{"id":197,"date":"2011-02-08T09:56:07","date_gmt":"2011-02-08T14:56:07","guid":{"rendered":"https:\/\/www.bu.edu\/nf-kb\/?page_id=197"},"modified":"2012-09-12T08:13:46","modified_gmt":"2012-09-12T12:13:46","slug":"interacting-proteins","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/nf-kb\/physiological-mediators\/interacting-proteins\/","title":{"rendered":"Protein-Protein Interactions"},"content":{"rendered":"

Proteins That Can Interact with Rel\/NF-kB\/IkB Signaling Proteins<\/strong><\/p>\n\n\n\n
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
PROTEIN<\/td>\nINTERACTING PARTNER(S)<\/td>\nREFERENCE<\/td>\n<\/td>\n<\/tr>\n
Heat shock protein<\/td>\nv-Rel; RelA; IKK<\/td>\nLim<\/a> et al, 1990 ; Guzhova<\/a> et al, 1997; Hinz<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
Unknown 200 kDa<\/td>\nv-Rel<\/td>\nMorrison<\/a> et al, 1989<\/td>\n<\/td>\n<\/tr>\n
Sp1<\/td>\nv-Rel, c-Rel, RelA<\/td>\nSif<\/a> & Gilmore, 1994; Perkins<\/a> et al, 1993; \u00a0 Majello<\/a> et al 1994<\/td>\n<\/td>\n<\/tr>\n
TBP<\/td>\nv-Rel, c-Rel, RelA, Dorsal<\/td>\nXu<\/a> et al, 1993; Kerr<\/a> et al, 1993; Norris<\/a> & Manley, 1992; Schmitz <\/a>et al, 1995<\/td>\n<\/td>\n<\/tr>\n
TFIIB<\/td>\nv-Rel, RelA<\/td>\nXu<\/a> et al, 1993; Schmitz <\/a>et al, 1995 : Xia<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
p300<\/td>\nRelA, c-Rel<\/td>\nPerkins<\/a> et al, 1997; Yu<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
AO7<\/td>\nRelA<\/td>\nAsamitsu<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
HDACs<\/td>\nRelA, p50,\u00a0 IkBa<\/td>\nAshburner<\/a> et al, 2001; Chen<\/a> et al, 2001; Viatour<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
TAFII105<\/td>\nRelA<\/td>\nYamit-Hezi<\/a> et al, 2000<\/td>\n<\/td>\n<\/tr>\n
Centrosomal P4.1-associated protein<\/td>\nRelA<\/td>\nKoyanagi<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
Trip6<\/td>\nv-Rel, RelA<\/td>\nKoedood Zhao<\/a> et al, 1999; Kassel<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
NFATc<\/td>\nc-Rel<\/td>\nPham<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
Bcl-2<\/td>\np50<\/td>\nHour<\/a> et al, 2000<\/td>\n<\/td>\n<\/tr>\n
CREB<\/td>\np50<\/td>\nHe<\/a> & Weber, 2004<\/td>\n<\/td>\n<\/tr>\n
DLC-1<\/td>\nIkBa<\/td>\nCrepieux <\/a>et al, 1997<\/td>\n<\/td>\n<\/tr>\n
ESE-1<\/td>\np50<\/td>\nRudders<\/a> et al, 2001<\/td>\n<\/td>\n<\/tr>\n
HMGI(Y)<\/td>\np50,RelA<\/td>\nThanos<\/a> & Maniatis, 1992; Du<\/a> et al, 1993<\/td>\n<\/td>\n<\/tr>\n
Importin alpha isoforms<\/td>\np50,RelA,p52, c-Rel, RelB<\/td>\nFagerlund<\/a> et al, 2005; 2008<\/a><\/td>\n<\/td>\n<\/tr>\n
Nucleophosmin<\/td>\np50,RelA<\/td>\nDhar<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
HMGA2<\/td>\np50<\/td>\nNoro<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
HMGB1<\/td>\np50<\/td>\nAgresti<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
Menin<\/td>\np50, p52, RelA<\/td>\nHeppner<\/a> et al, 2001<\/td>\n<\/td>\n<\/tr>\n
Steroid Receptor Coactivator-1 (SRC-1)<\/td>\np50<\/td>\nNa<\/a> et al, 1998<\/td>\n<\/td>\n<\/tr>\n
