{"id":85,"date":"2010-07-22T20:44:14","date_gmt":"2010-07-23T00:44:14","guid":{"rendered":"https:\/\/www.bu.edu\/hanlab\/?page_id=85"},"modified":"2025-11-22T09:44:19","modified_gmt":"2025-11-22T14:44:19","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/hanlab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Journal Articles, Refereed Conference Proceedings<\/strong><\/p>\n

86. Yangyang<\/span>\u00a0<\/span>Wang<\/span><\/span>,\u00a0<\/span>Cara<\/span>\u00a0<\/span>Ravasio<\/span><\/span>,\u00a0<\/span>Yuxin<\/span>\u00a0<\/span>Zhou<\/span><\/span>,\u00a0<\/span>Xue<\/span>\u00a0<\/span>Han, Prolonged Single Neuron Voltage Imaging in Behaving Mammals,<\/span><\/a> <\/span><\/span>bioRxiv 2025.05.29.656886;<\/p>\n

85. Shaw DC, Kondabolu K, Walsh KG, Abumuaileq M, Shi W, Isaac K, Steiner L, Rillosi E, Hsiung M, Dang L, Eden UT, Richardson RM, Kramer MA, Chu CJ, Han X<\/u>. Photothrombosis-induced cortical stroke mouse model produces focal electrographic epileptic human biomarkers.<\/a> Exp Neurol. 2025 Nov 4;396:115542. doi: 10.1016\/j.expneurol.2025.115542. PMID: 41192651.<\/p>\n

84. Emma<\/span>\u00a0Bortz<\/span><\/span>,\u00a0Erynne San<\/span>\u00a0Antonio<\/span><\/span>,\u00a0Jack<\/span>\u00a0Sherman<\/span><\/span>,\u00a0Hua-an<\/span>\u00a0Tseng<\/span><\/span>,\u00a0Laura<\/span>\u00a0Raiff<\/span><\/span>,\u00a0Xue<\/span>\u00a0Han, Transcranial ultrasound stimulation modulates neuronal membrane potentials across broad timescales in the awake mammalian brain<\/a>, Brain Stimul. 2025 Sep 11:S1935-861X(25)00323-7. doi: 10.1016\/j.brs.2025.09.004. PMID: 40945602.<\/span><\/span><\/span><\/p>\n

83. Jian Carlo <\/span>Nocon<\/span>, Isaac Paul Boyd, Howard Gritton<\/span>,\u00a0Xue\u00a0Han<\/span>,\u00a0Kamal Sen, Parvalbumin Neurons and Cortical Coding of Dynamic Stimuli: A Network Model<\/a>. J Neurophysiol. 2025 May 13. PMID: 40359150.<\/span><\/p>\n

82. Ravasio CR, Kondabolu K, Zhou S, Lowet E, San Antonio E, Mount RA, Bhogal SK, Han X. Kilohertz electrical stimulation evokes robust cellular responses like conventional frequencies but distinct population dynamics<\/a>. Commun Biol. 2025 Jan 7;8(1):19. doi: 10.1038\/s42003-024-07447-0. PMID: 39775118; PMCID: PMC11706954.<\/span><\/p>\n

81. Uroz M, Stoddard AE, Sutherland BP, Courbot O, Oria R, Li L, Ravasio CR, Ngo MT, Yang J, Tefft JB, Eyckmans J, Han X, Elosegui-Artola A, Weaver VM, Chen CS. Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option.<\/a> Nat Cell Biol. 2024 Dec;26(12):2144-2153. PMID: 39448802.<\/span><\/p>\n

80. Sudiksha Sridhar, Eric Lowet, Howard Gritton, Jennifer Freier, Chengqian Zhou, Florence Liang, Xue Han, <\/span>Beta-frequency sensory stimulation enhances gait rhythmicity through strengthened coupling between striatal networks and stepping movement<\/a>.\u00a0<\/span>Nat Commun<\/i>\u00a0<\/span>15<\/b>, 8336 (2024). https:\/\/doi.org\/10.1038\/s41467-024-52664-0<\/span><\/p>\n

79. Jack Sherman, Emma Bortz, Erynne San Antonio, Hua-an Tseng, Laura Raiff, Xue Han, Ultrasound pulse repetition frequency preferentially activates different neuron populations independent of cell type<\/a>, Journal of Neural Engineering (2024) 21(5):056008.\u00a0<\/span><\/p>\n

78. Wen Shi, Dana Shaw, Katherine G Walsh, Xue Han, Uri T Eden, Robert M Richardson, Stephen V Gliske, Julia Jacobs, Benjamin H Brinkmann, Gregory A Worrell, William C Stacey, Birgit Frauscher, John Thomas, Mark A Kramer, Catherine J Chu, Spike ripples localize the epileptogenic zone best: an international intracranial study<\/a>,\u00a0<\/span>Brain<\/em>, Volume 147, Issue 7, July 2024, Pages 2496\u20132506<\/span><\/p>\n

77. Sheng Xiao, William J Cunningham, Krishnakanth Kondabolu, Eric Lowet, Maria V Moya, Rebecca A Mount, Cara Ravasio, Emma Bortz, Dana Shaw, Michael N Economo, Xue Han, Jerome Mertz, Large-scale deep tissue voltage imaging with targeted-illumination confocal microscopy<\/a>, Nat Methods<\/i>\u00a021<\/b>, 1094\u20131102 (2024). https:\/\/doi.org\/10.1038\/s41592-024-02275-w<\/span><\/p>\n

