{"id":2353,"date":"2016-10-11T11:12:13","date_gmt":"2016-10-11T15:12:13","guid":{"rendered":"https:\/\/www.bu.edu\/ctsi\/?page_id=2353"},"modified":"2025-08-01T07:44:20","modified_gmt":"2025-08-01T11:44:20","slug":"bumc-thrombotic-microangiopathy-collaborative-butmac","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/ctsi\/support-for-research\/bumc-thrombotic-microangiopathy-collaborative-butmac\/","title":{"rendered":"Thrombotic Microangiopathy Collaborative (BU-TMAC)"},"content":{"rendered":"<div style=\"font-family: Arial, sans-serif; max-width: 850px; margin: auto; padding: 20px; background-color: #f9f9f9; border-radius: 12px; box-shadow: 0 4px 12px rgba(0,0,0,0.1);\">\n<h2 style=\"color: #8b0000; text-align: center;\">Boston University Thrombotic Microangiopathy Collaborative (BU-TMAC)<\/h2>\n<h4 style=\"font-style: italic; text-align: center; color: #444;\">Multidisciplinary Patient Care, Research &amp; Education<\/h4>\n<h4 style=\"color: #28ca9d; font-weight: bold; text-align: center;\">Advancing Diagnosis, Treatment, and Knowledge of TMA Syndromes<\/h4>\n<p style=\"line-height: 1.6; font-size: 16px; color: #333;\">The Boston University Thrombotic Microangiopathy Collaborative (BU-TMAC) provides a multidisciplinary approach to the care of patients with TMA. The multidisciplinary team is very unique in its structure and function, involving physicians from different subspecialties with great interest and expertise in managing patients with TMA.<\/p>\n<p style=\"line-height: 1.6; font-size: 16px; color: #333;\">The <span>Collaborative<\/span> combines basic and clinical research to advance the understanding of the TMA syndromes. We are an integral part of the <a href=\"https:\/\/www.bumc.bu.edu\/evanscenteribr\/\">Affinity Research Collaborative<\/a> (ARC) on Thrombosis and Homeostasis that consists of investigators from several academic departments with a common goal to investigate thrombosis in humans.<\/p>\n<div style=\"background-color: #e0f8f2; padding: 20px; border-left: 6px solid #f57c00; margin-top: 20px; border-radius: 8px;\">\n<h3 style=\"margin-top: 0; color: #83224f;\">Our Mission Includes:<\/h3>\n<ul style=\"line-height: 1.8; font-size: 16px; color: #444;\">\n<li>Evaluation, management, and treatment of patients with TMA.<\/li>\n<li>To educate other health providers and increase awareness of the TMA syndromes.<\/li>\n<li>Center for clinical trials and basic research on TMA syndromes.<\/li>\n<li>Role model for the management of patients with TMA through a multidisciplinary team approach.<\/li>\n<\/ul>\n<\/div>\n<div style=\"text-align: center; margin-top: 30px;\">\n<p><img src=\"\/ctsi\/files\/2016\/10\/TMA-Alg_Final1.png\" alt=\"TMA Algorithm\" style=\"max-width: 100%; height: auto; border-radius: 6px;\" \/><\/p>\n<p style=\"font-size: 14px; color: #666;\">*The information contained on this website is for general information purposes only \u2013 Diagnostic Algorithm.