TLS<\/td>\nRelA<\/td>\nUranishi<\/a> et al, 2001<\/td>\n<\/td>\n<\/tr>\n
EPRAP<\/td>\np105<\/td>\nMinami<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
Gas6<\/td>\np105<\/td>\nDemarchi<\/a> et al, 2001<\/td>\n<\/td>\n<\/tr>\n
G protein-coupled receptor kinase 5<\/td>\np105<\/td>\nParameswaran<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
IKKepsilon<\/td>\np52<\/td>\nWietek<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
Retinoid X Receptor<\/td>\nIkBbeta, p50, RelA, Bcl-3<\/td>\nNa et al, 1998<\/a> , 1999<\/a><\/td>\n<\/td>\n<\/tr>\n
ASPP<\/td>\nRelA<\/td>\nSullivan<\/a> & Lu, 2007<\/td>\n<\/td>\n<\/tr>\n
Daxx<\/td>\nRelA<\/td>\nPark<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
Dynein motor complex<\/td>\nRelA<\/td>\nMikenberg<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
FAD24<\/td>\nRelA<\/td>\nJohmura<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
p28(GANK)<\/td>\nRelA<\/td>\nChen<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
LZAP<\/td>\nRelA<\/td>\nWang<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
MYBBP1a<\/td>\nRelA<\/td>\nOwen<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
PDLIM2<\/td>\nRelA<\/td>\nTanaka<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
SIMPL<\/td>\nRelA<\/td>\nKwon<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
TTF-1<\/td>\nRelA<\/td>\nIslam<\/a> & Mendelson, 2002<\/td>\n<\/td>\n<\/tr>\n
CHFR<\/td>\nRelA<\/td>\nKashima<\/a> et al, 2009<\/td>\n<\/td>\n<\/tr>\n
Glucocorticoid Receptor<\/td>\nRelA<\/td>\nRay<\/a> & Prefontaine, 1994; Sheinman<\/a> et al, 1995<\/td>\n<\/td>\n<\/tr>\n
Clock<\/td>\nRelA<\/td>\nSpengler et al, 2012<\/td>\n<\/td>\n<\/tr>\n
Androgen Receptor<\/td>\nRelA, c-Rel<\/td>\nPalvimo<\/a> et al, 1996; Mukhopadhyay<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
Progesterone Receptor<\/td>\nRelA<\/td>\nKalkhoven<\/a> et al, 1996<\/td>\n<\/td>\n<\/tr>\n
Estrogen Receptor<\/td>\nc-Rel, RelA<\/td>\nGalien<\/a> & Garcia, 1997; Kalaitzidis<\/a> & Gilmore, 2005; Feldman<\/a> et al, 2007; Quaedackers<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
AH Receptor<\/td>\nRelA, p50, RelB<\/td>\nTian<\/a> et al, 1999; Vogel<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
ASC-1<\/td>\nRelA, p50<\/td>\nJung<\/a> et al, 2001<\/td>\n<\/td>\n<\/tr>\n
CDX2<\/td>\nRelA, p50<\/td>\nMutoh<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
ETS, PU.1, ELF-1<\/td>\nRelA, p50<\/td>\nBassuk<\/a> et al, 1997<\/td>\n<\/td>\n<\/tr>\n
GILZ<\/td>\nRelA, p50<\/td>\nRiccardi<\/a> et al, 2001; Marco<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
LSF (SEF)<\/td>\nRelA, p50<\/td>\nBing<\/a> et al, 2000<\/td>\n<\/td>\n<\/tr>\n
Notch1<\/td>\nRelA, p50, IKKa<\/td>\nWang<\/a> et al, 2001; Guan<\/a> et al, 1996; Song<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
NFBP<\/td>\nRelA, p50<\/td>\nSweet<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
PARP-1<\/td>\nRelA, p50<\/td>\nHassa<\/a> et al, 2001; Kitamura<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
SMRT<\/td>\nRelA, p50<\/td>\nLee<\/a> et al, 2000<\/td>\n<\/td>\n<\/tr>\n
