td>\nIKK activity<\/td>\nRaychaudhuri<\/a> et al, 2003<\/td>\n<\/tr>\n
Torque Teno virus ORF2<\/td>\nIKK activity<\/td>\nZheng<\/a> et al, 2007<\/td>\n<\/tr>\n
Piceatannol<\/td>\nIKK activity<\/td>\nIslam<\/a> et al, 2004<\/td>\n<\/tr>\n
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone)<\/td>\nIKK activity<\/td>\nSandur<\/a> et al, 2006<\/td>\n<\/tr>\n
IKKb peptide to NEMO binding domain<\/td>\nIKK-NEMO interaction<\/td>\nMay <\/a>et al, 2000<\/td>\n<\/tr>\n
NEMO CC2-LZ peptide<\/td>\nNEMO oligomerization<\/td>\nAgou <\/a>et al, 2004<\/td>\n<\/tr>\n
AGRO100 (G-quadraplex oligodeoxynucleotide)<\/td>\nNEMO binding<\/td>\nGirvan<\/a> et al, 2006<\/td>\n<\/tr>\n
PTEN (tumor suppressor)<\/td>\nActivation of IKK<\/td>\nGustin<\/a> et al, 2001<\/td>\n<\/tr>\n
Theaflavin (black tea component)<\/td>\nActivation of IKK<\/td>\nAneja<\/a> et al, 2004; Ukil<\/a> et al, 2006; Kalra<\/a> et al, 2007<\/td>\n<\/tr>\n
Tilianin<\/td>\nActivation of IKK<\/td>\nNam<\/a> et al, 2005<\/td>\n<\/tr>\n
Withanolides<\/td>\nActivation of IKK<\/td>\nIchikawa<\/a> et al, 2006<\/td>\n<\/tr>\n
Zerumbone<\/td>\nActivation of IKK<\/td>\nTakada<\/a> et al, 2005<\/td>\n<\/tr>\n
Silibinin<\/td>\nIKKa activity; nuclear translocation<\/td>\nDhanalakshmi<\/a> et al, 2002; Singh<\/a> et al, 2004; Min<\/a> et al, 2007<\/td>\n<\/tr>\n
Sulfasalazine<\/td>\nIKKa and IKKb kinase activity<\/td>\nWahl<\/a> et al, 1998: Weber<\/a> et al, 2000<\/td>\n<\/tr>\n
Sulfasalazine analogs<\/td>\nIKK kinase activity<\/td>\nHabens<\/a> et al, 2005<\/td>\n<\/tr>\n
Quercetin<\/td>\nIKK activity<\/td>\nPeet<\/a> & Li, 1999<\/td>\n<\/tr>\n
Rosmarinic acid<\/td>\nIKK activity<\/td>\nLee<\/a> et al, 2006<\/td>\n<\/tr>\n
Staurosporine<\/td>\nIKK activity<\/td>\nPeet<\/a> & Li, 1999<\/td>\n<\/tr>\n
gamma-Tocotrienol<\/td>\nIKK activity<\/td>\nShah<\/a> & Sylvester, 2005; Ahn<\/a> et al, 2006<\/td>\n<\/tr>\n
Wedelolactone<\/td>\nIKK activity<\/td>\nKobori<\/a> et al, 2003<\/td>\n<\/tr>\n
Betulinic acid<\/td>\nIKKa activity and p65 phosphorylation<\/td>\nTakada<\/a> & Aggarwal, 2003; Rabi<\/a> et al, 2008<\/td>\n<\/tr>\n
Ursolic acid<\/td>\nIKKa activity and p65 phosphorylation<\/td>\nShishodia<\/a> et al, 2003; Manu<\/a> & Kuttan, 2008<\/td>\n<\/tr>\n
Thalidomide (and thalidomide analogs)<\/td>\nIKK activity<\/td>\nKeifer<\/a> et al, 2001; Ge<\/a> et al, 2006; Carcache de-Blanco<\/a> et al, 2007<\/td>\n<\/tr>\n
Salubrinal<\/td>\nIKK activity\/degradation<\/td>\nHuang<\/a> et al, 2011<\/td>\n<\/tr>\n
Fas-associated factor-1<\/td>\nIKK assembly<\/td>\nPark<\/a> et al, 2007<\/td>\n<\/tr>\n
Interleukin-10<\/td>\nReduced IKKa and IKKb expression<\/td>\nTabary<\/a> et al, 2003<\/td>\n<\/tr>\n
MC160 (molluscum contagiosum virus)<\/td>\nReduced IKKa expression<\/td>\nNichols<\/a> & Shisler, 2006<\/td>\n<\/tr>\n
Monochloramine and glycine chloramine (NH2Cl)<\/td>\nOxidizes IkB<\/td>\nKim<\/a> et al, 2005; Midwinter<\/a> et al, 2006<\/td>\n<\/tr>\n
GS143<\/td>\nBlocks IkB ubiquitylation<\/td>\nNakajima<\/a> et al, 2008; Hirose<\/a> et al, 2008<\/td>\n<\/tr>\n
Salmonella Secreted Factor L<\/td>\nBlocks IkB ubiquitylation<\/td>\nLe Negrate<\/a> et al, 2008<\/td>\n<\/tr>\n
Anethole<\/td>\nPhosphorylation<\/td>\nChainy<\/a> et al, 2000<\/td>\n<\/tr>\n
Anti-thrombin III<\/td>\nPhosphorylation<\/td>\nOelschlager<\/a> et al, 2002<\/td>\n<\/tr>\n
Artemisia vestita<\/td>\nPhosphorylation<\/td>\nSun<\/a> et al, 2006<\/td>\n<\/tr>\n
