Funding Opportunity for HEAL Initiative

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Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN) (UC2 Clinical Trial Not Allowed)


The goal of RE-JOIN will be to define the innervation of the different articular and peri-articular tissues that collectively form the joint (including bone, cartilage, synovium, joint capsule, ligament, tendon, fascia, and muscle) by sensory neurons that mediate the sensation of pain. Knowledge about the types and distribution of neurites in joint tissues will facilitate the identification of key receptors and mediators that induce pain by activating specific sensory neurons. These mediators and their receptors will provide novel targets for reducing pain.

Research teams will map the sensory innervation of knee and/or temporomandibular joint tissues in animal models and/or human tissues and have the option of including additional joints. Research teams may also further adapt or develop technologies that would improve the ability to map neurons in joint tissues.

Data harmonization, integration, and visualization will require extensive coordination across teams. The goal will be to integrate data from the different teams to produce models of innervation in different joints.

Important Dates

  • Estimated Publication Date of Funding Opportunity Announcement: February 1, 2022
  • First Estimated Application Due Date: April 29, 2022
  • Earliest Estimated Award Date: September 1, 2022
  • Earliest Estimated Start Date: September 1, 2022

More information about the NIH HEAL Initiative can be found here.

Details and how to apply

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