{"id":6694,"date":"2023-03-07T12:59:12","date_gmt":"2023-03-07T17:59:12","guid":{"rendered":"https:\/\/www.bu.edu\/cte\/?page_id=6694"},"modified":"2026-04-13T11:25:01","modified_gmt":"2026-04-13T15:25:01","slug":"pathology-research","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/cte\/our-research\/pathology-research\/","title":{"rendered":"Pathology Research"},"content":{"rendered":"<p style=\"font-weight: 400;\"><span>The pathological research department at the BU CTE Center, operates the UNITE Brain Bank and BU ADRC Brain Bank, and works closely with the Framingham Heart Study (FHS) Brain Bank and Department of Veterans Affairs Biorepository Brain Bank (VABBB) to study tissue and fluid samples from brain donors. Our neuropathologists examine frozen and fixed tissue for genetic, molecular, and other projects, and to provide UNITE and BU ADRC brain donor families with diagnoses. They work to publicize the findings and maintain the storage of the tissue and samples.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400;\"><strong>UNITE Brain Bank<\/strong><\/p>\n<p style=\"font-weight: 400;\">The UNITE <span>B<\/span><span><\/span><span><\/span>rain Bank is the largest tissue repository in the world focused on traumatic brain injuries (TBI) and chronic traumatic encephalopathy (CTE). The brain bank collects central nervous system tissue samples (brain, spinal cord and eyes) from deceased athletes, military veterans, and others to better understand the long-term effects of repetitive head impacts, TBI and CTE. Ann McKee, MD and her team of neuropathologists, clinicians, and investigators have published more than 175 peer-reviewed papers and studies focused on CTE in highly regarded journals. They\u2019ve also written more than 30 grants to support the daily operations of the brain bank.<\/p>\n<h3>Team<\/h3>\n\n\t<div class=\"profile-listing\">\n\t\t<ul class=\"advanced\">\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/ann-mckee\/\">\n\t\t\t\t\t<figure><img width=\"150\" height=\"134\" src=\"\/cte\/files\/2017\/07\/AMC-headshot-June-2024-336x300.jpeg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Ann McKee<\/p>\n\t\t<p class=\"profile-title\">William Fairfield Warren Distinguished Professor of Neurology and Pathology, Boston University Chobanian &#038; Avedisian School of Medicine<br \/>\r\nDirector, BU Alzheimer&#8217;s Disease Research Center &#038; BU CTE Center<br \/>\r\nChief of Neuropathology, VA Boston Healthcare System<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/jon-cherry\/\">\n\t\t\t\t\t<figure><img width=\"113\" height=\"150\" src=\"\/cte\/files\/2017\/07\/Jon-Cherry.png\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Jon Cherry<\/p>\n\t\t<p class=\"profile-title\">Director, Digital Core, BU ADRC &#038; BU CTE Center<br \/>\r\nResearch Neuropathologist, BU ADRC &#038; BU CTE Center<br \/>\r\nAssistant Professor of Pathology and Laboratory Medicine, Boston University Avedisian &#038; Chobanian School of Medicine<br \/>\r\nResearch Health Scientist, VA Boston Healthcare System<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/thor-stein\/\">\n\t\t\t\t\t<figure><img width=\"107\" height=\"150\" src=\"\/cte\/files\/2017\/07\/Thor-Stein-5x7-1-214x300.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Thor Stein<\/p>\n\t\t<p class=\"profile-title\">Director, Molecular Research, BU CTE Center<br \/>\r\nDirector, Neuropathology Core, BU ADRC<br \/>\r\nAssociate Professor of Pathology and Laboratory Medicine, Boston University Avedisian &#038; Chobanian School of Medicine<br \/>\r\nNeuropathologist, VA Boston Healthcare System<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/victor-alvarez\/\">\n\t\t\t\t\t<figure><img width=\"150\" height=\"150\" src=\"\/cte\/files\/2017\/07\/Victor-Alvarez.jpeg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Victor Alvarez<\/p>\n\t\t<p class=\"profile-title\">Director of Laboratory Operations, BU CTE Center<br \/>\r\nAssistant Professor of Neurology, Boston University Chobanian &#038; Avedisian School of Medicine<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div><!