Aspirin, sodium salicylate<\/td>\nPhosphorylation, IKKbeta<\/td>\nFrantz<\/a> & O’Neill, 1995; Kopp<\/a> & Ghosh, 1994; Yin<\/a> et al, 1998<\/td>\n<\/tr>\n
Azidothymidine (AZT)<\/td>\nPhosphorylation<\/td>\nGhosh<\/a> et al, 2003; Kurokawa<\/a> et al, 2005<\/td>\n<\/tr>\n
Baoganning<\/td>\nPhosphorylation<\/td>\nTan<\/a> et al, 2005<\/td>\n<\/tr>\n
BAY-11-7082 <\/p>\n

(E3((4-methylphenyl)-sulfonyl)-2-propenenitrile)<\/td>\n

Phosphorylation<\/td>\nPierce<\/a> et al, 1997<\/td>\n<\/tr>\n
BAY-117083 <\/p>\n

(E3((4-t-butylphenyl)-sulfonyl)-2-propenenitrile)<\/td>\n

Phosphorylation<\/td>\nPierce<\/a> et al, 1997<\/td>\n<\/tr>\n
Benzyl isothiocyanate<\/td>\nPhosphorylation<\/td>\nSrivastava<\/a> & Singh, 2004<\/td>\n<\/tr>\n
Black raspberry extracts (cyanidin 3-O-glucoside, cyanidin 3-O-(2(G)-xylosylrutinoside), cyanidin 3-O-rutinoside)<\/td>\nPhosphorylation<\/td>\nHuang<\/a> et al, 2002; Hecht<\/a> et al, 2006<\/td>\n<\/tr>\n
Buddlejasaponin IV<\/td>\nPhosphorylation<\/td>\nWon<\/a> et al, 2006<\/td>\n<\/tr>\n
Cacospongionolide B<\/td>\nPhosphorylation<\/td>\nPosadas<\/a> et al, 2003<\/td>\n<\/tr>\n
Calagualine<\/td>\nPhosphorylation<\/td>\nManna<\/a> et al, 2003<\/td>\n<\/tr>\n
Carbon monoxide<\/td>\nPhosphorylation<\/td>\nSarady<\/a> et al, 2002<\/td>\n<\/tr>\n
Carboplatin<\/td>\nPhosphorylation<\/td>\nSingh<\/a> & Bhat, 2004<\/td>\n<\/tr>\n
Cardamonin<\/td>\nPhosphorylation<\/td>\nIsraf<\/a> et al, 2006<\/td>\n<\/tr>\n
Chorionic gonadotropin<\/td>\nPhosphorylation<\/td>\nManna<\/a> et al, 2000<\/td>\n<\/tr>\n
Cordycepin<\/td>\nPhosphorylation<\/td>\nKim<\/a> et al, 2006; Huang<\/a> et al., 2007<\/td>\n<\/tr>\n
Crassocephalum rabens galactolipid<\/td>\nPhosphorylation<\/td>\nHou<\/a> et al., 2007<\/td>\n<\/tr>\n
Cycloepoxydon; 1-hydroxy-2-hydroxymethyl-3-pent-1-enylbenzene<\/td>\nPhosphorylation<\/td>\nGehrt<\/a> et al, 1998<\/td>\n<\/tr>\n
Cytomegalovirus<\/td>\nPhosphorylation<\/td>\nJarvis<\/a> et al, 2006<\/td>\n<\/tr>\n
Decursin<\/td>\nPhosphorylation<\/td>\nKim<\/a> et al, 2006<\/td>\n<\/tr>\n
Delphinidin<\/td>\nPhosphorylation<\/td>\nSyed<\/a> et al, 2008<\/td>\n<\/tr>\n
Dexanabinol<\/td>\nPhosphorylation<\/td>\nJuttler<\/a> et al, 2004<\/td>\n<\/tr>\n
Digitoxin<\/td>\nPhosphorylation<\/td>\nSrivastava<\/a> et al, 2004; Jagielska<\/a> et al, 2009<\/td>\n<\/tr>\n
Dihydrotestosterone<\/td>\nPhosphorylation<\/td>\nXu<\/a> et al, 2011<\/td>\n<\/tr>\n
Diterpenes (synthetic)<\/td>\nPhosphorylation<\/td>\nChao<\/a> et al, 2005<\/td>\n<\/tr>\n
Docosahexaenoic acid<\/td>\nPhosphorylation<\/td>\nChen<\/a> et al, 2005; Zand<\/a> et al, 2008<\/td>\n<\/tr>\n
Entamoeba histolytica<\/td>\nPhosphorylation<\/td>\nKammanadiminti<\/a> & Chadee, 2006<\/td>\n<\/tr>\n
Extensively oxidized low density lipoprotein (ox-LDL), 4-Hydroxynonenal (HNE)<\/td>\nPhosphorylation<\/td>\nBrand<\/a> et al, 1997; Page<\/a> et al, 1999<\/td>\n<\/tr>\n
FBD<\/td>\nPhosphorylation<\/td>\nLin<\/a> et al, 2008<\/td>\n<\/tr>\n
FHIT (Fragile histidine triad protein)<\/td>\nPhosphorylation<\/td>\nNakagawa<\/a> & Akao, 2006<\/td>\n<\/tr>\n
Fructus Ligustrum lucidi<\/td>\nPhosphorylation<\/td>\nAn<\/a> et al, 2007<\/td>\n<\/tr>\n
Gabexate mesilate<\/td>\nPhosphorylation<\/td>\nUchiba<\/a> et al, 2003<\/td>\n<\/tr>\n
[6]-gingerol; casparol<\/td>\nPhosphorylation<\/td>\nKim<\/a> et al, 2005; Aktan<\/a> et al, 2006; Ishiguro<\/a> et al, 2007<\/td>\n<\/tr>\n