<\/p>\n<\/div>\n<details style=\"margin-top: 30px; margin-bottom: 10px; border: 1px solid #ccc; border-radius: 6px; background-color: #ffffff;\">\n<summary style=\"padding: 12px; font-size: 16px; font-weight: bold; color: #8b0000; cursor: pointer;\">Award &amp; Recognition<\/summary>\n<div style=\"padding: 10px 20px;\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" src=\"\/ctsi\/files\/2022\/04\/logoImage-636x145.png\" alt=\"BU-TMAC Logo\" width=\"298\" height=\"68\" \/><\/p>\n<h4 style=\"text-align: center; color: #993366;\">Congratulations to Dr. Francis for receiving the National Kidney Foundation New England Award \u2013 Excellence In Transplant and Nephrology.<\/h4>\n<p style=\"text-align: center;\"><img loading=\"lazy\" src=\"\/ctsi\/files\/2022\/04\/jean_francis-150x150.jpeg\" alt=\"Dr. Jean Francis\" width=\"150\" height=\"150\" \/><\/p>\n<div style=\"text-align: center;\"><strong style=\"color: #993366;\">Jean Francis, MD<\/strong><br \/>\nMedical Director of Kidney Transplantation (BUMC)<br \/>\nAssociate Professor of Medicine (BUSM)<br \/>\nMedical Director of Pancreas Transplant Program, Brigham and Women Hospital<br \/>\nAssociate Physician, Brigham and Women HospitalFor more information, visit the <a href=\"https:\/\/www.kidney.org\/events\/social-event\/nkf-new-england-honors#vip1\">NKF website<\/a>.<\/div>\n<\/div>\n<\/details>\n<details style=\"margin-bottom: 10px; border: 1px solid #ccc; border-radius: 6px; background-color: #ffffff;\">\n<summary style=\"padding: 12px; font-size: 16px; font-weight: bold; color: #8b0000; cursor: pointer;\">Meet BU-TMAC Team<\/summary>\n<div style=\"padding: 10px 20px;\">\n<div style=\"display: flex; flex-wrap: wrap; gap: 20px; justify-content: space-between;\">\n<div style=\"flex: 1 1 240px; text-align: center;\">\n<p><img src=\"\/ctsi\/files\/2016\/10\/JeanFrancis.jpg\" alt=\"Dr. Jean Francis\" style=\"width: 120px; height: 120px; border-radius: 8px; object-fit: cover;\" \/><\/p>\n<div style=\"margin-top: 10px;\"><strong style=\"color: #993366;\"><a href=\"http:\/\/profiles.bu.edu\/Jean.Francis\" target=\"_blank\" style=\"color: #993366;\" rel=\"noopener noreferrer\">Dr. Jean Francis<\/a><\/strong><br \/>\nCo-Director<br \/>\nAssociate Professor (BUSM)<br \/>\nNephrology<\/div>\n<\/div>\n<div style=\"flex: 1 1 240px; text-align: center;\">\n<p><img src=\"\/ctsi\/files\/2020\/06\/Mark-Sloan-3.jpg\" alt=\"Dr. Mark Sloan\" style=\"width: 120px; height: 120px; border-radius: 8px; object-fit: cover;\" \/><\/p>\n<div style=\"margin-top: 10px;\"><strong style=\"color: #993366;\"><a href=\"http:\/\/profiles.bu.edu\/J.Sloan\" target=\"_blank\" style=\"color: #993366;\" rel=\"noopener noreferrer\">Dr. Mark Sloan<\/a><\/strong><br \/>\nCo-Director<br \/>\nAssociate Professor (BUSM)<br \/>\nHematology &amp; Medical Oncology<\/div>\n<\/div>\n<div style=\"flex: 1 1 240px; text-align: center;\">\n<p><img src=\"\/ctsi\/files\/2021\/05\/Laurence-Beck-150x150.jpg\" alt=\"Dr. Laurence Beck\" style=\"width: 120px; height: 120px; border-radius: 8px; object-fit: cover;\" \/><\/p>\n<div style=\"margin-top: 10px;\"><strong><a href=\"https:\/\/profiles.bu.edu\/Laurence.Beck\" target=\"_blank\" style=\"color: #993366;\" rel=\"noopener noreferrer\">Laurence H. Beck Jr, MD, PhD<\/a><\/strong><br \/>\nAssociate Professor (BUSM)<br \/>\nNephrology<\/div>\n<\/div>\n<div style=\"flex: 1 1 240px; text-align: center;\">\n<p><img src=\"\/ctsi\/files\/2021\/05\/Regie-T-1.jpg\" alt=\"Dr. Reggie