{"id":173,"date":"2011-02-08T09:19:31","date_gmt":"2011-02-08T14:19:31","guid":{"rendered":"https:\/\/www.bu.edu\/nf-kb\/?page_id=173"},"modified":"2017-10-02T15:42:26","modified_gmt":"2017-10-02T19:42:26","slug":"target-genes","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/nf-kb\/gene-resources\/target-genes\/","title":{"rendered":"NF-kB Target Genes"},"content":{"rendered":"

Target Genes of NF-kB<\/strong><\/p>\n

Cytokines\/Chemokines and their Modulators
\nImmunoreceptors
\nProteins Involved in Antigen Presentation
\nCell Adhesion Molecules
\nAcute Phase Proteins
\nStress Response Genes
\nCell Surface Receptors
\nRegulators of Apoptosis
\nGrowth Factors, Ligands and their Modulators
\nEarly Response Genes
\nTranscription Factors and Regulators
\nViruses
\nEnzymes
\nMiscellaneous<\/p>\n

(*indicates that the gene has a kB site in the promoter but has not clearly been shown to be controlled by NF-kB; or the gene expression is associated with increased NF-kB activity but has not been shown to be a target directly)<\/p>\n

Cytokines\/Chemokines and their modulators<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAcc #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
BAFF<\/td>\nB-cell Activating Factor<\/td>\nMoon & Park , 2007<\/a><\/td>\nNM_006573<\/a><\/td>\nTNFSF13B<\/td>\n<\/tr>\n
BLIMP-1<\/td>\nB lymphocyte-induced maturation protein-1<\/td>\nCalame, 2008<\/a><\/td>\nNM_00198<\/a><\/td>\nBLIMP1 \/PRDM1<\/td>\n<\/tr>\n
CCL5<\/td>\nT-cell secreted factor<\/td>\nWickremasinghe et al, 2004 <\/a><\/td>\nNM_002985<\/a><\/td>\nCCL5<\/td>\n<\/tr>\n
CCL15\/Leukotactin\/ SCYA15<\/td>\nChemokine for cell attraction<\/td>\nShin et al, 2005<\/a><\/td>\nNM_032965<\/a><\/td>\nCCL15<\/td>\n<\/tr>\n
CCL17<\/td>\nChemokine<\/td>\nTakegawa et al, 2008 <\/a><\/td>\nNM_002987<\/a><\/td>\nCCL17<\/td>\n<\/tr>\n
CCL19<\/td>\nRecruitment of naive T cells to dendritic cells<\/td>\nPietila et al, 2007 <\/a><\/td>\nNM_006274<\/a><\/td>\nCCL19<\/td>\n<\/tr>\n
CCL20<\/td>\nLigand of CC chemokine receptor 6<\/td>\nLee et al, 2008<\/a>; Battaglia et al, 2007<\/a><\/td>\nNM_004591<\/a><\/td>\nCCL20<\/td>\n<\/tr>\n
CCL22<\/td>\nEpithelial cell chemokine at mucosa<\/td>\nNakayama et al, 2004 <\/a><\/td>\nNM_002990<\/a><\/td>\nCCL22<\/td>\n<\/tr>\n
CCL23\/SYA23<\/td>\nMonocyte chemokine<\/td>\nShin et al, 2007<\/a><\/td>\nNM_005064<\/a><\/td>\nCCL23<\/td>\n<\/tr>\n
CCL28<\/td>\nChemokine for T-cell attraction<\/td>\nOgawa et al, 2004 <\/a><\/td>\nNM_148672<\/a><\/td>\nCCL28<\/td>\n<\/tr>\n
CINC-1<\/td>\nCytokine-induced neutrophil chemoattractant<\/td>\nBlackwell et al, 1994<\/a> Ohtsuka et al, 1996<\/a><\/td>\nNM_001511<\/a><\/td>\nCXCL1<\/td>\n<\/tr>\n
*CXCL 11<\/td>\nChemokine ligand for CXCR3<\/td>\nTensen et al, 1999<\/a><\/td>\nNM_005409<\/a><\/td>\nCXCL11<\/td>\n<\/tr>\n
Eotaxin<\/td>\nbeta Chemokine, eosinphil-specific<\/td>\nHein et al, 1997<\/a><\/td>\nNM_001565. <\/a><\/td>\nCXCL10<\/td>\n<\/tr>\n
Fractalkine<\/td>\nTNF-induced chemokine<\/td>\nAhn et al, 2004<\/a>;Bhavsar et al, 2008<\/a><\/td>\nNP_002987<\/a><\/td>\nCXCL3<\/td>\n<\/tr>\n
Gro alpha<\/td>\nMelanoma growth stimulating activity<\/td>\nAnisowicz et al, 1991<\/a><\/td>\nNM_001511<\/a><\/td>\nCXCL1<\/td>\n<\/tr>\n
Gro beta<\/td>\nChemokine<\/td>\nAnisowicz et al, 1991<\/a><\/td>\nAAP13104<\/a><\/td>\nGRO-beta<\/td>\n<\/tr>\n
Gro gamma<\/td>\nChemokine<\/td>\nAnisowicz et al, 1991<\/a><\/td>\nAAP13105. <\/a><\/td>\nGRO-gamma<\/td>\n<\/tr>\n
Gro-1<\/td>\nGrowth regulated oncogene; chemokine<\/td>\nWood, 1995<\/a><\/td>\nNM_001511<\/a><\/td>\nCXCL1<\/td>\n<\/tr>\n
*ICOS<\/td>\nInducible co-stimulator<\/td>\nHaaning Anderson et al, 2003<\/a><\/td>\nNM_012092<\/a><\/td>\nICOS<\/td>\n<\/tr>\n
IFN-g<\/td>\nInterferon<\/td>\nSica et al, 1992<\/a>; Sica et al, 1997<\/a><\/td>\nNM_000619<\/a><\/td>\nIFNG<\/td>\n<\/tr>\n
IL-1a<\/td>\nInterleukin-1a<\/td>\nMori & Prager, 1996<\/a><\/td>\nNM_000575<\/a><\/td>\nIL1A<\/td>\n<\/tr>\n
IL-1b<\/td>\nInterleukin-1b<\/td>\nHiscott et al, 1993<\/a><\/td>\nNM_000576<\/a><\/td>\nIL1B<\/td>\n<\/tr>\n
IL-1 receptor antagonist<\/td>\nInhibitor of IL-1 activity<\/td>\nSmith et al, 1994<\/a><\/td>\nNM_173842<\/a><\/td>\nIL1RN<\/td>\n<\/tr>\n
IL-2<\/td>\nInterleukin-2<\/td>\nSerfling et al, 1989<\/a>; Hoyos et al, 1989<\/a>; Lai et al, 1995<\/a><\/td>\nNM_000586<\/a><\/td>\nIL2<\/td>\n<\/tr>\n
IL-6<\/td>\nInterleukin-6, inflammatory cytokine<\/td>\nLibermann & Baltimore, 1990<\/a>; Shimizu et al, 1990<\/a>;Son et al, 2008<\/a><\/td>\nNM_000600<\/a><\/td>\nIL6<\/td>\n<\/tr>\n
IL-8<\/td>\nInterleukin-8, alpha-chemokine<\/td>\nKunsch & Rosen, 1993<\/a>; Kang et al., 2007<\/a><\/td>\nNM_000584<\/a><\/td>\nIL8<\/td>\n<\/tr>\n
IL-9<\/td>\nInterleukin-9<\/td>\nZhu et al, 1996<\/a>; Chen et al, 2008<\/a><\/td>\nNM_000590<\/a><\/td>\nIL9<\/td>\n<\/tr>\n
IL-10<\/td>\nInterleukin-10<\/td>\nXu & Shu, 2002<\/a>; Cao et al, 2006<\/a><\/td>\nNM_000572<\/a><\/td>\nIL10<\/td>\n<\/tr>\n
IL-11<\/td>\nInterleukin-11<\/td>\nBitko et al, 1997<\/a><\/td>\nNM_000641<\/a><\/td>\nIL11<\/td>\n<\/tr>\n
IL-12B (p40)<\/td>\nInterleukin-12<\/td>\nMurphy et al, 1995<\/a><\/td>\nNM_002187<\/a><\/td>\nIL12B<\/td>\n<\/tr>\n
IL-12A (p35)<\/td>\nInterleukin-12<\/td>\nHomma et al, 2007<\/a><\/td>\nNM_000882<\/a><\/td>\nIL12A<\/td>\n<\/tr>\n
IL-13<\/td>\nInterleukin-13<\/td>\nHinz et al, 2002<\/a><\/td>\nNM_002188<\/a><\/td>\nIL13<\/td>\n<\/tr>\n
*IL-15<\/td>\nInterleukin-15<\/td>\nAzimi et al, 1998<\/a><\/td>\nNM_172174<\/a><\/td>\nIL15<\/td>\n<\/tr>\n
IL-17<\/td>\nInterleukin-17<\/td>\nShen et al, 2006<\/a><\/td>\nNM_002190<\/a><\/td>\nIL17<\/td>\n<\/tr>\n
IL-23A (p19)<\/td>\nInterleukin-23 (p19 gene)<\/td>\nCarmody et al, 2006<\/a>; Liu et al, 2007<\/a><\/td>\nNM_016584<\/a><\/td>\nIL23A<\/td>\n<\/tr>\n
IL-27 (p28)<\/td>\nInterleukin-27 (p28 subunit)<\/td>\nLiu et al, 2007<\/a><\/td>\nNM_145659<\/a><\/td>\nIL27<\/td>\n<\/tr>\n
EBI3\/IL-27B<\/td>\nEBV-induced gene 3 (IL-27beta chain)<\/td>\nPoleganov et al, 2008<\/a><\/td>\nNM_005755<\/a><\/td>\nEBI3<\/td>\n<\/tr>\n
beta-Interferon<\/td>\nInterferon<\/td>\nHiscott et al, 1989;<\/a><\/td>\n NM_002176<\/a><\/td>\nIFNB1<\/td>\n<\/tr>\n
Lenardo et al, 1989<\/a><\/td>\n<\/tr>\n
IP-10<\/td>\nalpha Chemokine<\/td>\nOhmori & Hamilton, 1993<\/a>; Yang et al, 2007<\/a><\/td>\nNM_002994<\/a><\/td>\nCXCL5<\/td>\n<\/tr>\n
KC<\/td>\nalpha Chemokine<\/td>\nOhmori et al, 1995<\/a><\/td>\nS79767<\/a><\/td>\nKC<\/td>\n<\/tr>\n
IiGp1<\/td>\nCytokine<\/td>\nBunting et al, 2007<\/a><\/td>\nNM_021792<\/a><\/td>\nIigp1<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\nNM_002994<\/a><\/td>\nCXCL5<\/td>\n<\/tr>\n
*LIX (mouse); ENA-78 (CXCL5) and GCP-2 (CXCL6) (human)<\/td>\nLPS-induced CXC chemokines<\/td>\nSmith et al, 2002<\/a><\/td>\nNM_002993<\/a><\/td>\nCXCL6<\/td>\n<\/tr>\n
Lymphotoxin a<\/td>\nTNF-like cytokine<\/td>\nWorm et al, 1998<\/a><\/td>\nNM_000595<\/a><\/td>\nLTA<\/td>\n<\/tr>\n
Lymphotoxin b<\/td>\nAnchors TNF to cell surface<\/td>\nKuprash et al, 1996<\/a><\/td>\nNM_002341<\/a><\/td>\nLTB<\/td>\n<\/tr>\n
MCP-1\/JE<\/td>\nMacrophage chemotactic protein, beta Chemokine<\/td>\nUeda et al, 1994<\/a>; Ueda et al, 1997<\/a><\/td>\nNM_002982<\/a><\/td>\nCCL2<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
Teferedegne et al, 2006<\/a>; Xing & Remick, 2007<\/a>; Ishikado et al, 2009<\/a><\/td>\n<\/td>\n<\/tr>\n
MIG<\/td>\nMonokine induced by IFN-gamma<\/td>\nBunting et al, 2007<\/a><\/td>\nNM_002416<\/a><\/td>\nCXCL9<\/td>\n<\/tr>\n
MIP-1a,b<\/td>\nMacrophage inflammatory protein-1, b Chemokine<\/td>\nGrove & Plumb, 1993<\/a>; Widmer et al, 1993<\/a><\/td>\nNM_002983<\/a><\/td>\nCCL3<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\nNM_002984<\/a><\/td>\nCCL4<\/td>\n<\/tr>\n
aka (LAG-1)<\/td>\nLymphocyte activation gene-1<\/td>\nXu et al, 2002<\/a>; Modi et al, 2001<\/a><\/td>\nNM_002984<\/a><\/td>\nCCL4<\/td>\n<\/tr>\n
MIP-2<\/td>\nMacrophage inflammatory protein-2, b Chemokine<\/td>\nWidmer et al, 1993<\/a>; Lee et al, 2005<\/a><\/td>\n NM_002090<\/a><\/td>\nCXCL3<\/td>\n<\/tr>\n
MIP-3alpha\/CCL20<\/td>\nMacrophage inflammatory protein-3a<\/td>\nKwon et al, 2002<\/a>; Tomimori et al, 2007<\/a><\/td>\nNM_004591<\/a><\/td>\nCCL20<\/td>\n<\/tr>\n
*mob-1<\/td>\nA C-X-C chemokine<\/td>\nVarley et al, 2003<\/a><\/td>\nNM_001565<\/a><\/td>\nCXCL10<\/td>\n<\/tr>\n
Neutrophil activating peptide-78<\/td>\nActivates neutrophils<\/td>\nKeates et al., 2001<\/a><\/td>\nNM_002994<\/a><\/td>\nCXCL5<\/td>\n<\/tr>\n
RANTES<\/td>\nRegulated upon Activation Normal T lymphocyte Expressed and Secreted,b Chemokine<\/td>\nMoriuchi et al, 1997<\/a><\/td>\nNM_002985<\/a><\/td>\nCCL5<\/td>\n<\/tr>\n
TCA3, T-cell activation gene 3<\/td>\nT-cell activation gene 3, beta chemokine<\/td>\nOh & Metcalfe, 1994<\/a><\/td>\nNM_002981<\/a><\/td>\nCCL1<\/td>\n<\/tr>\n