76. Bando Y. Rillai R, Kajita A, Hakeem FA, Quemener Y, Tseng HA, Piatkevich KD, Lunghu C, Han X, Boyden ES,<\/span>\u00a0“Real-time Neuron Segmentation for Voltage Imaging<\/a>,”\u00a0<\/span>2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)<\/em>, Istanbul, Turkiye, 2023, pp. 813-818, doi: 10.1109\/BIBM58861.2023.10385929.<\/span><\/p>\n

75. Mount RA, Athif M, O’Connor M, Saligrama A, Tseng HA, Sridhar S, Zhou C, Bortz E, San Antonio E, Kramer MA, Man HY, Han X. The autism spectrum disorder risk gene\u00a0<\/a><\/span>NEXMIF<\/i>\u00a0over-synchronizes hippocampal CA1 network and alters neuronal coding. Front Neurosci. 2023 Oct 27;17:1277501. doi: 10.3389\/fnins.2023.1277501. PMID: 37965217; PMCID: PMC10641898.<\/span><\/p>\n

74. Eric Lowet, Daniel J. Sheehan*, Ulises Chialva*, Rodrigo De Oliveira Pena*, Rebecca A. Mount, Sheng Xiao, Samuel L. Zhou, Hua-an Tseng, Howard Gritton, Sanaya Shroff, Krishnakanth Kondabolu, Cyrus Cheung, Yangyang Wang, Kiryl D. Piatkevich, Edward S. Boyden, Jerome Mertz, Michael E. Hasselmo, Horacio G. Rotstein, Xue Han<\/span>, Theta and gamma rhythmic coding through two spike output modes in the hippocampus during spatial navigation<\/a><\/span>, Cell Rep. 2023 Aug 2;42(8):112906. doi: 10.1016\/j.celrep.2023.112906. PMID: 37540599.<\/span><\/p>\n

73. Eom M, Han S, Park P, Kim G, Cho ES, Sim J, Lee KH, Kim S, Tian H, B\u00f6hm UL, Lowet E, Tseng HA, Choi J, Lucia SE, Ryu SH, R\u00f3zsa M, Chang S, Kim P, Han X, Piatkevich KD, Choi M, Kim CH, Cohen AE, Chang JB, Yoon YG. Statistically unbiased prediction enables accurate denoising of voltage imaging data. Nat Methods. 2023 Oct;20(10):1581-1592. doi: 10.1038\/s41592-023-02005-8. Epub 2023 Sep 18. PMID: 37723246; PMCID: PMC10555843.<\/p>\n

72. Nocon JC, Witter J, Gritton H, Han X, Houghton C, Sen K. A robust and compact population code for competing sounds in auditory cortex<\/a>. J Neurophysiol. 2023 Sep 1;130(3):775-787. doi: 10.1152\/jn.00148.2023. Epub 2023 Aug 30. PMID: 37646080; PMCID: PMC10642980.<\/span><\/p>\n

71. Nocon JC, Gritton HJ, James NM, Mount RA, Qu Z, Han X, Sen K. Parvalbumin neurons enhance temporal coding and reduce cortical noise in complex auditory scenes.<\/a> Commun Biol. 2023 Jul 19;6(1):751. doi: 10.1038\/s42003-023-05126-0. PMID: 37468561; PMCID: PMC10356822.<\/span><\/p>\n

70. Zeng J, Acin-Perez R, Assali EA, Martin A, Brownstein AJ, Petcherski A, Fern\u00e1ndez-Del-Rio L, Xiao R, Lo CH, Shum M, Liesa M, Han X, Shirihai OS, Grinstaff MW. Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease.<\/a> Nat Commun. 2023 May 4;14(1):2573. doi: 10.1038\/s41467-023-38165-6. PMID: 37142604; PMCID: PMC10160018.<\/span><\/p>\n

69. Sanaya N. Shroff\u2020, Eric Lowet\u2020, Sudiksha Sridhar, Howard J. Gritton, Mohammed Abumuaileq, Hua-An Tseng, Cyrus Cheung, Samuel L. Zhou, Krishnakanth Kondabolu, Xue Han, Striatal cholinergic interneuron membrane voltage tracks locomotor rhythms in mice,<\/a> Nat Commun<\/i>\u00a0<\/span>14<\/b>, 3802 (2023)<\/span>. \u2020equal contributions<\/p>\n

68. Eric<\/span> Lowet<\/span><\/span>, Krishnakanth<\/span> Kondabolu<\/span><\/span>, Samuel<\/span> Zhou<\/span><\/span>, Rebecca<\/span> A. Mount<\/span><\/span>, Yangyang Wang, Cara<\/span> R. Ravasio<\/span><\/span>, Xue<\/span> Han, <\/span><\/span><\/span>Deep brain stimulation creates informational lesion through membrane depolarization in mouse hippocampus.<\/a> Nat Commun<\/i> 13<\/b>, 7709 (2022). https:\/\/doi.org\/10.1038\/s41467-022-35314-1<\/p>\n

67. Abdelfattah et al, “Neurophotonic tools for microscopic measurements and manipulation: status report<\/a>,” Neurophotonics 9(S1) 013001 (27 April 2022)<\/p>\n

66. Wen Shi, Dana Zemel, Sudiksha Sridhar, Rebecca A. Mount, R. Mark Richardson, Uri T. Eden, Xue Han, Mark A. Kramer, Catherine J. Chu, Spike ripples in striatum correlate with seizure risk in two mouse models<\/a>, Epilepsy & Behavior Reports, 2022 Feb 8;18:100529. doi: 10.1016\/j.ebr.2022.100529.<\/p>\n

