{"id":78164,"date":"2022-07-25T10:18:59","date_gmt":"2022-07-25T14:18:59","guid":{"rendered":"https:\/\/www.bu.edu\/met\/?post_type=profile&#038;p=78164"},"modified":"2024-11-08T15:08:56","modified_gmt":"2024-11-08T20:08:56","slug":"derin-keskin","status":"publish","type":"profile","link":"https:\/\/www.bu.edu\/met\/profile\/derin-keskin\/","title":{"rendered":"Derin B. Keskin"},"content":{"rendered":"<p>Dr. Derin Keskin has more than twenty years of teaching experience, and has taught courses related to human physiology, anatomy, and health informatics at BU\u2019s Metropolitan College since 2015. Dr. Keskin is currently the principal scientist with the Translational Immunogenomics Lab at Harvard Medical School, teaching affiliate Dana-Farber Cancer Center. Keskin also serves as an affiliated associate professor at Denmark Technical Institute. He additionally holds a position as an affiliated research scientist at the Broad Institute of MIT and Harvard. Keskin\u2019s research focuses on vaccine immunotherapies, autoimmune diseases, and cancer immunology. He has been involved with preclinical development, such as efficacy and safety studies, in vaccine research and has more than a decade of experience in T cell-based vaccine design against cancers and viruses such as influenza, HIV, and HPV. Keskin has extensive experience planning and managing entire immunological projects, including people, study design, financials, execution, analysis, troubleshooting, and FDA\/IND applications\/reporting. He has been an ad hoc reviewer for journals such as <em>Nature Cancer<\/em>, <em>Annals of Oncology<\/em>, <em>Molecular Medicine<\/em>, <em>Journal of Immunological Methods<\/em>, <em>Advances in Clinical Chemistry<\/em>, <em>Neurotoxicity Research<\/em>, <em>Journal of Investigative Dermatology<\/em>, and the <em>European Academy of Dermatology and Venereology Journal<\/em>.<\/p>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h2 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Courses<\/h2><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<ul><div class=\"course-feed\"><\/p>\n<li>MET CS 570 \u2013 Biomedical Sciences and Health IT<\/li>\n<p><\/div><\/ul>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h2 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Scholarly Works<\/h2><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<h3>Select Publications<\/h3>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/derin.keskin.1\/bibliography\/public\/\">View all publications by Dr. Keskin<\/a>.<\/p>\n<p>Giacomo Oliveira, Kari Stromhaug, Susan Klaeger, Tomasz Kula, Dennie Frederick Tompers, Phuong Le, Juliet Forman, Teddy Huang, Shuqiang Li, Wandi Zhang, \u2026 , Sune Justesen, Gavin MacBeath, Steven Carr, Edward F. Fritsch, Nir Hacohen, Moshe Sade-Feldman, Kenneth J. Livak, Genevieve M. Boland, Patrick A. Ott,\u00a0Derin B. Keskin, and Catherine J. Wu. \u201cDefining the phenotype, specificity and avidity of anti-tumor CD8+ T cells in melanoma.\u201d <em>Nature<\/em> 605, no. 7910 (2021): 532\u2013538. doi: 10.1038\/s41586-022-04682-5<\/p>\n<p>Zhuting Hu, Donna E. Leet, Rosa L.Allesoe, Shuqiang Li, Giacomo Oliveira, Adrienne M. Luoma, Jinyan Liu, \u2026 , Dan H. Barouch, Kai Wucherpfennig, Edward F. Fritsch, Derin B. Keskin, Catherine J. Wu, and Patrick A. Ott. \u201cPersonal Neoantigen Vaccines Induce Persistent Memory T Cell Responses and Epitope Spreading in Melanoma Patients.