Thomasson\" style=\"width: 120px; height: 120px; border-radius: 8px; object-fit: cover;\" \/><\/p>\n<div style=\"margin-top: 10px;\"><strong><a href=\"https:\/\/profiles.bu.edu\/Reggie.Thomasson\" target=\"_blank\" style=\"color: #993366;\" rel=\"noopener noreferrer\">Reggie Thomasson, MD<\/a><\/strong><br \/>\nAssistant Professor (BUSM)<br \/>\nPathology &amp; Laboratory Medicine<\/div>\n<\/div>\n<div style=\"flex: 1 1 240px; text-align: center;\">\n<p><img src=\"\/ctsi\/files\/2021\/06\/Justine-Dickson-2-150x150.jpg\" alt=\"Justine E. Dickson\" style=\"width: 120px; height: 120px; border-radius: 8px; object-fit: cover;\" \/><\/p>\n<div style=\"margin-top: 10px;\"><strong><a href=\"https:\/\/www.bmc.org\/pharmacy-residency\/preceptors\" target=\"_blank\" style=\"color: #993366;\" rel=\"noopener noreferrer\">Justine E. Dickson, PharmD<\/a><\/strong><br \/>\nPharmacy Clinical Specialist<br \/>\nRenal Transplant \/ TMA<\/div>\n<\/div>\n<div style=\"flex: 1 1 240px; text-align: center;\">\n<p><img src=\"\/ctsi\/files\/2021\/06\/Michael-York-2-150x150.jpg\" alt=\"Michael R. York\" style=\"width: 120px; height: 120px; border-radius: 8px; object-fit: cover;\" \/><\/p>\n<div style=\"margin-top: 10px;\"><strong><a href=\"https:\/\/profiles.bu.edu\/Michael.York\" target=\"_blank\" style=\"color: #993366;\" rel=\"noopener noreferrer\">Michael R. York, MD<\/a><\/strong><br \/>\nAssistant Professor (BUSM)<br \/>\nRheumatology<\/div>\n<\/div>\n<div style=\"flex: 1 1 240px; text-align: center;\">\n<p><img src=\"\/ctsi\/files\/2021\/05\/Chitalia_Vipul-150x150.jpg\" alt=\"Dr. Vipul Chitalia\" style=\"width: 120px; height: 120px; border-radius: 8px; object-fit: cover;\" \/><\/p>\n<div style=\"margin-top: 10px;\"><strong><a href=\"http:\/\/profiles.bu.edu\/Vipul.Chitalia\" target=\"_blank\" style=\"color: #993366;\" rel=\"noopener noreferrer\">Dr. Vipul Chitalia<\/a><\/strong><br \/>\nCore Member, TMA Research Program<br \/>\nAssociate Professor (BUSM)<br \/>\nNephrology<\/div>\n<\/div>\n<div style=\"flex: 1 1 240px; text-align: center;\">\n<p><img src=\"\/ctsi\/files\/2016\/10\/KatyaRavid1.jpg\" alt=\"Dr. Katya Ravid\" style=\"width: 120px; height: 120px; border-radius: 8px; object-fit: cover;\" \/><\/p>\n<div style=\"margin-top: 10px;\"><strong><a href=\"http:\/\/profiles.bu.edu\/Katya.Ravid\" target=\"_blank\" style=\"color: #993366;\" rel=\"noopener noreferrer\">Dr. Katya Ravid<\/a><\/strong><br \/>\nProfessor of Medicine (BUSM)<br \/>\nCardiovascular Medicine<\/div>\n<\/div>\n<div style=\"flex: 1 1 240px; text-align: center;\">\n<p><img src=\"\/ctsi\/files\/2016\/10\/Salant-Photo1.png\" alt=\"Dr. David Salant\" style=\"width: 120px; height: 120px; border-radius: 8px; object-fit: cover;\" \/><\/p>\n<div style=\"margin-top: 10px;\"><strong><a href=\"http:\/\/profiles.bu.edu\/David.Salant\" target=\"_blank\" style=\"color: #993366;\" rel=\"noopener noreferrer\">Dr. David Salant<\/a><\/strong><br \/>\nProfessor (BUSM)<br \/>\nNephrology<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/details>\n<details style=\"margin-bottom: 10px; border: 1px solid #ccc; border-radius: 6px; background-color: #ffffff;\">\n<summary style=\"padding: 12px; font-size: 16px; font-weight: bold; color: #8b0000; cursor: pointer;\">BU-TMAC Research<\/summary>\n<div style=\"padding: 10px 20px;\">\n<ul style=\"line-height: 1.6; font-size: 16px; color: #333;\">\n<li><a href=\"https:\/\/www.bu.edu\/articles\/2024\/can-animal-organ-transplants-save-lives\/\" target=\"_blank\" rel=\"noopener noreferrer\">Can Animal Organ Transplants Save Lives?