65. Dana Zemel, Howard Gritton, Cyrus Cheung, Sneha Shankar, Mark Kramer, Xue Han, Dopamine depletion selectively disrupts interactions between striatal neuron subtypes and LFP oscillations<\/a>, Cell Reports, Volume 38, Issue 3, 110265, 2022<\/p>\n

64. E. Lowet, S. Xiao, J. Mertz, and X. Han, Ultrafast Voltage Imaging of Single Neurons at Ten Kilohertz in Behaving Mice<\/a>, Frontiers in Optics + Laser Science 2021<\/em>,\u00a0 Technical Digest Series (Optical Society of America, 2021), paper FM5E.1. PDF for academic use<\/a><\/p>\n

63. Sheng Xiao, Eric Lowet, Howard J. Gritton, Pierre Fabris, Yangyang Wang, Jack Sherman, Rebecca A. Mount, Hua-an Tseng, Heng-Ye Man, Christoph Straub, Kiryl D. Piatkevich, Edward S. Boyden, Jerome Mertz, Xue Han, Large-scale voltage imaging in behaving mice using targeted illumination<\/a>, iScience, Volume 24, Issue 11, 2021<\/p>\n

62. Hua-an Tseng, Jack Sherman, Emma Bortz, Ali Mohammed, Howard J. Gritton, Seth Bensussen, Rockwell Tang, Dana Zemel, Thomas Szabo, Xue Han, Region-Specific Effects of Ultrasound on Individual Neurons in the Awake Mammalian Brain<\/a>, iScience, 2021<\/p>\n

61. Nadalin JK, Eden UT, Han X, Richardson RM, Chu CJ, Kramer MA. Application of a convolutional neural network for fully-automated detection of spike ripples in the scalp electroencephalogram<\/a>. J Neurosci Methods. 2021 Jun 3:109239. doi: 10.1016\/j.jneumeth.2021.109239.<\/p>\n

60. Mount R*, Sridhar S*, Hansen KR*, Mohammed AI, Abdulkerim M, Kessel R, Nazer B, Gritton HJ, Han X. Distinct neuronal populations contribute to trace conditioning and extinction learning in the hippocampal CA1<\/a>. Elife. 2021 Apr 12;10:e56491. doi: 10.7554\/eLife.56491.*equal contributions<\/p>\n

59. Tsang JM, Gritton HJ, Das SL, Weber TD, Chen CS, Han X, Mertz J. Fast, multiplane line-scan confocal microscopy using axially distributed slits. Biomed Opt Express. 2021 Feb 9;12(3):1339-1350. doi: 10.1364\/BOE.417286. PMID: 33796357; PMCID: PMC7984773.<\/p>\n

58. Hua-an Tseng, Xue Han, Distinct Spiking Patterns of Excitatory and Inhibitory Neurons and LFP Oscillations in Prefrontal Cortex During Sensory Discrimination<\/a>, Frontiers in Physiology, 2021 Feb 11;12:618307. doi: 10.3389\/fphys.2021.618307. eCollection 2021.<\/p>\n

57. Marianna K. Keaveney, Bahar Rahsepar, Hua-an Tseng, Fernando R. Fernandez, Rebecca A. Mount, Tina Ta, John A. White, Jim Berg and Xue Han, CamKII\u03b1 Positive Interneurons Identified via A microRNA Based Viral Gene Targeting Strategy,<\/a> J Neurosci. 2020 Nov 5:JN-RM-2570-19. doi: 10.1523\/JNEUROSCI.2570-19.2020.<\/p>\n

56. Xiao, H. Gritton, H. Tseng, D. Zemel, X. Han, and J. Mertz, “High-contrast multifocus microscopy with a single camera and z-splitter prism<\/a>,” Optica 7, 1477-1486 (2020).<\/p>\n

55. Seth Bensussen, Sneha Shankar, Kimberley H Ching, Dana Zemel, Tina L Ta, Rebecca A Mount, Sanaya N Shroff, Howard J Gritton, Pierre Fabris, Hannah Vanbenschoten, Connor Beck, Heng-Ye Man, Xue Han, A Viral Toolbox of Genetically Encoded Fluorescent Synaptic Tags<\/a>, iScience . 2020 Jun 30;23(7):101330. doi: 10.1016\/j.isci.2020.101330.<\/p>\n

54. Or A Shemesh, Changyang Linghu, Kiryl D Piatkevich, Daniel Goodwin, Orhan Tunc Celiker, Howard J Gritton, Michael F Romano, Ruixuan Gao, Chih-Chieh Jay Yu, Hua-An Tseng, Seth Bensussen, Sujatha Narayan, Chao-Tsung Yang, Limor Freifeld, Cody A Siciliano, Ishan Gupta, Joyce Wang, Nikita Pak, Young-Gyu Yoon, Jeremy FP Ullmann, Burcu Guner-Ataman, Habiba Noamany, Zoe R Sheinkopf, Won Min Park, Shoh Asano, Amy E Keating, James S Trimmer, Jacob Reimer, Andreas S Tolias, Mark F Bear, Kay M Tye, Xue Han, Misha B Ahrens, Edward S Boyden, Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator<\/a>, Neuron . 2020 Jun 26;S0896-6273(20)30398-6. doi: 10.1016\/j.neuron.2020.05.029.<\/p>\n

53. Sanaya N Shroff, Shoshana L Das, Hua-An Tseng, Jad Noueihed, Fernando Fernandez, John A White, Christopher S Chen, Xue Han, Voltage Imaging of Cardiac Cells and Tissue Using the Genetically Encoded Voltage Sensor Archon1<\/a>, iScience. 2020 Mar 11;23(4):100974. PMID: 32299055 PMCID: PMC7160579<\/p>\n