TNFalpha<\/td>\nTumor necrosis factor alpha<\/td>\nShakhov et al, 1990<\/a>; Collart et al, 1990<\/a><\/td>\nNM_000594<\/a><\/td>\nTNF<\/td>\n<\/tr>\n
TNFbeta<\/td>\nTumor necrosis factor beta<\/td>\nPaul et al, 1990<\/a>; Messer et al, 1990<\/a><\/td>\nNM_000595<\/a><\/td>\nLTA<\/td>\n<\/tr>\n
TRAIL (aka Apo2 ligand)<\/td>\nCytokine<\/td>\nBaetu et al, 2001<\/a>; Matsuda et al, 2005<\/a><\/td>\nNM_003810<\/a><\/td>\nTNFSF10<\/td>\n<\/tr>\n
TFF3 (Treefoil factor)<\/td>\nPeptide in response to gut irritation<\/td>\nBaus-Loncar et al, 2004<\/a><\/td>\nNM_003226<\/a><\/td>\nTFF3<\/td>\n<\/tr>\n
VEGI<\/td>\nVascular endothelial growth inhibitor<\/td>\nXiao et al, 2005<\/a><\/td>\nNM_005118<\/a><\/td>\nTNFSF15<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Immunoreceptors<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAccess #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
B7.1 (CD80)<\/td>\nCo-stimulation of T cells via CD28 binding<\/td>\nFong et al, 1996<\/a>; Zhao et al, 1996<\/a><\/td>\nNM_005191<\/a><\/td>\nCD80<\/td>\n<\/tr>\n
BRL-1<\/td>\nB-cell homing receptor<\/td>\nWolf et al, 1998<\/a><\/td>\nNM_001716<\/a><\/td>\nBLR1<\/td>\n<\/tr>\n
CCR5<\/td>\nChemokine receptor<\/td>\nLiu et al, 1998<\/a><\/td>\nNM_000579<\/a><\/td>\nCCR5<\/td>\n<\/tr>\n
CCR7<\/td>\nChemokine receptor<\/td>\nHopken et al, 2002<\/a><\/td>\nNM_001838<\/a><\/td>\nCCR7<\/td>\n<\/tr>\n
CXCR<\/td>\nChemokine receptor<\/td>\nMaxwell et al, 2007<\/a><\/td>\nNM_000634<\/a><\/td>\nIL8RA<\/td>\n<\/tr>\n
CXCR2<\/td>\nChemokine receptor<\/td>\nMaxwell et al, 2007<\/a><\/td>\nNM_001557<\/a><\/td>\nIL8RB<\/td>\n<\/tr>\n
CD137<\/td>\nTNF-like receptor<\/td>\nKim et al, 2003<\/a><\/td>\nNM_001561<\/a><\/td>\nTNFRSF9<\/td>\n<\/tr>\n
CD154<\/td>\nCD40 ligand<\/td>\nSrahna et al, 2001<\/a>; Schubert et al, 2002<\/a>; Pham et al, 2005<\/a><\/td>\nNM_000074<\/a><\/td>\nCD40LG<\/td>\n<\/tr>\n
CD3gamma<\/td>\nT-cell marker<\/td>\nWillard-Gallo et al, 2005<\/a><\/td>\nNM_000073<\/a><\/td>\nCD3G<\/td>\n<\/tr>\n
CD21<\/td>\nB-cell surface molecule<\/td>\nDebnath et al, 2007<\/a><\/td>\nNM_001006658<\/a><\/td>\nCR2<\/td>\n<\/tr>\n
CD38<\/td>\nNAD to cADP ribose converting molecule<\/td>\nKang et al, 2006<\/a>; Tirumurugaan et al, 2008<\/a><\/td>\nNM_001775<\/a><\/td>\nCD38<\/td>\n<\/tr>\n
CD40<\/td>\nTNF-receptor family member<\/td>\nHinz et al, 2001<\/a><\/td>\nNM_001250<\/a><\/td>\nCD40<\/td>\n<\/tr>\n
CD48<\/td>\nAntigen of stimulated lymphocytes<\/td>\nKlaman & Thorley-Lawson, 1995<\/a><\/td>\nNM_001778<\/a><\/td>\nCD48<\/td>\n<\/tr>\n
CD83<\/td>\nT-cell development molecule<\/td>\nMcKinsey et al, 2000<\/a>; Berchtold et al, 2002<\/a><\/td>\nNM_004233<\/a><\/td>\nCD83<\/td>\n<\/tr>\n
CD86<\/td>\nDendritic cell development molecule<\/td>\nZou & Hu, 2005<\/a><\/td>\nNM_175862<\/a><\/td>\nCD86<\/td>\n<\/tr>\n
CD98<\/td>\nMembrane receptor, survival blood cells<\/td>\nYan et al, 2006<\/a><\/td>\nNM_001012661<\/a><\/td>\nSLC3A2<\/td>\n<\/tr>\n
CD134<\/td>\nTNF-like receptor<\/td>\nTone et al, 2007<\/a><\/td>\nNM_003327<\/a><\/td>\nTNFRSF4<\/td>\n<\/tr>\n
*F11-receptor<\/td>\nIg-like receptor for platelet adhesion<\/td>\nSobocki et al, 2005<\/a><\/td>\nNM_016946<\/a><\/td>\nF11R<\/td>\n<\/tr>\n
FcRn<\/td>\nNeonatal receptor for IgG<\/td>\nLiu et al, 2007<\/a><\/td>\nNM_004107<\/a><\/td>\nFCGRT<\/td>\n<\/tr>\n
Fc epsilon receptor II (CD23)<\/td>\nReceptor for IgE<\/td>\nRichards & Katz, 1997<\/a>; Lu et al, 2006<\/a>; Debnath et al, 2007<\/a><\/td>\nNM_002002<\/a><\/td>\nFCER2<\/td>\n<\/tr>\n
HLA-G<\/td>\nHuman leukocyte antigen-G<\/td>\nLangat et al., 2007<\/a><\/td>\n NM_002127<\/a><\/td>\nHLA-G<\/td>\n<\/tr>\n
*ICOS<\/td>\nT-cell activation factor<\/td>\nShilling et al., 2005<\/a><\/td>\nNM_012092<\/a><\/td>\nICOS<\/td>\n<\/tr>\n
IL-2 receptor a-chain<\/td>\nIL-2 receptor subunit<\/td>\nBallard et al., 1988<\/a><\/td>\nNM_000417<\/a><\/td>\nIL2RA<\/td>\n<\/tr>\n
Immunoglobulin Cgamma1<\/td>\nIgG heavy chain<\/td>\nLin & Stavnezer, 1996<\/a><\/td>\nJ00230<\/a><\/td>\nIGHG2<\/td>\n<\/tr>\n
Immunoglobulin gamma1<\/td>\nIgG heavy chain<\/td>\nDryer & Covey, 2005<\/a><\/td>\n J00228<\/a><\/td>\nIGHG1<\/td>\n<\/tr>\n
Immunoglobulin gamma4<\/td>\nIgG heavy chain<\/td>\nAgresti & Vercelli, 2002<\/a><\/td>\n K01316<\/a><\/td>\nIGHG4<\/td>\n<\/tr>\n
Immunoglobulin e heavy chain<\/td>\nIgE heavy chain<\/td>\nIciek et al, 1997<\/a><\/td>\n J00222<\/a><\/td>\nIGHE<\/td>\n<\/tr>\n
Immunoglobulin k light chain<\/td>\nAntibody light chain<\/td>\nSen & Baltimore, 1986<\/a><\/td>\n J00241<\/a><\/td>\nIGKC<\/td>\n<\/tr>\n
Invariant Chain II<\/sub><\/td>\nAntigen presentation<\/td>\nPessara & Koch, 1990<\/a><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Kinin B1 Receptor<\/td>\nCardiovascular homeostasis; inflammation<\/td>\nMerino et al, 2005<\/a><\/td>\nNM_000710<\/a><\/td>\nBDKRB1<\/td>\n<\/tr>\n
MHC class I (H-2Kb)<\/td>\nMajor histocompatibility antigen<\/td>\nIsra\u00ebl et al, 1989<\/a>a; Isra\u00ebl et al, 1989b<\/a><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
MHC Class I HLA-B7<\/td>\nMajor histocompatibility antigen<\/td>\nJohnson & Pober, 1994<\/a><\/td>\nNM_005514<\/a><\/td>\nHLA-B<\/td>\n<\/tr>\n
b2 Microglobulin<\/td>\nChaperone for MHC class I-like molecules<\/td>\nIsra\u00ebl et al, 1989a<\/a>; Isra\u00ebl et al, 1989<\/a>b; Gobin et al, 2002<\/a><\/td>\nNM_004048<\/a><\/td>\nB2M<\/td>\n<\/tr>\n
Nod2<\/td>\nIntracellular pathogen recognition<\/td>\nGutierrez et al, 2002<\/a><\/td>\nNM_022162<\/a><\/td>\nNOD2<\/td>\n<\/tr>\n
Polymeric Ig receptor<\/td>\nBinds Ig<\/td>\nSchjerven et al, 2001<\/a><\/td>\n AJ276452<\/a><\/td>\npIgR<\/td>\n<\/tr>\n
PGRP-S<\/td>\nPeptidoglycan recognition protein-S<\/td>\nLang et al, 2007<\/a><\/td>\nNM_005091<\/a><\/td>\nPGLYRP1<\/td>\n<\/tr>\n
T-cell receptor b chain<\/td>\nT-cell receptor subunit<\/td>\nJamieson et al, 1989<\/a>; McMillan & SIkes, 2008<\/a><\/td>\nNG_001333<\/a><\/td>\nTCRB<\/td>\n<\/tr>\n
T-cell receptor\/CD3gamma<\/td>\nT-cell receptor subunit<\/td>\nBadran et al, 2002<\/a><\/td>\nNM_000073<\/a><\/td>\nCD3G<\/td>\n<\/tr>\n
TLR-2<\/td>\nToll-like receptor<\/td>\nWang et al, 2001<\/a>; Johnson & Tapping, 2007<\/a><\/td>\nNM_003264<\/a><\/td>\nTLR2<\/td>\n<\/tr>\n
TLR9<\/td>\nToll-like receptor<\/td>\nTakeshita et al, 2004<\/a><\/td>\nNM_017442<\/a><\/td>\nTLR9<\/td>\n<\/tr>\n
*TNF-Receptor, p75\/80 (CD120B)<\/td>\nHigh-affinity TNF receptor<\/td>\nSantee & Owen-Schaub, 1996<\/a><\/td>\nNM_001066<\/a><\/td>\nTNFRSF1B<\/td>\n<\/tr>\n
TREM-1<\/td>\nNeutrophil\/monocyte Ig receptor<\/td>\nZeng et al, 2007<\/a><\/td>\nNM_018643<\/a><\/td>\nTREM1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Proteins involved in antigen presentation<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAcc #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
Complement B<\/td>\nActivator of alternative complement pathway<\/td>\nHuang et al, 2002<\/a><\/td>\nNM_001710<\/a><\/td>\nCFB<\/td>\n<\/tr>\n
Complement component 3<\/td>\nComponent of complement pathway<\/td>\nMoon et al, 1999<\/a><\/td>\n NM_000064<\/a><\/td>\nC3<\/td>\n<\/tr>\n
Complement Receptor 2<\/td>\nComplement receptor for B-cell response to Ag<\/td>\nTolnay et al, 2002<\/a><\/td>\n NM_001006658<\/a><\/td>\nCR2<\/td>\n<\/tr>\n
Proteasome Subunit LMP2<\/td>\nSubunit of 26S proteasome,cysteine protease<\/td>\nWright et al, 1995<\/a>; Marques et al, 2004<\/a><\/td>\nNM_002800<\/a><\/td>\nPSMB9<\/td>\n<\/tr>\n
Peptide Transporter TAP1<\/td>\nPeptide transporter for ER<\/td>\nWright et al, 1995<\/a>; Marques et al, 2004<\/a><\/td>\n NM_000593<\/a><\/td>\nTAP1<\/td>\n<\/tr>\n
Tapasin<\/td>\nMHC class I presentation and assembly<\/td>\nHerrmann et al, 2003<\/a><\/td>\nNM_003190<\/a><\/td>\nTAPBP<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Cell adhesion molecules<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAcc #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
CD44<\/td>\nCell-surface receptor for hyaluronic acid<\/td>\nHinz et al, 2002<\/a><\/td>\nNP_000601<\/a><\/td>\nCD44<\/td>\n<\/tr>\n
DC-SIGN<\/td>\nDendritic cell surface C-type lectin<\/td>\nLiu et al, 2003<\/a><\/td>\nNM_021155<\/a><\/td>\nCD209<\/td>\n<\/tr>\n
ELAM-1 (CD62E, E-selectin)<\/td>\nE-selectin, endothelial cell leukocyte adhesion molecule<\/td>\nWhelan et al, 1991<\/a>; Schindler & Baichwal, 1994<\/a><\/td>\nNM_000450<\/a><\/td>\nSELE<\/td>\n<\/tr>\n
Endoglin<\/td>\nEndothelial cell membrane glycoprotein<\/td>\nBotella et al, 2002<\/a><\/td>\nNM_000118<\/a><\/td>\nENG<\/td>\n<\/tr>\n
Fibronectin<\/td>\nExtracellular attachment<\/td>\nLee et al, 2002<\/a>; Norton et al, 2004<\/a><\/td>\n NM_002026<\/a><\/td>\nFN1<\/td>\n<\/tr>\n
ICAM-1<\/td>\nIntercellular adhesion molecule-1<\/td>\nvan de Stolpe et al., 1994<\/a>; Bunting et al, 2007<\/a><\/td>\nNM_000201<\/a><\/td>\nCD54<\/td>\n<\/tr>\n