<\/a><\/li>\n<li><a href=\"https:\/\/www.bumc.bu.edu\/camed\/news-events\/articles\/2025\/researchers-identify-pathway-responsible-for-calciphylaxis-a-rare-and-serious-condition\/\" target=\"_blank\" rel=\"noopener noreferrer\">New Pathway Identified in Calciphylaxis<\/a><\/li>\n<li><a href=\"https:\/\/www.bu.edu\/ctsi\/support-for-research\/bumc-thrombotic-microangiopathy-collaborative-butmac\/butmac-research-activities\/\">BU-TMAC Research Activities<\/a><\/li>\n<\/ul>\n<\/div>\n<\/details>\n<details style=\"margin-bottom: 10px; border: 1px solid #ccc; border-radius: 6px; background-color: #ffffff;\">\n<summary style=\"padding: 12px; font-size: 16px; font-weight: bold; color: #8b0000; cursor: pointer;\">TMA and COVID-19<\/summary>\n<div style=\"padding: 10px 20px;\">\n<ul style=\"line-height: 1.6; font-size: 16px; color: #333;\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32525010\/\">Thrombotic Microangiopathy in a Patient with COVID-19<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8028698\/\">Kidney TMA After COVID-19 Associated With C3 Gene Mutation<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32627622\/\">TMA, DIC-syndrome, and COVID-19: Link with Pregnancy Prothrombotic State<\/a><\/li>\n<\/ul>\n<\/div>\n<\/details>\n<details style=\"margin-top: 10px; margin-bottom: 10px; border: 1px solid #ccc; border-radius: 6px; background-color: #ffffff;\">\n<summary style=\"padding: 12px; font-size: 16px; font-weight: bold; color: #8b0000; cursor: pointer;\">Patients Frequently Asked Questions<\/summary>\n<div style=\"padding: 10px 20px;\">\n<details style=\"margin-bottom: 10px;\" open=\"open\">\n<summary style=\"background-color: #8b0000; color: white; padding: 12px; border-radius: 6px; cursor: pointer; font-size: 15px;\">What types of TMA syndromes do you treat at BU-TMAC?<\/summary>\n<div style=\"padding: 10px; background-color: #fff7f7; border-left: 4px solid #8b0000;\">We manage all types of TMA syndromes regardless of the underlying cause \u2014 including acute, chronic, primary, and secondary TMA. Contact us to schedule an appointment.<\/div>\n<\/details>\n<details style=\"margin-bottom: 10px;\" open=\"open\">\n<summary style=\"background-color: #8b0000; color: white; padding: 12px; border-radius: 6px; cursor: pointer; font-size: 15px;\">What will happen on my visit?<\/summary>\n<div style=\"padding: 10px; background-color: #fff7f7; border-left: 4px solid #8b0000;\">Before your visit, we review your medical records. You\u2019ll meet members of our TMA team who will evaluate and discuss a care plan based on multidisciplinary input.<\/div>\n<\/details>\n<details style=\"margin-bottom: 10px;\" open=\"open\">\n<summary style=\"background-color: #8b0000; color: white; padding: 12px; border-radius: 6px; cursor: pointer; font-size: 15px;\">Can I still see my current physician?