{"id":463,"date":"2013-05-14T20:11:57","date_gmt":"2013-05-15T00:11:57","guid":{"rendered":"https:\/\/www.bu.edu\/medal\/?p=463"},"modified":"2013-05-14T20:12:21","modified_gmt":"2013-05-15T00:12:21","slug":"article-published-in-the-journal-of-controlled-release","status":"publish","type":"post","link":"https:\/\/www.bu.edu\/medal\/2013\/05\/14\/article-published-in-the-journal-of-controlled-release\/","title":{"rendered":"Article published in the Journal of Controlled Release"},"content":{"rendered":"<p>Article published recently in the Journal of Controlled Release reviewing thermosensitive liposomes, including chemical formulation and clinically relevant heating sources for triggered drug release <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0168365913001958\">http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0168365913001958<\/a><\/p>\n<p><strong><a href=\"\/medal\/files\/2013\/05\/Screen-shot-2013-05-14-at-8.08.34-PM.png\"><img loading=\"lazy\" class=\"alignleft size-full wp-image-465\" height=\"173\" width=\"261\" title=\"Screen shot 2013-05-14 at 8.08.34 PM\" alt=\"Screen shot 2013-05-14 at 8.08.34 PM\" src=\"\/medal\/files\/2013\/05\/Screen-shot-2013-05-14-at-8.08.34-PM.png\" \/><\/a>Abstract<\/strong>: Liposomes are a promising class of nanomedicine with the potential to provide site-specific chemotherapy, thus improving the quality of cancer patient care. First-generation liposomes have emerged as one of the first nanomedicines used clinically for localized delivery of chemotherapy. Second-generation liposomes, i.e. stimuli-responsive liposomes, have the potential to not only provide site-specific chemotherapy, but also triggered drug release and thus greater spatial and temporal control of therapy. Temperature-sensitive liposomes are an especially attractive option, as tumors can be heated in a controlled and predictable manner with external energy sources. Traditional thermosensitive liposomes are composed of lipids that undergo a gel-to-liquid phase transition at several degrees above physiological temperature. More recently, temperature-sensitization of liposomes has been demonstrated with the use of lysolipids and synthetic temperature-sensitive polymers. The design, drug release behavior, and clinical potential of various temperature-sensitive liposomes, as well as the various heating modalities used to trigger release, are discussed in this review.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Article published recently in the Journal of Controlled Release reviewing thermosensitive liposomes, including chemical formulation and clinically relevant heating sources for triggered drug release http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0168365913001958 Abstract: Liposomes are a promising class of nanomedicine with the potential to provide site-specific chemotherapy, thus improving the quality of cancer patient care. First-generation liposomes have emerged as one of [&hellip;]<\/p>\n","protected":false},"author":1317,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/posts\/463"}],"collection":[{"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/users\/1317"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/comments?post=463"}],"version-history":[{"count":3,"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/posts\/463\/revisions"}],"predecessor-version":[{"id":468,"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/posts\/463\/revisions\/468"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/media?parent=463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/categories?post=463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/tags?post=463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}