\u201d <em>Nature Medicine<\/em> 27, no. 3 (2021): 515\u2013525. doi: 10.1038\/s41591-020-01206-4<\/p>\n<p>Sarkizova, S., Klaeger, S., Phuong, M. L., Letitia, W. L., Oliveira, G., &#8230; ,<sup>\u00a0<\/sup>Zhang,\u00a0GL., Clauser, K. L., Hacohen, N.,\u00a0Carr,\u00a0S. A., Wu, C. J., and\u00a0Keskin, D. B.\u00a0\u201cImproved prediction of endogenously presented HLA class I epitopes in human tumors based on 95 mono-allelic peptidomes.\u201d\u00a0<em>Nature Biotechnology<\/em> 38, no. 2 (2020):199\u2013209. doi: 10.1038\/s41587-019-0322-9<\/p>\n<p>Keskin, D. B., Anandappa, A. J., Sun, J., Tirosh, I., \u2026 , Wu, C. J., and Reardon, D. A. \u201cNeoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial.\u201d <em>Nature<\/em> 565, no. 7738 (2019): 234\u2013239. doi: 10.1038\/s41586-018-0792-9<\/p>\n<p>Shukla, S. S., Bachireddy, P., Schilling, B., Galonska, C., Zhan, Q., Lee, P.C., Keskin, D. B. et al. \u201cCancer-germline antigens discriminate clinical outcome to CTLA4 blockade.\u201d <em>Cell<\/em> 173, no. 3 (2018): 624\u2013633. DOI: 10.1016\/j.cell.2018.03.026<\/p>\n<p>Bae, J., Hideshima, T., Zhang, GL., Zhou, J., Keskin, D. B., Munshi, N. C., and Anderson, K. C. \u201cIdentification and characterization of HLA-A24 specific XBP1, CD138 (Syndecan-1), and CS1 (SLAMF7) peptides inducing antigens-specific memory cytotoxic T lymphocytes targeting multiple myeloma.\u201d <em>Leukemia <\/em>32, no. 3 (2017): 752\u00ad\u2013764. DOI: 10.1038\/leu.2017.316<\/p>\n<p>Yoshikawa, A., Bi, K., Keskin, D. B., Zhang, G., Reinhold, B., and Reinherz, E. L. \u201cTCR-pMHC encounter differentially regulates transcriptomes of- tissue-resident CD8 T cells.\u201d <em>European Journal of Immunology <\/em>28, no. 1 (2017): 128\u2013150. DOI: 10.1002\/eji.201747174<\/p>\n<p>Ott, P. A., Hu, Z., Keskin, D. B. et al. \u201cAn Immunogenic Personal Neoantigen Vaccine for Patients with Melanoma.\u201d <em>Nature<\/em> 547, no. 7662 (2017): 217\u2013221. DOI: 10.1038\/nature22991<\/p>\n<p>*Abelin, J. G., *Keskin, D. B., *Sarkizova, S., Hartigan, C.R., Zhang, W., Sidney, J., Stevens, J., Lane, W., Zhang, GL., Eisenhaure, T. M., Clauser, K. R., Hacohen, N., Rooney, M. S., Carr, S. A., and Wu, C. J. \u201cMass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction.\u201d <em>Immunity <\/em>46, no. 2 (2017): 315\u2013326. DOI: 10.1016\/j.immuni.2017.02.007<\/p>\n<p>Tabansky, I., Messina, M. D., Bangeranye, C., Goldstein, J., Blitz-Shabbir, K. M., Machado, S., Jeganathan, V., Wright, P., Najjar, S., Cao, Y., Sands, W., Keskin, D. B., and Stern, J. N. \u201cAdvancing drug delivery systems for the treatment of multiple sclerosis.\u201d <em>Immunologic Research<\/em> 63, no. 1\u20133 (2015) 58\u00ad\u201369. DOI: 10.1007\/s12026-015-8719-0<\/p>\n<p>Keskin, D. B., Reinhold, B., Zhang, GL., Ivanov, A., Karger, B., and Reinherz, E. L. \u201cReply to van de Sandt and Rimmelzwann: Matching epitope display with functional avidity.\u201d In <em>Proceedings of the National Academy of Sciences of the United States of America<\/em> 112, no. 19 (2015): E2418. DOI: 10.1073\/pnas.1503931112<\/p>\n<p>Bae, J., Keskin, D. B., Cowens, K., Lee, AH., Dranoff, G., Munshi, N. C., and Anderson, K. C. \u201cLenalidomide polarizes Th1-specific Anti-tumor immune response and expands XBP1 antigen specific central memory CD3+CD8+ T cells against various tumors.\u201d <em>Journal of Leukemia<\/em> 3, no. 2 (2015): 178. DOI: 10.4172\/2329-6917.1000178<\/p>\n<p>Keskin, D. B., Reinhold, B., Zhang, GL., Ivanov, A., Karger, B., and Reinherz, E. L. \u201cPhysical detection of influenza A epitopes identifies a silent subset on human lung epithelium evading natural CD8 T cell immunity.