{"id":4314,"date":"2017-07-10T16:33:58","date_gmt":"2017-07-10T20:33:58","guid":{"rendered":"https:\/\/www.bu.edu\/cte\/?post_type=profile&p=4314"},"modified":"2023-08-22T16:18:33","modified_gmt":"2023-08-22T20:18:33","slug":"lee-goldstein-md-phd","status":"publish","type":"profile","link":"https:\/\/www.bu.edu\/cte\/profile\/lee-goldstein-md-phd\/","title":{"rendered":"Lee Goldstein"},"content":{"rendered":"

Click\u00a0<\/span>here<\/a><\/strong>\u00a0to view Dr. Goldstein\u2019s lab website.<\/p>\n

Background<\/h4>\n

Dr. Lee Goldstein received a bachelor\u2019s degree in humanities and biology from Columbia University and went on to complete his medical and doctoral training at Yale University. Dr. Goldstein completed an internal medicine internship and residency program in psychiatry at Harvard Medical School. He was previously an Assistant Professor of Psychiatry at Harvard Medical School, as well as the Director of the Molecular Aging & Development Laboratory and Center for Biometals & Metallomics at the Brigham & Women\u2019s Hospital, Boston. Dr. Goldstein joined the Boston University School of Medicine, College of Engineering, Photonics Center, and the BU ADC in December 2007.<\/p>\n

Research Interests<\/h4>\n

Dr. Goldstein\u2019s work is focused on understanding the role of abnormal protein aggregation in chronic degenerative disorders of aging. The work in his laboratory concentrates on Alzheimer\u2019s disease, age-related cataracts, and other common diseases of aging that involve pathogenic protein aggregation. His team recently discovered the first evidence of Alzheimer\u2019s disease-associated amyloid pathology outside the brain as well as a new transcription factor that plays a crucial role in cellular differentiation within the lens and brain. He and his laboratory are developing a laser-based diagnostic technology that will hopefully detect Alzheimer\u2019s disease years before the first symptoms emerge.<\/p>\n

Awards\/Memberships<\/h4>\n

Dr. Goldstein has received honors from numerous organizations, including the Harvard Medical School, National Institute of Mental Health, National Alliance for Research on Schizophrenia and Affective Diseases, Alzheimer\u2019s Association, the American Psychiatric Association, and the Optical Society of America. He is a Diplomate of the American Academy of Neurology and Psychiatry.<\/p>\n

For a full list of publications, click\u00a0<\/span>here<\/a>.<\/strong><\/p>\n

\n

Selected Publications<\/strong><\/p>\n

Soscia SJ, Kirby JE, Tucker SM, Washicosky KJ, Hyman BH, Burton MA,\u00a0<\/span>Goldstein LE<\/strong>, Duong S, Moir RD, Tanzi RE. \u201cThe Alzheimer\u2019s disease amyloid \u00df-peptide is an antimicrobial peptide<\/a>\u201dPLoS One<\/em>\u00a0<\/span>5(3): e9505. (2010)<\/p>\n

Goldstein LE<\/strong>, et al. \u201cMethod diagnosing neurodegenerative disease\u201d US Patent 7,653,428. (2010)<\/p>\n

Goldstein LE<\/strong>, Muffat JA, Cherny RA, Moir RD, Ericsson MH, Huang X, Mavros C, Coccia JA, Faget KY, Fitch KA, Masters CL, Tanzi RE, Chylack LT, Bush AI. \u201cCytosolic \u00df-amyloid deposition & supranuclear cataracts in lenses from people with Alzheimer\u2019s disease<\/a>\u201cLancet<\/em>. 361:1258-65. (2003)<\/p>\n

Moncaster JA, Pineda R, Moir RM, Lu S, Burton M, Ghosh J, Ericsson M, Soscia SS, Mocofanescu A, R. Folkerth R, Robb RM, Clark JI, Tanzi RE, Hunter DG,\u00a0<\/span>Goldstein LE<\/strong>. \u201cAlzheimer\u2019s disease \u00df-amyloid and supranuclear cataracts in lenses from people with Down syndrome\u201d (Pending)<\/p>\n

Pubmed Citations (Goldstein Lee)<\/a><\/p>\n","protected":false},"author":12906,"template":"","_links":{"self":[{"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/profile\/4314"}],"collection":[{"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/profile"}],"about":[{"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/types\/profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/users\/12906"}],"version-history":[{"count":12,"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/profile\/4314\/revisions"}],"predecessor-version":[{"id":7728,"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/profile\/4314\/revisions\/7728"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/media?parent=4314"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}