Celina Pluim McDowell, MA

Fifth-year Doctoral Student, Clinical Psychology

  • Title Fifth-year Doctoral Student, Clinical Psychology
  • Office 900 Commonwealth Ave.
  • Phone 6173536476
  • Education B.S. in Psychology, University of California, San Diego, 2014
    M.A. in Psychology, Boston University, 2020

Research Interests

Broadly, I am interested in understanding predictors and outcomes of cognitive impairment in aging and neurodegenerative diseases. I have a more focused interest in frontal behaviors, quality of life, and care partner outcomes of neuropsychiatric changes in Parkinson’s disease, and modifiable lifestyle factors (such as sleep, mood, and life purpose) that increase or mitigate risk of cognitive decline in Alzheimer’s disease.

Current Projects

I work with Dr. Yakeel Quiroz in the Multicultural Alzheimer’s Prevention Program (MAPP) at Massachusetts General Hospital/Harvard Medical School, where we focus on culturally informed research, assessment, and clinical interventions in the prevention of Alzheimer’s disease. As part of an international collaboration examining the impact of COVID-19 on well-being and cognition in older individuals through an online study, I have been investigating the associations between purpose in life and subjective cognitive decline in ethnoracially diverse older adults in the US and Latin America. I also completed a T32 predoctoral fellowship with the Division of Sleep Medicine at Brigham & Women’s Hospital/Harvard Medical School (preceptor: Dr. Jeanne Duffy), where I am conducting a study to examine the relations between sleep, circadian rhythms, and cognitive functioning in older adults with and without cognitive impairment. I was recently awarded an F31 NRSA from the National Institute on Aging to support this project as part of my doctoral dissertation.

Relevant Experience

After graduating from the University of California, San Diego, I worked as a research assistant with Dr. Vincent Filoteo and Dr. Dawn Schiehser in the Neurocognition and Movement Lab (NCML) at the VA San Diego, studying neuropsychiatric changes in Parkinson’s disease longitudinally and examining the effectiveness of a cognitive rehabilitation program for individuals with PD and mild cognitive impairment. My major research projects in the NCML focused on concordance between care partner and patient reports of frontal behaviors in PD over time, and predictors of care partner depression and burden.

Since beginning my doctoral training at BU, I have examined PD patient and informant concordance of self-reported motor and non-motor symptoms of PD through our Boston University Online Survey Study of PD (BOSS-PD) under Dr. Cronin-Golomb’s mentorship, and I have explored the relation between purpose in life and subjective cognitive decline in older adults in the US and Latin America, including differences in these relations between ethnic groups and countries of residence, under Dr. Quiroz’s mentorship. Presently, I am investigating circadian rhythms and their associations with subjective and objective cognitive functioning in older adults with healthy cognition, subjective cognitive decline, and mild cognitive impairment, using dim light melatonin onset testing, actigraphy, and neuropsychological assessments under the co-mentorship of Dr. Duffy, Dr. Quiroz, and Dr. Cronin-Golomb.

Hobbies and Interests

During my free time, I enjoy baking delicious treats and exploring the city. I also love outdoor activities like camping, hiking, and backpacking – I’ve visited 13 US national parks and have several more on my bucket list! At the end of most days, I like to wind down by watching something funny or scary on Netflix, reading a book, and spending time with my husband, Ryan.

Publications

Munro, C. E., Boyle, R., …, Pluim, C. F., …, & Amariglio, R. (in press). Recent contributions to the field of subjective cognitive decline in aging: A literature review. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring.

Vila-Castelar, C., Chen, Y., …, Pluim McDowell, C., …, & Quiroz, Y. T. (in press). Sex differences in blood-based biomarkers and cognitive performance in individuals with autosomal dominant Alzheimer’s disease. Alzheimer’s & Dementia.

Yucebas, D., Fox-Fuller, J. T., Cabrera, A. B., Baena, A., McDowell, C. P., Aduen, P., Vila-Castelar, C., Bocanegra, Y., Tirado, V., Sanchez, J. S., Cronin-Golomb, A., Lopera, F.,  & Quiroz, Y. T. (2023). Associations of category fluency clustering performance with in vivo brain pathology in autosomal dominant Alzheimer’s disease. Journal of the International Neuropsychological Society, 1-7.