52. Ying Jiang, Hyeon Jeong Lee, Lu Lan, Hua-an Tseng, Chen Yang, Heng-Ye Man, Xue Han, Ji-Xin Cheng, Optoacoustic brain stimulation at submillimeter spatial precision<\/a>, Nat Commun . 2020 Feb 14;11(1):881. doi: 10.1038\/s41467-020-14706-1.<\/p>\n

51. Piatkevich KD*, Bensussen S*, Tseng HA*, Shroff SN, Lopez-Huerta VG, Park D, Jung EE, Shemesh OA, Straub C, Gritton HJ, Romano MF, Costa E, Sabatini BL, Fu Z, Boyden ES\u2020, Han X\u2020. Population imaging of neural activity in awake behaving mice.<\/a> Nature. 2019 Oct 9. doi: 10.1038\/s41586-019-1641-1. PubMed PMID: 31597963.*equal contributions. \u2020co-corresponding authors<\/p>\n

50. J Zeng, A Martin, X Han, OS Shirihai, MW Grinstaff, Biodegradable PLGA nanoparticles restore lysosomal acidity and protect neural PC-12 cells against mitochondrial toxicity<\/a>, Ind. Eng. Chem. Res. 2019, 58, 31, 13910-13917<\/p>\n

49. Gritton HJ*, Howe WM*, Romano MF*, DiFeliceantonio AG, Kramer MA, Saligrama V, Bucklin ME, Zemel D, Han X. Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement.<\/a> Nat Neurosci. 2019 Feb 25. doi: 10.1038\/s41593-019-0341-3.\u00a0 Matlab data analysis code used in the paper. <\/a>*equal contributions<\/p>\n

48. Ergan S, Radwan A, Zou Z, Tseng H-a, Han X. Quantifying Human Experience in Architectural Spaces with Integrated Virtual Reality and Body Sensor Networks<\/a>. Journal of Computing in Civil Engineering. 2019;33(2):04018062. doi: doi:10.1061\/(ASCE)CP.1943-5487.0000812.<\/p>\n

47. Romano M, Bucklin M, Gritton H, Mehrotra D, Kessel R, Han X. A Teensy microcontroller-based interface for optical imaging camera control during behavioral experiments.<\/a> J Neurosci Methods. 2019 Apr 1. pii: S0165-0270(19)30103-7. doi: 10.1016\/j.jneumeth.2019.03.019. PubMed PMID: 30946877. Related computer code for the paper.<\/a><\/p>\n

46. Amaury Badon, Seth Bensussen, Howard J. Gritton, Mehraj R. Awal, Christopher V. Gabel, Xue Han, and Jerome Mertz, Video-rate large-scale imaging with Multi-Z confocal microscopy<\/a>, Optica, Vol. 6, Issue 4, pp.389-395, 2019<\/p>\n

45. Angela L Nocera, Sarina K Mueller, Jules R Stephan, Loretta Hing, Philip Seifert, Xue Han, Derrick T Lin, Mansoor M Amiji, Towia Libermann, Benjamin S Bleier, Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide<\/a>, J Allergy Clin Immunol . 2019 Apr;143(4):1525-1535.e1. doi: 10.1016\/j.jaci.2018.08.046.<\/p>\n

44. James NM*, Gritton HJ*, Kopell N, Sen K, Han X., Muscarinic receptors regulate auditory and prefrontal cortical communication during auditory processing<\/a>, Neuropharmacology<\/span>. 2018 Oct 20. pii: S0028-3908(18)30814-1. doi: 10.1016\/j.neuropharm.2018.10.027. *equal contributions<\/p>\n

43. Simon P Shen*, Hua-an Tseng*, Kyle R Hansen, Ruofan Wu, Howard Gritton, Jennie Si, Xue Han, Automatic Cell Segmentation by Adaptive Thresholding (ACSAT) for large scale calcium imaging datasets<\/a>, eNeuro, Sep 13;5(5):ENEURO.0056-18.2018. doi: 10.1523\/ENEURO.0056-18.2018. eCollection 2018 Sep-Oct. \u00a0(Download Matlab Scripts on GitHub<\/a>). *equal contributions<\/p>\n

42. Marianna K. Keaveney, Hua-an Tseng, Tina L. Ta, Howard J. Gritton, Heng-Ye Man and Xue Han, A microRNA-based gene targeting tool for virally labeling interneurons in the rodent cortex<\/a>, Cell Reports, 2018 Jul 10;24(2):294-303. doi: 10.1016\/j.celrep.2018.06.049.<\/p>\n

41.Benjamin R. Pittman-Polletta, Allison Quach, Ali I. Mohammed, Michael Romano, Krishnakanth Kondabolu, Nancy J. Kopell, Xue Han, Michelle M. McCarthy, Striatal cholinergic receptor activation causes a rapid, selective, state-dependent rise in corticostriatal \u03b2 activity<\/a>, European Journal of Neuroscience, 2018 Oct;48(8):2857-2868. doi: 10.1111\/ejn.13906.<\/p>\n

40. William J. Shain, Nicholas A. Vickers, Jiang Li, Xue Han, Thomas Bifano, and Jerome Mertz, Axial localization with modulated-illumination extended-depth-of-field microscopy<\/a>, Biomedical Optics Express 9(4) 1771-1782, 2018<\/p>\n

39. Xiao S, Tseng HA, Gritton H, Han X, Mertz J. Video-rate volumetric neuronal imaging using 3D targeted illumination<\/a>. Sci Rep. 2018 May 21;8(1):7921.<\/p>\n

