![\"\"](\"\/cte\/files\/2025\/11\/DIAGNOSE-CTE-Football-Flyer_UPDATED-11.18.25--232x300.png\")
<\/h3>\nDIAGNOSE CTE-II (DxCTE-II) is a follow-up to The DIAGNOSE CTE Research Project conducted from 2015-2023. The goal of DxCTE-II is to continue towards a scientific breakthrough by finding methods of diagnosing CTE during life. The study will also increase our understanding of why some people do or do not get CTE.<\/p>\n
Participation includes <\/span>a <\/span>two-day, in-person visit for a physical, neurological exam, thinking, memory & mood testing, blood draw, and brain imaging at one of five study sites. <\/span>Participants may receive up to $400 compensation and travel expenses may be covered.<\/p>\n <\/p>\n CURRENTLY ENROLLING: For more information, please contact diagnose@bu.edu<\/a><\/span> or visit diagnosecte.org<\/a>.<\/span><\/p>\n Participation includes a brain donation pledge, one-time online survey completion*, and a blood draw at your local Quest Diagnostics. After completion of all three components, participants will receive a $100 gift card.\u00a0<\/span>\u00a0<\/span><\/p>\n CURRENTLY ENROLLING:\u00a0<\/b> * If you have completed the HITSS survey and are interested in participating, please contact the study team\u00a0\u00a0<\/em><\/p>\n \u00a0<\/span>For more information, please contact <\/span>bankcte<\/span>@bu.edu<\/span><\/a> or visit <\/span>www.bankcte.org<\/span><\/a>\u00a0<\/span><\/p>\n\n\t Keaden Morisaki<\/p>\n\t\t Research Assistant, BANK CTE<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div>\n\n We are recruiting participants with a history of contact sports to help us understand how repetitive head impacts affect a person\u2019s risk of developing later-life neurologic disorders.<\/p>\n CURRENTLY ENROLLING:<\/strong> Contact sport athletes \u2013 both men & women<\/em><\/p>\n To participate, please contact Rachael Layden at rlayden@bu.edu<\/a><\/p>\n <\/p>\n\n\t Rachael Layden<\/p>\n\t\t Research Assistant<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div>\n\n The primary goal of this research is to create methods of diagnosing CTE during life so that interventions can be developed to help those affected by this disease. CTE is a progressive degenerative brain disease linked to repetitive hits to the head, like those endured in football and other contact sports. Currently, CTE can only be diagnosed after death. This study hopes to address this knowledge gap. This research study is not designed to provide diagnosis or treatment to participants. You will earn $200 for your participation.<\/p>\n<\/div>\n Participation will include two Positron Emission Tomography (PET) scans, an ADRC evaluation (neurological exam, cognitive exam, self-report mood and behavior exam), advanced magnetic resonance imaging (MRI) scans, and a blood sample.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n CURRENTLY ENROLLING:<\/strong> Former American football players between the ages of 50 and 70 with at least 11 years of American football play, including 2 years of college<\/em><\/p>\n For more information or to enroll, please c<\/span>ontact Racheal Layden at rlayden@bu.edu<\/a><\/span><\/p>\n\n\t Rachael Layden<\/p>\n\t\t Research Assistant<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div>\n\n\n\n The Head Impact & Trauma Surveillance Study (HITSS) was developed\u00a0<\/span>to answer questions about risks of developing later life brain health issues from repetitive head impacts in contact sports. The study is funded by the National Institutes of Health (NIH).\u00a0<\/span>Participation\u00a0<\/span>is a fully-online survey that includes questionnaires on sports participation, medical history and behavior and mood, and brain games. It only takes approximately two hours to complete, and can be completed at any time and over several days, if desired. Participants are then asked to take a follow up assessment online one year later.<\/span><\/p>\n CURRENTLY ENROLLING:<\/strong> Anyone aged 40 or older who played soccer or tackle football at any level \u2013 youth, high school, college or pro\/elite<\/em><\/p>\n To learn more or to participate visit\u00a0www.HITSS.org<\/a>. <\/span>Contact HITSS at HITSS@BU.edu<\/a> or (617) 358-6864 or contact Matt Roebuck at mroebuck@bu.edu<\/a>\u00a0with any questions.