Kinger, S. B., Juneau, T., Kaplan, R. I., Pluim, C. F., Fox-Fuller, J. T., Wang, T., Mukadam, N, Neargarder, S., Salazar, R. D., Cronin-Golomb, A. (2023). Changes in Apathy, Depression, and Anxiety in Parkinson’s Disease from Before to During the COVID-19 Era. Brain Sciences, 13(2) 199.

Pluim, C. F., Anzai, J. A. U., Martinez, J. E., Munera, D., Garza-Naveda, A. P., Vila-Castelar, C., Guzmán-Vélez, E., Ramirez-Gomez, L., Bustin, J., Serrano, C. M., Babulal, G. M., Okada de Oliveira, M., & Quiroz, Y. T. (2023). Associations Among Loneliness, Purpose in Life and Subjective Cognitive Decline in Ethnoracially Diverse Older Adults Living in the United States. Journal of Applied Gerontology, 42(3), 376-386.

Whiteley, N., Pluim, C. F., Split, M., Cabrera Tuazon, A., Moore, R. C.,  Litvan, I., Lessig, S., Filoteo, J. V., Schiehser, D. M. (2022). Prospective Predictors of Care Partner Burden and Depression in Parkinson’s disease. International Journal of Geriatric Psychiatry.

Quiroz, Y. T., Solis, M., …, Pluim, C. F., …, & Sexton, C. (2022). Addressing the Disparities in Dementia Risk, Early Detection and Care in Latino Populations: Highlights from the Second Latinos and Alzheimer’s Symposium. Alzheimer’s & Dementia.

Fox-Fuller, J. T., Torrico-Teave, H., …, Pluim, C., …, & Quiroz, Y. T. (2021). Cortical Thickness Across the Lifespan in a Colombian Cohort with Autosomal Dominant Alzheimer’s Disease: A Cross-Sectional Study. Alzheimer’s & Dementia: Diagnosis, Assessment, & Disease Monitoring.

Fox-Fuller, J. T., Ngo, J., Pluim, C. F., Kaplan, R. I., Kim, D. H., Anzai, J. A., Yucebas, D., Briggs, S. M., Aduen, P. A., & Quiroz, Y. T. (2021). Initial Investigation of Test-Retest Reliability of Home-to-Home Teleneuropsychological Assessment in Healthy, English-Speaking Adults. The Clinical Neuropsychologist, 1-15.

Baena, A., Bocanegra, Y., Torres, V., Vila-Castelar, C., Guzmán-Vélez, E., Fox-Fuller, J. T., Gatchel, J. R., Sánchez, J., Pluim, C. F., Ramirez-Gómez, L., Martínez, J., Pineda, D., Lopera, F., & Quiroz, Y. T. (2021). Neuroticism Is Associated with Tau Pathology in Cognitively Unimpaired Individuals with Autosomal Dominant Alzheimer’s Disease. Journal of Alzheimer’s Disease, 82(4):1809-1822.

Babulal, G., Torres, V. L., …, Pluim, C., …, & Quiroz, Y. T. (2021). The Impact of COVID-19 on the Well-being and Cognition of Older Adults living in the United States and Latin America. EClinical Medicine. 2021 Apr 27;35:100848. doi: 10.1016/j.eclinm.2021.100848. eCollection 2021 May.

Pluim, C. F., Nakhla, M. Z., Split, M., Filoteo, J. V., Litvan, I., Moore, R. C., Lessig, S. & Schiehser, D. M. (2020). Changes in Self-and Informant-Reported Frontal Behaviors in Parkinson’s Disease: A Longitudinal Study. Journal of Geriatric Psychiatry and Neurology, 0891988720964257.

