Ensuring strong demand for vaccination is critical to ending the COVID-19 public health emergency.  However, demand for vaccination among communities who identify as Black, Indigenous, or people of color (BIPOC) has been lower than for White people, despite the increased COVID-19 vulnerability for BIPOC communities.  Contributing to this challenge is the BIPOC communities’ distrust of government, researchers, and health institutions due to historic and recent abuses, as well as widespread disinformation about the vaccine. Community engagement is critical to building trust for the vaccine and to develop communication strategies that will meet the needs of diverse populations but it has lagged behind the “warp speed” vaccine development process.  When community partners of the CTSI Community Engagement Program expressed concern about being able to conduct a successful COVID-19 vaccination campaign for BIPOC communities, the CTSI responded with a RFA for vaccine hesitancy.  The goal of the RFA was to provide timely and actionable COVID-19 vaccine communication strategy for BMC health system’s BIPOC communities and for other health systems who serve similar populations.