{"id":773,"date":"2021-08-10T21:12:45","date_gmt":"2021-08-11T01:12:45","guid":{"rendered":"https:\/\/www.bu.edu\/muhlbergerlab\/?page_id=773"},"modified":"2022-03-31T14:12:24","modified_gmt":"2022-03-31T18:12:24","slug":"filoviruses","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/muhlbergerlab\/filoviruses\/","title":{"rendered":"Lloviu &#8211; a virus that needs attention"},"content":{"rendered":"<p>Have you ever heard about Lloviu virus? It is a filovirus that is closely related to Marburg and Ebola viruses and circulates in Schreiber&#8217;s bats (<em>Miniopterus schreibersii<\/em>) in Europe. About 100 million people live in the geographic range of the Schreiber&#8217;s bats. Until recently, Lloviu virus was just a viral sequence with incomplete genome ends. It was not possible to study this virus. We generated recombinant Lloviu virus and complemented the missing sequence with the homologous regions from Ebola and Marburg virus.\u00a0 We show that Lloviu virus is able to infect human cells, including primary macrophages, hepatocytes and lung cells. Therapeutic antibodies against Ebola virus won&#8217;t stop Lloviu virus. Much work to do to be prepared for this one. Check out our recent work, including the first EM images ever of Lloviu virus:<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35120176\/\"><span style=\"color: #0000ff;\"><strong>Recombinant Lloviu virus as a tool to study viral replication and host responses<\/strong><\/span><\/a><\/p>\n<p>Our collaborator <a href=\"https:\/\/twitter.com\/gaborkemenesi\">Dr. Gabor Kemenesi<\/a> and his colleagues at the National Laboratory of Virology, Szent\u00e1gothai Research Centre, University of P\u00e9cs, Hungary recently isolated <span style=\"text-decoration: underline;\"><strong>infectious Lloviu virus<\/strong><\/span> from Schreiber&#8217;s bats in Hungary. They also found the virus in ectoparasites of the bats. Super interesting work.<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-022-29298-1\"><strong><span style=\"text-decoration: underline;\"><span style=\"color: #0000ff; text-decoration: underline;\">Isolation of infectious Lloviu virus from Schreiber\u2019s bats in Hungary<\/span><\/span><\/strong><\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Have you ever heard about Lloviu virus? It is a filovirus that is closely related to Marburg and Ebola viruses and circulates in Schreiber&#8217;s bats (Miniopterus schreibersii) in Europe. About 100 million people live in the geographic range of the Schreiber&#8217;s bats. Until recently, Lloviu virus was just a viral sequence with incomplete genome ends. [&hellip;]<\/p>\n","protected":false},"author":17733,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/muhlbergerlab\/wp-json\/wp\/v2\/pages\/773"}],"collection":[{"href":"https:\/\/www.bu.edu\/muhlbergerlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/muhlbergerlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/muhlbergerlab\/wp-json\/wp\/v2\/users\/17733"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/muhlbergerlab\/wp-json\/wp\/v2\/comments?post=773"}],"version-history":[{"count":17,"href":"https:\/\/www.bu.edu\/muhlbergerlab\/wp-json\/wp\/v2\/pages\/773\/revisions"}],"predecessor-version":[{"id":884,"href":"https:\/\/www.bu.edu\/muhlbergerlab\/wp-json\/wp\/v2\/pages\/773\/revisions\/884"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/muhlbergerlab\/wp-json\/wp\/v2\/media?parent=773"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}