\u201d In <em>Proceedings of the National Academy of Sciences of the United States of America<\/em> 112, no. 7 (2015): 2151\u20136. DOI: 10.1073\/pnas.1423482112<\/p>\n<p>Das, D. K., Feng, Y., Mallis, R. J., Li, X., Keskin, D. B., Hussey, R. E., Brady, S. K., Wang, JH., Wagner, G., Reinherz, E. L., and Lang, M. J. \u201cA force-dependent transition in the T cell receptor subunit allosterically regulates peptide discrimination and pMHC bond lifetime.\u201d In <em>Proceedings of the National Academy of Sciences of the United States of America<\/em> 112, no. 5 (2015): 1517\u201322. DOI: 10.1073\/pnas.1424829112<\/p>\n<p>Reinherz, E. L., Keskin, D. B., Reinhold, B. \u201cForward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides.\u201d <em>Frontiers in Immunology<\/em> vol. 5 (2014): 418. DOI: 10.3389\/fimmu.2014.00418<\/p>\n<p>Bae, J., Samur, M., Munshi, A., Hideshima, T., Kimmelman, A., Lee, AH., Keskin, D. B., Dranoff, G., Anderson, K. C., Munshi, N. C. \u201cHeteroclitic XBP1 Peptides Evoke Tumor-Specific Memory Cytotoxic T Lymphocytes against Breast Cancer, Colon Cancer, and Pancreatic Cancer Cells.\u201d <em>Oncoimmunology<\/em> 3, no. 12 (2014): e970914. DOI: 10.4161\/21624011.2014.970914<\/p>\n<p>Zhang, GL., Keskin, D. B., Lin, HN., Lin, H. H., DeLuca, D. S., Leppanen, S., Milford, E. L., Reinherz, E. L., Brusic, V. \u201cHuman Leukocyte Antigen typing using a knowledge base coupled with a high throughput oligonucleotide probe array analysis.\u201d <em>Frontiers in Immunology<\/em> vol. 5 (2014): 597. DOI: 10.3389\/fimmu.2014.00597<\/p>\n<p>Brazin, K. N., Mallis, R. J., Li, C., Keskin, D. B., Arthanari, H., Gao, Y., Wu, SL., Karger, B. L., Wagner, G., and Reinherz, E. L. \u201cConstitutively oxidized CxxC motifs within each CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.\u201d <em>Journal of Biological Chemistry<\/em> 289, no. 27 (2014): 18880-92. DOI: 10.1074\/jbc.M114.574996<\/p>\n<p>Rajasagi, M., Shukla, S., Keskin, D. B., Kim, J., Zhang, W., DeLuca, D., Sidney, J., Brusic, V., Neuberg, D. S., Getz, G., Lander, E. S., Hacohen, N., and Wu, C. J. \u201cSystematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.\u201d <em>Blood<\/em> 124, no. 3 (2014): 453\u201362. DOI: 10.1182\/blood-2014-04-567933<\/p>\n<p>Tabansky, I., Lenarcic, A., Draft, R., Loulier, K., Keskin, D. B., Rosains, J., Rivera-Feliciano, J., Lichtman, J., Livet, J., Stern, J. N., Sanes, J. R., and Eggan K. \u201cDevelopmental bias in cleavage-stage mouse blastomeres.\u201d <em>Current Biology<\/em> 23, no. 1 (2013): 21\u201331. DOI: 10.1016\/j.cub.2012.10.054<\/p>\n<p>Cai, A., Keskin, D. B., DeLuca, D., Alonso, A., Zhang, W., Zhang, GL., Hammond, N. N., Nardi, V., Stone, R., Neuberg, D., Sidney, J., Brusic, V., and Wu, C. J. \u201cMutated BCR-ABL Generates Immunogenic T Cell Epitopes In CML Patients.\u201d <em>Clinical Cancer Research<\/em> 18, no. 20 (2012): 5761\u201372. DOI: 10.1158\/1078-0432.CCR-12-1182<\/p>\n<p>Keskin, D. B., Reinhold, B., Lee SY, Zhang, GL., Lank S, O&#8217;Connor D, Berkowitz RS, Brusic, V., Kim SJ, Reinherz, E. L. \u201cDirect identification of an HPV-16 tumor antigen from cervical cancer biopsy specimens. <em>Frontiers in Immunology<\/em> vol. 2 (2011): 75. DOI: 10.3389\/fimmu.2011.00075<\/p>\n<p>Lank, S. M., Golbach, B. A., Creager, H. M., Wiseman, R. W., Keskin, D. B., Reinherz, E. L., Brusic, V., and O&#8217;Connor, D. H. \u201cUltra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing.\u201d <em>BMC Genomics<\/em> vol. 13 (2012): 378. DOI: 10.1186\/1471-2164-13-378<\/p>\n<p>Riemer, A. B., Keskin, D. B., and Reinherz, E. L. \u201cIdentification of valid reference genes for gene expression studies in primary and malignant human keratinocytes in different immunological experimental conditions.\u201d <em>Experimental Dermatology<\/em> 21, no. 8 (2012): 625\u20139.<\/p>\n<p>Zakka, L. R., Fradkov, E., Keskin, D. B., Tabansky, I., Stern, J. N., and Ahmed, A. R. \u201cThe role of natural killer cells in autoimmune blistering diseases.\u201d <em>Autoimmunity<\/em> 45, no. 1 (2012): 44\u201354. DOI: 10.3109\/08916934.2011.606446<\/p>\n<p>Olsen, L. R., Zhang, GL., Keskin, D. B., Reinherz, E. L., Brunak, S., and Brusic, V. \u201cConservation analysis of dengue virus T-cell epitope-based vaccine candidates using peptide block entropy analysis.\u201d <em>Frontiers in Immunology<\/em> vol. 2 (2011): 69. DOI: 10.3389\/fimmu.2011.00069<\/p>\n<p>DeLuca, D. S., Keskin, D. B., Zhang, GL., Reinherz, E. L., and Brusic, V. \u201cPB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.\u201d <em>BMC Bioinformatics<\/em> 12 Suppl 13 (2011): S6. DOI: 10.1186\/1471-2105-12-S13-S6<\/p>\n<p>Touma, M., Keskin, D. B., Clayton, L. K., and Reinherz, E. L. \u201cImpaired B cell development and function in the absence of IkappaBNS.\u201d <em>Journal of Immunology<\/em> 187, no. 8 (2011): 3942\u201352. DOI: 10.4049\/jimmunol.1002109<\/p>\n<p>Zhang, GL., Lin, H. H., Keskin, D. B., Reinherz, E. L., and Brusic, V. \u201cDana-Farber repository for machine learning in immunology.\u201d <em>Journal of Immunological Methods<\/em> 374, no. 1\u20132 (2011): 18\u00ad25. DOI: 10.1016\/j.jim.2011.07.007<\/p>\n<p>Zhang, Z., Tongchusak, S., Mizukami, Y., Kang, Y. J., Ioji, T., Touma, M., Reinhold, B., Keskin, D. B., Reinherz, E. L., and Sasada, T. \u201cInduction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery.\u201d <em>Biomaterials<\/em> 32, no. 14 (2011): 3666\u201378. DOI: 10.1016\/j.biomaterials.2011.01.067<\/p>\n<p>Zhang, GL., DeLuca, D.; Keskin, D. B., Reinherz, E. L.; Chitkushev, L., Zlateva, T., and Brusic, V. \u201cMULTIPRED2: A computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles.\u201d <em>Journal of Immunological Methods<\/em> 374, no. 1\u20132 (2011): 53\u00ad61. DOI: 10.1016\/j.jim.2010.11.009<\/p>\n<p>Zakka, L. R., Keskin, D. B., Reche, P., and Ahmed, A. R. \u201cRelationship between target antigens and major histocompatibility complex (MHC) class II genes in producing two pathogenic antibodies simultaneously.\u201d <em>Clinical and Experimental Immunology<\/em> 162, no. 2 (2010): 224\u00ad\u201336. DOI: 10.1111\/j.1365-2249.2010.04239.x<\/p>\n<p>Reinhold, B., Keskin, D. B., and Reinherz, E. L. \u201cMolecular detection of targeted major histocompatibility complex I-bound peptides using a probabilistic measure and nanospray MS3 on a hybrid quadrupole-linear ion trap.\u201d <em>Analytical Chemistry<\/em> 82, no. 21 (2010): 9090\u20139.<\/p>\n<p>Mabrouk, D., G\u00fcrcan, H. M., Keskin, D. B., Christen, W. G., and Ahmed, A. R. \u201cAssociation between cancer and immunosuppressive therapy\u2014analysis of selected studies in pemphigus and pemphigoid.