MadCAM-1<\/td>\nMucosal addressin cell adhesion molecule<\/td>\nTakeuchi & Baichwal, 1995<\/a><\/td>\n NM_130760<\/a><\/td>\nMADCAM1<\/td>\n<\/tr>\n
NCAM<\/td>\nNeural cell adhesion molecule<\/td>\nSimpson & Morris, 2000<\/a><\/td>\nNM_000615<\/a><\/td>\nNCAM<\/td>\n<\/tr>\n
P-selectin<\/td>\nPlatelet adhesion receptor<\/td>\nPan & McEver, 1995<\/a><\/td>\n NM_003005<\/a><\/td>\nSELP<\/td>\n<\/tr>\n
Tenascin-C<\/td>\nECM protein controls cell attachment and migration, cell growth<\/td>\nMettouchi et al, 1997<\/a><\/td>\nNM_002160<\/a><\/td>\nTNC<\/td>\n<\/tr>\n
VCAM-1<\/td>\nVascular cell adhesion molecule<\/td>\nIademarco et al, 1992<\/a><\/td>\nNM_001078<\/a><\/td>\nVCAM1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Acute phase proteins<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAcc #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
Angiotensinogen (Angiotensin II)<\/td>\nAngiotensin precursor, regulates blood pressure<\/td>\nBrasier et al, 1990<\/a>; Ron et al, 1990<\/a><\/td>\nNM_000029<\/a><\/td>\nAGT<\/td>\n<\/tr>\n
beta-defensin-2<\/td>\nAnti-microbial peptide<\/td>\nDiamond et al, 2000<\/a>; Tsutsumi-Ishii & Nagaoka, 2002<\/a>; Kao et al, 2008<\/a><\/td>\n AF040153<\/a><\/td>\nDEFB2<\/td>\n<\/tr>\n
C4b binding protein<\/td>\nComplement binding protein<\/td>\nMoffat & Tack, 1992<\/a><\/td>\nNM_000715<\/a><\/td>\nC4BPA<\/td>\n<\/tr>\n
Complement factor B<\/td>\nComplement factor<\/td>\nNonaka & Huang, 1990<\/a><\/td>\nNM_001710<\/a><\/td>\nCFB<\/td>\n<\/tr>\n
Complement factor C4<\/td>\nActivates extrinsic pathway of complement activation<\/td>\nYu et al, 1989<\/a><\/td>\n NM_007293<\/a><\/td>\nC4A<\/td>\n<\/tr>\n
C-reactive protein<\/td>\nHost defense protein<\/td>\nZhang et al, 1995<\/a>; Agrawal et al, 2003a
\n<\/a>Agrawal et al, 2003b<\/a><\/td>\n		 NM_000567<\/a><\/td>\nCRP<\/td>\n<\/tr>\n
Hepcidin<\/td>\nAcute phase protein<\/td>\nLiao et al, 2006<\/a><\/td>\nNM_021175<\/a><\/td>\nHAMP<\/td>\n<\/tr>\n
Lipopolysaccharide binding protein<\/td>\nBinds to LPS receptor (CD14) with LPS<\/td>\nSchumann, 1995<\/a><\/td>\nNM_004139<\/a><\/td>\nLBP<\/td>\n<\/tr>\n
Pentraxin PTX3<\/td>\nPentraxin<\/td>\nBasile et al, 1997<\/a><\/td>\nNM_002852<\/a><\/td>\nPTX3<\/td>\n<\/tr>\n
Serum amyloid A proteins (SAA1, SAA2, SAA3)<\/td>\nSerum components<\/td>\nEdbrooke et al, 1991<\/a>; Li & Liao, 1991<\/a>; Thorn & Whitehead, 2002<\/a>; Son et al, 2004<\/a><\/td>\nNM_000331<\/a><\/td>\nSAA1<\/td>\n<\/tr>\n
Serum amyloid A proteins (SAA1, SAA2, SAA3)<\/td>\nSerum components<\/td>\n<\/td>\nNM_030754<\/a><\/td>\nSAA2<\/td>\n<\/tr>\n
Serum amyloid A proteins (SAA1, SAA2, SAA3)<\/td>\nSerum components<\/td>\n<\/td>\nS73444<\/a><\/td>\nSAA3<\/td>\n<\/tr>\n
Tissue factor-1<\/td>\nActivates extrinsic pathway of complement activation<\/td>\nMackman et al, 1991<\/a><\/td>\nNM_001993<\/a><\/td>\nF3<\/td>\n<\/tr>\n
Urokinase-type plasminogen activator<\/td>\nActivates fibrinogen for fibrin clot lysis<\/td>\nNovak et al, 1991<\/a><\/td>\nNM_002658<\/a><\/td>\nPLAU<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Stress response genes<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAcc #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
*CYP2E1<\/td>\nCytochrome p450<\/td>\nAbdel-Razak et al, 2004<\/a><\/td>\n NM_000773<\/a><\/td>\nCYP2E1<\/td>\n<\/tr>\n
CYP2C11<\/td>\nCytochrome p450<\/td>\nMorgan et al, 2002<\/a><\/td>\nX79081<\/a><\/td>\nCYP2C11<\/td>\n<\/tr>\n
CYP7b<\/td>\nCytochrome p450<\/td>\nDulos et al, 2005<\/a><\/td>\nNM_004820<\/a><\/td>\nCYP7B1<\/td>\n<\/tr>\n
COX-2<\/td>\nCyclooxygenase, prostaglandin endoperoxide synthase<\/td>\nYamamoto et al, 1995<\/a>;Ackerman et al, 2008<\/a>; Kaltschmidt et al, 2002<\/a><\/td>\n NM_000963<\/a><\/td>\nPTGS2<\/td>\n<\/tr>\n
Ferritin H chain<\/td>\nIron storage protein<\/td>\nKwak et al, 1995<\/a><\/td>\nNM_002032<\/a><\/td>\nFTH1<\/td>\n<\/tr>\n
Glutamate-cysteine ligase<\/td>\nGSH biosynthesis<\/td>\nPeng et al, 2010<\/a><\/td>\n<\/td>\nGCLC<\/td>\n<\/tr>\n
Glutamate-cysteine ligase modifier<\/td>\nGCLC modifier protein<\/td>\nPeng et al, 2010<\/a><\/td>\n<\/td>\nGCLM<\/td>\n<\/tr>\n
HSP90-alpha<\/td>\nHeat shock protein<\/td>\nAmmirante et al, 2007<\/a><\/td>\nNM_001017963<\/a><\/td>\nHSP90AA1<\/td>\n<\/tr>\n
*5-Lipoxygenase (guinea pig)<\/td>\nArachidonic acid metabolic enzyme, leukotriene synthesis<\/td>\nChopra et al, 1992<\/a><\/td>\nXM_001127464<\/a><\/td>\nALOX5<\/td>\n<\/tr>\n
12-Lipoxygenase<\/td>\nArachidonic acid metabolic enzyme<\/td>\nArakawa et al, 1995<\/a><\/td>\n NM_000697<\/a><\/td>\nALOX12<\/td>\n<\/tr>\n
Inducible NO-Synthase<\/td>\nNO synthesis<\/td>\nGeller et al, 1993<\/a><\/td>\nNM_000625<\/a><\/td>\nNOS2A<\/td>\n<\/tr>\n
*MAP4K1<\/td>\nActivator of stress-induced protein kinase pathway<\/td>\nCarter et al, 2002<\/a><\/td>\nNM_001042600<\/a><\/td>\nMAP4K1<\/td>\n<\/tr>\n
SENP2<\/td>\nSUMO-specific protease<\/td>\nS Miyamoto, pers commun<\/td>\nNC_0000013.10<\/a><\/td>\nSENP2<\/td>\n<\/tr>\n
Cu\/Zn SOD<\/td>\nSuperoxide dismutase<\/td>\nRojo et al, 2004<\/a><\/td>\nNM_000454<\/a><\/td>\nSOD1<\/td>\n<\/tr>\n
SOD1<\/td>\nManganese uperoxide dismutase<\/td>\nDas et al, 1995<\/a><\/td>\nNM_000454<\/a><\/td>\nSOD1<\/td>\n<\/tr>\n
SOD2<\/td>\nManganese superoxide dismutase<\/td>\nXu et al, 1999a; <\/a>1991b<\/a>; 2007a<\/a>; 2007b<\/a><\/td>\nNM_000636<\/a><\/td>\nSOD2<\/td>\n<\/tr>\n
*Mx1<\/td>\nViral resistance gene<\/td>\nGerardin et al, 2004<\/a><\/td>\nNM_002462<\/a><\/td>\nMX1<\/td>\n<\/tr>\n
NAD(P)H quinone oxidoreductase (DT-diaphorase)<\/td>\nBioreductive enzyme<\/td>\nYao & O’Dwyer, 1995<\/a><\/td>\nNM_000903<\/a><\/td>\nNQO1<\/td>\n<\/tr>\n
Phospholipase A2<\/td>\nFatty acid metabolism<\/td>\nMorri et al, 1994<\/a><\/td>\nAF058921<\/a><\/td>\nPLA2<\/td>\n<\/tr>\n
SEPS1<\/td>\nInvolved in cytokine production<\/td>\nGao et al, 2006<\/a><\/td>\n NM_018445<\/a><\/td>\nSELS<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Cell-surface receptors<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAcc #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
ABCA1<\/td>\nATP-binding cassette transporter<\/td>\nGerbod-Giannone et al, 2006<\/a><\/td>\nNM_005502<\/a><\/td>\nABCA1<\/td>\n<\/tr>\n
ABCC6<\/td>\nATP-binding, multidrug resistance-associated protein 6 transporter<\/td>\nJiang et al, 2005<\/a><\/td>\nNM_001171<\/a><\/td>\nABCC6<\/td>\n<\/tr>\n
A1 adenosine receptor<\/td>\nPleiotropic physiological effects<\/td>\nNie et al, 1998<\/a>; Jhaveri et al, 2007<\/a><\/td>\nNM_000674<\/a><\/td>\nADORA1<\/td>\n<\/tr>\n
A2A<\/td>\nAdenosine receptor<\/td>\nMorello et al, 2006<\/a><\/td>\n NM_000675<\/a><\/td>\nADORA2A<\/td>\n<\/tr>\n
*ADAM19<\/td>\nDendritic cell marker<\/td>\nEhrnsperger et al, 2005<\/a><\/td>\n NM_023038<\/a><\/td>\nADAM19<\/td>\n<\/tr>\n
Amiloride-sensitive sodium channel<\/td>\nSodium channel<\/td>\nBaines et al, 2002<\/a>; Haddad, 2005<\/a><\/td>\nNM_001038<\/a><\/td>\nSCNN1A<\/td>\n<\/tr>\n
*alpha2B-adrenergic receptor<\/td>\nadrenergic receptor<\/td>\nCayla et al, 2004<\/a><\/td>\nNM_000682<\/a><\/td>\nADRA2B<\/td>\n<\/tr>\n
Bradykinin B1-Receptor<\/td>\nPleiotropic physiological effects<\/td>\nNi et al, 1998<\/a><\/td>\nNM_000710<\/a><\/td>\nBDKRB1<\/td>\n<\/tr>\n
*CD23<\/td>\nCell-surface molecule<\/td>\nTinnell et al, 1998<\/a><\/td>\n NM_002002<\/a><\/td>\nFCER2\/CD23<\/td>\n<\/tr>\n
CD69<\/td>\nLectin mainly on activated T cells<\/td>\nLopez-Cabrera et al, 1995<\/a><\/td>\nNM_001781<\/a><\/td>\nC69<\/td>\n<\/tr>\n
DOR<\/td>\nDelta opiod receptor<\/td>\nChen et al, 2005, 2006<\/a><\/td>\n NM_000911<\/a><\/td>\nOPRD1<\/td>\n<\/tr>\n
Epidermal Growth Factor Receptor<\/td>\nReceptor for EGF<\/td>\nNishi et al, 2003<\/a>; Thornburg & Raab-Traub, 2007<\/a><\/td>\nNM_005228<\/a><\/td>\nEGFR<\/td>\n<\/tr>\n
ErbB2<\/td>\nEGF-like receptor<\/td>\nKitamura et al, 2005<\/a><\/td>\nNM_001005862<\/a><\/td>\nERBB2<\/td>\n<\/tr>\n
Gal1 Receptor<\/td>\nGalanin receptor, neuroendocrine peptide<\/td>\nLorimer et al, 1997<\/a><\/td>\n NM_002256<\/a><\/td>\nKISS1<\/td>\n<\/tr>\n
Lox-1<\/td>\nReceptor for Oxidized low density lipoprotein<\/td>\nNagase et al, 1998<\/a><\/td>\nNM_002543<\/a><\/td>\nOLR1<\/td>\n<\/tr>\n
Ly49<\/td>\nReceptor on NK cells<\/td>\nPascal et al, 2007<\/a><\/td>\n NM_006611<\/a><\/td>\nKLRA1<\/td>\n<\/tr>\n
Mdr1<\/td>\nMultiple drug resistance mediator (P-glycoprotein)<\/td>\nZhou & Kuo, 1997<\/a>; Wang et al, 2007<\/a><\/td>\nNM_018849<\/a><\/td>\nABCB4<\/td>\n<\/tr>\n
Mu-opioid receptor<\/td>\nOpioid Receptor<\/td>\nKraus et al, 2003<\/a><\/td>\nEU360599<\/a><\/td>\nOPRM1<\/td>\n<\/tr>\n
mGlu2<\/td>\nMetabotropic glutamate receptor 2<\/td>\nChiechio et al, 2006<\/a><\/td>\nNM_000839<\/a><\/td>\nGRM2<\/td>\n<\/tr>\n
Neuropeptide Y-Y1 receptor<\/td>\nPleiotropic physiological effects<\/td>\nMusso et al, 1997<\/a><\/td>\nNM_000909<\/a><\/td>\nNPY1R<\/td>\n<\/tr>\n