UXT<\/td>\nRelA, p50, c-Rel<\/td>\nSun<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
LYL1<\/td>\np105<\/td>\nFerrier<\/a> et al, 1999<\/td>\n<\/td>\n<\/tr>\n
ZUD<\/td>\np105, RelA<\/td>\nZhang<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
p53<\/td>\nIkBa, RelA<\/td>\nChang<\/a>, 2002 ; Zhou<\/a> et al, 2003; Jeong<\/a> et al, 2004; Dreyfus<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
p73<\/td>\nIKKa<\/td>\nFuruya<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
Huntingtin<\/td>\nIkBa, RelA<\/td>\nGoswami<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
HOXB7<\/td>\nIkBa<\/td>\nChariot<\/a> et al, 1999<\/td>\n<\/td>\n<\/tr>\n
Beta TrCP<\/td>\nIkBa<\/td>\nKroll<\/a> et al, 1999<\/td>\n<\/td>\n<\/tr>\n
Beta Arrestin2<\/td>\nIkBa, p105<\/td>\nGao<\/a> et al, 2004; Parmameswaran<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
RASGAPSH3BP2<\/td>\nIkBa<\/td>\nPrigent<\/a> et al, 2000<\/td>\n<\/td>\n<\/tr>\n
ANT<\/td>\nIkBa<\/td>\nBottero<\/a> et al, 2001<\/td>\n<\/td>\n<\/tr>\n
CDK4<\/td>\nIkBa<\/td>\nLi<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
Calpain 3<\/td>\nIkBa<\/td>\nMarcilhac<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
Dynein light chain LC8<\/td>\nIkBa<\/td>\nJung<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
Fibronectin<\/td>\nphospho-IkBa<\/td>\nOlson<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
HnRNPA1<\/td>\nIkBa<\/td>\nHay<\/a> et al, 2000<\/td>\n<\/td>\n<\/tr>\n
c-Abl<\/td>\nIkBa<\/td>\nKawai<\/a> et al, 2002<\/td>\n<\/td>\n<\/tr>\n
MIG-6<\/td>\nIkBa<\/td>\nTsunoda<\/a> et al, 2002; Mabuchi<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
HDACs, nuclear co-repressors<\/td>\nIkBa<\/td>\nAguilera<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
HDAC3<\/td>\nIkBa<\/td>\nGao<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
Nrpo (Swine fever virus)<\/td>\nIkBa<\/td>\nDoceul<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
Bcl10<\/td>\nBcl-3; IKKb<\/td>\nYeh<\/a> et al, 2005; Wegener<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
LCK<\/td>\nBcl-3<\/td>\nZhao<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
Cot\/Tpl2<\/td>\nc-Rel, p50\/p105, p52\/p100, RelA<\/td>\nBouwmeester<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
ABIN2<\/td>\nc-Rel, RelA, p105<\/td>\nBouwmeester<\/a> et al, 2004; Lang et al, 2004<\/td>\n<\/td>\n<\/tr>\n
PAPOLA<\/td>\nc-Rel<\/td>\nBouwmeester<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
IQGAP2<\/td>\nIkBb, RelA<\/td>\nBouwmeester<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
CDK9<\/td>\np50, RelA<\/td>\nAmini<\/a> et al, 2002<\/td>\n<\/td>\n<\/tr>\n
PKA<\/td>\nIkBa, IkBbeta , p50<\/td>\nZhong<\/a> et al, 1997; Guan <\/a>et al, 2005<\/td>\n<\/td>\n<\/tr>\n
Proteasome<\/td>\np100delta C-term<\/td>\nQing<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
Erbin<\/td>\nc-Rel<\/td>\nRess<\/a> & Moelling, 2006<\/td>\n<\/td>\n<\/tr>\n
JNK1<\/td>\nc-Rel<\/td>\nMeyer<\/a> et al, 1996<\/td>\n<\/td>\n<\/tr>\n