\u201d <em>Annals of Pharmacotherapy<\/em> 44, no. 11 (2010): 1770\u20136. DOI: 10.1345\/aph.1P309<\/p>\n<p>*Stern, J. N., *Keskin, D. B., Kato, Z., Waldner, H., Schallenberg, S., Anderson, A., von Boehmer, H., Kretschmer, K., and Strominger, J. L. \u201cPromoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells.\u201d In <em>Proceedings of the National Academy of Sciences of the United States of America<\/em> 107, no. 40 (2010): 17280\u20135. DOI: 10.1073\/pnas.1010263107<\/p>\n<p>*Riemer, A. B., *Keskin, D. B., Zhang, G., Handley, M., Anderson, K. S., Brusic, V., Reinhold, B., and Reinherz, E. L. \u201cA conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers.\u201d <em>Journal of Biological Chemistry<\/em> 285, no. 38 (2010): 29608\u201322.\u00a0DOI: 10.1074\/jbc.M110.126722<\/p>\n<p>*G\u00fcrcan, H. M., *Keskin, D. B., and Ahmed, A. R. \u201cInformation for healthcare providers on general features of IGIV with emphasis on differences between commercially available products.\u201d <em>Autoimmunity Reviews<\/em> 9, no. 8 (2010): 553\u20139. DOI: 10.1016\/j.autrev.2010.03.003<\/p>\n<p>Ofran, Y., Kim, H. T., Brusic, V., Blake, L., Mandrell, M., Wu, C. J., Sarantopoulos, S., Bellucci, R., Keskin, D. B., Soiffer, R. J., Antin, J. H., and Ritz, J. \u201cDiverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes.\u201d <em>Clinical Cancer Research<\/em> 16, no. 5 (2010): 1642\u201351. DOI: 10.1158\/1078-0432.CCR-09-2701<\/p>\n<p>Bhasin, M., Yuan, L., Keskin, D. B., Libermann, T. A., and Oettgen, P. \u201cBioinformatics identification and characterization of human endothelial cell-restricted genes.\u201d <em>BMC Genomics<\/em> vol. 11 (2010): 342. DOI: 10.1186\/1471-2164-11-342<\/p>\n<p>*Stern, J. N., *Keskin, D. B., Romero, V., Zuniga, J., Encinales, L., Li, C., Awad, C., Yunis, E. J. \u201cMolecular signatures distinguishing active from latent tuberculosis in peripheral blood mononuclear cells, after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD) or Candida: a preliminary report.\u201d <em>Immunologic Research<\/em> 45, no. 1 (2009): 1\u201312. DOI: 10.1007\/s12026-008-8024-2<\/p>\n<p>*G\u00fcrcan, H. M., *Keskin, D. B., Stern, J. N., Nitzberg, M. A., Shekhani, H., and Ahmed, A. R. \u201cA review of the current use of rituximab in autoimmune diseases.\u201d <em>International Immunopharmacology<\/em> 9, no. 1 (2009): 10\u00ad\u201325. DOI: 10.1016\/j.intimp.2008.10.004<\/p>\n<p>Chung, J., Serezani, C. H., Huang, S. K., Stern, J. N., Keskin, D. B., Jagirdar, R., Brock, T. G., Aronoff, D. M., Peters-Golden, M. \u201cRap1 activation is required for Fc gamma receptor-dependent phagocytosis.\u201d<em> Journal of immunology <\/em>181, no. 8 (2008): 5501\u20139. DOI: 10.4049\/jimmunol.181.8.5501<\/p>\n<p>Stern, J. N., and Keskin, D. B. \u201cStrategies for the identification of loci responsible for the pathogenesis of multiple sclerosis<em>.<\/em>\u201d<em> Cellular &amp; Molecular Biology Letters <\/em>13, no. 4 (2008): 656\u201366. DOI: 10.2478\/s11658-008-0030-9<\/p>\n<p>*Stern, J. N., *Keskin, D. B., Zhang, H., Lv, H., and Strominger, J. L. \u201cAmino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice.\u201d In <em>Proceedings of the National Academy of Sciences of the United States of America<\/em> 105, no. 13 (2008): 5172\u20136. DOI: 10.1073\/pnas.0712131105<\/p>\n<p>*Stern, J. N., *Keskin, D. B., Barteneva, N., Zuniga, J., Yunis, E. J., and Ahmed, A. R. \u201cPossible role of natural killer cells in pemphigus vulgaris\u2014preliminary observations.