*NMDA receptor subunit 2A (rat)<\/td>\nNeural receptor for N-methyl-D-aspartate<\/td>\nRichter et al, 2002<\/a><\/td>\nNM_000833<\/a><\/td>\nGRIN2A<\/td>\n<\/tr>\n
*NMDA receptor subunit NR-1 (GRIN1 gene)<\/td>\nSubunit of neural receptor for N-methyl-D-aspartate<\/td>\nBegni et al, 2003<\/a><\/td>\nNM_021569<\/a><\/td>\nGRIN1<\/td>\n<\/tr>\n
Oxytocin receptor<\/td>\nOxytocin receptor<\/td>\nTerizidou et al, 2006<\/a><\/td>\nNM_000916<\/a><\/td>\nOXTR<\/td>\n<\/tr>\n
PAF receptor 1<\/td>\nPlatelet activator receptor<\/td>\nMutoh et al, 1994<\/a><\/td>\nNM_000952<\/a><\/td>\nPTAFR<\/td>\n<\/tr>\n
P-gp<\/td>\nP-glycoprotein-Drug resistance<\/td>\nWang et al, 2007<\/a><\/td>\nNM_000927<\/a><\/td>\nABCB1<\/td>\n<\/tr>\n
RAGE- receptor for advanced glycation end products<\/td>\nReceptor for Advanced Glycation End products<\/td>\nLi & Schmidt, 1997<\/a><\/td>\nNM_001136<\/a><\/td>\nAGER<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Regulators of apoptosis<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAcc #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
ASC<\/td>\nApoptosis-associated speck-like protein containing a CARD<\/td>\nSun et al, 2007<\/a><\/td>\nNM_013258<\/a><\/td>\nPYCARD<\/td>\n<\/tr>\n
Bax<\/td>\nPro-apoptotic Bcl-2 homologue<\/td>\nGrimm et al, 2004<\/a><\/td>\nNM_004324<\/a><\/td>\nBAX<\/td>\n<\/tr>\n
Bfl1\/A1<\/td>\nPro-survival Bcl-2 homologue<\/td>\nGrumont et al, 1999<\/a>; Zong et al, 1999<\/a><\/td>\n NM_004049<\/a><\/td>\nBCL2A1<\/td>\n<\/tr>\n
Bcl-xL<\/td>\nPro-survival Bcl-2 homologue<\/td>\nChen et al, 1999; Lee et al, 1999<\/a><\/td>\nNM_138578<\/a><\/td>\nBCL2L1<\/td>\n<\/tr>\n
Bcl-2<\/td>\nPro-survival factor<\/td>\nCatz & Johnson, 2001<\/a><\/td>\nNM_000633<\/a><\/td>\nBCL2<\/td>\n<\/tr>\n
Bim<\/td>\nPro-apoptotic Bcl-2 homolog<\/td>\nWang et al, 2008<\/a><\/td>\nNM_138621<\/a><\/td>\nBCL2L11<\/td>\n<\/tr>\n
B7-H1<\/td>\nProgrammed cell death ligand 1<\/td>\nLee et al, 2005<\/a><\/td>\nNM_014143<\/a><\/td>\nCD274<\/td>\n<\/tr>\n
BNIP3<\/td>\nHypoxia-inducible death factor<\/td>\nBaetz et al, 2005<\/a>; Shaw et al, 2006<\/a><\/td>\n NM_004052<\/a><\/td>\nBNIP3<\/td>\n<\/tr>\n
Caspase-11<\/td>\nCaspase<\/td>\nSchauvliege et al, 2002<\/a><\/td>\nNM_001225<\/a><\/td>\nCASP4<\/td>\n<\/tr>\n
Nr13<\/td>\nPro-survival Bcl-2 homologue<\/td>\nLee et al, 1999<\/a><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
c-FLIP<\/td>\nPro-survival factor<\/td>\nKreuz et al, 2001<\/a><\/td>\nNM_003879<\/a><\/td>\nCFLAR<\/td>\n<\/tr>\n
CD95 (Fas)<\/td>\nPro-apoptotic receptor<\/td>\nChan et al, 1999<\/a>; Zhou et al, 2005; Singh et al, 2006<\/a><\/td>\nNM_000043<\/a><\/td>\nFAS<\/td>\n<\/tr>\n
CIDEA<\/td>\nCell death-inducing DFFA-like effector A<\/td>\nPettersson et al, 2008<\/a><\/td>\nNP_001270.1<\/a>; NP_938031.1<\/a><\/td>\nCIDEA<\/td>\n<\/tr>\n
*Fas-associated phosphatase-1<\/td>\nProtein phosphatase<\/td>\nIrie et al, 2001<\/a><\/td>\n NM_006264<\/a><\/td>\nPTPN13<\/td>\n<\/tr>\n
Fas-Ligand<\/td>\nInducer of apoptosis<\/td>\nMatsui et al, 1998<\/a>; Singh et al, 2006<\/a><\/td>\nNM_000639<\/a><\/td>\nFASLG<\/td>\n<\/tr>\n
IAPs<\/td>\nInhibitors of Apoptosis<\/td>\nYou et al, 1997<\/a>; Stehlik et al, 1998a<\/a>, 1998b<\/a><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
IEX-1L<\/td>\nImmediate early gene<\/td>\nWu et al, 1998<\/a><\/td>\n NM_052815<\/a><\/td>\nIER3<\/td>\n<\/tr>\n
TRAF-1<\/td>\nTNF-receptor associated factor<\/td>\nSchwenzer et al, 1999<\/a><\/td>\n NM_005658<\/a><\/td>\nTRAF1<\/td>\n<\/tr>\n
TRAF-2<\/td>\nTNF-receptor associated factor<\/td>\nWang et al, 1998<\/a><\/td>\nNM_021138<\/a><\/td>\nTRAF2<\/td>\n<\/tr>\n
*TRAF-2 binding protein (Carp)<\/td>\nTRAF2 binding protein<\/td>\nChang et al, 2005<\/a><\/td>\nNM_052864<\/a><\/td>\nTIFA<\/td>\n<\/tr>\n
XIAP<\/td>\nX-linked inhibitor of apoptosis<\/td>\nTurner et al, 2007<\/a><\/td>\nNM_001167<\/a><\/td>\nXIAP<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Growth factors, ligands, and their modulators<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAcc #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
Activin A<\/td>\nTGF-beta-like factor<\/td>\nAlexander et al, 2007<\/a><\/td>\nNM_002192<\/a><\/td>\nINHBA<\/td>\n<\/tr>\n
Angiopoietin<\/td>\nTie-2 receptor ligand<\/td>\nScott et al, 2005<\/a><\/td>\n NM_001146<\/a><\/td>\nANGPT1<\/td>\n<\/tr>\n
BCAP<\/td>\nB-cell Adaptor for Phosphoinositide 3-kinase<\/td>\nGupta et al, 2008<\/a><\/td>\nNM_152309<\/a><\/td>\nPI3KAP1<\/td>\n<\/tr>\n
BDNF<\/td>\nBrain-derived neurotrophic factor<\/td>\nSaha et al, 2007<\/a><\/td>\nNM_001709<\/a><\/td>\nBDNF<\/td>\n<\/tr>\n
BLyS<\/td>\nB-lymphocyte stimulator<\/td>\nFu et al, 2006<\/a><\/td>\nNM_006573<\/a><\/td>\nTNFSF13B<\/td>\n<\/tr>\n
BLNK<\/td>\nB-cell linker<\/td>\nGupta et al, 2008<\/a><\/td>\nNM_013314<\/a><\/td>\nBLNK<\/td>\n<\/tr>\n
BMP-2<\/td>\nBone Morphogenic Protein-2<\/td>\nFeng et al, 2003<\/a>; Fukui et al, 2006<\/a><\/td>\n NM_001200<\/a><\/td>\nBMP2<\/td>\n<\/tr>\n
BMP-4<\/td>\nBone Morphogenic Protein-4<\/td>\n Zhu et al, 2007<\/a><\/td>\nNM_001202<\/a><\/td>\nBMP4<\/td>\n<\/tr>\n
CGRP<\/td>\nCalcitonin gene-related peptide<\/td>\nBowen et al, 2005<\/a><\/td>\nNM_000728<\/a><\/td>\nCALCB<\/td>\n<\/tr>\n
FGF8<\/td>\nFibroblast Growth Factor 8<\/td>\nArmstrong et al, 2006<\/a><\/td>\nNM_006119<\/a><\/td>\nFGF8<\/td>\n<\/tr>\n
FLRG<\/td>\nFollistatin-related gene<\/td>\nBartholin et al, 2007<\/a><\/td>\nNM_005860<\/a><\/td>\nFSTL3<\/td>\n<\/tr>\n
G-CSF<\/td>\nGranulocyte Colony Stimulating Factor<\/td>\nNishizawa & Nagata, 1990<\/a><\/td>\nNM_000759<\/a><\/td>\nCSF3<\/td>\n<\/tr>\n
GM-CSF<\/td>\nGranulocyte Macrophage Colony Stimulating Factor<\/td>\nSchreck & Baeuerle, 1990<\/a>; Bunting et al, 2007<\/a><\/td>\n NM_000758<\/a><\/td>\nCSF2<\/td>\n<\/tr>\n
*HGF\/SF<\/td>\nHepatocyte growth factor\/scatter factor<\/td>\nHarrison & Farzaneh, 2000<\/a><\/td>\nNM_000601<\/a><\/td>\nHGF<\/td>\n<\/tr>\n
EPO<\/td>\nErythropoietin<\/td>\nFigueroa et al, 2002<\/a><\/td>\nNM_000799<\/a><\/td>\nEPO<\/td>\n<\/tr>\n
*IGFBP-1<\/td>\nInsulin-like growth factor binding protein-1<\/td>\nLang et al, 1999<\/a><\/td>\nNM_001013029<\/a><\/td>\nIGFBP1<\/td>\n<\/tr>\n
IGFBP-2<\/td>\nInsulin-like growth factor binding protein-2<\/td>\nCazals et al, 1999<\/a><\/td>\nNM_000597<\/a><\/td>\nIGFBP2<\/td>\n<\/tr>\n
M-CSF (CSF-1)<\/td>\nMacrophage Colony Stimulating Factor<\/td>\nBrach et al, 1991<\/a>; Hohensinner et al, 2007<\/a><\/td>\nNM_000757<\/a><\/td>\nCSF1<\/td>\n<\/tr>\n
Midkine (neurite growth promoting factor-2)<\/td>\nHeparin Binding Growth Factor<\/td>\nYou et al, 2008<\/a><\/td>\nNM_001012334<\/a><\/td>\nMDK<\/td>\n<\/tr>\n
NGF<\/td>\nNerve Growth Factor<\/td>\nHeese et al, 2006<\/a><\/td>\nNM_002506<\/a><\/td>\nNGFB<\/td>\n<\/tr>\n
NK-1R<\/td>\nNeurokinin-1 Receptor<\/td>\nSimeonidis et al, 2003<\/a>; Ramkissoon et al, 2007<\/a><\/td>\nNM_015727<\/a><\/td>\nTACR1<\/td>\n<\/tr>\n
NK4<\/td>\nHepatocyte growth factor<\/td>\nZhou et al, 2003<\/a><\/td>\nNM_001012635<\/a><\/td>\nNK4<\/td>\n<\/tr>\n
Nrg1<\/td>\nNeuregulin<\/td>\nFrensing et al, 2007<\/a><\/td>\nNM_004495<\/a><\/td>\nNRG1<\/td>\n<\/tr>\n
OPN<\/td>\nOsteopontin<\/td>\nSamant et al, 2007<\/a><\/td>\n NM_001040058<\/a><\/td>\nSPP1<\/td>\n<\/tr>\n
PDGF B chain<\/td>\nPlatelet-derived Growth Factor<\/td>\nKhachigian et al, 1995<\/a>; Au et al, 2005<\/a><\/td>\nNM_002608<\/a><\/td>\nPDGFB<\/td>\n<\/tr>\n
PlGF<\/td>\nPlacenta Growth Factor<\/td>\nCramer et al, 2005<\/a><\/td>\nNM_002643<\/a><\/td>\nPIGF<\/td>\n<\/tr>\n
Proenkephalin<\/td>\nHormone<\/td>\nRattner et al, 1991<\/a><\/td>\nNM_006211<\/a><\/td>\nPENK<\/td>\n<\/tr>\n
Prolactin<\/td>\nPituitary hormone<\/td>\nFriedrichsen et al, 2005<\/a><\/td>\nNM_000948<\/a><\/td>\nPRL<\/td>\n<\/tr>\n
Stem Cell Factor<\/td>\nMast Cell Growth Factor<\/td>\nDa Silva et al, 2003<\/a>; 2004<\/a><\/td>\nNM_000899<\/a><\/td>\nKITLG<\/td>\n<\/tr>\n
*Thrombospondin-1 (TSP-1)<\/td>\nMatrix glycoprotein t<\/td>\nYang et al, 2003<\/a><\/td>\nNM_003246<\/a><\/td>\nTHBS1<\/td>\n<\/tr>\n
*Thrombospondin-2 (THBS2)<\/td>\nMatrix glycoprotein t<\/td>\nAdolph et al, 1997<\/a><\/td>\nNM_003247<\/a><\/td>\nTHBS2<\/td>\n<\/tr>\n
VEGF C<\/td>\nVascular Endothelial Growth Factor<\/td>\nChilov et al, 1997<\/a><\/td>\nNM_005429<\/a><\/td>\nVEGFC<\/td>\n<\/tr>\n
*WNT10B<\/td>\nSecreted glycoprotein<\/td>\nKatoh & Katoh, 2007<\/a><\/td>\n NM_003394<\/a><\/td>\nWNT10B<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Early response genes<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAcc #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
*B94<\/td>\nEarly response gene<\/td>\nZhou et al, 2003<\/a><\/td>\nNM_006291<\/a><\/td>\nTNFAIP2<\/td>\n<\/tr>\n
*Egr-1<\/td>\nMitogen-induced early response gene; zinc finger<\/td>\nZhou et al, 2003<\/a><\/td>\nNM_001964<\/a><\/td>\nEGR1<\/td>\n<\/tr>\n