38. Kyle R. Hansen*, Gloria J. DeWalt*, Ali I. Mohammed*, Hua-an Tseng*, Moona E. Abdulkerim, Seth Bensussen, Venkatesh Saligrama, Bobak Nazer, William D. Eldre and Xue Han, Mild Blast Injury Produces Acute Changes in Basal Intracellular Calcium Levels and Activity Patterns in Mouse Hippocampal Neurons<\/a>, Journal of Neurotrauma, 2018,\u00a0PubMed PMID: 29343209.\u00a0 PDF for academic use<\/a>\u00a0(Download Matlab Scripts on GitHub)<\/a>\u00a0(Download Supplemental Videos). <\/a>*equal contributions<\/p>\n

37. Kodandaramaiah SB, Flores FJ, Holst GL, Singer AC, Han X, Brown EN, Boyden ES, Forest CR. Multi-neuron intracellular recording in vivo via interacting autopatching robots<\/a>. Elife. 2018 Jan 3;7. pii: e24656. PubMed PMID: 29297466.<\/p>\n

36. Wang G, Li S, Gilbert J, Gritton HJ, Wang Z, Li Z, <\/strong>Han X, Selkoe DJ, Man HY. Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and\u00a0 Memory<\/a>. Cell Rep. 2017 Aug 8;20(6):1335-1347. PMID: 28793258; PMCID: PMC5584878.<\/p>\n

35. Nocera AL, Miyake MM, Seifert P, Han X, Bleier BS. Exosomes mediate interepithelial transfer of functional P-glycoprotein in chronic rhinosinusitis with nasal polyps. Laryngoscope. 2017 Sep;127(9):E295-E300. PMID: 28485529.<\/p>\n

34. Kunkhyen T, McCarthy EA, Korzan WJ, Doctor D, Han X, Baum MJ, Cherry JA. Optogenetic Activation of Accessory Olfactory Bulb Input to the Forebrain Differentially Modulates Investigation of Opposite versus Same-Sex Urinary Chemosignals and Stimulates Mating in Male Mice<\/a>. eNeuro. 2017 Mar 23;4(2). pii: ENEURO.0010-17.2017. PMID: 28374006; PMCID: PMC5362934.<\/p>\n

33.Zhuo JM, Tseng HA, Desai M, Bucklin ME, Mohammed AI, Robinson NT, Boyden ES, Rangel LM, Jasanoff AP, Gritton HJ, Han X. Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks.<\/a> Elife. 2016 PubMed PMID: 27914197; PubMed Central PMCID: PMC5156524. PDF for academic use<\/a>\u00a0 (Download Matlab Scripts on GitHub)<\/a> (Request Plasmids through Addgene)<\/a><\/p>\n

32. Krishnakanth Kondabolu, Erik A Roberts, Mark Bucklin, Michelle M McCarthy, Nancy Kopell, Xue Han. Striatal Cholinergic Interneurons Generate Beta and Gamma Oscillations in the Corticostriatal Circuit and Produce Motor Deficits<\/a>, PNAS 2016 May 31;113(22):E3159-68. PDF for academic use<\/a><\/p>\n

31. Kohman RE, Cha SS, Man HY, Han X. Light-Triggered Release of Bioactive Molecules from DNA Nanostructures. <\/a>Nano Letters, 2016 Apr 13;16(4):2781-5. doi: 10.1021\/acs.nanolett.6b00530. PDF for academic use<\/a><\/p>\n

30. Rueckemann JW, DiMauro AJ, Rangel LM, Han X, Boyden ES, Eichenbaum H. Transient optogenetic inactivation of the medial entorhinal cortex biases the active population of hippocampal neurons. <\/a>Hippocampus. 2016 Feb;26(2):246-60. doi: 10.1002\/hipo.22519. PDF for academic use<\/a><\/p>\n

29. Ali I. Mohammed*, Howard J. Gritton*, Hua-an Tseng*, Mark E. Bucklin*, Zhaojie Yao & Xue Han. An integrative approach for analyzing hundreds of neurons in task performing mice using wide-field calcium imaging\u00a0 <\/a>Scientific Reports, 2016 Feb 8;6:20986. doi: 10.1038\/srep20986. PDF<\/a>\u00a0 (Download Matlab package<\/a>). *equal contributions<\/p>\n

28. Nocera AL, Meurer AT, Miyake MM, Sadow PM, Han X, Bleier BS. Secreted P-glycoprotein is a noninvasive biomarker of chronic rhinosinusitis. Laryngoscope. 2017 Jan;127(1):E1-E4. doi: 10.1002\/lary.26249. Epub 2016 Aug 31. \u00a0PMID: 27577924.<\/p>\n

27. Nocera AL, Meurer AT, Singleton A, Simons C, BuSaba J, Tara Gass N, Han X, Bleier BS. Intact soluble P-glycoprotein is secreted by sinonasal epithelial cells. Am J Rhinol Allergy. 2016 Jul;30(4):246-9. PMID: 27456593.<\/p>\n

26. Bleier BS, Singleton A, Nocera AL, Kocharyan A, Petkova V, Han X. P-glycoprotein regulates Staphylococcus aureus enterotoxin B-stimulated interleukin-5 and thymic stromal lymphopoietin secretion in organotypic mucosal explants. Int Forum Allergy Rhinol. 2016 Feb;6(2):169-77.\u00a0 PMID: 26625351.<\/p>\n