--\/.profile-listing-->\n\n<p>&nbsp;<\/p>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h5 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Meet the UNITE Study Research Faculty<\/h5><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p>\n\t<div class=\"profile-listing\">\n\t\t<ul class=\"basic\">\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/brigid-dwyer\/\">\n\t\t\t\t\t<figure><img width=\"40\" height=\"60\" src=\"\/cte\/files\/2022\/07\/Headshot-low-resolution-copy-199x300.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Brigid Dwyer<\/p>\n\t\t<p class=\"profile-title\">Associate Professor of Neurology at Chobanian &#038; Avedisian SOM<br \/>\r\nInvestigator, Chobanian &#038; Avedisian SOM<br \/>\r\nDirector, Vascular Brain Injury Program, Encompass Health Rehabilitation Hospital of Braintree<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/dan-daneshvar\/\">\n\t\t\t\t\t<figure><img width=\"60\" height=\"60\" src=\"\/cte\/files\/2022\/07\/Dan-Daneshvar.jpeg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Daniel H. Daneshvar<\/p>\n\t\t<p class=\"profile-title\">Chief of Brain Injury Rehabilitation, Department of PM&#038;R, Harvard Medical School<br \/>\r\nVice President of Medical Staff, Spaulding Rehabilitation<br \/>\r\nCo-Director of Sports Concussion, Mass General Brigham<br \/>\r\nAssociate Professor, Harvard Medical School<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/doug-katz\/\">\n\t\t\t\t\t<figure><img width=\"40\" height=\"60\" src=\"\/cte\/files\/2022\/07\/Medium-Douglas-Katz_743_2x3.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Doug Katz<\/p>\n\t\t<p class=\"profile-title\">Professor, Neurology, Boston University Chobanian &#038; Avedisian School of Medicine<br \/>\r\nMedical Director, Brain Injury Program, Encompass Health Braintree Rehabilitation<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/jesse-mez\/\">\n\t\t\t\t\t<figure><img width=\"40\" height=\"60\" src=\"\/cte\/files\/2017\/07\/Jesse-Mez-200x300.png\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Jesse Mez<\/p>\n\t\t<p class=\"profile-title\">Co-Director, Clinical Research, BU CTE Center<br \/>\r\nAssociate Director, BU ADRC<br \/>\r\nAssociate Professor of Neurology, Boston University Chobanian &#038; Avedisian School of Medicine<br \/>\r\nCo-Leader, Framingham Heart Study Brain Aging Program Clinical Core<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/jon-cherry\/\">\n\t\t\t\t\t<figure><img width=\"45\" height=\"60\" src=\"\/cte\/files\/2017\/07\/Jon-Cherry.png\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Jon Cherry<\/p>\n\t\t<p class=\"profile-title\">Director, Digital Core, BU ADRC &#038; BU CTE Center<br \/>\r\nResearch Neuropathologist, BU ADRC &#038; BU CTE Center<br \/>\r\nAssistant Professor of Pathology and Laboratory Medicine, Boston University Avedisian &#038; Chobanian School of Medicine<br \/>\r\nResearch Health Scientist, VA Boston Healthcare System<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/lee-goldstein-md-phd\/\">\n\t\t\t\t\t<figure><img width=\"47\" height=\"60\" src=\"\/cte\/files\/2017\/07\/Screen-Shot-2017-07-19-at-10.47.29-AM-237x300.png\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Lee Goldstein<\/p>\n\t\t<p class=\"profile-title\">Associate Professor of Psychiatry, Neurology, Ophthalmology, Pathology and Laboratory Medicine, Boston University Avedisian &#038; Chobanian School of Medicine<br \/>\r\nBiomedical Engineering and Biomarker Core Co-Leader<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/michael-alosco\/\">\n\t\t\t\t\t<figure><img width=\"43\" height=\"60\" src=\"\/cte\/files\/2017\/07\/Alosco_Michael-5x7-214x300.