Gleditsia sinensis thorns extract<\/td>\nPhosphorylation<\/td>\nHa<\/a> et al, 2008<\/td>\n<\/tr>\n
Gleevec (Imatanib)<\/td>\nPhosphorylation<\/td>\nWolf<\/a> et al, 2005<\/td>\n<\/tr>\n
Glossogyne tenuifolia<\/td>\nPhosphorylation<\/td>\nWu<\/a> et al, 2004; Ha<\/a> et al, 2006<\/td>\n<\/tr>\n
Guggulsterone<\/td>\nPhosphorylation<\/td>\nShishodia<\/a> & Aggarwal, 2004<\/td>\n<\/tr>\n
4-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone<\/td>\nPhosphorylation<\/td>\nLai<\/a> et al, 2007<\/td>\n<\/tr>\n
Hydroquinone<\/td>\nPhosphorylation<\/td>\nKerzic<\/a> et al, 2003<\/td>\n<\/tr>\n
Ibuprofen<\/td>\nPhosphorylation<\/td>\nPalayoor<\/a> et al, 1998<\/td>\n<\/tr>\n
Indirubin-3′-oxime<\/td>\nPhosphorylation<\/td>\nMak<\/a> et al, 2004<\/td>\n<\/tr>\n
Inonotus obliquus ethanol extract<\/td>\nPhosphorylation<\/td>\nKim<\/a> et al, 2007<\/td>\n<\/tr>\n
Interferon-alpha<\/td>\nPhosphorylation<\/td>\nManna<\/a> et al, 2000<\/td>\n<\/tr>\n
Inhaled isobutyl nitrite<\/td>\nPhosphorylation<\/td>\nPonnappan<\/a> et al, 2004<\/td>\n<\/tr>\n
Kaempferol<\/td>\nPhosphorylation<\/td>\nGarcia-Mediavilla<\/a> et al, 2006; Kim<\/a> et al, 2007<\/td>\n<\/tr>\n
Kushen flavonoids and kurarinone<\/td>\nPhosphorylation<\/td>\nHan<\/a> et al, 2006<\/td>\n<\/tr>\n
Licorce extracts<\/td>\nPhosphorylation<\/td>\nKim<\/a> et al, 2006: Kwon<\/a> et al, 2007<\/td>\n<\/tr>\n
Melatonin<\/td>\nPhosphorylation<\/td>\nAlonso<\/a> et al, 2006; Tamura<\/a> et al, 2009<\/td>\n<\/tr>\n
Marine natural products (several)<\/td>\nIKKb\/proteasome<\/td>\nFolmer<\/a> et al, 2009<\/td>\n<\/tr>\n
Methotrexate<\/td>\nPhosphorylation<\/td>\nMajumdar<\/a> & Aggarwal, 2001; Yozai<\/a> et al, 2005<\/td>\n<\/tr>\n
Monochloramine<\/td>\nPhosphorylation<\/td>\nOmori<\/a> et al, 2002<\/td>\n<\/tr>\n
Nafamostat mesilate<\/td>\nPhosphorylation<\/td>\nNoguchi<\/a> et al, 2003<\/td>\n<\/tr>\n
Obovatol<\/td>\nPhosphorylation<\/td>\nLee<\/a> et al, 2008<\/td>\n<\/tr>\n
Oleandrin<\/td>\nPhosphorylation<\/td>\nManna<\/a> et al, 2000; Sreeivasan<\/a> et al, 2003<\/td>\n<\/tr>\n
Oleanolic acid (Aralia elata)<\/td>\nPhosphorylation<\/td>\nSuh<\/a> et al, 2007<\/td>\n<\/tr>\n
Omega 3 fatty acids<\/td>\nPhosphorylation<\/td>\nNovak<\/a> et al, 2003<\/td>\n<\/tr>\n
Panduratin A (from Kaempferia pandurata, Zingiberaceae)<\/td>\nPhosphorylation<\/td>\nYun<\/a> et al, 2003<\/td>\n<\/tr>\n
Petrosaspongiolide M<\/td>\nPhosphorylation<\/td>\nPosadas<\/a> et al, 2003<\/td>\n<\/tr>\n
Pinosylvin<\/td>\nPhosphorylation<\/td>\nLee<\/a> et al, 2006<\/td>\n<\/tr>\n
Plagius flosculosus extract polyacetylene spiroketal<\/td>\nPhosphorylation<\/td>\nCalzado<\/a> et al, 2005<\/td>\n<\/tr>\n
Phytic acid (inositol hexakisphosphate)<\/td>\nPhosphorylation<\/td>\nFerry<\/a> et al, 2002<\/td>\n<\/tr>\n
Pomegranate fruit extract<\/td>\nPhosphorylation<\/td>\nAhmed<\/a> et al, 2005<\/td>\n<\/tr>\n
Prostaglandin A1<\/td>\nPhosphorylation\/IKK<\/td>\nRossi<\/a> et al, 1997, 2000<\/a><\/td>\n<\/tr>\n
Protocatechuic Aldehyde<\/td>\nPhosphorylation<\/td>\nXu<\/a> et al, 2011<\/td>\n<\/tr>\n
20(S)-Protopanaxatriol (ginsenoside metabolite)<\/td>\nPhosphorylation<\/td>\nOh<\/a> et al, 2004; Lee<\/a> et al, 2005<\/td>\n<\/tr>\n
Rengyolone<\/td>\nPhosphorylation<\/td>\nKim <\/a>et al, 2006<\/td>\n<\/tr>\n
Rottlerin<\/td>\nPhosphorylation<\/td>\nKim<\/a> et al, 2005; Torricelli<\/a> et al, 2008<\/td>\n<\/tr>\n