NIK<\/td>\nc-Rel<\/td>\nSanchez-Valdepenas<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
PKA-Cbeta<\/td>\nc-Rel<\/td>\nYu<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
S9<\/td>\np100<\/td>\nFong<\/a> et al, 2002<\/td>\n<\/td>\n<\/tr>\n
Actin<\/td>\nRelA<\/td>\nFazal<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
Alpha-actinin-4<\/td>\nRelA<\/td>\nBabakov<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
RAI<\/td>\nRelA<\/td>\nYang<\/a> et al, 1999<\/td>\n<\/td>\n<\/tr>\n
NRF<\/td>\nRelA<\/td>\nNourbakhsh<\/a> & Hauser, 1999<\/td>\n<\/td>\n<\/tr>\n
nAKAP95<\/td>\nRelA<\/td>\nBouwmeester<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
53BP2<\/td>\nRelA<\/td>\nYang<\/a> et al, 1999<\/td>\n<\/td>\n<\/tr>\n
PPAR-a, b, d<\/td>\nRelA<\/td>\nDelerive<\/a> et al, 1999; Planavila<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
MOZ<\/td>\nRelA<\/td>\nChan<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
AES<\/td>\nRelA<\/td>\nTetsuka<\/a> et al, 2000<\/td>\n<\/td>\n<\/tr>\n
COMMD1<\/td>\nRelA<\/td>\nBurstein<\/a> et al, 2005; de Bie<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
DEK<\/td>\nRelA<\/td>\nSammons<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
gankyrin<\/td>\nRelA<\/td>\nHigashitsuji<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
PML<\/td>\nRelA<\/td>\nWu<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
Egr-1<\/td>\nRelA<\/td>\nLee <\/a>et al, 2005<\/td>\n<\/td>\n<\/tr>\n
Egr\u00a0-3, Egr-4<\/td>\nRelA, p50<\/td>\nWieland<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
FBI-1<\/td>\nRelA<\/td>\nChapman<\/a> & Perkins, 2000<\/td>\n<\/td>\n<\/tr>\n
OCT1<\/td>\nRelA<\/td>\nvan Heel<\/a> et al, 2002; dela Paz<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
X11L<\/td>\nRelA<\/td>\nTomita<\/a> et al, 2000<\/td>\n<\/td>\n<\/tr>\n
HEXIM1<\/td>\nRelA<\/td>\nOuchida<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
ING4<\/td>\nRelA<\/td>\nGarkavtsev<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
Casein kinase II<\/td>\nRelA<\/td>\nWang<\/a> et al, 2000<\/td>\n<\/td>\n<\/tr>\n
c-Src<\/td>\nRelA<\/td>\nBijli<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
p38-MAPK<\/td>\nRelA<\/td>\nRajaiya<\/a> et al, 2007; von Brandenstein<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
PIAS1<\/td>\nRelA<\/td>\nLiu<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
PKC-zeta<\/td>\nRelA<\/td>\nLeitges<\/a> et al, 2001<\/td>\n<\/td>\n<\/tr>\n
Ribosomal protein S3<\/td>\nRelA<\/td>\nWan<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
RIP140<\/td>\nRelA<\/td>\nZschiedrich<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
RNA Helicase A<\/td>\nRelA<\/td>\nTetsuka<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
TAD binding proteins<\/td>\nRelA<\/td>\nOwen<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
T-box transcription factor<\/td>\nRelA<\/td>\nHwang<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
VP1686 (Vibrio)<\/td>\nRelA<\/td>\nBhattacharjee<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