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Michael Alosco<\/p>\n\t\t<p class=\"profile-title\">Co-Director of Clinical Research, BU CTE Center<br \/>\r\nVice Chair of Research and Professor of Neurology, Boston University Chobanian &#038; Avedisian School of Medicine <br \/>\r\nLeader, Boston University Alzheimer\u2019s Disease Research Center Clinical Core<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/neil-kowall\/\">\n\t\t\t\t\t<figure><img width=\"40\" height=\"60\" src=\"\/cte\/files\/2022\/07\/Neil-Kowall-200x300.jpeg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Neil Kowall<\/p>\n\t\t<p class=\"profile-title\">Director Emeritus of the BU ADRC<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li>\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/nurgul-aytan\/\">\n\t\t\t\t\t\t\t\t\t<p class=\"profile-name\">Nurgul Aytan<\/p>\n\t\t\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/robert-cantu\/\">\n\t\t\t\t\t<figure><img width=\"40\" height=\"60\" src=\"\/cte\/files\/2022\/07\/Robert-Cantu.jpeg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Robert Cantu<\/p>\n\t\t<p class=\"profile-title\">Medical Director and Director of Clinical Research, Dr. Robert C. Cantu Concussion Center<br \/>\r\nChief of Neurosurgery Service and Director of Sports Medicine at Emerson Health <br \/>\r\nClinical Professor of Neurology and Neurosurgery, Clinical Therapeutics Leader AD-CTE Center, Boston University Medical Center<br \/>\r\nFounding Member &#038; Medical Director, Concussion Legacy Foundation<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/robert-stern\/\">\n\t\t\t\t\t<figure><img width=\"41\" height=\"60\" src=\"\/cte\/files\/2017\/07\/Stern-Headshot.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Robert Stern<\/p>\n\t\t<p class=\"profile-title\">Professor of Neurology, Neurosurgery, and Anatomy &#038; Neurobiology, Boston University Chobanian &#038; Avedisian School of Medicine<br \/>\r\nCo-Founder &#038; Director of Clinical Research, Chronic Traumatic Encephalopathy Center<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div><!--\/.profile-listing-->\n<\/p>\n<p><\/div>\n<\/div>\n\n<p>&nbsp;<\/p>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h5 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Post-Docs<\/h5><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p>\n\t<div class=\"profile-listing\">\n\t\t<ul class=\"basic\">\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/jenna-groh\/\">\n\t\t\t\t\t<figure><img width=\"60\" height=\"48\" src=\"\/cte\/files\/2023\/08\/Jenna-Groh.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Jenna R. Groh<\/p>\n\t\t<p class=\"profile-title\">Postdoctoral Associate<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div><!--\/.profile-listing-->\n<\/p>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h5 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Doctoral Students<\/h5><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p>\n\t<div class=\"profile-listing\">\n\t\t<ul class=\"basic\">\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/anna-aaronson\/\">\n\t\t\t\t\t<figure><img width=\"57\" height=\"60\" src=\"\/cte\/files\/2024\/10\/Anna-Aaronson-284x300.png\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Anna Aaronson<\/p>\n\t\t<p class=\"profile-title\">PhD Student<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/kerry-breen\/\">\n\t\t\t\t\t<figure><img width=\"52\" height=\"60\" src=\"\/cte\/files\/2023\/08\/Kerry-Breen.png\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Kerry Breen<\/p>\n\t\t<p class=\"profile-title\">PhD Student<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/samantha-calderazzo\/\">\n\t\t\t\t\t<figure><img width=\"40\" height=\"60\" src=\"\/cte\/files\/2022\/07\/IMG_5867-2_Samantha-Calderazzo-200x300.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Samantha Calderazzo<\/p>\n\t\t<p class=\"profile-title\">MD\/PhD Student<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/annalise-miner\/\">\n\t\t\t\t\t<figure><img width=\"40\" height=\"60\" src=\"\/cte\/files\/2023\/08\/Annalise-Miner-Headshot.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Annalise Miner<\/p>\n\t\t<p class=\"profile-title\">PhD Candidate<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div><!--\/.profile-listing-->\n<\/p>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h5 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Histologists<\/h5><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p>\n\t<div class=\"profile-listing\">\n\t\t<ul class=\"basic\">\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/kerry-cormier\/\">\n\t\t\t\t\t<figure><img width=\"52\" height=\"60\" src=\"\/cte\/files\/2017\/07\/Cormier-headshot-260x300.