{"id":93,"date":"2011-08-09T22:29:35","date_gmt":"2011-08-10T02:29:35","guid":{"rendered":"https:\/\/www.bu.edu\/lvn\/?page_id=93"},"modified":"2011-08-09T22:54:55","modified_gmt":"2011-08-10T02:54:55","slug":"child-3","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/lvn\/research-interests\/child-3\/","title":{"rendered":"Hydrogen Sulfide"},"content":{"rendered":"<p>Hydrogen sulfide (H<sub>2<\/sub>S)  has been recently proposed as the third gaseous neurotransmitter,  following NO and CO. Cystathionine beta-synthase (CBS) and cystathionine  gamma-lyase (CGL) are responsible for the endogenous production of  hydrogen sulfide in mammalian tissues, with CBS as the predominant  enzyme in the brain and nervous system. CGL is mainly expressed in the  liver, kidney, arteries and veins only traces found in the brain. CBS is  strongly expressed in the whole neural tube and primary brain vesicles.  CBS mRNA is found in the neuroblastic layer of the retina and lens at  all developmental stages. Relatively high levels of H<sub>2<\/sub>S have been found in rat, human, and bovine brains (50-160\u00b5M).<\/p>\n<p>Physiological concentrations of H<sub>2<\/sub>S  are found to facilitate LTP induction in the hippocampus of rats and  regulate release of corticotropin-releasing hormone from the  hypothalamus, which further supports the role of H<sub>2<\/sub>S as a neuromodulator in the brain. In astrocytes, H<sub>2<\/sub>S  is found to increase intracellular calcium and induce calcium waves,  while in hippocampal slices, it enhances the responses of neurons to  glutamate. Another role for H<sub>2<\/sub>S is to increase levels of the  antioxidant glutathione through enhancing gamma-glutamylcysteine  synthetase activity and upregulating cysteine transport, thereby  protecting neurons in primary cultures from oxidative stress.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hydrogen sulfide (H2S) has been recently proposed as the third gaseous neurotransmitter, following NO and CO. Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) are responsible for the endogenous production of hydrogen sulfide in mammalian tissues, with CBS as the predominant enzyme in the brain and nervous system. CGL is mainly expressed in the liver, kidney, [&hellip;]<\/p>\n","protected":false},"author":1807,"featured_media":0,"parent":8,"menu_order":3,"comment_status":"closed","ping_status":"open","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/lvn\/wp-json\/wp\/v2\/pages\/93"}],"collection":[{"href":"https:\/\/www.bu.edu\/lvn\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/lvn\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/lvn\/wp-json\/wp\/v2\/users\/1807"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/lvn\/wp-json\/wp\/v2\/comments?post=93"}],"version-history":[{"count":5,"href":"https:\/\/www.bu.edu\/lvn\/wp-json\/wp\/v2\/pages\/93\/revisions"}],"predecessor-version":[{"id":122,"href":"https:\/\/www.bu.edu\/lvn\/wp-json\/wp\/v2\/pages\/93\/revisions\/122"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/lvn\/wp-json\/wp\/v2\/pages\/8"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/lvn\/wp-json\/wp\/v2\/media?parent=93"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}