Symposia and Selected Poster Presentations

Pluim, C. F., Ussui Anzai, J. A., Martinez, J. E., Garza-Naveda, A. P., Vila-Castelar, C., Guzmán-Vélez, E., Ramirez-Gomez, L., Bustin, J., Serrano, C. M., Babulal, G. M., Okada de Oliveira, M., & Quiroz, Y. T. (2023). Purpose in Life, Loneliness, and Subjective Cognitive Decline in an Ethnically Diverse U.S. Sample. Poster presented at the 51st annual International Neuropsychological Society Meeting, San Diego, CA.

Pluim, C. F., Kaplan, R. I., Kinger, S. B., Fox-Fuller, J. T., Cronin-Golomb, A. Predictors of Quality of Life in Care Partners of Person’s with Parkinson’s disease: Results from an Online Survey. Poster accepted for presentation at the 50th annual International Neuropsychological Society Meeting, New Orleans, LA.

Kaplan, R. I., Pluim, C. F., Kinger, S., B., Fox-Fuller, J. T., Cronin-Golomb, A. Coping Strategies Used by Persons with Parkinson’s disease During the COVID-19 Pandemic. Poster accepted for presentation at the 50th annual International Neuropsychological Society Meeting, New Orleans, LA.

Kinger, S. B., Kaplan, R. I., Pluim, C. F., Fox-Fuller, J. T., Cronin-Golomb, A. Relating the Impact of the COVID-19 Pandemic to Non-motor Symptoms in Parkinson’s disease: Results from an Online Survey. Poster accepted for presentation at the 50th annual International Neuropsychological Society Meeting, New Orleans, LA.

Pluim, C. F., Anzai, J. A. U., Martinez, J. E., Munera, D., Garza-Naveda, A. P., Vila-Castelar, C., Guzmán-Vélez, E., Ramirez-Gomez, L., Torres, V. L., Bustin, J., Thumala, D., Acosta, D., Aguilar-Navarro, S., Soto-Añari, M., Gutiérrez-Gutiérrez, L., Slachevsky, A., Serrano, C. M., & Quiroz, Y. T. (May 2021). Purpose in Life and Subjective Cognitive Decline in Older Adults Living in Latin America. Oral presentation at the 2nd Latinos and Alzheimer’s Disease Symposium: Addressing Disparities in Risk, Early Detection, and Care. (virtual).

Pluim, C. F., Rentz, D., Fox-Fuller, J. T., Martinez, J. E., Vila-Castelar, C., Aduen, P. A., Baena, A., Sperling, R. A., Papp, K., Lopera, F., Quiroz, Y. T. (2021) Digital Clock Drawing and Markers of Brain Pathology in Preclinical Autosomal Dominant Alzheimer’s Disease. Poster presented at the 49th annual International Neuropsychological Society Meeting, San Diego, CA.

Ussui Anzai, J. A., Pluim, C. F., Martinez, J. E., Munera, D., Garza-Naveda, A. P., Vila-Castelar, C., Guzmán-Vélez, E., Ramirez-Gomez, L., Torres, V. L., Quiroz, Y. T. (2021) Associations Between Purpose in Life and Subjective Cognitive Decline in Ethnically Diverse Older Adults. Poster presented at the 49th annual International Neuropsychological Society Meeting, San Diego, CA.

Kaplan, R. I., Wall, J., Pluim, C. F., Cronin-Golomb, A. (2021) Discordance Between Reports of Symptoms in Persons with Parkinson’s Disease and Informants in an Online Survey Sample. Poster presented at the 49th annual International Neuropsychological Society Meeting, San Diego, CA.

Fox-Fuller, J. T., Kim, D., Pluim, C., Ngo, J., Ussui Anzai, J., Baena, A., Kim, M., Palacios-Navarro, G., García-Magariño, I., Cronin-Golomb, A., Quiroz, Y. T. (2021) Preliminary Evidence of Reliability and Validity of the Computerized Memory for Semantically Related Objects (MESERO) Test – a Pilot Study in Healthy Young Adults. Poster presented at the 49th annual International Neuropsychological Society Meeting, San Diego, CA.