<\/summary>\n<div style=\"padding: 10px; background-color: #fff7f7; border-left: 4px solid #8b0000;\">Yes, our care can complement your existing treatment. We coordinate closely with your doctors and maintain open communication throughout your care.<\/div>\n<\/details>\n<details style=\"margin-bottom: 10px;\" open=\"open\">\n<summary style=\"background-color: #8b0000; color: white; padding: 12px; border-radius: 6px; cursor: pointer; font-size: 15px;\">How do I schedule an appointment?<\/summary>\n<div style=\"padding: 10px; background-color: #fff7f7; border-left: 4px solid #8b0000;\">Contact Dr. Jean Francis at <a href=\"mailto:Jean.Francis@bmc.org\">Jean.Francis@bmc.org<\/a> or Dr. Vipul Chitalia at <a href=\"mailto:Vipul.Chitalia@bmc.org\">Vipul.Chitalia@bmc.org<\/a>.<\/div>\n<\/details>\n<\/div>\n<\/details>\n<details style=\"margin-bottom: 10px; border: 1px solid #ccc; border-radius: 6px; background-color: #ffffff;\">\n<summary style=\"padding: 12px; font-size: 16px; font-weight: bold; color: #8b0000; cursor: pointer;\">Important Publications<\/summary>\n<div style=\"padding: 20px;\">\n<div style=\"display: flex; flex-direction: column; gap: 20px;\">\n<div style=\"background-color: #fef6f6; padding: 16px; border-left: 5px solid #8b0000; border-radius: 8px;\"><strong>Napoleon MA, Yang X, Zhang Y, Morrissey A, Krinsky S, <span data-markjs=\"true\" class=\"outlook-search-highlight\">Francis<\/span> J. et al.<\/strong><br \/>\n<em><em>Activation and targetability of TYMP-IL-6-TF signaling in the skin microenvironment in uremic calciphylaxis. <\/em><\/em>Sci Transl Med. 2025 Apr 23;17(795):eadn5772. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40267216\/\">PMID: 40267216<\/a><span><a class=\"OWAAutoLink elementToProof\" id=\"OWAb631d08b-2dfc-9861-9d2d-36f5f52910d1\" target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/38225975\" title=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/38225975\" data-outlook-id=\"5cfb5e36-4eae-4dfc-bd7f-2da913d7b037\" rel=\"noopener noreferrer\"><\/a><\/span><\/div>\n<div style=\"background-color: #fef6f6; padding: 16px; border-left: 5px solid #8b0000; border-radius: 8px;\"><strong>Trivin-Avillach C, Jaberi A, Henderson JM, Beck LH, <span data-markjs=\"true\" class=\"outlook-search-highlight\">Francis<\/span> J. Eculizumab<\/strong><br \/>\n<em>Use in Scleroderma Renal Crisis With Thrombotic Microangiopathy: A Case Report.<\/em><br \/>\nKidney Med. 2024 Jan; 6. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/38225975\">PMID: <span>38225975<\/span><\/a><\/div>\n<div style=\"background-color: #fef6f6; padding: 16px; border-left: 5px solid #8b0000; border-radius: 8px;\"><strong>Singh P, Chen H, Gordon CE, Ghai S, Sloan JM, et al.<\/strong><br \/>\n<em>Monoclonal IgG4\/2? Deposition Following Eculizumab Therapy<\/em><br \/>\nKidney Med. 2019 May-Jun; 1(3):139-143. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32734194\/\">PMID: 32734194<\/a><\/div>\n<div style=\"background-color: #fef6f6; padding: 16px; border-left: 5px solid #8b0000; border-radius: 8px;\"><strong>Kamel MH, Jaberi A, Gordon CE, Beck LH, Francis J.