p22\/PRG1<\/td>\nRat homologue of IEX<\/td>\nSchafer et al, 1998<\/a><\/td>\nNM_052815<\/a><\/td>\nIER3<\/td>\n<\/tr>\n
*p62<\/td>\nNon-proteasomal multi-ubiquitin chain binding protein<\/td>\nVadlamudi & Shin, 1998<\/a><\/td>\nNM_016221<\/a><\/td>\nDCTN4<\/td>\n<\/tr>\n
*TIEG<\/td>\nTGF-b early response gene; zinc finger protein<\/td>\nZhou et al, 2003<\/a><\/td>\n NM_001032282<\/a><\/td>\nKLF10<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Transcription factors and their modulators<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAcc #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
A20<\/td>\nTNF-inducible zinc finger<\/td>\nKrikos et al, 1992<\/a><\/td>\nNM_006290<\/a><\/td>\nTNFAIP3<\/td>\n<\/tr>\n
ABIN-3<\/td>\nNF-kB inhibitor<\/td>\nVerstrepen et al, 2007<\/a><\/td>\nNM_024873<\/a><\/td>\nTNIP3<\/td>\n<\/tr>\n
Androgen receptor<\/td>\nHormone receptor<\/td>\nZhang et al, 2004<\/a><\/td>\nNM_000044<\/a><\/td>\nAR<\/td>\n<\/tr>\n
Bcl-3<\/td>\nCoactivator for NF-kB p50 and p52<\/td>\n Brocke-Heidrich et al, 2006<\/a><\/td>\nNM_005178<\/a><\/td>\nBCL3<\/td>\n<\/tr>\n
BMI-1<\/td>\nPolycomb chromatin modifier<\/td>\nDutton et al, 2006<\/a><\/td>\nNM_005180<\/a><\/td>\nBMI1<\/td>\n<\/tr>\n
CDX1<\/td>\nHomeobox protein<\/td>\nWong et al, 2005<\/a><\/td>\nNM_001804<\/a><\/td>\nCDX1<\/td>\n<\/tr>\n
*c-fos (fish gene)<\/td>\nProto-oncogene<\/td>\nLi et al, 2004<\/a><\/td>\nNM_005252<\/a><\/td>\nFOS<\/td>\n<\/tr>\n
c-myb<\/td>\nProto-oncogene<\/td>\nToth et al, 1995<\/a><\/td>\nNM_005375<\/a><\/td>\nMYB<\/td>\n<\/tr>\n
c-myc<\/td>\nProto-oncogene<\/td>\nDuyao et al, 1990<\/a><\/td>\n NM_002467<\/a><\/td>\nMYC<\/td>\n<\/tr>\n
c-rel<\/td>\nProto-oncogene<\/td>\nHannink & Temin, 1990<\/a>; Capobianco & Gilmore, 1991<\/a><\/td>\nNM_002908<\/a><\/td>\nREL<\/td>\n<\/tr>\n
C\/EBPdelta<\/td>\nTranscription factor<\/td>\nLiu et al, 2007<\/a><\/td>\nNM_005195<\/a><\/td>\nCEBPD<\/td>\n<\/tr>\n
*DC-SCRIPT<\/td>\nDendritic cell zinc finger protein<\/td>\nTriantis et al, 2006<\/a><\/td>\nNM_152625<\/a><\/td>\nZNF366<\/td>\n<\/tr>\n
Dmp1<\/td>\nMyb-like transcription factor<\/td>\nTaneja et al, 2007<\/a><\/td>\nNM_001079911<\/a><\/td>\nDMP1<\/td>\n<\/tr>\n
E2F3a<\/td>\nCell cycle regulator<\/td>\nCheng et al, 2003<\/a><\/td>\nNM_001949<\/a><\/td>\nE2F3<\/td>\n<\/tr>\n
Elf3<\/td>\nEts family transcription factor<\/td>\nHou et al, 2004<\/a><\/td>\nNM_004433<\/a><\/td>\nELF3<\/td>\n<\/tr>\n
*ELYS<\/td>\nEmbryonic large molecule derived from yolk sac<\/td>\nOkita et al, 2003<\/a><\/td>\nNM_015446<\/a><\/td>\nAHCTF1<\/td>\n<\/tr>\n
*ETR101<\/td>\nTPA-inducible, Jun-like transcription factor<\/td>\nZhou et al, 2003<\/a><\/td>\nNM_004907<\/a><\/td>\nIER2<\/td>\n<\/tr>\n
Gata-3<\/td>\nT-cell differentiation Factor<\/td>\nCorn et al, 2005<\/a><\/td>\n NM_001002295<\/a><\/td>\nGATA3<\/td>\n<\/tr>\n
*Glucocorticoid receptor<\/td>\nPromoter 1B of the GR<\/td>\nSchaff & Cidlowski, 2002<\/a><\/td>\nNM_000176<\/a><\/td>\nNR3C1<\/td>\n<\/tr>\n
HIF-1alpha<\/td>\nHypoxia-inducible factor<\/td>\nBonello et al, 2007<\/a>; Belaiba et al, 2007<\/a>; van Uden et al, 2008<\/a>; Gorlach & Bonello, 2008<\/a><\/td>\nNM_001530<\/a><\/td>\nHIF1A<\/td>\n<\/tr>\n
HOXA9<\/td>\nHomeobox protein<\/td>\nTrivedi et al, 2007<\/a><\/td>\nNM_152739<\/a><\/td>\nHOXA9<\/td>\n<\/tr>\n
IRF-1<\/td>\nInterferon regulatory factor-1<\/td>\nHarada et al, 1994<\/a>; Robinson et al, 2006<\/a><\/td>\nNM_002198<\/a><\/td>\nIRF1<\/td>\n<\/tr>\n
IRF-2<\/td>\nInterferon regulatory factor-2<\/td>\nHarada et al, 1994<\/a><\/td>\nNM_002199<\/a><\/td>\nIRF2<\/td>\n<\/tr>\n
IRF-4<\/td>\nInterferon regulatory factor-4<\/td>\nGrumont & Gerondakis, 2000<\/a>; Saito et al, 2007<\/a><\/td>\n NM_002460<\/a><\/td>\nIRF4<\/td>\n<\/tr>\n
IRF-7<\/td>\nInterferon regulatory\u00a0\u00a0\u00a0\u00a0 factor -7<\/td>\nLu et al, 2002<\/a><\/td>\nNM_001572<\/a><\/td>\nIRF7<\/td>\n<\/tr>\n
IkB-a<\/td>\nInhibitor of Rel\/NF-kB<\/td>\nHaskill et al, 1991;<\/a><\/td>\nNM_020529<\/a><\/td>\nNFKBIA<\/td>\n<\/tr>\n
Sun et al, 1993<\/a><\/td>\n<\/tr>\n
de Martin et al, 1993<\/a><\/td>\n<\/tr>\n
IkB-e<\/td>\nInhibitor of Rel\/NF-kB<\/td>\nTian et al, 2005<\/a><\/td>\nNM_004556<\/a><\/td>\nNFKBIE<\/td>\n<\/tr>\n
junB<\/td>\nProto-oncogene<\/td>\nBrown et al, 1995<\/a><\/td>\n NM_002229<\/a><\/td>\nJUNB<\/td>\n<\/tr>\n
jmjD3<\/td>\nHistone lysine demethylase<\/td>\nG Natoli, pers comm<\/td>\nXM_043272<\/a><\/td>\nJMJD3<\/td>\n<\/tr>\n
Lef1<\/td>\nTranscription factor in Wnt\/b-catenin pathway<\/td>\nYun et al, 2007<\/a><\/td>\nNM_016269<\/a><\/td>\nLEF1<\/td>\n<\/tr>\n
LZIP<\/td>\nLeukocyte cell mobility<\/td>\nJang et al, 2007<\/a><\/td>\nNM_006368<\/a><\/td>\nCREB3<\/td>\n<\/tr>\n
Mail<\/td>\nIkB-like protein<\/td>\nShiina et al, 2001<\/a>; Ito et al, 2004<\/a><\/td>\nNM_001005474<\/a><\/td>\nNFKBIZ<\/td>\n<\/tr>\n
nfkb2<\/td>\nNF-kB p100 precursor<\/td>\nLombardi et al, 1995<\/a><\/td>\nNM_001077493<\/a><\/td>\nNFKB2<\/td>\n<\/tr>\n
nfkb1<\/td>\nNF-kB p105 precursor<\/td>\nTen et al, 1992<\/a><\/td>\nNM_003998<\/a><\/td>\nNFKB1<\/td>\n<\/tr>\n
NLRP2<\/td>\nNF-kB pathway inhibitor<\/td>\nFontalba et al, 2007<\/a><\/td>\nNM_017852<\/a><\/td>\nNLRP2<\/td>\n<\/tr>\n
NURR1<\/td>\nNuclear orphan receptor<\/td>\nMcEvoy et al, 2002<\/a><\/td>\n NM_006186<\/a><\/td>\nNR4A2<\/td>\n<\/tr>\n
Osterix<\/td>\nBone transcription factor<\/td>\nLu et al, 2006<\/a><\/td>\nAF477981<\/a><\/td>\nOsterix<\/td>\n<\/tr>\n
p53<\/td>\nTF, Tumor suppressor<\/td>\nWu & Lozano, 1994<\/a>; Schumm et al, 2006<\/a><\/td>\nNM_000546<\/a><\/td>\nTP53<\/td>\n<\/tr>\n
Progesterone receptor<\/td>\nTranscription factor<\/td>\nCondon et al, 2005<\/a><\/td>\nNM_000926<\/a><\/td>\nPGR<\/td>\n<\/tr>\n
PU.1<\/td>\nTranscription factor<\/td>\nBonadies et al, 2009<\/a><\/td>\nNM_001080547.1<\/a><\/td>\nSPI1<\/td>\n<\/tr>\n
relb<\/td>\nTranscription factor<\/td>\nBren et al, 2001<\/a><\/td>\n NM_006509<\/a><\/td>\nRELB<\/td>\n<\/tr>\n
Snail<\/td>\nTranscription factor<\/td>\nBarbera et al, 2004<\/a>; Julien et al, 2007<\/a><\/td>\nNM_005985<\/a><\/td>\nSNAI1<\/td>\n<\/tr>\n
Sox9<\/td>\nTranscription factor<\/td>\nMurakami et al, 2000<\/a><\/td>\nNM_000346<\/a><\/td>\nSOX9<\/td>\n<\/tr>\n
Stat5a<\/td>\nTranscription factor<\/td>\nHinz et al, 2002<\/a><\/td>\nNM_003152<\/a><\/td>\nSTAT5A<\/td>\n<\/tr>\n
Tfec<\/td>\nTranscription factor<\/td>\nRehli et al, 2005<\/a><\/td>\n NM_001018058<\/a><\/td>\nTFEC<\/td>\n<\/tr>\n
Twist<\/td>\nTranscription repressor<\/td>\nHorikawa et al, 2007<\/a>; Pham et al, 2007<\/a><\/td>\nNM_000474<\/a><\/td>\nTWIST1<\/td>\n<\/tr>\n
WT1<\/td>\nZinc finger transcription factor<\/td>\nDehbi et al, 1998<\/a>; Chen & Williams, 2000<\/a><\/td>\nNM_000378<\/a><\/td>\nWT1<\/td>\n<\/tr>\n
YY1<\/td>\nTranscription factor<\/td>\nWang et al, 2007<\/a><\/td>\n NM_003403<\/a><\/td>\nYY1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Enzymes<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAcc #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
*ABC Transporters<\/td>\nATP-binding membrane transporters<\/td>\nMutch et al, 2003<\/a><\/td>\nNM_019625<\/a><\/td>\nABCB9<\/td>\n<\/tr>\n
*N-acetylglucosaminyltransferase I (rat gene)<\/td>\nN-acetylglucosaminyltransferase<\/td>\nFukuda et al, 2003<\/a><\/td>\nNM_001097634<\/a><\/td>\nGCNT1<\/td>\n<\/tr>\n
ADH<\/td>\nLiver alcohol dehydrogenase<\/td>\nPotter et al, 2002<\/a><\/td>\nNM_000667<\/a><\/td>\nADH1A<\/td>\n<\/tr>\n
AID<\/td>\nActivation-induced cytidine deaminase<\/td>\nGourzi et al, 2007<\/a>; Endo et al, 2007<\/a><\/td>\nNM_020661<\/a><\/td>\nAICDA<\/td>\n<\/tr>\n
AMACR<\/td>\nalpha-methylacyl-CoA racemase<\/td>\nChen et al, 2007<\/a><\/td>\nNM_014324<\/a><\/td>\nAMACR<\/td>\n<\/tr>\n
ARF-related protein-1<\/td>\nGTPase<\/td>\nMueller et al, 2007<\/a><\/td>\nNM_003224<\/a><\/td>\nARFRP1<\/td>\n<\/tr>\n
Argininosuccinate synthetase<\/td>\nArginine synthesis<\/td>\nFan et al, 2005; Brasse-Lagnel et al, 2007<\/a><\/td>\nNM_000050<\/a><\/td>\nASS1<\/td>\n<\/tr>\n
Aromatase (promoter II)<\/td>\nEstrogen synthesis<\/td>\nBrasse-Lagnel et al, 2004<\/a><\/td>\nNM_000103<\/a><\/td>\nCYP19A1<\/td>\n<\/tr>\n
ART2.1<\/td>\nEcto-ADP-ribosyltransferase<\/td>\n Hong et al, 2007<\/a><\/td>\nNM_004314<\/a><\/td>\nART1<\/td>\n<\/tr>\n
alpha 1ACT<\/td>\nAnti-chymotrypsin<\/td>\nKiss et al, 2005<\/a><\/td>\nNM_001085<\/a><\/td>\nSERPINA3<\/td>\n<\/tr>\n
BACE-1<\/td>\nbeta site APP cleaving enzyme<\/td>\nSambamurti et al, 2004<\/a>; Rossner et al, 2006<\/a>: Bourne et al, 2007<\/a>; Bruggia-Prevot et al, 2008<\/a><\/td>\nNM_012104<\/a><\/td>\nBACE1<\/td>\n<\/tr>\n
Btk<\/td>\nBruton’s Tyrosine kinase<\/td>\nYu et al, 2008<\/a><\/td>\nNM_000061<\/a><\/td>\nBTK<\/td>\n<\/tr>\n
Cathepsin B<\/td>\nLysosomal cysteine protease<\/td>\nBien et al, 2004<\/a><\/td>\nNM_001908<\/a><\/td>\nCTSB<\/td>\n<\/tr>\n