\u201d <em>Clinical and Experimental Immunology<\/em> 152, no. 3 (2008): 472\u201381. DOI: 10.1111\/j.1365-2249.2008.03638.x<\/p>\n<p>Keskin, D. B., Stern, J. N., Fridkis-Hareli, M., and Ahmed, A. R. \u201cCytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapy.\u201d <em>Cytokine<\/em> 41, no. 3 (2008): 315\u201321. DOI: 10.1016\/j.cyto.2007.12.007<\/p>\n<p>Touma, M., Antonini, V., Kumar, M., Osborn, S. L., Bobenchik, A. M., Keskin, D. B., Connolly, J. E., Grusby, M. J., Reinherz, E. L., and Clayton, L. K. \u201cFunctional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption.\u201d <em>Journal of Immunology<\/em> 179, no. 3 (2007): 1681\u201392. DOI: 10.4049\/jimmunol.179.3.1681<\/p>\n<p>Keskin, D. B., Allan, D. S., Rybalov, B., Andzelm, M. M., Stern, J. N., Kopcow, H. D., Koopman, L. A., and Strominger, J. L. \u201cTGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells.\u201d In <em>Proceedings of the National Academy of Sciences of the United States of America<\/em> 104, no. 9 (2007): 3378\u201383. DOI: 10.1073\/pnas.0611098104<\/p>\n<p>Keskin, D. B., Marshall, B., Munn, D., Mellor, A. L., and Gearhart, D. A. \u201cDecreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase.\u201d <em>Cellular &amp; Molecular Biology Letters<\/em> 12, no. 1 (2007): 82\u2013102. DOI: 10.2478\/s11658-006-0048-9<\/p>\n<p>*Reche, P. A., *Keskin, D. B., Hussey, R. E., Ancuta, P., Gabuzda, D., and Reinherz, E. L. \u201cElicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes.\u201d <em>Medical Immunology<\/em> vol. 5 (2006): 1. DOI: 10.1186\/1476-9433-5-1<\/p>\n<p>Ill\u00e9s, Z., Stern, J. N. H., Keskin, D. B., Reddy, J., Kuchroo, V. K., and Strominger, J. L. \u201cCopolymer effects on microglia and T cells in the central nervous system of humanized mice.\u201d <em>European Journal of Immunology<\/em> 35, no. 12 (2005): 3683\u201393. DOI: 10.1002\/eji.200526121<\/p>\n<p>Stern, J. N., Ill\u00e9s, Z., Reddy, J., Keskin, D. B., Brosnan, C., Fridkis-Hareli, M., Kuchroo, V. K., and Strominger, J. L. \u201cPeptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis.\u201d In <em>Proceedings of the National Academy of Sciences of the United States of America<\/em> 102, no. 5 (2005): 1620\u20135. DOI: 10.1073\/pnas.0409022102<\/p>\n<p>Stern, J. N., Ill\u00e9s, Z., Reddy, J., Keskin, D. B., Sheu, E., Fridkis-Hareli, M., Nishimura, H., Santambrogio, L., Brosnan, C. F., Kuchroo, V. K., and Strominger, J. L. \u201cAmelioration of PLP 139-151-induced EAE in SJL mice by modified amino acid copolymers and their mechanisms.\u201d In <em>Proceedings of the National Academy of Sciences of the United States of America<\/em> vol. 101 (2004): 11743\u20138.<\/p>\n<p>Mellor, A. L., Munn, D., Chandler, P., Keskin, D. B., Johnson, T., Marshall, B., Jhaver, K., Baban, B. \u201cTryptophan catabolism and T cell responses.\u201d <em>Advances in Experimental Medicine and Biology<\/em> vol. 527 (2003): 27\u201335. DOI: 10.1007\/978-1-4615-0135-0_3<\/p>\n<p>Keskin, D. B. \u201cRegulation of T cell immunity by cells expressing Indoleamine 2.3-dioxygenase.\u201d PhD thesis, Medical College of Georgia (ProQuest publishers, 2003). ISBN: 97804937428310<\/p>\n<p>Munn, D. H., Sharma, M. D., Lee, J. R., Jhaver, K. G., Johnson, T. S., Keskin, D. B., Marshall, B., Antonia, S. J., Burgess, R., Slingluff, C. L., and Mellor, A. L. \u201cPotential regulatory function of human dendritic cells expressing indoleamine 2,3, dioxygenase.\u201d <em>Science <\/em>297, no. 5588 (2002): 1867\u201370. DOI: 10.1126\/science.1073514<\/p>\n<p>Mellor, A. L., Keskin, D. B., Johnson, T., Chandler, P., and Munn, D. \u201cCells expressing IDO inhibit T cell responses.