Saikosaponin-d<\/td>\nPhosphorylation; Increased IkB<\/td>\nLeung<\/a> et al, 2005; Dang<\/a> et al, 2007<\/td>\n<\/tr>\n
Saline (low Na+ istonic)<\/td>\nPhosphorylation<\/td>\nTabary<\/a> et al, 2003<\/td>\n<\/tr>\n
Salvia miltiorrhizae water-soluble extract<\/td>\nPhosphorylation<\/td>\nKim<\/a> et al, 2005<\/td>\n<\/tr>\n
Sanguinarine (pseudochelerythrine, 13-methyl-[1,3]-benzodioxolo-[5,6-c]-1,3-dioxolo-4,5 phenanthridinium)<\/td>\nPhosphorylation<\/td>\nChaturvedi<\/a> et al, 1997<\/td>\n<\/tr>\n
Scoparone<\/td>\nPhosphorylation<\/td>\nJang<\/a> et al, 2005<\/td>\n<\/tr>\n
Sesaminol glucosides<\/td>\nPhosphorylation<\/td>\nLee<\/a> et al, 2006<\/td>\n<\/tr>\n
Shikonins<\/td>\nPhosphorylation<\/td>\nNam<\/a> et al, 2008<\/td>\n<\/tr>\n
Silymarin<\/td>\nPhosphorylation<\/td>\nManna<\/a> et al, 1999; Saliou<\/a> et al, 1998<\/td>\n<\/tr>\n
Snake venom toxin (Vipera lebetina turanica)<\/td>\nPhosphorylation<\/td>\nSon<\/a> et al, 2007<\/td>\n<\/tr>\n
SOCS1<\/td>\nPhosphorylation<\/td>\nKinjyo<\/a> et al, 2002; Nakagawa<\/a> et al, 2002<\/td>\n<\/tr>\n
Spilanthol<\/td>\nPhosphorylation<\/td>\nWu<\/a> et al, 2008<\/td>\n<\/tr>\n
Statins (several)<\/td>\nPhosphorylation<\/td>\nHilgendorff <\/a>et al, 2003; Han et al, 2004; Planavila<\/a> et al, 2005<\/td>\n<\/tr>\n
Sulindac<\/td>\nIKK\/Phosphorylation<\/td>\nYamamato<\/a> et al, 1999<\/td>\n<\/tr>\n
THI 52 (1-naphthylethyl-6,7-dihydroxy-1,2,3,4- <\/p>\n

tetrahydroisoquinoline)<\/td>\n

Phosphorylation<\/td>\nKang<\/a> et al, 2003<\/td>\n<\/tr>\n
1,2,4-thiadiazolidine derivatives<\/td>\nPhosphorylation<\/td>\nManna<\/a> et al, 2004<\/td>\n<\/tr>\n
Tomatidine<\/td>\nPhosphorylation<\/td>\nChiu<\/a> & Lin, 2008<\/td>\n<\/tr>\n
Vesnarinone<\/td>\nPhosphorylation<\/td>\nManna<\/a> & Aggarwal, 2000; Harada<\/a> et al, 2005<\/td>\n<\/tr>\n
Xanthoangelol D<\/td>\nPhosphorylation<\/td>\nSugii<\/a> et al, 2005<\/td>\n<\/tr>\n
YC-1<\/td>\nPhosphorylation<\/td>\nHuang<\/a> et al, 2005<\/td>\n<\/tr>\n
YopJ (encoded by Yersinia pseudotuberculosis)<\/td>\nDeubiquintinase for IkBa; Acetylation of IKKbeta<\/td>\nSchesser<\/a> et al, 1998; Zhou<\/a> et al, 2005; Mittal<\/a> et al, 2006; Mukherjee<\/a> & Orth, 2008<\/td>\n<\/tr>\n
Osmotic stress<\/td>\nIkB ubiquitination<\/td>\nHuangfu<\/a> et al, 2007<\/td>\n<\/tr>\n
Acetaminophen<\/td>\nDegradation<\/td>\nMancini<\/a> et al, 2003<\/td>\n<\/tr>\n
Activated Protein C (APC)<\/td>\nDegradation<\/td>\nYuksel<\/a> et al, 2002<\/td>\n<\/tr>\n
Alachlor<\/td>\nDegradation<\/td>\nShimomura-Shimizu<\/a> <\/strong>et al, 2005<\/td>\n<\/tr>\n
Allylpyrocatechol<\/td>\nDegradation<\/td>\nSarkar<\/a> <\/strong>et al, 2008<\/td>\n<\/tr>\n
a-melanocyte-stimulating hormone (a-MSH)<\/td>\nDegradation<\/td>\nManna<\/a> & Aggarwal, 1998<\/td>\n<\/tr>\n
Amentoflavone<\/td>\nDegradation<\/td>\nBanerjee<\/a> et al, 2002; Guruvayoorappan<\/a> & Kuttan, 2007<\/td>\n<\/tr>\n
Angelica dahurica radix extract<\/td>\nDegradation<\/td>\nKang<\/a> et al, 2006<\/td>\n<\/tr>\n
Apple extracts<\/td>\nDegradation\/proteasome<\/td>\nYoon<\/a> & Liu, 2007<\/td>\n<\/tr>\n
Artemisia capillaris Thunb extract (capillarisin)<\/td>\nDegradation<\/td>\nHong<\/a> et al, 2004; Kim<\/a> et al, 2007; Lee<\/a> et al, 2007<\/td>\n<\/tr>\n
Artemisia iwayomogi extract<\/td>\nDegradation<\/td>\nKim<\/a> et al, 2005<\/td>\n<\/tr>\n
L-ascorbic acid<\/td>\nDegradation<\/td>\nHan<\/a> et al, 2004<\/td>\n<\/tr>\n
