The Respiratory and Physiological Systems Identification Laboratory is currently involved in the development of novel linear and nonlinear systems identification approaches for probing mechanisms associated with healthy and diseased physiological systems and with principal applications in respiratory physiology.

• Advanced application of mechanistic, morphometric, and anatomic based models for developing an integrated understanding of the structure-function relations in the lung with emphasis on the role of smooth muscle and inflammation on static and dynamic lung function in asthma.
• Development of novel measurement, monitoring and signal processing techniques that provide new insights on the structural airway and tissue conditions of the healthy and diseased lung.
• Advancing new paradigms and technologies for mechanical ventilation base on fundamental biological principals so as to improve diagnostic and therapeutic applications. Emphasis on role of mechanical stress on ventilator induced lung injury and function.
• Advancing linear and nonlinear sensitivity and systems identification science to evaluate the efficacy of applying models to physiological data with emphasis on structural lung models.
• Understanding the origins of linear and nonlinear properties of physiological systems.
  

© 2004 Boston University's Respiratory and Physiological Systems Identification Laboratory

Human Lung (top left) from Tawhai et al. 2000