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Kerry Cormier<\/p>\n\t\t<p class=\"profile-title\">Histologist<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/carol-kubilus\/\">\n\t\t\t\t\t<figure><img width=\"46\" height=\"60\" src=\"\/cte\/files\/2017\/07\/CAROL-KUBILUS-230x300.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Carol Kubilus<\/p>\n\t\t<p class=\"profile-title\">Histologist<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/rebecca-mathias\/\">\n\t\t\t\t\t<figure><img width=\"45\" height=\"60\" src=\"\/cte\/files\/2017\/07\/Rebecca-Mathias-HT-ASCP.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Rebecca Mathias<\/p>\n\t\t<p class=\"profile-title\">Senior Neuropathology Technician<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div><!--\/.profile-listing-->\n<\/p>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h5 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Brain Processing Staff<\/h5><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p>\n\t<div class=\"profile-listing\">\n\t\t<ul class=\"basic\">\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/ray-nicks\/\">\n\t\t\t\t\t<figure><img width=\"46\" height=\"60\" src=\"\/cte\/files\/2017\/07\/Ray-Nicks-228x300.jpeg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Ray Nicks<\/p>\n\t\t<p class=\"profile-title\">Senior Neuropathology Research Fellow<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li>\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/petra-ypsilantis\/\">\n\t\t\t\t\t\t\t\t\t<p class=\"profile-name\">Petra Ypsilantis<\/p>\n\t\t\t<\/a>\n<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div><!--\/.profile-listing-->\n<\/p>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h5 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Research Assistants & Administrative Staff<\/h5><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p>\n\t<div class=\"profile-listing\">\n\t\t<ul class=\"basic\">\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/bobby-abdolmohammadi\/\">\n\t\t\t\t\t<figure><img width=\"60\" height=\"60\" src=\"\/cte\/files\/2022\/07\/thumbnail-300x300.jpeg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Bobby Abdolmohammadi<\/p>\n\t\t<p class=\"profile-title\">Research Data Analyst III<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/amanda-cabral\/\">\n\t\t\t\t\t<figure><img width=\"40\" height=\"60\" src=\"\/cte\/files\/2022\/07\/Amanda-Cabral-200x300.jpeg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Amanda Cabral<\/p>\n\t\t<p class=\"profile-title\">Social Media and Digital Marketing Specialist<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/kelsey-goostrey\/\">\n\t\t\t\t\t<figure><img width=\"43\" height=\"60\" src=\"\/cte\/files\/2023\/07\/Kelsey-Goostrey-5x7-1.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Kelsey Goostrey<\/p>\n\t\t<p class=\"profile-title\">Research Program Manager<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/rachael-layden\/\">\n\t\t\t\t\t<figure><img width=\"48\" height=\"60\" src=\"\/cte\/files\/2023\/08\/Rachael-Layden.png\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Rachael Layden<\/p>\n\t\t<p class=\"profile-title\">Research Assistant<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/lisa-mchale\/\">\n\t\t\t\t\t<figure><img width=\"60\" height=\"60\" src=\"\/cte\/files\/2018\/01\/Lisa-McHale.png\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Lisa McHale<\/p>\n\t\t<p class=\"profile-title\">Director of Legacy Family Relations<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/kelly-mclean\/\">\n\t\t\t\t\t<figure><img width=\"51\" height=\"60\" src=\"\/cte\/files\/2021\/03\/Kelly-McLean-Photo-255x300.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Kelly McLean<\/p>\n\t\t<p class=\"profile-title\">Senior Research Program Manager<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bu.edu\/cte\/profile\/sophia-nosek\/\">\n\t\t\t\t\t<figure><img width=\"43\" height=\"60\" src=\"\/cte\/files\/2023\/07\/Sophia-Nosek_Headshot-214x300.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Sophia Nosek<\/p>\n\t\t<p class=\"profile-title\">Research Program Manager<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div><!