{"id":181,"date":"2011-02-08T09:37:44","date_gmt":"2011-02-08T14:37:44","guid":{"rendered":"https:\/\/www.bu.edu\/nf-kb\/?page_id=181"},"modified":"2015-06-08T19:34:30","modified_gmt":"2015-06-08T23:34:30","slug":"gene-knockouts","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/nf-kb\/gene-resources\/gene-knockouts\/","title":{"rendered":"Mouse Gene Knockouts"},"content":{"rendered":"

Phenotypes of Mouse<\/strong> <\/strong>Rel\/NF-kB\/IkB\/IKK Knockouts<\/strong><\/p>\n

Most of the genes encoding the transcription factors (Rel\/NF-kB), inhibitors (IkB), and kinases (IKK) in the Rel\/NF-kB signal transduction pathway have been disrupted in mice.These gene knockouts lead to a variety of phenotypes, which are summarized in the table below.There are also links to the primary references for this information, as on PubMed.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Gene<\/td>\nPhenotype<\/td>\nReference<\/td>\n<\/td>\n<\/tr>\n
rela<\/td>\nEmbryonic lethal;liver apoptosis;sensitivity to TNF<\/td>\nBeg & Baltimore, 1996<\/a><\/td>\n<\/td>\n<\/tr>\n
c-rel<\/td>\nImpaired T and B cell activation; systemic arthritis resistance<\/td>\nKontgen et al, 1995<\/a>Grumont et al, 1998<\/a>Campbell et al, 2000<\/a><\/td>\n<\/td>\n<\/tr>\n
relb<\/td>\nDefects in acquired and innate immunity; T-cell infiltration of organs; skin inflammation<\/td>\nBurkly et al, 1995<\/a>Weih et al, 1995<\/a>Freyschmidt<\/a> et al, 2007<\/td>\n<\/td>\n<\/tr>\n
nfkb1<\/td>\nImmune response defects due to abnormal B-cell response; resistance to arthritis; neural degeneration; sleep irregularities<\/td>\nSha et al, 1995<\/a>Campbell et al, 2000<\/a>Lu et al, 2006<\/a>; Jhaveri<\/a> et al, 2006<\/td>\n<\/td>\n<\/tr>\n
nfkb2<\/td>\nAbnormal spleen and lymph node architecture; defective T-cell response<\/td>\nCaamano et al, 1998<\/a>Franzoso et al, 1998<\/a><\/td>\n<\/td>\n<\/tr>\n
c-reldelta C<\/td>\nLymphoid cell hyperplasia<\/td>\nCarrasco et al, 1998<\/a><\/td>\n<\/td>\n<\/tr>\n
nfkb1<\/p>\n

delta C<\/td>\n

Splenomegaly; enlarged lymph nodes; infiltrations of lung & liver; susceptibility to pathogens<\/td>\nIshikawa et al, 1998<\/a><\/td>\n<\/td>\n<\/tr>\n
nfkb2delta C<\/td>\nMultiple post-natal organ defects<\/td>\nIshikawa et al, 1997<\/a><\/td>\n<\/td>\n<\/tr>\n
nfkb1\/relb<\/td>\nLethal 3-4 weeks post-natal;Increased organ inflammation<\/td>\nWeih et al, 1997<\/a><\/td>\n<\/td>\n<\/tr>\n
nfkb1\/nfkb2<\/td>\nReduced growth; cranofacial abnormalities; bone defects; B-cell defects<\/td>\nFranzoso et al, 1997<\/a>Iotsova et al, 1997<\/a><\/td>\n<\/td>\n<\/tr>\n
nfkb1\/c-rel<\/td>\nDecreased humoral immunity<\/td>\nPohl et al, 2002<\/a><\/td>\n<\/td>\n<\/tr>\n
nfkb1SSAA\/SSAA<\/td>\nNo T-cell dependent antibody responses<\/td>\nJacque et al, 2014<\/a><\/td>\n<\/td>\n<\/tr>\n
c-rel\/rela<\/td>\nEmbryonic lethal early liver apoptosis; skin epidermus development<\/td>\nGrossmann et al, 1999<\/a>; Gugasyan et al., 2004<\/a><\/td>\n<\/td>\n<\/tr>\n
ikba<\/td>\nEarly neonatal lethal inflammatory dermatitis and granulocytosis<\/td>\nBeg et al, 1995<\/a>Klement et al, 1996<\/a><\/td>\n<\/td>\n<\/tr>\n
ikbb<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
ikbe<\/td>\nReduction in number of CDD44-CD25+ T cells<\/td>\nMemet et al, 1999<\/a><\/td>\n<\/td>\n<\/tr>\n
bcl-3<\/td>\nDefects in B- and T-cell responses to antigens<\/td>\nFranzoso et al, 1997<\/a>Schwartz et al, 1997<\/a><\/td>\n<\/td>\n<\/tr>\n
IKKa<\/td>\nEarly neonatal lethal;Skin defects<\/td>\nHu et al, 1999<\/a>Takeda et al, 1999<\/a><\/td>\n<\/td>\n<\/tr>\n
IKKb<\/td>\nEmbryonic lethal;Liver apoptosis;Sensitivity to TNF; B-cell survival (conditional)<\/td>\nLi et al, 1999<\/a>Takeda et al, 1999<\/a>Li et al., 2003<\/a><\/td>\n<\/td>\n<\/tr>\n
IKKa\/IKKb<\/td>\nEmbryonic lethal;\u00a0 Liver apoptosis; Sensitivity to TNF; Neural defects<\/td>\nLi et al, 2000<\/a><\/td>\n<\/td>\n<\/tr>\n
IKKg (NEMO)<\/td>\nEmbryonic lethal;\u00a0 Liver apoptosis; Sensitivity to TNF; Heterozygotes are model for incontinentia pigmenti<\/td>\nRudolph et al, 2000<\/a> Makris et al, 2000<\/a><\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Phenotypes of Mouse Rel\/NF-kB\/IkB\/IKK Knockouts Most of the genes encoding the transcription factors (Rel\/NF-kB), inhibitors (IkB), and kinases (IKK) in the Rel\/NF-kB signal transduction pathway have been disrupted in mice.These gene knockouts lead to a variety of phenotypes, which are summarized in the table below.There are also links to the primary references for this information, […]<\/p>\n","protected":false},"author":4258,"featured_media":0,"parent":328,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/181"}],"collection":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/users\/4258"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/comments?post=181"}],"version-history":[{"count":6,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/181\/revisions"}],"predecessor-version":[{"id":1091,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/181\/revisions\/1091"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/328"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/media?parent=181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}