{"id":718,"date":"2010-12-08T13:02:51","date_gmt":"2010-12-08T18:02:51","guid":{"rendered":"http:\/\/www.bu.edu\/?page_id=718"},"modified":"2010-12-08T13:07:32","modified_gmt":"2010-12-08T18:07:32","slug":"advanced-glaucoma-intervention-study-agis","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/eye\/evidence-based-medicine\/glaucoma-studies\/advanced-glaucoma-intervention-study-agis\/","title":{"rendered":"Advanced Glaucoma Intervention Study (AGIS)"},"content":{"rendered":"<p><strong>Advanced Glaucoma Intervention Study (AGIS)<\/strong><\/p>\n<p><strong> <\/strong><\/p>\n<p><strong>Purpose:<\/strong> To evaluate the outcomes of sequences of  interventions involving trabeculectomy and ALT in eyes that have failed  medical treatment for glaucoma<\/p>\n<p><strong>Description:<\/strong><\/p>\n<p>&#8211;\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 To provide assessment of the long range outcomes of medical  and surgical management in advanced glaucoma using visual function status for  comparison<\/p>\n<p>&#8211;\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 789 eyes (ages 35-80) with advanced glaucoma was enrolled and patients were followed for a minimum of 5 yrs<\/p>\n<p>&#8211;\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Eyes were randomly assigned to one of two intervention sequences; supplemented by medical therapy as needed<\/p>\n<p>1.\u00a0 Trab then ALT if trab fails, then 2<sup>nd<\/sup> trab if ALT fails (trab\/ALT\/trab)<\/p>\n<p>2.\u00a0 ALT, then trab if ALT fails, then 2<sup>nd<\/sup> trab if 1<sup>st<\/sup> trab fails (ALT\/trab\/trab)<\/p>\n<p>(If the eyes fail the above sequences, then individualized therapy)<\/p>\n<p>&#8211;\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Primary outcome is decrease of vision, secondary outcomes  include sustained decrease of vision, failure of interventions, number  of prescribed glaucoma medications and level of intraocular pressure.<\/p>\n<p><strong>Results:<\/strong><\/p>\n<p>&#8211;\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Followup at 7yrs, revealed that the vision in the eyes of  black patients with advanced glaucoma were better preserved in the  program that started with ALT<\/p>\n<p>&#8211;\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Initially (1<sup>st<\/sup> 4yrs), vision in the eyes of white patients tended to be better preserved however, over 7yr f\/u, the reverse is true.<\/p>\n<p><strong>Conclusions:<\/strong><\/p>\n<p>&#8211; \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 It is recommended that black patients with advanced  glaucoma start a therapy program with laser surgery, while whites  without life threatening health problems should begin with  trabeculectomy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Advanced Glaucoma Intervention Study (AGIS) Purpose: To evaluate the outcomes of sequences of interventions involving trabeculectomy and ALT in eyes that have failed medical treatment for glaucoma Description: &#8211;\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 To provide assessment of the long range outcomes of medical and surgical management in advanced glaucoma using visual function status for comparison &#8211;\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 789 eyes (ages [&hellip;]<\/p>\n","protected":false},"author":1980,"featured_media":0,"parent":700,"menu_order":1,"comment_status":"closed","ping_status":"open","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/eye\/wp-json\/wp\/v2\/pages\/718"}],"collection":[{"href":"https:\/\/www.bu.edu\/eye\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/eye\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/eye\/wp-json\/wp\/v2\/users\/1980"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/eye\/wp-json\/wp\/v2\/comments?post=718"}],"version-history":[{"count":5,"href":"https:\/\/www.bu.edu\/eye\/wp-json\/wp\/v2\/pages\/718\/revisions"}],"predecessor-version":[{"id":801,"href":"https:\/\/www.bu.edu\/eye\/wp-json\/wp\/v2\/pages\/718\/revisions\/801"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/eye\/wp-json\/wp\/v2\/pages\/700"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/eye\/wp-json\/wp\/v2\/media?parent=718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}