25. Bleier BS, Kohman RE, Guerra K, Nocera AL, Ramanlal S, Kocharyan AH, Curry WT, Han X. Heterotopic Mucosal Grafting Enables the Delivery of Therapeutic Neuropeptides Across the Blood Brain Barrier.<\/a> Neurosurgery, 2016 Mar;78(3):448-57; discussion 457. doi: 10.1227\/NEU.0000000000001016.<\/p>\n

24. Sayeg, Marianna*; Weinberg, Benjamin*; Cha, Susie; Goodloe, Michael; Wong, Wilson; Han, Xue. \u201cRationally designed microRNA-based genetic classifiers target specific neurons in the brain<\/a>“. ACS Syn Bio, 2015 Jul 17;4(7):788-795. doi: 10.1021\/acssynbio.5b00040. PDF <\/a>(Request Plasmids from Addgene<\/a>)*equal contributions<\/p>\n

23. Bleier BS, Kocharyan A, Singleton A, Han X. Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants. Int Forum Allergy Rhinol. 2015 Jan;5(1):10-3. doi: 10.1002\/alr.21436. PMID: 25330767.<\/p>\n

22 Lam A, Hoang JD, Singleton A, Han X, Bleier BS. Itraconazole and clarithromycin inhibit P-glycoprotein activity in primary human sinonasal epithelial cells. Int Forum Allergy Rhinol. 2015 Jun;5(6):477-80. doi: 10.1002\/alr.21454. PubMed PMID: 25907295.<\/p>\n

21. Richie E. Kohman, and Xue Han. “Light-Sensitization of DNA Nanostructures via Incorporation of Photo-Cleavable Spacers<\/a>.” Chem. Commun. 2015 Apr 4;51(26):5747-50. doi: 10.1039\/c5cc00082c. PMID: 25720373 PDF,\u00a0 <\/a>Download: caDNAno file for the spheres<\/a><\/p>\n

20. Kohman RE, Han X, Bleier BS. Heterotopic mucosal engrafting procedure for direct drug delivery to the brain in mice<\/a>. J Vis Exp. 2014. PMID: 25077554<\/p>\n

19. Chuong, A. S., Miri, M. L.*, Busskamp, V.*, Matthews, G.A.C.*, Acker, L.C.*, Soresnsen, A.T., Young, A., Klapoetke, N. C., Henninger, M.A., Kodandaramaiah, S.B., Ogawa, M., Ramanlal, S. B., Bandler, R. C., Allen, B. D., Forest, C.R., Chow, B.Y., Han, X., Lin, Y., Tye, K.M., Roska, R., Cardin, J.A., Boyden, E. S. Noninvasive optical inhibition with a red-shifted microbial rhodopsin, <\/a>Nature Neuroscience 2014 Aug;17(8):1123-9. doi: 10.1038\/nn.3752. PMID: 24997763 PDF<\/a><\/p>\n

18. Kocharyan A, Feldman R, Singleton A, Han X, Bleier BS. P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants. Int Forum Allergy Rhinol. 2014 Sep;4(9):734-8. doi: 10.1002\/alr.21361. PMID: 25145685.<\/p>\n

17. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Alvarez U, Feldman RE, Han X. P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps.<\/a> Int Forum Allergy Rhinol. 2014 Jun;4(6):488-94. doi: 10.1002\/alr.21316. Epub 2014 Mar 5. PMID: 24599606<\/p>\n

16. <\/strong>Bleier BS, Nocera AL, Iqbal H, Hoang JD, Feldman RE, Han X, P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells<\/a>, Int Forum Allergy Rhinol. 2013 Jun;3(6):433-8. doi: 10.1002\/alr.21166. Epub 2013 Mar 20. PMID: 23520057 PDF<\/a><\/p>\n

15. Zhang XX, LaManna CM, Kohman RE, Mclntosh TJ, Han X, Grinstaff MW, Lipid-mediated DNA and siRNA transfection efficiency depends on peptide headgroup<\/a>, Soft Matter 2013 May 5;9(17):10.1039\/C3SM27633C. doi: 10.1039\/C3SM27633C. PDF<\/a><\/p>\n

14.<\/strong> Bleier BS, Kohman RE, Feldman RE, Ramanlal S, Han X, Permeabilization of the Blood-Brain Barrier via Mucosal Engrafting: Implications for Drug Delivery to the Brain<\/a>, PloS One 2013 Apr 24;8(4):e61694. \u00a0doi: 10.1371\/journal.pone.0061694. PDF<\/a><\/p>\n

13.\u00a0 Madisen L, Mao T, Koch H, Zhuo JM, Berenyi A, Fujisawa S, Hsu YW, Garcia AJ 3rd, Gu X, Zanella S, Kidney J, Gu H, Mao Y, Hooks BM, Boyden ES, Buzs\u00e1ki G, Ramirez JM, Jones AR, Svoboda K, Han X, Turner EE, Zeng H. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing<\/a>. Nat Neurosci\u00a015<\/b>, 793\u2013802 (2012). PDF<\/a><\/p>\n

12.\u00a0 M. M. McCarthy, C. Moore-Kochlacs, X. Gu, E. S. Boyden, X. Han, and N. Kopell, Striatal origin of the pathologic beta oscillations in Parkinson’s disease<\/a>, PNAS\u00a0 108:11620-11625 <\/cite>(2011) PDF<\/a><\/p>\n

11.\u00a0 Han, X.*, Chow, B. Y.*, Zhou, H., Klapoetke, N. C., Chuong, A., Rajimehr, R., Yang, A., Baratta, M. V., Winkle, J., Desimone, R., Boyden, E. S. (2011) A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex<\/a>. Frontiers in Systems Neuroscience. 5:18. doi: 10.3389\/fnsys.2011.00018 (2011) (* co-first authors) PDF<\/a><\/p>\n