Antrodia camphorata<\/td>\nDegradation<\/td>\nHseu<\/a> et al, 2005<\/td>\n<\/tr>\n
Aucubin<\/td>\nDegradation<\/td>\nJeong<\/a> et al, 2002<\/td>\n<\/tr>\n
Baicalein<\/td>\nDegradation<\/td>\nMa<\/a> et al, 2004<\/td>\n<\/tr>\n
N-(quinolin-8-yl)benzenesulfonamindes<\/td>\nDegradation<\/td>\nXie<\/a> et al, 2007<\/td>\n<\/tr>\n
beta-lapachone<\/td>\nDegradation<\/td>\nManna<\/a> et al, 1999<\/td>\n<\/tr>\n
Blackberry extract<\/td>\nDegradation<\/td>\nPergola<\/a> et al, 2006<\/td>\n<\/tr>\n
1-Bromopropane<\/td>\nDegradation<\/td>\nYoshida<\/a> et al, 2006<\/td>\n<\/tr>\n
Buchang-tang<\/td>\nDegradation<\/td>\nShin<\/a> et al, 2005<\/td>\n<\/tr>\n
Capsaicin (8-methyl-N-vanillyl-6-nonenamide)<\/td>\nDegradation<\/td>\nSingh<\/a> et al, 1996; Mori<\/a> et al, 2006; Kang<\/a> et al, 2007<\/td>\n<\/tr>\n
Catalposide<\/td>\nDegradation<\/td>\nKim<\/a> et al, 2004<\/td>\n<\/tr>\n
Clerodendron trichotomum Tunberg Leaves<\/td>\nDegradation<\/td>\nPark<\/a> & Kim, 2007<\/td>\n<\/tr>\n
Clomipramine\/imipramine<\/td>\nDegradation<\/td>\nHwang<\/a> et al, 2008<\/td>\n<\/tr>\n
Coptidis rhizoma extract<\/td>\nDegradation<\/td>\nKim<\/a> et al, 2007<\/td>\n<\/tr>\n
Cyclolinteinone (sponge sesterterpene)<\/td>\nDegradation<\/td>\nD’Acquisto<\/a> et al, 2000<\/td>\n<\/tr>\n
DA-9601 (Artemisia asiatica extract)<\/td>\nDegradation<\/td>\nChoi<\/a> et al, 2006<\/td>\n<\/tr>\n
Diamide (tyrosine phosphatase inhibitor)<\/td>\nDegradation<\/td>\nToledano<\/a> & Leonard, 1991; Singh<\/a> & Aggarwal, 1995<\/td>\n<\/tr>\n
Dihydroarteanniun<\/td>\nDegradation<\/td>\nLi<\/a> et al, 2006<\/td>\n<\/tr>\n
Dobutamine<\/td>\nDegradation<\/td>\nLoop<\/a> et al, 2004<\/td>\n<\/tr>\n
Docosahexaenoic acid<\/td>\nDegradation<\/td>\nWeldon<\/a> et al, 2006<\/td>\n<\/tr>\n
E-73 (cycloheximide analog)<\/td>\nDegradation<\/td>\nSugimoto<\/a> et al, 2000<\/td>\n<\/tr>\n
Ecabet sodium<\/td>\nDegradation<\/td>\nKim<\/a> et al, 2003<\/td>\n<\/tr>\n
Electrical stimulation of vagus nerve<\/td>\nDegradation<\/td>\nGuarini<\/a> et al, 2003<\/td>\n<\/tr>\n
Emodin (3-methyl-1,6,8-trihydroxyanthraquinone)<\/td>\nDegradation<\/td>\nKumar<\/a> et al, 1998; Huang<\/a> et al, 2004<\/td>\n<\/tr>\n
Ephedrae herba (Mao)<\/td>\nDegradation<\/td>\nAoki<\/a> et al, 2005<\/td>\n<\/tr>\n
Equol<\/td>\nDegradation<\/td>\nKang<\/a> et al, 2005<\/td>\n<\/tr>\n
Erbstatin (tyrosine kinase inhibitor)<\/td>\nDegradation<\/td>\nNatarajan<\/a> et al, 1998<\/td>\n<\/tr>\n
Estrogen (E2)<\/td>\nDegradation\/and various other steps<\/td>\nSun<\/a> et al, 1998; Kalaitzidis<\/a> & Gilmore, 2005; Steffan<\/a> et al, 2006<\/td>\n<\/tr>\n
Ethacrynic acid<\/td>\nDegradation (and DNA binding)<\/td>\nHan<\/a> et al, 2004<\/td>\n<\/tr>\n
Fludarabine<\/td>\nDegradation<\/td>\nNishioka<\/a> et al, 2007<\/td>\n<\/tr>\n
Fosfomycin<\/td>\nDegradation<\/td>\nYoneshima<\/a> et al, 2003<\/td>\n<\/tr>\n
Fungal gliotoxin<\/td>\nDegradation<\/td>\nPahl<\/a> et al, 1999<\/td>\n<\/tr>\n
Gabexate mesilate<\/td>\nDegradation<\/td>\nYuksel<\/a> et al, 2003<\/td>\n<\/tr>\n
Gamisanghyulyunbueum<\/td>\nDegradation<\/td>\nShin<\/a> et al, 2005<\/td>\n<\/tr>\n
Genistein (tyrosine kinase inhibitor)<\/td>\nDegradation; caspase cleavage of IkBa<\/td>\nNatarajan<\/a> et al, 1998; Baxa<\/a> & Yoshimura, 2003<\/td>\n<\/tr>\n
Genipin<\/td>\nDegradation<\/td>\nKoo<\/a> et al, 2004<\/td>\n<\/tr>\n
Glabridin<\/td>\nDegradation<\/td>\nKang<\/a> et al, 2004<\/td>\n<\/tr>\n