<\/strong><br \/>\n<em>The Complement System in the Modern Era of Kidney Transplantation<\/em><br \/>\nSemin Nephrol. 2022 Jan; 42(1):14-28. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35618392\/\">PMID: 35618392<\/a><\/div>\n<div style=\"background-color: #fef6f6; padding: 16px; border-left: 5px solid #8b0000; border-radius: 8px;\"><strong>Haddad G, Lorenzen JM, Ma H, et al.<\/strong><br \/>\n<em>Altered glycosylation of lgG4 in membranous nephropathy<\/em><br \/>\nJ Clin Invest. 2021;131(5):e140453. <a href=\"https:\/\/www.jci.org\/articles\/view\/140453\">Full Text<\/a><\/div>\n<div style=\"background-color: #fef6f6; padding: 16px; border-left: 5px solid #8b0000; border-radius: 8px;\"><strong>Kamel MH, Yin W, Zavaro C, Francis JM, Chitalia VC.<\/strong><br \/>\n<em>Hyperthrombotic Milieu in COVID-19 Patients<\/em><br \/>\nCells. 2020 Oct 31; 9(11). <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33142844\/\">PMID: 33142844<\/a><\/div>\n<div style=\"background-color: #fef6f6; padding: 16px; border-left: 5px solid #8b0000; border-radius: 8px;\"><strong>Reddy YN, Siedlecki AM, Francis JM.<\/strong><br \/>\n<em>Breaking down the complement system<\/em><br \/>\nCurr Opin Nephrol Hypertens. 2017 Mar; 26(2):123-128. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27977428\/\">PMID: 27977428<\/a><\/div>\n<div style=\"background-color: #fef6f6; padding: 16px; border-left: 5px solid #8b0000; border-radius: 8px;\"><strong>Gordon CE, Chitalia VC, Sloan JM, Salant DJ, et al.<\/strong><br \/>\n<em>Thrombotic Microangiopathy: A Multidisciplinary Team Approach<\/em><br \/>\nAm J Kidney Dis. 2017 Nov; 70(5):715-721. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28720207\/\">PMID: 28720207<\/a><\/div>\n<\/div>\n<\/div>\n<\/details>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Boston University Thrombotic Microangiopathy Collaborative (BU-TMAC) Multidisciplinary Patient Care, Research &amp; Education Advancing Diagnosis, Treatment, and Knowledge of TMA Syndromes The Boston University Thrombotic Microangiopathy Collaborative (BU-TMAC) provides a multidisciplinary approach to the care of patients with TMA. The multidisciplinary team is very unique in its structure and function, involving physicians from different subspecialties with [&hellip;]<\/p>\n","protected":false},"author":7251,"featured_media":0,"parent":289,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/ctsi\/wp-json\/wp\/v2\/pages\/2353"}],"collection":[{"href":"https:\/\/www.bu.edu\/ctsi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/ctsi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/ctsi\/wp-json\/wp\/v2\/users\/7251"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/ctsi\/wp-json\/wp\/v2\/comments?post=2353"}],"version-history":[{"count":51,"href":"https:\/\/www.bu.edu\/ctsi\/wp-json\/wp\/v2\/pages\/2353\/revisions"}],"predecessor-version":[{"id":18139,"href":"https:\/\/www.bu.edu\/ctsi\/wp-json\/wp\/v2\/pages\/2353\/revisions\/18139"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/ctsi\/wp-json\/wp\/v2\/pages\/289"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/ctsi\/wp-json\/wp\/v2\/media?parent=2353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}