10.\u00a0 Lindskog, M., Li, L., Groth R.D., Poburko, D., Thiagarajan, T.C.,\u00a0 Han, X., and Tsien, R.W. Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivity,<\/a> PNAS 107:21806-11\u00a0 (2010) PDF<\/a><\/p>\n

9.\u00a0 Chow, B. Y.*, Han, X.*, Dobry, A. S., Qian, X., Chuong, A. S., Li, M., Henninger, M. A., Belfort, G. M., Lin, Y., Monahan, P. E., Boyden, E. S. High-performance genetically targetable optical neural silencing by light-driven proton pumps,<\/a> Nature 463:98-102. (2010), (* co-first authors) PDF<\/a><\/p>\n

8.\u00a0 Xue Han, Sherry X. Xian, and Tirin Moore, \u201cDynamic sensitivity of area V4 neurons during saccade preparation\u201d, <\/a>PNAS 106(31):13046-51 (2009) PDF<\/a><\/span><\/p>\n

7.\u00a0 Xue Han, Xiaofeng Qian, Jacob G. Bernstein, Hui-hui Zhou, Giovanni Talei Franzesi, Patrick Stern, Roderick T. Bronson, Ann M. Graybiel, Robert Desimone and Edward S. Boyden, \u201cMillisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain,\u201d<\/a> Neuron 62(2):191-8 (2009) PDF<\/a><\/p>\n

6.\u00a0 Xue Han, Xiaofeng<\/span> Qian<\/span>, Patrick Stern, Amy Chuong<\/span> and Edward S. Boyden, \u201cInformational lesions: optical perturbation of spike timing and neural synchrony via microbial opsin<\/span> gene fusions\u201d,<\/a> Front. Mol. Neurosci<\/span> 2009 Aug 27;2:12. doi: 10.3389\/neuro.02.012.2009. PDF<\/a>
\n<\/span><\/span><\/p>\n

5. Bernstein, J. G., Han, X., Henninger, M. A., Ko, E. Y., Qian, X., Franzesi, G. T., McConnell, J. P., Stern, P., Desimone, R., and Boyden, E. S. (2008) Prosthetic systems for therapeutic optical activation and silencing of genetically-targeted neurons.<\/a> Proc Soc Photo Opt Instrum Eng, 6854:68540H.<\/p>\n

4.\u00a0 Xue Han and Edward S. Boyden.<\/span> “Multiple-Color Optical Activation, Silencing, and Desynchronization<\/span> of Neural Activity, with Single-Spike Temporal Resolution.” <\/a>PLoS<\/em><\/span> ONE<\/em>, 2(3):e299. (2007) PDF<\/a><\/p>\n

3.\u00a0 Xue Han and Meyer B. Jackson.<\/span> \u201cStructural Transitions in the Synaptic SNARE Complex during Calcium triggered exocytosis<\/span>.\u201d<\/a>J Cell Biol. 172(2): 281-93 (2006) PDF<\/a><\/p>\n

2.\u00a0 Xue Han and Meyer B. Jackson.<\/span> \u201cElectrostatic interactions between the syntaxin membrane anchor and neurotransmitter passing through the fusion pore.\u201d <\/a> Biophys<\/span> J. 88 (3): L20-2 (2005) PDF<\/a><\/p>\n

1.\u00a0 Xue Han, Chih-Tien<\/span> Wang, Jihong<\/span> Bai<\/span>, Edwin R. Chapman and Meyer B. Jackson.<\/span> \u201cTransmembrane<\/span> segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis<\/span>.\u201d<\/a> Science 304 (5668): 289-92 (2004) PDF<\/a><\/p>\n

 <\/p>\n

Preprints<\/strong><\/p>\n

Susie S.Cha,\u00a0Mark E.Bucklin,\u00a0Xue\u00a0Han<\/strong>,\u00a0Removable cranial window for sustained wide-field optical imaging in mouse neocortex<\/a>, bioRxiv 2020.01.14.905851\u00a0 <\/span><\/p>\n

Howard J.Gritton,\u00a0Jian C.Nocon,\u00a0Nicholas M.\u00a0James, Eric\u00a0Lowet, Moona\u00a0Abdulkerim, Kamal\u00a0Sen, Xue Han<\/strong>,\u00a0Oscillatory activity in alpha\/beta frequencies coordinates auditory and prefrontal cortices during extinction learning<\/a>, bioRxiv\u00a02020.10.30.362962<\/p>\n

Hua-an Tseng, Rebecca A. Mount, Eric Lowet, Howard J. Gritton, Cyrus Cheung, Xue Han,\u00a0 <\/span>Membrane Voltage Dynamics of Parvalbumin Interneurons Orchestrate Hippocampal Theta Rhythmicity<\/a>, bioRxiv 2022.11.14.516448; doi: https:\/\/doi.org\/10.1101\/2022.11.14.516448<\/span><\/p>\n