PKR<\/td>\nIKK<\/td>\nBonnet<\/a> et al, 2000 ; 2006<\/a><\/td>\n<\/td>\n<\/tr>\n
Protein Phosphatase 2Cb<\/td>\nIKK\u00a0complex<\/td>\nPrajapati<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
Protein Phosphatase X<\/td>\nc-Rel<\/td>\nHu<\/a> et al, 1998<\/td>\n<\/td>\n<\/tr>\n
Protein Phosphatase 2A<\/td>\nRelA; IKK, NF-kB; NEMO<\/td>\nYang<\/a> et al, 2001; Li<\/a> et al, 2006; Hong<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
E2F1<\/td>\np50, RelA<\/td>\nKundu<\/a> et al, 1997; Lim<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
Myc<\/td>\nRelA<\/td>\nChapman<\/a> et al, 2002<\/td>\n<\/td>\n<\/tr>\n
SF-1<\/td>\nNF-kB<\/td>\nHong<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
p21\u00a0(recombinant)<\/td>\nNF-kB<\/td>\nKhanna <\/a>et al, 2005<\/td>\n<\/td>\n<\/tr>\n
P47phox<\/td>\nRelA<\/td>\nGu<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
BRCA1<\/td>\nRelA<\/td>\nBenezra<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
Telomerase<\/td>\nRelA<\/td>\nAkiyama<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
Replication Factor C<\/td>\nRelA<\/td>\nAnderson<\/a> & Perkins, 2003<\/td>\n<\/td>\n<\/tr>\n
Beta-catenin<\/td>\nRelA<\/td>\nDeng<\/a> et al, 2002<\/td>\n<\/td>\n<\/tr>\n
14-3-3 proteins<\/td>\nRelA, IkBa<\/td>\nAguilera<\/a> et al, 2006; Matta<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
Karyopherin alpha<\/td>\nRelA<\/td>\nCunningham<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
SIRT1<\/td>\nRelA<\/td>\nYeung<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
Sir2<\/td>\nRelA<\/td>\nYang<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
REPS2<\/td>\nRelA<\/td>\nPenninkhof<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
ELKS<\/td>\nIKKa, IKKb, IKKg<\/td>\nDucut Sigala<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
ENaC<\/td>\nIKKb<\/td>\nLebowitz<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
NIBP<\/td>\nIKKb, NIK<\/td>\nHu<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
HCV Core protein<\/td>\nIKKb<\/td>\nJoo<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
ABIN-1<\/td>\nNEMO<\/td>\nMauro<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
Bcl-10<\/td>\nNEMO<\/td>\nWu<\/a> & Ashwell, 2008<\/td>\n<\/td>\n<\/tr>\n
CARMA1 and 3<\/td>\nNEMO<\/td>\nStilo<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
CIKS<\/td>\nNEMO<\/td>\nMauro<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
HIF2alpha<\/td>\nNEMO<\/td>\nBracken<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
PIDD<\/td>\nNEMO (and RIP-1)<\/td>\nJanssens<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
RIP-1<\/td>\nNEMO<\/td>\nWu<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
c-Src<\/td>\nNEMO<\/td>\nFunakoshi-Tago<\/a> <\/strong>et al, 2005<\/td>\n<\/td>\n<\/tr>\n
TANK<\/td>\nNEMO<\/td>\nChariot<\/a> et al, 2002<\/td>\n<\/td>\n<\/tr>\n
TRAF1,2<\/td>\nNEMO<\/td>\nDevin<\/a> et al, 2001<\/td>\n<\/td>\n<\/tr>\n
Lys-63 ubiquitin<\/td>\nNEMO<\/td>\nWu<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
ZNF216<\/td>\nNEMO<\/td>\nHuang<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