Ginsenoside Re<\/td>\nDegradation<\/td>\nZhang<\/a> et al, 2007<\/td>\n<\/tr>\n
Glimepiride<\/td>\nDegradation<\/td>\nSchiekofer<\/a> et al, 2003<\/td>\n<\/tr>\n
Glucosamine (sulfate or carboxybutyrylated)<\/td>\nDegradation<\/td>\nLargo<\/a> et al, 2003; Rafi<\/a> et al, 2007; Rajapakse<\/a> et al, 2008<\/td>\n<\/tr>\n
gamma-glutamylcysteine synthetase<\/td>\nDegradation<\/td>\nManna<\/a> et al, 1999<\/td>\n<\/tr>\n
Glutamine<\/td>\nDegradation<\/td>\nSingleton<\/a> et al, 2005; Fillmann<\/a> et al, 2007; Chen<\/a> et al, 2008<\/td>\n<\/tr>\n
Glycochenodeoxycholate<\/td>\nDegradation<\/td>\nBucher<\/a> et al, 2006<\/td>\n<\/tr>\n
Guave leaf extract<\/td>\nDegradation<\/td>\nChoi<\/a> et al, 2008<\/td>\n<\/tr>\n
Gumiganghwaltang<\/td>\nDegradation<\/td>\nKim<\/a> et al, 2005<\/td>\n<\/tr>\n
Gum mastic<\/td>\nDegradation<\/td>\nHe<\/a> et al, 2007<\/td>\n<\/tr>\n
Heat shock protein-70<\/td>\nDegradation<\/td>\nChan<\/a> et al, 2004; Shi<\/a> et al, 2006<\/td>\n<\/tr>\n
Herbal mixture (Cinnamomi ramulus, Anemarrheriae rhizoma, Officinari rhizoma)<\/td>\nDegradation<\/td>\nJeong<\/a> et al, 2008<\/td>\n<\/tr>\n
Hypochlorite<\/td>\nDegradation<\/td>\nMohri<\/a> et al, 2002<\/td>\n<\/tr>\n
Ibudilast<\/td>\nDegradation<\/td>\nKiebala & Maggirwar<\/a>, 1998<\/td>\n<\/tr>\n
IL-13<\/td>\nDegradation<\/td>\nManna & Aggarwal<\/a>, 1998<\/td>\n<\/tr>\n
Incensole acetate<\/td>\nDegradation<\/td>\nMoussaieff et al, 2007<\/td>\n<\/tr>\n
Intravenous immunoglobulin<\/td>\nDegradation<\/td>\nIchiyama<\/a> et al, 2004<\/td>\n<\/tr>\n
Isomallotochromanol and isomallotochromene<\/td>\nDegradation<\/td>\nIshii<\/a> et al, 2003<\/td>\n<\/tr>\n
K1L (Vaccinia virus protein)<\/td>\nDegradation<\/td>\nShisler<\/a> & Jin, 2004<\/td>\n<\/tr>\n
Kochia scoparia fruit (methanol extract)<\/td>\nDegradation<\/td>\nShin<\/a> et al, 2004<\/td>\n<\/tr>\n
Kummerowia striata (Thunb.) Schindl (ethanol extract)<\/td>\nDegradation<\/td>\nTao<\/a> et al, 2008<\/td>\n<\/tr>\n
Leflunomide metabolite (A77 1726)<\/td>\nDegradation<\/td>\nManna<\/a> & Aggarwal, 1999<\/td>\n<\/tr>\n
Lidocaine<\/td>\nDegradation<\/td>\nFeng<\/a> et al, 2007; Lahat<\/a> et al, 2008<\/td>\n<\/tr>\n
Lipoxin A4<\/td>\nDegradation<\/td>\nZhang<\/a> et al, 2007<\/td>\n<\/tr>\n
Losartan<\/td>\nDegradation\/NF-kB expression<\/td>\nChen<\/a> et al, 2002; Zhu<\/a> et al, 2007<\/td>\n<\/tr>\n
Low level laser therapy<\/td>\nDegradation<\/td>\nRizzi<\/a> et al, 2006<\/td>\n<\/tr>\n
LY294002 (PI3-kinase inhibitor)\u00a0 [2-(4-morpholinyl)-8-phenylchromone]<\/td>\nDegradation<\/td>\nPark<\/a> et al, 2002<\/td>\n<\/tr>\n
MC159 (Molluscum contagiosum virus)<\/td>\nDegradation of IkBb<\/td>\nMurao<\/a> & Shisler, 2005<\/td>\n<\/tr>\n
Melatonin<\/td>\nDegradation<\/td>\nZhang<\/a> et al, 2004<\/td>\n<\/tr>\n
Meloxicam<\/td>\nDegradation<\/td>\nLiu<\/a> et al, 2007<\/td>\n<\/tr>\n
5′-methylthioadenosine<\/td>\nDegradation<\/td>\nHevia<\/a> et al, 2004<\/td>\n<\/tr>\n
Midazolam<\/td>\nDegradation<\/td>\nKim<\/a> et al, 2006<\/td>\n<\/tr>\n
Momordin I<\/td>\nDegradation<\/td>\nHwang<\/a> et al, 2005<\/td>\n<\/tr>\n
Morinda officinalis extract<\/td>\nDegradation<\/td>\nKim<\/a> et al, 2005<\/td>\n<\/tr>\n
Mosla dianthera extract<\/td>\nDegradation<\/td>\nLee <\/a>et al, 2006<\/td>\n<\/tr>\n
Mume fructus extract<\/td>\nDegradation<\/td>\nChoi<\/a> et al, 2007<\/td>\n<\/tr>\n
Murr1 gene product<\/td>\nDegradation<\/td>\nGanesh<\/a> et al, 2003<\/td>\n<\/tr>\n