\u201d <em>Journal of Immunology<\/em> 168, no. 8 (2002):3771\u20133776. DOI: https:\/\/doi.org\/10.4049\/jimmunol.168.8.3771<\/p>\n<p>Mellor, A. L., Chandler, P., Lee, G. K., Johnson, T., Keskin, D. B., Lee, J., and Munn, D. H. \u201cIndoleamine 2,3 dioxygenase, immunosuppression and pregnancy.\u201d <em>Journal of Reproductive Immunology<\/em> 57, no. 1\u20132 (2002): 143\u201350. DOI: 10.1016\/s0165-0378(02)00040-2<\/p>\n<p>Fallarino, F., Vacca, C., Orabona, C., Belladonna, M., Bianchi, R., Marshall, B., Keskin, D. B., Mellor, A. L., Fioretti, M. C., Grohmann, U., and Puccetti, P. \u201cFunctional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells.\u201d <em>International Immunology<\/em> 14, no. 1 (2002): 65\u20138. DOI: 10.1093\/intimm\/14.1.65<\/p>\n<p>Marshall, B., Keskin, D. B., and Mellor, A. L. \u201cRegulation of prostaglandin synthesis and cell adhesion by a Tryptophan catabolizing enzyme.\u201d <em>BMC Biochemistry<\/em> vol. 2 (2001): 5. DOI: 10.1186\/1471-2091-2-5<\/p>\n<p><em>*Contributed equally as first author.<\/em><\/p>\n<p><strong>Research Grants<\/strong><\/p>\n<p>2022: Principal Investigator (PI), R01 HL157174-01A1: \u201cSystematic identification of minor histocompatibility antigens to address GVHD.\u201d<\/p>\n<p>2018: Principal Investigator (PI), R21 CA216772-01A1: \u201cPhysical detection of HLA-C binding peptides to identify and predict immunogenic personal neoepitopes for improving cancer vaccines.\u201d<\/p>\n<p>2017: Principal Investigator (PI), DFCI\/Medical Oncology Departmental Grant.<\/p>\n<p>2016\u20132017: Principal Investigator (PI), 2P50CA10194211A1: DF\/HCC Kidney Cancer SPORE<\/p>\n<p><strong>Patents<\/strong><\/p>\n<p>Keskin, D. B. \u201cMS-based accurate epitope prediction algorithms.\u201d Broad Institute. Filed in 2017.<\/p>\n<p>Reinherz, E. L., Brusic, V., Zhang, GL., Keskin, D. B., and DeLuca, D. S. \u201cOligonucleotide array for precise HLA typing.\u201d 00530-00287P01, December 2010.<\/p>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h2 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Faculty Q&amp;A<\/h2><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<div id=\"FacultyQA\">\n<h3>MET Professor Researches Revolutionary Cancer Treatments<\/h3>\n<p><strong>What is your area of expertise?<\/strong><br \/>\nMy area of research expertise is focused on vaccine immunotherapies and cancer immunology. My long-term scientific interest and expertise is in developing vaccines to combat infectious and malignant diseases.<\/p>\n<p><strong>Please tell us about your work. Can you share any current research or recent publications?<\/strong><br \/>\nI am part of a large group of researchers and clinicians studying neoantigen-targeting personalized cancer vaccines (PCV), which have the potential to revolutionize cancer treatment. These personalized vaccines rely on accurate epitope prediction and selection. We previously reported phase I trials of <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33479501\/\" target=\"_blank\" rel=\"noopener noreferrer\">neoantigen targeting PCV in melanoma<\/a> and <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30568305\/\" target=\"_blank\" rel=\"noopener noreferrer\">glioblastoma multiforme (GBM)<\/a>.