TFG<\/td>\nNEMO, TANK<\/td>\nMiranda<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
vIRF3 (KSHV)<\/td>\nIKKbeta<\/td>\nSeo<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
AKT<\/td>\nIKKbeta; RelA<\/td>\nVandermoere<\/a> et al, 2006; Lam<\/a> et al, 2007; Kwon<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
Fas-Associated Factor-1<\/td>\nIKKbeta<\/td>\nPark<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
alpha-catulin<\/td>\nIKKbeta<\/td>\nWiesner<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
MUC1<\/td>\nIKKbeta; NEMO<\/td>\nAhmad<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
mTOR<\/td>\nIKK complex<\/td>\nA Baldwin, personal communication<\/td>\n<\/td>\n<\/tr>\n
cdc37<\/td>\nIKK complex<\/td>\nHinz<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
CUEDC2<\/td>\nIKKa, IKKb<\/td>\nLi<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
Heat Shock Protein 27<\/td>\nIKKa, IKKb<\/td>\nPark<\/a> et al, 2003; Kammanadiminti<\/a> & Chadee, 2006<\/td>\n<\/td>\n<\/tr>\n
Hematopoietic kinase 1<\/td>\nIKK complex<\/td>\nBrenner<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
Tgat (Rho guanine exchange factor)<\/td>\nIKK complex<\/td>\nYamada<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
STAP-2<\/td>\nIKKa\/b<\/td>\nSekine<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
TNAP<\/td>\nNIK, Traf2, Traf3<\/td>\nHu<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
c-Jun<\/td>\np50, RelA, IkBa, IkBb, NEMO<\/td>\nStein<\/a> et al, 1993; Kaszubuska<\/a> et al, 1993 ; Cooper<\/a> et al, 2005; Shifera<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
JunD<\/td>\np50-RelA<\/td>\nToualbi-Abed<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
c-Fos<\/td>\nRelA,NEMO<\/td>\nStein<\/a> et al, 1993; Shifera<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
C\/EBPalpha<\/td>\np50<\/td>\nPaz-Priel<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
C\/EBPbeta<\/td>\np50, RelA,c-Rel<\/td>\nStein<\/a> et al, 1993; LeClair<\/a> et al, 1992 ; Zwergal<\/a> et al, 2006; Cha-Molstad<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
GABPbeta<\/td>\nRelA<\/td>\nBruder<\/a> et al, 1993<\/td>\n<\/td>\n<\/tr>\n
ATFa, ATF2, ATF3<\/td>\np50, RelA<\/td>\nKaszubuska<\/a> et al, 1993<\/td>\n<\/td>\n<\/tr>\n
YY1<\/td>\nRelB<\/td>\nSepulveda<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
Elf-1<\/td>\np50<\/td>\nJohn<\/a> et al, 1995<\/td>\n<\/td>\n<\/tr>\n
HBXAP<\/td>\np50, RelA<\/td>\nHuang<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
Nucleophosmin\/B23<\/td>\np50, RelA<\/td>\nLin<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
KPNA3<\/td>\np50\/p105, RelA<\/td>\nBouwmeester<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
IRF-1<\/td>\np50, RelA<\/td>\nDrew<\/a> et al, 1995; Sgarbanti<\/a> et al, 2008<\/td>\n<\/td>\n<\/tr>\n
IRF-2<\/td>\np50<\/td>\nDrew<\/a> et al, 1995<\/td>\n<\/td>\n<\/tr>\n
IRF-8<\/td>\nc-Rel<\/td>\nLiu<\/a> & Ma, 2006<\/td>\n<\/td>\n<\/tr>\n
CDX2<\/td>\nRelA<\/td>\nKim<\/a> et al, 2004<\/td>\n<\/td>\n<\/tr>\n