Aduen, P. A., Martinez, J. E., Baena, A., Bocanegra, Y., Gatchel., J. R., Ramirez-Gomez, L., Guzmán-Vélez, E., Vila-Castelar, C., Fox-Fuller, J. T., Pluim, C. F., Lopera, F., Slavich, G. M., Quiroz, Y. T. (2021) Association of Lifetime Stress Exposure with Cognition and Brain Pathology in Autosomal Dominant Alzheimer’s Disease: Preliminary Findings from the COLBOS Project. Poster presented at the 49th annual International Neuropsychological Society Meeting, San Diego, CA.

Pluim, C. F., Kaplan, R. I., Fox-Fuller, J. T., Kinger, S. B., Neargarder, S., Salazar, R. D., Cronin-Golomb, A. (2020). Discordance in ratings of quality of life in persons with Parkinson’s disease and their informants through online survey. Poster accepted for presentation at the Cognitive Aging Conference, Atlanta, GA.

Fox-Fuller, J. T., Kinger, S. B., Pluim, C. F., Kaplan, R. I., McLarin, A., Moran, J. M., Salazar, R.D., Neargarder, S., Cronin-Golomb, A. (2020). Association between perceived stigma and discussion of experiences in Parkinson’s disease: Findings from an online survey. Poster accepted for presentation at the Cognitive Aging Conference, Atlanta, GA.

Ramirez Gomez, L., Bocanegra, Y., Pluim, C., Baena, A., Vila-Castelar, C., Jain, F., Giraldo, M., Munoz, C., Tirado, V., Henao, E., Lopera, F., Quiroz, Y. T. (2020). Intrusions in episodic memory in preclinical autosomal dominant Alzheimer’s disease: Contributions of education and occupation to optimal recall. Poster accepted for presentation at the American Academy of Neurology Annual Meeting, Toronto, Ontario, Canada.

Pluim, C. F., Whiteley, N., Tuazon, A. C., Nakhla, M. Z., McMann, T., Moore, R. C., Lessig, S., Litvan, I., Filoteo, J. V., & Schiehser, D. M. (2019). Do subjective complaints of dysexecutive behavior predict future neuropsychological test performance in Parkinson’s disease? JINS, 25(S1), 132. Poster presented at the 47th annual International Neuropsychological Society Meeting, New York, NY.

Cabrera Tuazon, A. E., Pluim, C. F., Pirogovsky-Turk, E., Whiteley, N., Nakhla, M. Z., Filoteo, J. V., Lessig, S., Litvan, I., Schiehser, D. M. (February 2019). Apathy predicts cognitive decline in individuals with Parkinson’s disease. JINS, 25(S1), 128. Poster presented at the 47th annual International Neuropsychological Society Meeting, New York, NY.

Whiteley, N., Tuazon, A. C., Pluim, C. F., McCallum, E., Lessig, S., Litvan, I., Filoteo, J. V., & Schiehser, D. M. (2019). A history of traumatic brain injury exacerbates poor quality of life in Parkinson’s disease. JINS, 25(S1), 135-136. Poster presented at the 47th annual International Neuropsychological Society Meeting, New York, NY.

Pluim, C. F., Split, M., Lopez, F. V., Whiteley, N., Lessig, S., Litvan, I., Filoteo, J .V., & Schiehser, D. M. (2018). Are apathy and fatigue distinct symptoms in Parkinson’s disease? JINS, 24(S1), 205-206. Poster presented at the 46th annual International Neuropsychological Society Meeting, Washington, DC.

Pluim, C., Filoteo, J. V., Moore, R., Turk, E., Litvan, I., Lessig, S., Song, D., & Schiehser, D. M. (2017). Changes in self- and caregiver-reported frontal behaviors in Parkinson’s disease: a longitudinal study. JINS, 23(S1), 237. Poster presented at the 45th annual International Neuropsychological Society Meeting, New Orleans, LA.

Pluim, C., Nguyen, L., Schiehser, D., Turk, E., Lessig, S., Song, D., Litvan, I. & Filoteo, J. (2016). The Impact of Dopamine Agonists on Sensitivity to Punishment and Sensitivity to Reward in Individuals with Parkinson’s Disease. Archives of Clinical Neuropsychology, 31(6), 662-662. Poster presented at the 36th annual National Academy of Neuropsychology Conference, Seattle, WA.

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