--\/.profile-listing-->\n<\/p>\n<p><\/div>\n<\/div>\n\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400;\"><strong>Pathology Images<\/strong><\/p>\n<p style=\"font-weight: 400;\">Source: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34876229\/\">Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE<\/a><\/p>\n<p style=\"font-weight: 400;\"><strong><u><img loading=\"lazy\" src=\"\/cte\/files\/2022\/11\/Alosco-2021-Structural-MRI-Figure-4-425x300.jpeg\" alt=\"\" width=\"425\" height=\"300\" class=\"alignnone size-medium wp-image-6344\" srcset=\"https:\/\/www.bu.edu\/cte\/files\/2022\/11\/Alosco-2021-Structural-MRI-Figure-4-425x300.jpeg 425w, https:\/\/www.bu.edu\/cte\/files\/2022\/11\/Alosco-2021-Structural-MRI-Figure-4.jpeg 708w\" sizes=\"(max-width: 425px) 100vw, 425px\" \/><\/u><\/strong><\/p>\n<p style=\"font-weight: 400;\"><strong>Figure 4.<\/strong><strong> MRI and autopsy patterns of atrophy and P-tau deposition in a brain donor with CTE<\/strong><\/p>\n<p style=\"font-weight: 400;\">The figure shows an antemortem axial (A) and coronal (D) T1 MRI sequence and corresponding gross atrophy at autopsy (B, C, E) of a male former professional American football player with CTE stage IV. The antemortem MRI scan was done when he was in his early 60\u2019s and he died in his mid-70s and donated his brain. The antemortem MRI and neuropathological examination both showed frontal and temporal cortical atrophy (A\u2013E) along with atrophy of medial temporal lobe structures (C, E) including the hippocampus and amygdala.<\/p>\n<p style=\"font-weight: 400;\">Source: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34819338\/\">Association Between Antemortem FLAIR White Matter Hyperintensities and Neuropathology in Brain Donors Exposed to Repetitive Head Impacts<\/a><\/p>\n<p style=\"font-weight: 400;\"><img loading=\"lazy\" src=\"\/cte\/files\/2023\/04\/NEUROLOGY2021171323f1-650x188.jpeg\" alt=\"\" width=\"650\" height=\"188\" class=\"alignnone size-medium wp-image-6883\" srcset=\"https:\/\/www.bu.edu\/cte\/files\/2023\/04\/NEUROLOGY2021171323f1-650x188.jpeg 650w, https:\/\/www.bu.edu\/cte\/files\/2023\/04\/NEUROLOGY2021171323f1.jpeg 680w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p style=\"font-weight: 400;\"><strong>Figure 1. Example of FLAIR and Lesion Segmentation From the Lesion Prediction Algorithm of the Lesion Segmentation Toolbox\u00a0<\/strong><\/p>\n<p style=\"font-weight: 400;\">Fluid-attenuated inversion recovery (FLAIR) scan of a mid-70-year-old former professional American football player with autopsy-confirmed stage III\/IV chronic traumatic encephalopathy. White matter hyperintensities were quantified using log-transformed values for the total lesion volume, calculated using the lesion prediction algorithm (LPA) from the Lesion Segmentation Toolbox. The LPA segments lesions in new images by providing an estimate for the lesion probability for each voxel. Total lesion volume in milliliters is extracted by thresholding derived lesion probability maps at a threshold kappa of 0.5 (default LPA recommendation) and only lesions with volume &gt;0.015 mL are counted. The top row (A) contains the native FLAIR sequence and the bottom row (B) contains the corresponding lesion belief maps overlaid on the FLAIR with lesion threshold at 0.5 using Slicer.<\/p>\n<p style=\"font-weight: 400;\">Source: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20720505\/\">TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy<\/a><strong><span>\u00a0<\/span><\/strong><\/p>\n<p><img loading=\"lazy\" src=\"\/cte\/files\/2023\/04\/Picture1-255x300.jpg\" alt=\"\" width=\"255\" height=\"300\" class=\"alignnone size-medium wp-image-6884\" srcset=\"https:\/\/www.bu.edu\/cte\/files\/2023\/04\/Picture1-255x300.jpg 255w, https:\/\/www.bu.edu\/cte\/files\/2023\/04\/Picture1.jpg 275w\" sizes=\"(max-width: 255px) 100vw, 255px\" \/><\/p>\n<p style=\"font-weight: 400;\"><strong>FIGURE 2\u00a0<\/strong><\/p>\n<p style=\"font-weight: 400;\">Spinal cord pathology in chronic traumatic encephalopathy (CTE) with TAR DNA-binding protein of approximately 43 kd (TDP-43) proteinopathy, tauopathy, and motor neuron disease (CTE + MND).