Stat1 (aceytlated)<\/td>\nRelA<\/td>\nKramer<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
Stat3<\/td>\nRelA<\/td>\nYu<\/a> et al, 2002 ; Yu<\/a> & Kone, 2004; Yang<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
Stat6<\/td>\nRelA, p50<\/td>\nShen<\/a> & Stavnezer, 1998<\/td>\n<\/td>\n<\/tr>\n
SRF<\/td>\nRelA<\/td>\nFranzoso<\/a> et al, 1996<\/td>\n<\/td>\n<\/tr>\n
Twist<\/td>\nDorsal<\/td>\nJiang<\/a> & Levine, 1993<\/td>\n<\/td>\n<\/tr>\n
Twist 1,2<\/td>\nRelA<\/td>\nSosic<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
Pin1<\/td>\nRelA, c-Rel<\/td>\nFan<\/a> et al, 2009<\/td>\n<\/td>\n<\/tr>\n
Calmodulin<\/td>\nc-Rel<\/td>\nAntonsson<\/a> et al, 2003; Khan<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
Cdk2\/cyclinE<\/td>\nc-Rel<\/td>\nChen<\/a> & Li, 1998<\/td>\n<\/td>\n<\/tr>\n
Myotrophin\/V-1<\/td>\nc-Rel, RelA, p50<\/td>\nKnuefermann<\/a> et al, 2002<\/td>\n<\/td>\n<\/tr>\n
Snail<\/td>\nDorsal<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
DSP-1<\/td>\nDorsal, p50<\/td>\nLehming<\/a> et al, 1994<\/td>\n<\/td>\n<\/tr>\n
Tax<\/td>\np50<\/td>\nSuzuki<\/a> et al, 1993<\/td>\n<\/td>\n<\/tr>\n
<\/td>\nRelA<\/td>\nSuzuki<\/a> et al, 1994<\/td>\n<\/td>\n<\/tr>\n
<\/td>\nc-Rel<\/td>\nSuzuki <\/a>et al, 1994<\/td>\n<\/td>\n<\/tr>\n
<\/td>\nIkBa<\/td>\nHirai<\/a> et al, 1994; Petropoulos<\/a> & Hiscott, 1998<\/td>\n<\/td>\n<\/tr>\n
<\/td>\np100<\/td>\nB\u00e9raud<\/a> et al, 1994; Lanoix<\/a> et al, 1994; Murakami<\/a> et al, 1995; Xiao<\/a> et al, 2001<\/td>\n<\/td>\n<\/tr>\n
<\/td>\np105<\/td>\nHirai<\/a> et al, 1992<\/td>\n<\/td>\n<\/tr>\n
<\/td>\nIKK-Tak1<\/td>\nWu<\/a> & Sun, 2007; Chu<\/a> et al, 1998<\/td>\n<\/td>\n<\/tr>\n
<\/td>\nNEMO<\/td>\nChu<\/a> et al, 1999; Harhaj<\/a> & Sun, 1999; Xiao<\/a> et al, 2000<\/td>\n<\/td>\n<\/tr>\n
BZLF1\u00a0\u00a0(EBV)<\/td>\nRelA<\/td>\nGutsch<\/a> et al, 1994<\/td>\n<\/td>\n<\/tr>\n
HIV-1 Resistance Factor<\/td>\np50<\/td>\nLesner<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
HHV-8 vFLIP<\/td>\nNEMO<\/td>\nLiu<\/a> et al, 2002; Field<\/a> et al, 2003<\/td>\n<\/td>\n<\/tr>\n
HHV-8 K13 protein<\/td>\nIKK complex<\/td>\nMatta<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
Adenovirus E3-14.7K<\/td>\nNEMO, p50<\/td>\nLi<\/a> et al, 1999 ; Carmondy<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
HBV\u00a0 X protein<\/td>\nIkBa<\/td>\nWeil<\/a> et al, 1999<\/td>\n<\/td>\n<\/tr>\n
HCV\u00a0NS5B<\/td>\nIKKa<\/td>\nChoi<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
Torque Teno Virus ORF2<\/td>\nIKKa, IKKb<\/td>\nZheng<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
M protein (SARS-Coronavirus)<\/td>\nIKKb<\/td>\nFang<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
Microplitis demolitor bracovirus H4, N5<\/td>\nDif, Relish<\/td>\nThoetkiattikul<\/a> et al, 2005<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Rual et al<\/a> (2005) have used a high-throughput yeast two-hybrid screen to identify many interacting partners for the following NF-kB signaling proteins:<\/p>\n

