EVENING PRIMROSE OIL
WHAT IS IT?
EPO is from the seed of the evening primrose plant and contains an omega-6 essential fatty acid called gamma-linolenic acid (GLA) which is believed to be its active ingredient.
WHAT IS IT USED FOR?
Hot flashes (possibly ineffective)
Breast pain
PMS
Eczema
High Cholesterol
Osteoporosis
Diabetic Neuropathy
RESEARCH/STUDIES
- There is mixed data on the effects of EPO on breast cancer cells.
- Studies combining EPO and Tamoxifen for the treatment of breast cancer have shown quicker tumor response to the Tamoxifen.
- One clinical trial found that EPO was not any better than a placebo in relieving hot flashes.
- Some studies indicate EPO may decrease the risk of seizures, other studies show it may increase the risk of seizures, especially in patients with schizophrenia on phenothiazines.
IS IT SAFE?
- EPO is likely safe when used orally in recommended doses for up to one year.
- Long term safety information greater than 1 year is not available.
SIDE EFFECTS, WARNINGS AND PRECAUTIONS
Generally well tolerated; other side effects include:
Headache
Low Blood pressure
Nausea
Bloating
Gas
Seizures
Increased bowel movements (diarrhea)
Skin Rash
Stomach pain
THINGS TO REMEMBER
- EPO does not appear to affect menopausal symptoms but more studies are needed.
- EPO may enhance the effects of Tamoxifen.