<\/span><\/p>\n\n\t Matt Roebuck<\/p>\n\t\t Recruitment Coordinator<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div>\n\n <\/p>\n The Laboratory for Science and Health in Artistic Performance at The Ohio University and the Boston University CTE Center are working with stunt performer communities to undertake an important, groundbreaking research project.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n Stunt performers are crucial to the success of motion picture and television productions. <\/span>They are regarded as professional athletes in their field<\/span>; thus, for their long-term health and wellness, stunt performers should receive the same type of attention, healthcare, and research that sports athletes receive. <\/span>We strongly suspect that stunt performers also may suffer from CTE <\/span>because of the head trauma, whiplash actions, and body impacts that occur throughout their careers. <\/span><\/p>\n As a research group, we are firmly committed to advocating for stunt performers\u2019 well-being. <\/span>This is why we want to explore the possibility of CTE in the stunt performing community. Participating in this research provides <\/span>an opportunity for current performers to play an important role <\/span>in the reduction of risk and treatment of head injuries for future stunt performing generations.<\/span><\/p>\n How you can help: 1) <\/span>Consider donating your brain <\/span>to this research upon your passing, and 2) <\/span>Inform your family <\/span>about your wishes<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n CURRENTLY ENROLLING:<\/strong> Stunt performers<\/em><\/p>\n For more information or to enroll, please c<\/span>ontact Sophia Nosek at snosek@bu.edu<\/a>.<\/span><\/p>\n\n\t Sophia Nosek<\/p>\n\t\t Research Program Manager<\/p>\t<\/a>\n<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div>\n\n\n\n S.A.V.E. stands for Study of Axonal and Vascular Effects from repetitive head impacts. The major goal of this study is to determine how repeated head impacts from playing contact sports can lead to long-term thinking, memory, and mood problems. The results of this study could inform on strategies to treat and prevent symptoms associated with head impacts from contact sports. Participation includes: a\u00a01-2 day study visit at either Boston University or the University of California, San Francisco<\/i>. <\/span>Each visit will consist of an advanced MRI of the brain; neurological, cognitive, self-report mood and behavior exams; blood samples; and an optional lumbar puncture. <\/span>Participants will return annually.\u00a0<\/span><\/p>\n CURRENTLY ENROLLING:<\/strong><\/em> Men and women age 50 or older who played 5+ years of a contact sport, including American football, ice hockey, soccer, lacrosse, boxing, full contact martial arts, rugby, and wrestling<\/em><\/p>\n To participate in Boston,<\/strong> please call (617) 358-6545 or email joinhope@bu.edu<\/a>.<\/p>\n To participate in San Francisco<\/strong>, please email Karen Smith at karen.smith@ucsf.edu<\/a>.\u00a0<\/span><\/p>\n The major goal of this research project is to develop methods of diagnosing CTE during life, so that interventions can be developed to help those affected by this disease. This research study is not designed to provide a diagnosis or treatment to participants. Participation will include study visits at one of the two study sites for the FIND-CTE evaluation which includes two positron emission tomography (PET) scans; as well as an Alzheimer\u2019s Disease Research Center evaluation including neurological, cognitive, self-report mood and behavior exams; advanced magnetic resonance imaging (MRI) scans; and a collection of blood samples.\u00a0<\/span><\/p>\n ENROLLMENT PERIOD HAS ENDED<\/em>.<\/strong><\/p>\n <\/strong>This new project entitled Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation (DIAGNOSE) of Chronic Traumatic Encephalopathy (CTE) is looking to develop diagnostic criteria for CTE. Dr. Stern is the contact PI (other PI\u2019s are J. Cummings, E. Reiman, and M. Shenton) of this $16 million, multi-center, multi-disciplinary, 7-year grant to further his initial work on the development of in vivo biomarkers for CTE and clinical diagnostic criteria. This study is funded by the NIH\/NINDS and began recruitment in Spring 2016. Former NFL players, former college football players, and \u201ccontrol\u201d participants between the ages of 45 and 74 were recruited for examinations held at one of four locations (Boston, New York, Las Vegas, Scottsdale\/Phoenix).