IKKgamma(NEMO):\u00a0 NEMO, PPM1B, TANK, RIPK, MAP3K14, TNFRSF1A, HSPCA, COPS3, HSPA1A, ZA2OD2, TRPC4AP, C6ORF4, TAB3, UBB, RNF11<\/p>\n

RelA:\u00a0 STAT3, NR3C1 (glucocorticoid receptor), HIS1, PML, IkBbeta, HDAC3, HDAC1, beta-TRCP, POU2F1, PRKCzeta, PIAS3, IRF2, ITGB3BP, RNF25, KPNA2, ETHE1, PPP4C, FOS, TLE1, CAMkinase4, ING4, MEN1, TRIP4, PPARA<\/p>\n

IkBalpha:\u00a0 G3BP2, S6 kinase, p53, BTRC, K-alpha-1, RTN4, TUBA2, CAPN1, FBXW11, ARRB1, RAB6IP2, ARRB1, RAB6IP2, POM121<\/p>\n

IkBbeta:\u00a0 BTRC, RXRA, RelA<\/p>\n

IkBepsilon:\u00a0 IL1A, JUP<\/p>\n

Feldman<\/a> et al, 2007 used co-precipitation\/mass spec analysis to identify several proteins on the NF-kB DNA complex (although in many cases a direct interaction was not verified).\u00a0 These proteins include the following:\u00a0 ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase); U5 snRNP-specific protein, 116 kDa; Similar to heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Splicing factor 3B subunit 3 (spliceosome-associated protein 130) (SF3b130) (pre-mRNA splicing factor SF3b 130 kDa subunit); RNA helicase A; Unnamed protein product; Splicing factor proline\/glutamine rich (polypyrimidine tract-binding protein associated) PTB-associated splicing factor; Actinin, alpha 4; Human DNA topoisomerase I (70 kDa) in noncovalent complex with a 22-base pair DNA duplex; KIAA0432; Thyroid autoantigen 70 kDa (Ku antigen); thyroid autoantigen 70 kDa (Ku antigen); ATP-dependent DNA helicase II; PARP-1; Similar to nucleolin (protein C23); Hsp89-alpha-delta-N; Chaperone protein HSP90 beta; DEAD\/H (Asp-Glu-Ala-Asp\/His) box polypeptide 17 isoform 1; Structure-specific recognition protein 1; Interferon-inducible IFI 16; Similar to splicing factor proline\/glutamine rich; Ras-GAP SH3 binding protein; Unknown (protein for IMAGE:3503708); Coronin, actin binding protein, 1C; coronin, actin-binding protein, 1C; Proliferation-associated 2G4; Neural precursor cell expressed; Beta actin; B23 nucleophosmin; Replication factor C; Ribosomal protein, large, P0<\/p>\n","protected":false},"excerpt":{"rendered":"

Proteins That Can Interact with Rel\/NF-kB\/IkB Signaling Proteins PROTEIN INTERACTING PARTNER(S) REFERENCE Heat shock protein v-Rel; RelA; IKK Lim et al, 1990 ; Guzhova et al, 1997; Hinz et al, 2007 Unknown 200 kDa v-Rel Morrison et al, 1989 Sp1 v-Rel, c-Rel, RelA Sif & Gilmore, 1994; Perkins et al, 1993; \u00a0 Majello et al […]<\/p>\n","protected":false},"author":4258,"featured_media":0,"parent":334,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/197"}],"collection":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/users\/4258"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/comments?post=197"}],"version-history":[{"count":5,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/197\/revisions"}],"predecessor-version":[{"id":781,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/197\/revisions\/781"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/334"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/media?parent=197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}