*Cathepsin L<\/td>\nLysosomal cysteine protease<\/td>\nSeth et al, 2003<\/a><\/td>\nNM_001912<\/a><\/td>\nCTSL1<\/td>\n<\/tr>\n
cdk6<\/td>\nCell-dependent kinase 6<\/td>\nIwanaga et al, 2008<\/a><\/td>\n<\/td>\nCDK6<\/td>\n<\/tr>\n
*Ceramide glycosyltransferase<\/td>\nGlycosphingolipid<\/td>\nIchikawa et al, 1998<\/a><\/td>\nNM_020120<\/a><\/td>\nUGCGL1<\/td>\n<\/tr>\n
Chitinase 3-like protein<\/td>\nChitinase<\/td>\nRecklies et al, 2005<\/a><\/td>\nNM_001276<\/a><\/td>\nCHI3L1<\/td>\n<\/tr>\n
*cis-retinoid\/androgen dehydrogenase type 1 (CRAD1)<\/td>\nShort chain dehydrogenase<\/td>\nChai et al, 2001<\/a><\/td>\nNM_080436<\/a><\/td>\nRdh1<\/td>\n<\/tr>\n
*cis-retinoid\/androgen dehydrogenase type 2 (CRAD2)<\/td>\nShort chain dehydrogenase<\/td>\nTomita et al, 2000<\/a><\/td>\n NM_017473<\/a><\/td>\nRdh7<\/td>\n<\/tr>\n
Collagenase 1<\/td>\nMatrix metalloproteinase<\/td>\nVincenti et al, 1998<\/a><\/td>\nNM_002421<\/a><\/td>\nMMP1<\/td>\n<\/tr>\n
*Dihydrodiol dehydrogenase<\/td>\nOxidoreductase, oxidation of trans-hydodiols<\/td>\nCiaccio et al, 1996<\/a><\/td>\nNM_00135<\/a><\/td>\nAKR1C1<\/td>\n<\/tr>\n
*DYPD<\/td>\nDihydropyrimidine dehydrogenase<\/td>\nUkon et al, 2005<\/a><\/td>\nNM_000110<\/a><\/td>\nDPYD<\/td>\n<\/tr>\n
DNASIL2<\/td>\nDNAse-like endonuclease<\/td>\nShiokawa et al, 2004<\/a><\/td>\nNM_001374<\/a><\/td>\nDNASE1L2<\/td>\n<\/tr>\n
EL<\/td>\nEndothelial lipase<\/td>\nKempe et al, 2005<\/a><\/td>\nNM_006033<\/a><\/td>\nLIPG<\/td>\n<\/tr>\n
*ENO2<\/td>\nEnolase 2 gamma<\/td>\nCarter et al, 2002<\/a><\/td>\nNM_001975<\/a><\/td>\nENO2<\/td>\n<\/tr>\n
*GAD67<\/td>\nGlutamic acid decarboxylase<\/td>\nSzabo et al, 1996<\/a><\/td>\nNM_000817<\/a><\/td>\nGAD1<\/td>\n<\/tr>\n
GD3-synthase<\/td>\nSialyltransferase<\/td>\nZeng et al, 1998<\/a>: Kang et al, 2007<\/a><\/td>\nNM_003034<\/a><\/td>\nST8SIA1<\/td>\n<\/tr>\n
gp91 phox<\/td>\nSubunit of NADPH oxidase<\/td>\n Anrather et al, 2006<\/a><\/td>\nNM_007052<\/a><\/td>\nNOX1<\/td>\n<\/tr>\n
Gelatinase B<\/td>\nMatrix metalloproteinase<\/td>\nHe, 1996<\/a><\/td>\nNM_004994<\/a><\/td>\nMMP9<\/td>\n<\/tr>\n
GSTP1-1<\/td>\nGlutathione S-transferase<\/td>\nXia et al, 1996<\/a><\/td>\nNM_000852<\/a><\/td>\nGSTP1<\/td>\n<\/tr>\n
Glutamate-cysteine ligase<\/td>\nGlutathione S-transferase synthesis enzyme<\/td>\nYang et al, 2001<\/a>; Nagashima et al, 2007<\/a><\/td>\nNM_001498<\/a><\/td>\nGCLC<\/td>\n<\/tr>\n
GCLC<\/td>\nGlutamate-cysteine ligase catalytic subunit<\/td>\nYang et al, 2005<\/a><\/td>\nNM_001498<\/a><\/td>\nGCLC<\/td>\n<\/tr>\n
*Glutamate-cysteine ligase modifier<\/td>\nGlutathione S-transferase synthesis enzyme<\/td>\n Yang et al, 2001<\/a><\/td>\nNM_002061<\/a><\/td>\nGCLM<\/td>\n<\/tr>\n
*gamma glutamylcysteine synthetase<\/td>\nGlutatamylcysteine synthesis<\/td>\nCheng et al, 2005<\/a><\/td>\nNM_001498<\/a><\/td>\nGCLC<\/td>\n<\/tr>\n
*Glucose l-6-phosphate dehydrogenase<\/td>\nHexose monophosphate<\/td>\nGarcia-Nogales et al, 1999<\/a><\/td>\nNM_000402<\/a><\/td>\nG6PD<\/td>\n<\/tr>\n
Glucose-6-phosphatase<\/td>\nHexose phosphatase<\/td>\n Xu et al, 2007<\/a><\/td>\nNM_000151<\/a><\/td>\nG6PC<\/td>\n<\/tr>\n
GnRH II<\/td>\nGonadotropin-releasing hormone II<\/td>\nHoo et al, 2007<\/a><\/td>\nNM_001501<\/a><\/td>\nGNRH2<\/td>\n<\/tr>\n
Granzyme B<\/td>\nNK cell cytotoxicity<\/td>\nHuang et al, 2006<\/a><\/td>\nNM_004131<\/a><\/td>\nGZMB<\/td>\n<\/tr>\n
*Soluble Guanylyl cyclase alpha (1)<\/td>\nReceptor for NO<\/td>\nVazquez-Padron et al, 2004<\/a><\/td>\nNM_000855<\/a><\/td>\nGUCY1A2<\/td>\n<\/tr>\n
*Heparanase<\/td>\nCleaves heparin<\/td>\nCao et al, 2005<\/a><\/td>\nNM_006665<\/a><\/td>\nHPSE<\/td>\n<\/tr>\n
HO-1<\/td>\nHemeoxygenase<\/td>\nLavrovsky et al, 1994<\/a>; Rushworth & O’Connell, 2004<\/a>; Wu et al, 2004<\/a>; Lin et al, 2007<\/a><\/td>\nNM_002133<\/a><\/td>\nHMOX1<\/td>\n<\/tr>\n
Hyaluronan synthase<\/td>\nSynthesizes hyaluronic acid<\/td>\nOhkawa et al, 1999<\/a>; Kim, 2006<\/a>; Saavalainen et al, 2007<\/a><\/td>\nNM_001523<\/a><\/td>\nHAS1<\/td>\n<\/tr>\n
11bHSD2<\/td>\n11beta-hydroxysteroid dehydrogenase type 2<\/td>\n Kostadinova et al, 2005<\/a><\/td>\nNM_000196<\/a><\/td>\nHSD11B2<\/td>\n<\/tr>\n
*17bHSD<\/td>\n17beta-hydroxysteroid dehydrogenase<\/td>\nVillar et al, 2007<\/a><\/td>\nNM_014234<\/a><\/td>\nHSD17B8<\/td>\n<\/tr>\n
H+-K+ATPase alpha2<\/td>\nRole in potassium homeostasis<\/td>\nZhang & Kone, 2002<\/a>;Saha et al 2008<\/a><\/td>\nNM_000702<\/a><\/td>\nATP1A2<\/td>\n<\/tr>\n
Iodothyronine deiodinase (type 2)<\/td>\nConverts T4 to T3<\/td>\nFekete et al, 2003<\/a>; Zeold et al, 2006<\/a><\/td>\nNM_000793<\/a><\/td>\nDIO2<\/td>\n<\/tr>\n
*Indoleamine 2,3-dioxygenase<\/td>\nEnzyme for Trp synthesis<\/td>\nOgasawara et al, 2009<\/a><\/td>\nNM_002164<\/a><\/td>\nIDO1<\/td>\n<\/tr>\n
Lipocalin-type prostaglandin D synthase (L-PGDS)<\/td>\nProstaglandin D2 synthase in brain<\/td>\nFujimori et al, 2003<\/a><\/td>\nNM_000954<\/a><\/td>\nPTGDS<\/td>\n<\/tr>\n
Lysozyme<\/td>\nHydrolyzes bacterial cell walls<\/td>\nPhi van, 1996<\/a><\/td>\nNM_000239<\/a><\/td>\nLYZ<\/td>\n<\/tr>\n
Mthfr<\/td>\nMethylenetetrahydrofolate reductase<\/td>\nPickell et al, 2005<\/a><\/td>\nNM_005957<\/a><\/td>\nMTHFR<\/td>\n<\/tr>\n
*MKP-1<\/td>\nMAP kinase phosphatase<\/td>\nZhou et al, 2003<\/a><\/td>\nNM_004417<\/a><\/td>\nDUSP1<\/td>\n<\/tr>\n
MMP-3, matrix metalloproteinaase-3<\/td>\nSecreted collagenase involved in metastasis<\/td>\nBorghaei et al, 2004<\/a><\/td>\nNM_002422<\/a><\/td>\nMMP3<\/td>\n<\/tr>\n
MMP-9, matrix metalloproteinaase-9<\/td>\nSecreted collagenase involved in metastasis<\/td>\nBond et al, 1998<\/a>; Farina et al, 1999<\/a>; Yan et al, 2004<\/a><\/td>\nNM_004994<\/a><\/td>\nMMP9<\/td>\n<\/tr>\n
MLCK<\/td>\n(Long) Myosin light chain kinase<\/td>\nGraham et al, 2006<\/a><\/td>\nNM_053025<\/a><\/td>\nMYLK<\/td>\n<\/tr>\n
iNOS<\/td>\nInducible nitric oxide synthase<\/td>\nMorris et al, 2003<\/a>; Guo et al, 2006<\/a>; Hughes et al, 2008<\/a><\/td>\nNM_000625<\/a><\/td>\nNOS2A<\/td>\n<\/tr>\n
n-NOS<\/td>\nNeuronal nitric oxide synthase<\/td>\nNakata et al, 2006<\/a>; Li et al, 2007a<\/a>, 2007b<\/a><\/td>\nNM_000620<\/a><\/td>\nNOS1<\/td>\n<\/tr>\n
*PDE7A1<\/td>\nPhosphodiesterase 7A1<\/td>\nTorras-Llort, & Azorin, 2003<\/a><\/td>\nNM_002603<\/a><\/td>\nPDE7A<\/td>\n<\/tr>\n
PIM-1<\/td>\nSer\/Thr kinase<\/td>\nZhu et al, 2002<\/a><\/td>\nNM_002648<\/a><\/td>\nPIM1<\/td>\n<\/tr>\n
Plk3<\/td>\nPolo-like (Ser\/Thr) kinase 3<\/td>\nLi et al, 2005<\/a><\/td>\nNM_004073<\/a><\/td>\nPLK3<\/td>\n<\/tr>\n
PIK3CA<\/td>\nPhosphatidylinositol 3-kinase catalytic subunit<\/td>\nYang et al, 2008<\/a><\/td>\nNM_006218<\/a><\/td>\nPIK3CA<\/td>\n<\/tr>\n
*PP5<\/td>\nProtein phosphatase 5<\/td>\nMatsuda et al, 2003<\/a><\/td>\nNM_006247<\/a><\/td>\nPPP5C<\/td>\n<\/tr>\n
PKAalpha<\/td>\nProtein kinase A isoform<\/td>\nKaltschmidt et al, 2006<\/a><\/td>\nNM_002730<\/a><\/td>\nPRKACA<\/td>\n<\/tr>\n
PKCdelta<\/td>\nProtein kinase D isoform<\/td>\nSuh et al, 2003<\/a><\/td>\nNM_006254<\/a><\/td>\nPRKCD<\/td>\n<\/tr>\n
PLCdelta 1<\/td>\nPhospholipase C isoform<\/td>\nKim et al, 2003<\/a><\/td>\nNM_006225<\/a><\/td>\nPLCD1<\/td>\n<\/tr>\n
*PTGIS, prostaglandin synthase<\/td>\nProstaglandin synthase<\/td>\nYokoyama et al, 1996<\/a><\/td>\nNM_000961<\/a><\/td>\nPTGIS<\/td>\n<\/tr>\n
*PGES, prostaglandin E synthase<\/td>\nProstaglandin synthase<\/td>\nZhou et al, 2003<\/a><\/td>\nNM_004878<\/a><\/td>\nPTGES<\/td>\n<\/tr>\n
PTP1B<\/td>\nProtein tyrosine phosphatase 1B<\/td>\nZabolotny et al, 2008<\/a><\/td>\nNM_002827<\/a><\/td>\nPTPN1<\/td>\n<\/tr>\n
PTHrP<\/td>\nParathryroid hormone related protein<\/td>\nNadella et al, 2007<\/a><\/td>\nNM_002820<\/a><\/td>\nPTHLH<\/td>\n<\/tr>\n
RACK1<\/td>\nReceptor for Activated C kinase<\/td>\nChoi et al, 2003<\/a><\/td>\nNM_006098<\/a><\/td>\nGNB2L1<\/td>\n<\/tr>\n
*REV3<\/td>\nDNA polymerase zeta<\/td>\nYu et al, 2004<\/a><\/td>\nNM_002912<\/a><\/td>\nREV3L<\/td>\n<\/tr>\n
Slfn-2<\/td>\nSchlafen-2 DNA\/RNA helicase<\/td>\nSohn et al, 2007<\/a><\/td>\nNM_011408<\/a><\/td>\nSlfn2<\/td>\n<\/tr>\n
Serpin 2A<\/td>\nSerine protease<\/td>\nHampson et al, 2001<\/a><\/td>\nXM_372532<\/a><\/td>\nSERPINA2<\/td>\n<\/tr>\n
SIAT1<\/td>\nSialyltransferase<\/td>\nLo & Lau, 1999<\/a><\/td>\nNM_173216<\/a><\/td>\nST6GAL1<\/td>\n<\/tr>\n
SNARK<\/td>\nSNF1\/AMPK-related kinase<\/td>\nLegembre et al, 2004<\/a><\/td>\nNM_030952<\/a><\/td>\nNUAK2<\/td>\n<\/tr>\n
SSAT<\/td>\nSpermidine\/spermine N1-acetyltransferase<\/td>\nBabbar et al, 2006<\/a><\/td>\nNM_002970<\/a><\/td>\nSAT1<\/td>\n<\/tr>\n
*SUV3<\/td>\nATP-dependent RNA and DNA helicase<\/td>\nMinczuk et al, 2005<\/a><\/td>\nNM_003171<\/a><\/td>\nSUPV3L1<\/td>\n<\/tr>\n
TERT<\/td>\nTelomerase catalytic subunit<\/td>\nYin et al, 2000<\/a>: Hrdlickova et al, 2006<\/a><\/td>\nNM_198253<\/a><\/td>\nTERT<\/td>\n<\/tr>\n
Transglutaminase<\/td>\nForms isopeptide bonds<\/td>\nMirza et al, 1997<\/a><\/td>\nNM_000359<\/a><\/td>\nTGM1<\/td>\n<\/tr>\n