<\/p>\n<p>Recently we concluded a trial in renal cell carcinoma (RCC) where the neoantigen targeting PCV was immunogenic in all patients, targeted cancer drivers, and demonstrated in vitro reactivity to primary patient tumors. None of these vaccinated RCC patients had a relapse of their cancer, which was remarkable.<\/p>\n<p><strong>How does the subject you work in apply in practice? What is its application?<\/strong><br \/>\nWe develop neoantigen-targeting personalized cancer vaccines at Dana Farber Cancer Institute. These are personalized vaccines that we design for each patient using the genetic information gleaned from the patient&#8217;s own tumor. These vaccines are in clinical trials.<\/p>\n<p><strong>What course(s) do you teach at MET? What &#8220;real-life&#8221; exercises do you bring to class?<\/strong><br \/>\nI teach <a href=\"https:\/\/www.bu.edu\/met\/courses\/computer-science-it\/#course-METCS570\">Biomedical Sciences and Health IT (MET CS 570)<\/a>. I also developed the self-paced Medical Terminology Pre-Lab (MET HE 100).<\/p>\n<p>I have a long-standing interest in T cell-based vaccines for infectious diseases. This is an overlooked aspect of immunology. I give a lecture on infectious diseases in the Biomedical Sciences course, in which I provide a lot of real-life examples. How many infectious diseases are out there ready to get us is eye-opening.<\/p>\n<p><strong>What do you consider to be the unique value being of an adjunct faculty member who maintains a strong presence in the world of field research? What does that bring to the classroom?<\/strong><br \/>\nI am involved with a lot of cutting-edge research at Harvard Medical School, the Dana Farber Cancer Institute (DFCI) and the Broad Institute. I provide information on very current advances in biomedicine during the course.<\/p>\n<p><strong>Can you provide examples of fruitful collaboration with full-time faculty on research activities? <\/strong><br \/>\nI collaborate extensively with the <a href=\"https:\/\/www.bu.edu\/met\/programs\/computer-science-it\/\" target=\"_blank\" rel=\"noopener noreferrer\">MET Computer Science Department<\/a>. We recently got an R01 grant to study Merkel cell carcinoma. Dr. <a href=\"https:\/\/www.bu.edu\/met\/profile\/guanglan-zhang\/\">Guanglan Zhang<\/a>, associate professor and chair of the MET Computer Science Department, will be providing bioinformatics support for this funded study. I have other funded projects studying the rare cancers NUT carcinoma, and Lynch syndrome. My BU collaborations also benefit these projects.<\/p>\n<p><strong>Is there anything else you would like to add?<\/strong><br \/>\nTeaching graduate courses to working adults has been extremely rewarding. Our students come to the classroom with extensive real-life experience. I have learned a lot from the students.\n<\/div>\n<p><\/div>\n<\/div>\n\n","protected":false},"author":2836,"template":"","_links":{"self":[{"href":"https:\/\/www.bu.edu\/met\/wp-json\/wp\/v2\/profile\/78164"}],"collection":[{"href":"https:\/\/www.bu.edu\/met\/wp-json\/wp\/v2\/profile"}],"about":[{"href":"https:\/\/www.bu.edu\/met\/wp-json\/wp\/v2\/types\/profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/met\/wp-json\/wp\/v2\/users\/2836"}],"version-history":[{"count":16,"href":"https:\/\/www.bu.edu\/met\/wp-json\/wp\/v2\/profile\/78164\/revisions"}],"predecessor-version":[{"id":90403,"href":"https:\/\/www.bu.edu\/met\/wp-json\/wp\/v2\/profile\/78164\/revisions\/90403"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/met\/wp-json\/wp\/v2\/media?parent=78164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}