Neurofibromatosis-2 (NF-2; merlin) protein<\/td>\nDegradation<\/td>\nKim<\/a> et al, 2002<\/td>\n<\/tr>\n
Opuntia ficus indica va saboten extract<\/td>\nDegradation<\/td>\n <\/a>Lee<\/a> et al, 2006<\/td>\n<\/tr>\n
Ozone (aqueous)<\/td>\nDegradation<\/td>\nHuth<\/a> et al, 2007<\/td>\n<\/tr>\n
Paeony total glucosides<\/td>\nDegradation<\/td>\nChen<\/a> et al, 2007<\/td>\n<\/tr>\n
Pectenotoxin-2<\/td>\nDegradation<\/td>\nKim<\/a> et al, 2008<\/td>\n<\/tr>\n
Penetratin<\/td>\nDegradation<\/td>\nLetoya<\/a> et al, 2006<\/td>\n<\/tr>\n
Pervanadate (tyrosine phosphatase inhibitor)<\/td>\nDegradation<\/td>\nSingh<\/a> & Aggarwal, 1995; Singh<\/a> et al, 1996<\/td>\n<\/tr>\n
Phenylarsine oxide (PAO, tyrosine phosphatase inhibitor)<\/td>\nDegradation<\/td>\nMahboubi<\/a> et al, 1998; Singh<\/a> & Aggarwal, 1995<\/td>\n<\/tr>\n
beta-Phenylethyl (PEITC) and 8-methylsulphinyloctyl isothiocyanates (MSO) (watercress)<\/td>\nDegradation<\/td>\nRose<\/a> et al, 2005<\/td>\n<\/tr>\n
Phenytoin<\/td>\nDegradation<\/td>\nKato et al, 2005<\/td>\n<\/tr>\n
c-phycocyanin<\/td>\nDegradation<\/td>\nCherng<\/a> et al, 2007<\/td>\n<\/tr>\n
Platycodin saponins<\/td>\nDegradation<\/td>\nAhn<\/a> et al, 2005; Lee<\/a> et al, 2008<\/td>\n<\/tr>\n
Polymeric formula<\/td>\nDegradation<\/td>\nde Jong<\/a> et al, 2007<\/td>\n<\/tr>\n
Polymyxin B<\/td>\nDegradation<\/td>\nJiang<\/a> et al, 2006<\/td>\n<\/tr>\n
Poncirus trifoliata fruit extract<\/td>\nDegradation; phosphorylation of IkBa<\/td>\nShin<\/a> et al, 2006; Kim<\/a> et al, 2007<\/td>\n<\/tr>\n
Probiotics<\/td>\nDegradation<\/td>\nPetrof<\/a> et al, 2004<\/td>\n<\/tr>\n
Pituitary adenylate cyclase-activating polypeptide (PACAP)<\/td>\nDegradation<\/td>\nDelgado<\/a> & Ganea, 2001<\/td>\n<\/tr>\n
Prostaglandin 15-deoxy-Delta(12,14)-PGJ(2)<\/td>\nDegradation<\/td>\nCuzzocrea<\/a> et al, 2003; Chatterjee<\/a> et al, 2004<\/td>\n<\/tr>\n
Prodigiosin (Hahella chejuensis)<\/td>\nDegradation<\/td>\nHuh<\/a> et al, 2007<\/td>\n<\/tr>\n
PS-341<\/td>\nDegradation\/proteasome<\/td>\nHideshima<\/a> et al, 2002<\/td>\n<\/tr>\n
Radix asari extract<\/td>\nDegradation<\/td>\nSong<\/a> et al, 2007<\/td>\n<\/tr>\n
Radix clematidis extract<\/td>\nDegradation<\/td>\nLee<\/a> et al, 2009<\/td>\n<\/tr>\n
Resiniferatoxin<\/td>\nDegradation<\/td>\nSingh<\/a> et al, 1996<\/td>\n<\/tr>\n
Sabaeksan<\/td>\nDegradation<\/td>\nChoi<\/a> et al, 2005<\/td>\n<\/tr>\n
SAIF (Saccharomyces boulardii anti-inflammatory factor)<\/td>\nDegradation<\/td>\nSougioultzis<\/a> et al, 2006<\/td>\n<\/tr>\n
Sanguis Draconis<\/td>\nDegradation<\/td>\nChoy<\/a> et al, 2007<\/td>\n<\/tr>\n
San-Huang-Xie-Xin-Tang<\/td>\nDegradation<\/td>\nShih<\/a> et al, 2007<\/td>\n<\/tr>\n
Schisandra fructus extract<\/td>\nDegradation<\/td>\nKang<\/a> et al, 2006; Guo<\/a> et al, 2008<\/td>\n<\/tr>\n
Scutellarin<\/td>\nDegradation<\/td>\nTan<\/a> et al, 2007<\/td>\n<\/tr>\n
Sesquiterpene lactones (parthenolide; ergolide; guaianolides; alpha-humulene; trans-caryophyllene)<\/td>\nDegradation<\/td>\nHehner<\/a> et al, 1998; Whan Han<\/a> et al, 2001; Schorr<\/a> et al, 2002; Medeiros<\/a> et al, 2007<\/td>\n<\/tr>\n
Sevoflurane\/isoflurane<\/td>\nDegradation<\/td>\nBoost<\/a> et al, 2009<\/td>\n<\/tr>\n
Siegeskaurolic acid (from Siegesbeckia pubescens root)<\/td>\nDegradation<\/td>\nPark<\/a> et al, 2007<\/td>\n<\/tr>\n