TTG<\/td>\nTissue transglutaminase<\/td>\nChen et al, 2008<\/a><\/td>\nNM_004613<\/a><\/td>\nTGM2<\/td>\n<\/tr>\n
Type II-secreted phospholipase A2<\/td>\nProinflammatory phospholipase<\/td>\nCouturier et al, 1999<\/a><\/td>\nNM_000437<\/a><\/td>\nPAFAH2<\/td>\n<\/tr>\n
Uridine phosphorylase<\/td>\n5-fluorouracil and capecitabine metabolism<\/td>\nWan et al, 2006<\/a><\/td>\nNM_003364<\/a><\/td>\nUPP1<\/td>\n<\/tr>\n
*Xanthine Dehydrogenase<\/td>\nOxidative metabolism of purines<\/td>\nXu et al, 1996<\/a><\/td>\nNM_000379<\/a><\/td>\nXDH<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Miscellaneous<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\nAcc #<\/td>\nHuman Gene Name<\/td>\n<\/tr>\n
*ABCG5 (bovine)<\/td>\nATP-binding cassette sterol transporters<\/td>\n Viturro et al, 2006<\/a><\/td>\nNM_022436<\/a><\/td>\nABCG5<\/td>\n<\/tr>\n
ABCG8 (bovine)<\/td>\nATP-binding cassette sterol transporters<\/td>\n Viturro et al, 2006<\/a><\/td>\nNM_022437<\/a><\/td>\nABCG8<\/td>\n<\/tr>\n
AbetaH-J-J<\/td>\nTripartite gene: aspartyl-beta-hydroxylase, junctin), junctate<\/td>\nFeriotto et al, 2005<\/a><\/td>\nNM_004318<\/a><\/td>\nASPH<\/td>\n<\/tr>\n
alpha-1 acid glycoprotein<\/td>\nSerum protein<\/td>\nMejdoubi et al, 1999<\/a><\/td>\nNM_000607<\/a><\/td>\nORM1<\/td>\n<\/tr>\n
alpha-fetoprotein<\/td>\nLiver cancer marker<\/td>\nCavin et al, 2004<\/a><\/td>\nNM_001134<\/a><\/td>\nAFP<\/td>\n<\/tr>\n
AMH<\/td>\nAnti-Mullerian hormone<\/td>\nLukas-Croisier et al, 2003<\/a><\/td>\nNM_000479<\/a><\/td>\nAMH<\/td>\n<\/tr>\n
*beta-amyloid<\/td>\nAlzheimer’s precursor<\/td>\nSong & Lahiri, 1998<\/a><\/td>\nNM_000484<\/a><\/td>\nA4<\/td>\n<\/tr>\n
APOBEC2<\/td>\nApolipoportein B mRNA-editing enzyme catalytic subunit 2<\/td>\nMatsumoto et al, 2006<\/a><\/td>\nNM_006789<\/a><\/td>\nAPOBEC2<\/td>\n<\/tr>\n
Apolipoprotein C III<\/td>\nApoprotein of HDL<\/td>\nGruber et al, 1994<\/a><\/td>\nNM_000040<\/a><\/td>\nAPOC3<\/td>\n<\/tr>\n
Apolipoprotein D<\/td>\nPlasma lipocalin<\/td>\nDo Carmo et al, 2007<\/a><\/td>\nNM_001647<\/a><\/td>\nAPOD<\/td>\n<\/tr>\n
Apolipoprotein E<\/td>\nProtein assoc. with Alzheimers<\/td>\nLahiri, 2004<\/a>; Du et al, 2005<\/a><\/td>\nNM_000041<\/a><\/td>\nAPOE<\/td>\n<\/tr>\n
AQP4<\/td>\nAquaporin 4<\/td>\nIto et al, 2006<\/a><\/td>\nNM_001650<\/a><\/td>\nAQP4<\/td>\n<\/tr>\n
*Biglycan<\/td>\nConnective tissue proteoglycan<\/td>\nUngefroren & Krull, 1996<\/a><\/td>\nNM_001711<\/a><\/td>\nBGN<\/td>\n<\/tr>\n
BRCA2<\/td>\nBreast Cancer Susceptibility protein-2<\/td>\nWu et al, 2000<\/a><\/td>\nNM_000059<\/a><\/td>\nBRCA2<\/td>\n<\/tr>\n
Calsarcin-1<\/td>\nMuscle cell calcineurin-interacting protein<\/td>\nWang et al, 2007<\/a><\/td>\nNM_021245<\/a><\/td>\nMYOZ1<\/td>\n<\/tr>\n
*Caveolin-1<\/td>\nLipid raft protein<\/td>\nDeregowski et al, 2002<\/a><\/td>\nNM_001753<\/a><\/td>\nCAV1<\/td>\n<\/tr>\n
*Clone 330<\/td>\nPossible secreted protein<\/td>\nMatsuda et al, 2003<\/a><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
*Clone 156<\/td>\nUnknown NF-kB inducer<\/td>\nMatsuda et al, 2003<\/a><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
*Clone 68<\/td>\nUnknown NF-kB inducer<\/td>\nMatsuda et al, 2003<\/a><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
*p21-CIP1<\/td>\nCyclin-dependent kinase inhibitor<\/td>\nHinata et al, 2003<\/a><\/td>\nNM_000389<\/a><\/td>\nCDKN1A<\/td>\n<\/tr>\n
*Claudin-2<\/td>\nGap junction protein<\/td>\nYamamoto et al, 2004<\/a><\/td>\nNM_020384<\/a><\/td>\nCLDN2<\/td>\n<\/tr>\n
a2(I) collagen<\/td>\nType I collagen<\/td>\nNovitskiy et al, 2004<\/a>; Nieto, 2007<\/a><\/td>\nNM_000089<\/a><\/td>\nCOL1A2<\/td>\n<\/tr>\n
*Connexin32<\/td>\nGap junction protein<\/td>\nYamamoto et al, 2004<\/a><\/td>\nNM_000166<\/a><\/td>\nGJB1<\/td>\n<\/tr>\n
Cyclin D1<\/td>\nCell-cycle regulation<\/td>\nGuttridge et al, 1999<\/a>; Hinz et al, 1999<\/a>; Toualbi-Abed et al, 2008<\/a><\/td>\nNM_053056<\/a><\/td>\nCCND1<\/td>\n<\/tr>\n
Cyclin D2<\/td>\nCell-cycle regulation<\/td>\nHuang et al, 2004<\/a>; Iwanaga et al, 2008<\/a><\/td>\nNM_001759<\/a><\/td>\nCCND2<\/td>\n<\/tr>\n
*Cyclin D3<\/td>\nCell-cycle regulation<\/td>\nWang et al, 1996<\/a><\/td>\nNM_001760<\/a><\/td>\nCCND3<\/td>\n<\/tr>\n
DIF2<\/td>\nMonocyte differentiation gene<\/td>\nWitcher et al, 2007<\/a><\/td>\nNM_003897<\/a><\/td>\nIER3<\/td>\n<\/tr>\n
DMT1<\/td>\nDivalent metal ion transporter<\/td>\nParadkar et al, 2005<\/a><\/td>\nNM_000617<\/a><\/td>\nSLC11A2<\/td>\n<\/tr>\n
Elafin<\/td>\nProteinase inhibitor<\/td>\nBingle et al, 2001<\/a><\/td>\nNM_002638<\/a><\/td>\nSKALP, PI3<\/td>\n<\/tr>\n
Endothelin 1<\/td>\nVasoconstrictor peptide\/mitogen<\/td>\nQuehenberger et al, 2000<\/a><\/td>\nNM_001955<\/a><\/td>\nEDN1<\/td>\n<\/tr>\n
Ephrin-A1<\/td>\nCell-cycle regulation<\/td>\nDeregowski et al, 2002<\/a><\/td>\nNM_005232<\/a><\/td>\nEPHA1<\/td>\n<\/tr>\n
Factor VIII<\/td>\nHemostasis<\/td>\nFigueiredo & Brownlee, 1995<\/a><\/td>\nNM_000132<\/a><\/td>\nF8<\/td>\n<\/tr>\n
Ferritin Heavy Chain<\/td>\nAnti-oxidant<\/td>\nKwak et al, 1995<\/a><\/td>\nNM_002032<\/a><\/td>\nFTH1<\/td>\n<\/tr>\n
Gadd45beta<\/td>\nDNA repair\/cell cycle<\/td>\nDe Smaele et al, 2001<\/a>; Qiu et al, 2004<\/a><\/td>\nNM_015675<\/a><\/td>\nGADD45B<\/td>\n<\/tr>\n
Galpha i2<\/td>\nG protein<\/td>\nArinze & Kawai, 2005<\/a><\/td>\nNM_002070<\/a><\/td>\nGNAI2<\/td>\n<\/tr>\n
*GIF<\/td>\nCys-rich metal binding protein<\/td>\nHinata et al, 2003<\/a><\/td>\nNM_005954<\/a><\/td>\nMT3<\/td>\n<\/tr>\n
Galectin 3<\/td>\nb-galactosidase-binding lectin<\/td>\nHsu et al, 1996<\/a><\/td>\nNR_003225<\/a><\/td>\nLGALS3<\/td>\n<\/tr>\n
GBP-1<\/td>\nGTPase guanylate binding protein<\/td>\nNaschberger et al, 2004<\/a><\/td>\nNM_002053<\/a><\/td>\nGBP1<\/td>\n<\/tr>\n
epsilon-Globin<\/td>\nGlobin protein<\/td>\nHou et al, 2002<\/a>, 2004<\/a><\/td>\nNM_005330<\/a><\/td>\nHBE1<\/td>\n<\/tr>\n
zeta-Globin<\/td>\nGlobin protein<\/td>\nWang & Liebhaber, 1999<\/a><\/td>\nNM_005332<\/a><\/td>\nHBZ<\/td>\n<\/tr>\n
*GS3686<\/td>\nHomology to microtubule aggregating protein<\/td>\nCarter et al, 2002<\/a><\/td>\nNM_006820<\/a><\/td>\nIFI44L<\/td>\n<\/tr>\n
Hair K5 keratin<\/td>\nHair keratin protein<\/td>\nGilon et al, 2007<\/a><\/td>\nNM_000424<\/a><\/td>\nKRT5<\/td>\n<\/tr>\n
*HCCS1<\/td>\nHepatocarcinoma suppressor 1<\/td>\nZhu et al, 2006<\/a><\/td>\nNM_018289<\/a><\/td>\nVPS53<\/td>\n<\/tr>\n
HMG14<\/td>\nHigh mobility group 14<\/td>\nWalker & Enrietto, 1996<\/a><\/td>\nNM_004965<\/a><\/td>\nHMGN1<\/td>\n<\/tr>\n
IBABP<\/td>\nIleal bile acid binding protein<\/td>\nFang et al, 2007<\/a><\/td>\nNM_001445<\/a><\/td>\nFABP6<\/td>\n<\/tr>\n
IMP2<\/td>\nInsulin-like growth factor-II mRNA binding protein<\/td>\nCleynen et al, 2007<\/a><\/td>\nNM_000597<\/a><\/td>\nIGFBP2<\/td>\n<\/tr>\n
K3 Keratin<\/td>\nIntermediate filament protein<\/td>\nWu et al, 1994<\/a><\/td>\nNM_057088<\/a><\/td>\nKRT3<\/td>\n<\/tr>\n
K6b Keratin<\/td>\nIntermediate filament protein<\/td>\nKomine et al, 2000<\/a><\/td>\nNM_005555<\/a><\/td>\nKRT6B<\/td>\n<\/tr>\n
K15 Keratin<\/td>\nIntermediate filament protein<\/td>\nRadoja et al, 2004<\/a><\/td>\nNM_002275<\/a><\/td>\nKRT15<\/td>\n<\/tr>\n
*Lactoferrin<\/td>\nMilk protein<\/td>\nZheng et al, 2005<\/a><\/td>\nNM_002343<\/a><\/td>\nLTF<\/td>\n<\/tr>\n
Laminin B2 Chain<\/td>\nBasement membrane protein<\/td>\nRichardson et al, 1995<\/a><\/td>\nNM_002292<\/a><\/td>\nLAMB2<\/td>\n<\/tr>\n
Lipocalin-2<\/td>\nIron-siderophore-binding protein<\/td>\nFujino et al, 2005<\/a><\/td>\nNM_005564<\/a><\/td>\nLCN2<\/td>\n<\/tr>\n
Mts1<\/td>\nMultiple tumor suppressor<\/td>\nTulchinsky et al, 1997<\/a><\/td>\nNM_002961<\/a><\/td>\nS100A4<\/td>\n<\/tr>\n
Mir125b<\/td>\nMicro-RNA TNFa<\/td>\nTili et al, 2007<\/a><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Mir146a, b<\/td>\nMicro-RNA for IRAK and Traf6<\/td>\nTaganov et al, 2006<\/a><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Mir155<\/td>\nMicro-RNA for FADD, IKKe, Ripk1<\/td>\nTili et al, 2007<\/a><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
MNE1<\/td>\nMonocyte\/neutrophil elastase inhibitor<\/td>\nZeng et al, 2000<\/a><\/td>\nNM_030666<\/a><\/td>\nSERPINB1<\/td>\n<\/tr>\n
Mucin (MUC-2)<\/td>\nAirway defense glycoprotein<\/td>\nJono et al, 2002<\/a>; Lee et al, 2000<\/a><\/td>\nNM_002457<\/a><\/td>\nMUC2<\/td>\n<\/tr>\n
Myelin basic protein<\/td>\nNeural sheath<\/td>\nPaez et al, 2006<\/a><\/td>\nNM_001025081<\/a><\/td>\nMBP<\/td>\n<\/tr>\n
MCT1<\/td>\nMonocarboxylate transporter isoform 1<\/td>\nBorthakur et al, 2007<\/a><\/td>\nNM_003051<\/a><\/td>\nSLC16A1<\/td>\n<\/tr>\n
Naf1<\/td>\nAssociates with HIV Nef<\/td>\nTian et al, 2005<\/a><\/td>\nNM_006058<\/a><\/td>\nTNIP1<\/td>\n<\/tr>\n
Neutrophil gelatinase-associated lipocalin<\/td>\nAnti-microbial protein in lung<\/td>\nCowland et al, 2003<\/a><\/td>\nNM_005564<\/a><\/td>\nLCN2<\/td>\n<\/tr>\n