P.<\/span>Leman<\/span>,\u00a0I.A.Chen<\/span>,\u00a0K.A.\u00a0Bolding<\/span>,\u00a0J.\u00a0Tai<\/span>,\u00a0L.K.\u00a0Wilmerding<\/span>,\u00a0H.J.\u00a0Gritton<\/span>, Y.\u00a0Cohen<\/span>,\u00a0W.W.\u00a0Yen<\/span>, L.N. <\/span>Perkins<\/span>,\u00a0W.A., Liberti<\/span>\u00a0III<\/span>,\u00a0K.\u00a0Kilic<\/span>,\u00a0X.\u00a0Han<\/span>,\u00a0A.\u00a0Cruz-Mart\u00edn<\/span>,\u00a0T.J. Gardner<\/span>,\u00a0T.M.\u00a0Otchy<\/span>,\u00a0I.G.\u00a0Davison, <\/span>Large-scale cellular-resolution imaging of neural activity in freely behaving mice<\/span><\/span><\/a>, <\/u>bioRxiv\u00a0<\/span>2021.01.15.426462;\u00a0<\/span>doi:<\/span>\u00a0https:\/\/doi.org\/10.1101\/2021.01.15.426462<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Reviews\u00a0<\/strong><\/p>\n

3.\u00a0 Xue Han, In vivo Application of Optogenetics for Neural Circuit Analysis<\/a>. ACS Chem. Neurosci. <\/em><\/cite> (2012) PDF<\/a><\/p>\n

2.\u00a0 Brian Y. Chow, Xue Han, Edward S. Boyden, Genetically encoded molecular tools for light-driven silencing of targeted neurons<\/a>, Prog Brain Res, 196:49-61, (2012) PDF<\/a><\/p>\n

1.\u00a0 Xue Han, Optogenetics in the nonhuman primate<\/a>, Prog Brain Res, 196:215-33, (2012) PDF<\/a><\/p>\n

 <\/p>\n

Commentaries<\/strong><\/p>\n

1. Xue Han, Control Neural Networks in \u201cWhat is the Key Conceptual or Methodological Bottleneck to Controlling Neural Biology<\/a>?\u201d Cell Syst<\/em>. 2020;10(6):461-462. doi:10.1016\/j.cels.2020.06.001, PMID: <\/span>32585154<\/p>\n

 <\/p>\n

Book Chapters<\/strong><\/p>\n

6. Kondabolu K, Kowalski MM, Roberts EA, Han X. Optogenetics and deep brain stimulation neurotechnologies. Handb Exp Pharmacol. 2015;228:441-50. PMID: 25977092. (2015)<\/p>\n

5. Richie Kohman, Hua-an Tseng, and Xue Han (2014) “Optogenetics” The OMICs, Applications in Neuroscience, Oxford<\/p>\n

4. Quach, Allison, Nicholas James, and Xue Han. (2014) “Optogenetics” Nanotechnology and Neuroscience: Nano-electronic, Photonic and Mechanical Neuronal Interfacing<\/i>. Springer New York, 2014. 269-282.<\/p>\n

3. Hua-an Tseng, Richie E. Kohman, and Xue Han. \u201cChapter on Optogenetics\u201d Basic Electrophysiological Methods, Oxford University Press. (2013)<\/p>\n

2. Chow, B. Y., Han, X., Bernstein, J. G., Monahan, P. E., Boyden, E. S. (2011) Light-Activated Ion Pumps and Channels for Temporally Precise Optical Control of Activity in Genetically Targeted Neurons<\/a>, Chapter 6, Photosensitive Molecules for Controlling Biological Function, edited by James J. Chambers and Richard H. Kramer, Neuromethods Series Volume 55, 2011, DOI: 10.1007\/978-1-61779-031-7, Humana Press.<\/p>\n

1. Boyden, E. S., Han, X., Talei Franzesi, G., Chan, S., Bernstein, J., Qian, X., Li, M. (2009) New Techniques for Investigating Brain Rhythms: Optical Neural Control and Multielectrode Recording,” In: Rhythms of the Neocortex: Where Do They Come From and What Are They Good For? (Kopell N., ed.) pp. 65-75. Washington, DC: Society for Neuroscience.<\/p>\n

 <\/p>\n

Patents<\/strong><\/p>\n

Light-stimulated release of cargo from oligonucleotides<\/a>, Xue Han, Richie Kohman and Susie Cha, U.S. Patent No. US10617759B2 (granted 2020)<\/p>\n

Red-shifted opsin molecules and uses thereof.<\/a> Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han, US patent No. US10106584B2 (granted 2018)<\/p>\n

Back to Top<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Journal Articles, Refereed Conference Proceedings 86. Yangyang\u00a0Wang,\u00a0Cara\u00a0Ravasio,\u00a0Yuxin\u00a0Zhou,\u00a0Xue\u00a0Han, Prolonged Single Neuron Voltage Imaging in Behaving Mammals, bioRxiv 2025.05.29.656886; 85. Shaw DC, Kondabolu K, Walsh KG, Abumuaileq M, Shi W, Isaac K, Steiner L, Rillosi E, Hsiung M, Dang L, Eden UT, Richardson RM, Kramer MA, Chu CJ, Han X. Photothrombosis-induced cortical stroke mouse model produces focal […]<\/p>\n","protected":false},"author":3417,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/hanlab\/wp-json\/wp\/v2\/pages\/85"}],"collection":[{"href":"https:\/\/www.bu.edu\/hanlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/hanlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/hanlab\/wp-json\/wp\/v2\/users\/3417"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/hanlab\/wp-json\/wp\/v2\/comments?post=85"}],"version-history":[{"count":51,"href":"https:\/\/www.bu.edu\/hanlab\/wp-json\/wp\/v2\/pages\/85\/revisions"}],"predecessor-version":[{"id":1653,"href":"https:\/\/www.bu.edu\/hanlab\/wp-json\/wp\/v2\/pages\/85\/revisions\/1653"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/hanlab\/wp-json\/wp\/v2\/media?parent=85"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}