\u00a0<strong>(A, B)<\/strong>\u00a0Whole-mount 50-\u03bcm sections of lumbar and thoracic spinal cord immunostained with antibody AT8 showing abundant tau immunostaining in the ventral horns.\u00a0<strong>(C)<\/strong>\u00a0Tau-positive astrocytic tangles in the ventral horn of Case 1 (AT8 immunostain, original magnification: 100\u00d7).\u00a0<strong>(D)<\/strong>\u00a0Whole-mount 10-\u03bcm section through high thoracic spinal cord showing marked myelin and axonal loss in the lateral and ventral corticospinal tracts. Atrophic ventral roots are not visible. Luxol fast blue hematoxylin and eosin stain, original magnification: 1\u00d7.\u00a0<strong>(E)<\/strong>\u00a0Whole-mount 50-\u03bcm section of high thoracic cord showing intense immunoreactivity for activated microglia and macrophages in lateral and corticospinal tracts (LN-3 immunostain, original magnification: 1\u00d7).\u00a0<strong>(F)<\/strong>\u00a0Tau-positive neurofibrillary tangles in ventral horn of Case 3, AT8 immunostain, original magnification: 600\u00d7.\u00a0<strong>(G)<\/strong>\u00a0TDP-43 immunoreactivity in ventral horn, original magnification: 50\u00d7.\u00a0<strong>(H)<\/strong>\u00a0TDP-43 immunoreactive filamentous neuronal inclusions (FNIs), ring-shaped glial inclusions (RGIs), and ring-shaped neurites (RNs) in the ventral horns of the lumbar spinal cord in Case 3, original magnification: 200\u00d7.\u00a0<strong>(I)<\/strong>\u00a0Tau-positive astrocytes and their processes surrounding degenerating anterior horn cells in the thoracic spinal cord (AT8 immunostain, original magnification: 350\u00d7).\u00a0<strong>(J)<\/strong>\u00a0TDP-43\u2013positive FNIs, RGIs, and RNs in the ventral horns of the lumbar spinal cord in Case 2, original magnification: 200\u00d7.\u00a0<strong>(K)<\/strong>\u00a0TDP-43\u2013positive FNI in the anterior horn, original magnification: 400\u00d7.<strong>(L)<\/strong>\u00a0Double immunostained sections show tau-positive astrocytes (brown) and their processes surrounding anterior horn neurons containing TDP-43\u2013positive filamentous inclusions (red), PHF-1 and TDP-43 immunostains, original magnification: 400\u00d7.\u00a0<strong>(M)<\/strong>\u00a0TDP-43\u2013positive FNIs, RGIs, and RNs in the lumbar ventral horns in Case 1, original magnification: 200\u00d7.\u00a0<strong>(N)<\/strong>\u00a0TDP-43\u2013positive FNIs in the anterior horn, original magnification: 400\u00d7.\u00a0<strong>(O)<\/strong>\u00a0Double immunostained sections showing tau-positive astrocytes (brown) and their processes surrounding anterior horn neurons containing TDP-43\u2013positive FNIs (red), PHF-1 and TDP-43 immunostains, original magnification: 600\u00d7.<\/p>\n<p style=\"font-weight: 400;\"><em>To request access to biological samples from the UNITE Brain Bank, please review our <a href=\"https:\/\/www.bu.edu\/cte\/our-research\/data-requests\/\">data request process<\/a>. <\/em><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The pathological research department at the BU CTE Center, operates the UNITE Brain Bank and BU ADRC Brain Bank, and works closely with the Framingham Heart Study (FHS) Brain Bank and Department of Veterans Affairs Biorepository Brain Bank (VABBB) to study tissue and fluid samples from brain donors. Our neuropathologists examine frozen and fixed tissue [&hellip;]<\/p>\n","protected":false},"author":21100,"featured_media":0,"parent":12,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/pages\/6694"}],"collection":[{"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/users\/21100"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/comments?post=6694"}],"version-history":[{"count":20,"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/pages\/6694\/revisions"}],"predecessor-version":[{"id":10184,"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/pages\/6694\/revisions\/10184"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/pages\/12"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/cte\/wp-json\/wp\/v2\/media?parent=6694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}