{"id":667,"date":"2019-12-06T14:26:09","date_gmt":"2019-12-06T19:26:09","guid":{"rendered":"https:\/\/www.bu.edu\/medal\/?page_id=667"},"modified":"2019-12-06T15:13:52","modified_gmt":"2019-12-06T20:13:52","slug":"brain-microenvironment-models","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/medal\/research\/brain-microenvironment-models\/","title":{"rendered":"Brain Microenvironment Models"},"content":{"rendered":"<p>A major thrust in the group is the development of in vitro models that recapitulate various aspects of the neuromuscular unit. \u00a0We have started with a model of the blood-brain barrier composed of primary human endothelial cells derived from iPSCs as well as primary human pericytes and\/or astrocytes. \u00a0We have established barriers in both transwells and microfluidc devices, characterized by high transendothelial electrical resistance (&gt;2000 ohm cm^2) and low solute permeability coefficients (&lt;10^-6 cm\/s). \u00a0 We have used the models to investigate the impact of flow-induced shear stress on receptor-mediated transport of nanoparticles across the BBB as well as cytokine-mediated permeabilization of the BBB. \u00a0We are also using the platform as the basis for a model of the neuromuscular unit, which will be used to investigate the biological consequences of persistent microglia activation on the BBB and neurons.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A major thrust in the group is the development of in vitro models that recapitulate various aspects of the neuromuscular unit. \u00a0We have started with a model of the blood-brain barrier composed of primary human endothelial cells derived from iPSCs as well as primary human pericytes and\/or astrocytes. \u00a0We have established barriers in both transwells [&hellip;]<\/p>\n","protected":false},"author":2751,"featured_media":0,"parent":85,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/pages\/667"}],"collection":[{"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/users\/2751"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/comments?post=667"}],"version-history":[{"count":5,"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/pages\/667\/revisions"}],"predecessor-version":[{"id":689,"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/pages\/667\/revisions\/689"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/pages\/85"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/medal\/wp-json\/wp\/v2\/media?parent=667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}