Associate Professor, Microbiology
The family Filoviridae includes Ebola virus and Marburg virus, which are associated with sporadic outbreaks and high case fatality rates. A maximum containment laboratory (Biosafety Level-4) is required to study the infectious forms of these viruses. Dr. Griffiths’ laboratory is interested in multiple aspects of filovirus biology with a view to exploiting this knowledge to further the development of vaccines and therapeutics.
We have basic science projects that investigate viral pathogenesis, evolution, gene expression, model development, transmission, and persistence. We also work toward the advanced development of vaccines and therapeutics, which includes regulated studies in maximum containment that will facilitate licensure by the FDA.
- Alfson KJ, Avena LE, Worwa G, Carrion R, Griffiths A. 2017. Development of a Lethal Intranasal Exposure Model of Ebola Virus in the Cynomolgus Macaque. Viruses. 9(11). pii: E319. PMID: 29109373; PMCID: PMC5707526.
- Alfson KJ, Worwa G, Carrion R Jr, Griffiths A. 2015. Determination and Therapeutic Exploitation of Ebola Virus Spontaneous Mutation Frequency. J Virol. 90(5):2345-55. PMID: 26676781; PMCID: PMC4810732.
- Kuhn JH, Amarasinghe GK, Basler CF, Bavari S, Bukreyev A, Chandran K, Crozier I, Dolnik O, Dye JM, Formenty PBH, Griffiths A, Hewson R, Kobinger GP, Leroy EM, Mühlberger E, Netesov SV, Palacios G, Pályi B, Paweska JT, Smither SJ, Takada A, Towner JS, Wahl V, ICTV Report Consortium. ICTV Virus Taxonomy Profile: Filoviridae. J Gen Virol. 2019 06; 100(6):911-912. PMID: 31021739.