NLF1<\/td>\nIL-1beta induced<\/td>\nWarton et al, 2004<\/a><\/td>\nNM_207322<\/a><\/td>\nFAM148A<\/td>\n<\/tr>\n
*p11<\/td>\nAnnexin II ligand<\/td>\nHuang et al, 2003<\/a><\/td>\nNM_002966<\/a><\/td>\nS100A10<\/td>\n<\/tr>\n
PA28 alpha<\/td>\nProteasome activator<\/td>\nOssendorp et al, 2005<\/a><\/td>\nNM_006263<\/a><\/td>\nPSME1<\/td>\n<\/tr>\n
PA28 beta<\/td>\nProteasome activator<\/td>\nOssendorp et al, 2005<\/a><\/td>\nNM_002818<\/a><\/td>\nPSME2<\/td>\n<\/tr>\n
PAI-1<\/td>\nPlasminogen activator inhibitor<\/td>\nHou et al, 2004<\/a><\/td>\nNM_000602<\/a><\/td>\nSERPINE1, PAI-1<\/td>\n<\/tr>\n
*Pax8<\/td>\nPaired box gene<\/td>\nOkladnova et al, 1997<\/a><\/td>\nNM_003466<\/a><\/td>\nPAX8<\/td>\n<\/tr>\n
*PCBD<\/td>\n6-pyruvoyl-tetrahydropterin synthase<\/td>\nCarter et al, 2002<\/a><\/td>\nNM_000317<\/a><\/td>\nPTS<\/td>\n<\/tr>\n
Perforin<\/td>\nPore-forming effector molecule<\/td>\nZhou et al, 2002<\/a><\/td>\nNM_005041<\/a><\/td>\nPRF1<\/td>\n<\/tr>\n
PGC-1\u03b2<\/td>\nmitochondrial regulator PPAR-\u03b3 coactivator 1\u03b2<\/td>\nBakkar et. al. 2012<\/a><\/td>\n\n
NM_001172698.1<\/a><\/pre>\n<\/td>\n
PPARGC1B<\/td>\n<\/tr>\n
*PGK1<\/td>\nPhosphoglycerate kinase 1<\/td>\nCarter et al, 2002<\/a><\/td>\nNM_000291<\/a><\/td>\nPGK1<\/td>\n<\/tr>\n
POMC<\/td>\nProopiomelanocortin<\/td>\nKaralis et al, 2004<\/a>; Asaba et al, 2007<\/a><\/td>\n NM_000939<\/a><\/td>\nPOMC<\/td>\n<\/tr>\n
Pregnancy-specific glycoprotein rnCGM3<\/td>\nPlacental expression<\/td>\nWang et al, 2001<\/a><\/td>\nNM_019126<\/a><\/td>\nCGM3<\/td>\n<\/tr>\n
Prodynorphin<\/td>\nNeuropeptide<\/td>\nBakalkin et al, 1994<\/a><\/td>\nNM_024411<\/a><\/td>\nPDYN<\/td>\n<\/tr>\n
Prostate-specific antigen<\/td>\nSerum protein in prostate cancer<\/td>\nChen & Sawyers, 2002<\/a><\/td>\nNM_001030047<\/a><\/td>\nKLK3<\/td>\n<\/tr>\n
PTEN<\/td>\nTumor suppressor<\/td>\nXia et al, 2007<\/a><\/td>\nNM_000314<\/a><\/td>\nPTEN<\/td>\n<\/tr>\n
RAG-1<\/td>\nImmunoglobulin recombinase genes<\/td>\nVerkoczy et al, 2005<\/a><\/td>\nNM_000448<\/a><\/td>\nRAG1<\/td>\n<\/tr>\n
RAG-2<\/td>\nImmunoglobulin recombinase genes<\/td>\nVerkoczy et al, 2005<\/a><\/td>\nNM_000536<\/a><\/td>\nRAG2<\/td>\n<\/tr>\n
RbAp48<\/td>\nRetinoblastoma-associated protein 48<\/td>\nPacifico et al, 2007<\/a><\/td>\nNM_005610<\/a><\/td>\nRBBP4<\/td>\n<\/tr>\n
*RICK<\/td>\nAdaptor<\/td>\nMatsuda et al, 2003<\/a><\/td>\nNM_003821<\/a><\/td>\nRIPK2<\/td>\n<\/tr>\n
SerpinE2<\/td>\nSerine protease inhibitor<\/td>\nSuzuki et al, 2006<\/a><\/td>\nNM_006216<\/a><\/td>\nSERPINE2<\/td>\n<\/tr>\n
S100A6 (calcyclin)<\/td>\nCalcium binding protein<\/td>\nJoo et al, 2003<\/a><\/td>\nNM_014624<\/a><\/td>\nS100A6<\/td>\n<\/tr>\n
SH3BGRL<\/td>\nSH3-binding glutamic acid-rich protein<\/td>\nMajid et al, 2005<\/a><\/td>\nNM_003022<\/a><\/td>\nSH3BGRL<\/td>\n<\/tr>\n
SK2 channels<\/td>\nSmall-conductance Ca2+-activated channels<\/td>\nKye et al, 2007<\/a><\/td>\nNM_021614<\/a><\/td>\nKCNN2<\/td>\n<\/tr>\n
Skp2<\/td>\nS-phase kinase-associated protein 2<\/td>\nSchneider et al, 2006<\/a><\/td>\nNM_005983<\/a><\/td>\nSKP2<\/td>\n<\/tr>\n
*Spergen-1<\/td>\nSperm-specific mitochondrial protein<\/td>\nMatsuoka et al, 2004<\/a><\/td>\nNM_174927<\/a><\/td>\nSPATA19<\/td>\n<\/tr>\n
SWS1<\/td>\nRainbow trout opsin<\/td>\nDann et al, 2004<\/a><\/td>\nNM_001708<\/a><\/td>\nOPN1SW<\/td>\n<\/tr>\n
Syncytin-1<\/td>\nEnv glycoprotein of endogenous human retrovirus<\/td>\nMameli et al, 2007<\/a><\/td>\nNM_014590<\/a><\/td>\nERVWE1<\/td>\n<\/tr>\n
Syndecan-4<\/td>\nHeparin sulfate proteoglycan<\/td>\nZhang et al, 1999<\/a><\/td>\nNM_002999<\/a><\/td>\nSDC4<\/td>\n<\/tr>\n
TAUT<\/td>\nTaurine Uptake Transporter<\/td>\nMochizuki et al, 2005<\/a><\/td>\nNM_003043<\/a><\/td>\nSLC6A6<\/td>\n<\/tr>\n
TASK-2<\/td>\nTandem P domain potassium channel<\/td>\nBrazier et al, 2005<\/a><\/td>\nNM_003740<\/a><\/td>\nKCNK5<\/td>\n<\/tr>\n
*Tissue factor pathway inhibitor-2 (TFPI-2)<\/td>\nSerine protease inhibitor<\/td>\nKonduri et al, 2003a<\/a>, 2003b<\/a>; Hube et al, 2003<\/a><\/td>\nNM_006528<\/a><\/td>\nTFPI2<\/td>\n<\/tr>\n
*Transferrin (mosquito)<\/td>\nProbable iron transport protein<\/td>\nHarizanova et al, 2005<\/a><\/td>\nNM_001063<\/a><\/td>\nTF<\/td>\n<\/tr>\n
TRIF<\/td>\nTIR-containing adaptor protein inducing interferon beta<\/td>\nHardy et al, 2004<\/a><\/td>\nNM_014261<\/a><\/td>\nTICAM1<\/td>\n<\/tr>\n
TRPC1<\/td>\nThrombin activation of protease-activated receptor-1<\/td>\nParia et al, 2006<\/a><\/td>\nNM_003304<\/a><\/td>\nTRPC1<\/td>\n<\/tr>\n
*UBE2M<\/td>\nUbiquitin conjugating enzyme E2M<\/td>\nCarter et al, 2002<\/a><\/td>\nNM_003969<\/a><\/td>\nUBE2M<\/td>\n<\/tr>\n
*UCP-2<\/td>\nUncoupling protein-2<\/td>\nLee et al, 1999<\/a><\/td>\nNM_003355<\/a><\/td>\nUCP2<\/td>\n<\/tr>\n
Uroplakin Ib<\/td>\nSurface structural protein on urothelial cells<\/td>\nVarga et al, 2004<\/a><\/td>\nNM_006952<\/a><\/td>\nUPK1B<\/td>\n<\/tr>\n
25-hydroxyvtamin D3 1alpha hydroxylase<\/td>\nEnzyme for liver vitamin D3 production<\/td>\nEbert et al, 2004<\/a><\/td>\nNM_000785<\/a><\/td>\nCYP27B1<\/td>\n<\/tr>\n
Vimentin<\/td>\nIntermediate filament protein<\/td>\nLilienbaum et al, 1990<\/a>; Zheng et al, 2005<\/a><\/td>\nNM_003380<\/a><\/td>\nVIM<\/td>\n<\/tr>\n
a1-antitrypsin<\/td>\nProtease inhibitor<\/td>\nRay et al, 1995<\/a><\/td>\nNM_000295<\/a><\/td>\nSERPINA1<\/td>\n<\/tr>\n
Gro-1<\/td>\nGrowth regulated oncogene; chemokine<\/td>\nWood, 1995<\/a><\/td>\nNM_001511<\/a><\/td>\nCXCL1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Viruses<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Gene<\/td>\nFunction<\/td>\nReference<\/td>\n<\/td>\n<\/tr>\n
Adenovirus (E3 region)<\/td>\nAdenovirus<\/td>\nWilliams et al, 1990<\/a><\/td>\n<\/td>\n<\/tr>\n
Avian Leukosis Virus<\/td>\nCauses avian leukosis<\/td>\nBowers et al, 1996<\/a><\/td>\n<\/td>\n<\/tr>\n
Bovine Leukemia Virus<\/td>\nCauses bovine leukemia<\/td>\nBrooks et al, 1998<\/a><\/td>\n<\/td>\n<\/tr>\n
CMV<\/td>\nCytomegalovirus<\/td>\nSambucetti et al, 1989<\/a><\/td>\n<\/td>\n<\/tr>\n
EBV (Wp promoter)<\/td>\nEpstein-Barr virus<\/td>\nSugano et al, 1997<\/a><\/td>\n<\/td>\n<\/tr>\n
HBV (pregenomic promoter)<\/td>\nHepatitis B virus<\/td>\nKwon & Rho, 2002<\/a><\/td>\n<\/td>\n<\/tr>\n
HIV-1<\/td>\nHuman immunodeficiency virus<\/td>\nNabel & Baltimore, 1987<\/a>; Griffin et al, 1989<\/a><\/td>\n<\/td>\n<\/tr>\n
HSV (ICP90, ICPO)<\/td>\nHerpes simplex virus<\/td>\nRong et al, 1992<\/a>; La Frazia et al, 2006<\/a><\/td>\n<\/td>\n<\/tr>\n
JC Virus<\/td>\nPolyoma virus<\/td>\nRanganathan & Khalili, 1993<\/a><\/td>\n<\/td>\n<\/tr>\n
HPV type 16<\/td>\nHuman Papillomavirus<\/td>\nFontaine et al, 2000<\/a><\/td>\n<\/td>\n<\/tr>\n
SIV<\/td>\nSimian immunodeficiency virus<\/td>\nBellas et al, 1993<\/a><\/td>\n<\/td>\n<\/tr>\n
SV-40<\/td>\nSimian virus 40<\/td>\nKanno et al, 1989<\/a><\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

For 135 additional potential NF-kB target genes, which are predicted by computer-based methods to have\u00a0 composite NF-kB\/C\/EBP regulatory sites, see Shelest et al., 2003<\/a>.<\/p>\n

For 9 additional potential NF-kB immune function target genes, see Liu<\/a> et al., 2003.<\/p>\n

For several hundred predicted NF-kB target genes in pancreatic cells, see Naamane<\/a> et al, 2007.<\/p>\n

For additional c-Rel-specific target genes, see Bunting<\/a> et al, 2007.<\/p>\n

For 23 possible additional NF-kB targets from microarrays see Takase<\/a> et al, 2008<\/p>\n

See also http:\/\/bioinfo.lifl.fr\/NF-KB\/<\/a>for target gene information and binding sites.<\/p>\n


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Target Genes of NF-kB Cytokines\/Chemokines and their Modulators Immunoreceptors Proteins Involved in Antigen Presentation Cell Adhesion Molecules Acute Phase Proteins Stress Response Genes Cell Surface Receptors Regulators of Apoptosis Growth Factors, Ligands and their Modulators Early Response Genes Transcription Factors and Regulators Viruses Enzymes Miscellaneous (*indicates that the gene has a kB site in the […]<\/p>\n","protected":false},"author":3621,"featured_media":0,"parent":328,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/173"}],"collection":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/users\/3621"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/comments?post=173"}],"version-history":[{"count":30,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/173\/revisions"}],"predecessor-version":[{"id":1143,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/173\/revisions\/1143"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/pages\/328"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/nf-kb\/wp-json\/wp\/v2\/media?parent=173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}