ST2 (IL-1-like receptor secreted form)<\/td>\nDegradation<\/td>\nTakezako<\/a> et al, 2006<\/td>\n<\/tr>\n
Synadenium carinatum latex lectin<\/td>\nDegradation<\/td>\nRogerio<\/a> et al, 2007<\/td>\n<\/tr>\n
Taiwanofungus camphoratus<\/td>\nDegradation<\/td>\nLiu<\/a> et al, 2007<\/td>\n<\/tr>\n
Taurene bromamine<\/td>\nDegradation<\/td>\nTokunaga<\/a> et al, 2007<\/td>\n<\/tr>\n
Thiopental<\/td>\nDegradation<\/td>\nLoop et al, 2002<\/a><\/td>\n<\/tr>\n
Tipifarnib<\/td>\nDegradation<\/td>\nXue<\/a> et al, 2005<\/td>\n<\/tr>\n
Titanium<\/td>\nDegradation<\/td>\nYang<\/a> et al, 2003<\/td>\n<\/tr>\n
TNP-470 (angiogenesis inhibitor)<\/td>\nDegradation<\/td>\nMauriz et al, 2003<\/a><\/td>\n<\/tr>\n
Stinging nettle (Urtica dioica) plant extracts<\/td>\nDegradation<\/td>\nRiehemann<\/a> et al, 1999<\/td>\n<\/tr>\n
Trichomomas vaginalis infection<\/td>\nDegradation<\/td>\nChang<\/a> et al, 2004<\/td>\n<\/tr>\n
Triglyceride-rich lipoproteins<\/td>\nDegradation<\/td>\nKumwenda<\/a> et al, 2002<\/td>\n<\/tr>\n
Tussilagone (Farfarae fios)<\/td>\nDegradation<\/td>\nLim<\/a> et al, 2008<\/td>\n<\/tr>\n
U0126 (MEK inhibitor)<\/td>\nDegradation<\/td>\n Takaya<\/a> et al, 2003<\/td>\n<\/tr>\n
Ursodeoxycholic acid<\/td>\nDegradation<\/td>\nJoo<\/a> et al, 2004<\/td>\n<\/tr>\n
Xanthium strumarium L. (methanol extract)<\/td>\nDegradation<\/td>\nKim et al, 2005<\/a>; Yoon<\/a> et al, 2008<\/td>\n<\/tr>\n
Yulda-Hanso-Tang<\/td>\nDegradation<\/td>\nJeong<\/a> et al, 2007<\/a><\/td>\n<\/tr>\n
Zinc<\/td>\nDegradation<\/td>\nUzzo<\/a> et al, 2006<\/a>; Bao<\/a> et al, 2006<\/td>\n<\/tr>\n
Molluscum contagiosum virus MC159 protein<\/td>\nIkBbeta degradation<\/td>\nMurao & Shisler, 2005<\/a><\/td>\n<\/tr>\n
Vasoactive intestinal peptide<\/td>\nDegradation (and CBP-RelA interaction)<\/td>\nDelgado<\/a> & Ganea, 2001; Delgado<\/a>, 2002<\/td>\n<\/tr>\n
HIV-1 Vpu protein<\/td>\nTrCP ubiquitin ligase inhibitor<\/td>\nBour<\/a> et al, 2001<\/td>\n<\/tr>\n
Epoxyquinone A monomer<\/td>\nIKKb\/DNA binding<\/td>\nLiang<\/a> et al, 2006<\/td>\n<\/tr>\n
Ro106-9920 (small molecule)<\/td>\nIkBa ubiqutination inhibitor<\/td>\nSwinney<\/a> et al, 2002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n
Furonaphthoquinone<\/td>\nIKK activity<\/td>\nShin <\/a>et al, 2006<\/td>\n<\/tr>\n
\u03b2-TrCP<\/td>\nDegradation<\/td>\nKanarek<\/a> et al, 2012<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Table 2b IkBa phosphorylation and\/or degradation inhibitors Molecule Point of Inhibition References Desloratadine; diphenhydramine Histamine H1 receptor Wu et al, 2004; Scadding, 2005; Roumestan et al, 2008 Bikunin LPS receptor agonists Kobayashi, 2006; Kanayama et al, 2007 Ron Tyrosine kinase receptor Suppresses TNF production Lentsch et al, 2007 TAK-242 TLR4 intracellular domain Kawamoto et al, […]<\/p>\n","protected":false},"author":3621,"featured_media":0,"parent":0,"menu_order":9,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/92"}],"collection":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/users\/3621"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/comments?post=92"}],"version-history":[{"count":22,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/92\/revisions"}],"predecessor-version":[{"id":426,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/92\/revisions\/426"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/media?parent=92"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}