<\/p>\n Read some of our published results from the DIAGNOSE CTE Research Project here: <\/span><\/p>\n https:\/\/pubmed.ncbi.nlm.nih.gov\/34384490\/<\/a><\/p>\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9808953\/<\/a><\/p>\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9816291\/<\/a><\/p>\n ENROLLMENT PERIOD HAS ENDED.<\/strong><\/em><\/p>\n Visit the DIAGNOSE CTE Research Project website<\/a>\u00a0to learn more. Please contact Rachael Layden at rlayden@bu.edu<\/a>\u00a0for further questions.<\/p>\n The study focuses on examining the effects of repetitive head impacts (like one may receive playing some organized sports) in living people. Participants completed online questionnaires and talked with a member of our study staff once a year over the phone to gather information on concussions, athletic history, medical history, and cognitive functioning. Some participants also chose to provide a saliva sample for genetic analysis. The goal is to track our participants\u2019 progress over time, so we can see who develops problems down the road and who does not. <\/span><\/p>\n Read some of our published results from the LEGEND Study here: <\/span><\/p>\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5639242\/<\/a><\/p>\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4019619\/<\/a><\/p>\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3713446\/<\/a><\/p>\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5220530\/<\/a><\/p>\n ENROLLMENT PERIOD HAS ENDED.<\/em><\/strong><\/p>\n Learn More here<\/a>. Please contact Rachael Layden at rlayden@bu.edu<\/a>\u00a0for further questions.<\/p>\n This study is the first research project on CTE ever funded by the National Institutes of Health (NIH), with support from the National Institute of Neurologic Diseases and Stroke (NINDS), the National Institute on Aging (NIA), and the National Institute of Child Health and Human Development (NICHD). The ultimate goal of this study is to develop methods of diagnosing CTE during life through the use of a variety of tests, including MRI scans (such as diffusion tensor imaging), MRS scans (also known as a \u201cvirtual biopsy\u201d), blood tests, and measures of proteins in spinal fluid. Participants also had neurological, psychiatric, and cognitive assessments, as well as genetic testing. <\/span><\/p>\n Read some of our published results from the DETECT Study here:<\/span><\/p>\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6131058\/<\/a><\/p>\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5312499\/<\/a><\/p>\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8926024\/<\/a><\/p>\n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8633029\/<\/a><\/p>\n
\n<\/b><\/em>Men age 50 or older who:<\/em>
\n– Played 4 or more seasons of professional football, with minimum of 12 seasons of organized tackle football overall OR
\n– Played 3 or more seasons of college football with minimum of 6 seasons of organized tackle football and did not play professionally OR
\n– Have not played contact\/collision sports, have no other sources of repetitive head impacts, and have no symptoms
\n<\/em><\/p>\n
\nBlood Analysis with Neuropathological Knowledge of CTE (BANK CTE)<\/span><\/b>\u00a0<\/span><\/h3>\n
![\"\"](\"\/cte\/files\/2024\/10\/NEW-BANK-CTE-Poster-232x300.png\")
Currently, CTE can only be diagnosed after death. The BANK CTE study will combine the three essential components of our current research: brain donation, clinical data, and blood biomarkers to work towards a significant scientific breakthrough by discovering a way to diagnose CTE during a person\u2019s lifetime. <\/span>\u00a0<\/span><\/p>\n
\n<\/em>– Men & women aged 40 & older who have played 5+ years of contact sports including 2+ years of high school level or higher\u00a0<\/span>
\n<\/span>– OR served in the military<\/span>
\n<\/span>– OR did NOT play 5+ years of a contact sport<\/span><\/p>\n\n\t\t\n\t\t\t\t\t\t\t\n
![\"\"](\"\/cte\/files\/2025\/07\/Headshot_Keaden-Morisaki.jpeg\")
<\/figure>\t\t\t\t
\nHealth Outreach Program for the Elderly (HOPE) Program Extension<\/strong><\/h3>\n
![\"\"](\"\/cte\/files\/2023\/08\/8.30.23-HOPE-Study-Graphic-358x300.png\")
<\/p>\n\n\t\t\n\t\t\t\t\t\t\t\n
![\"\"](\"\/cte\/files\/2023\/08\/Rachael-Layden.png\")
<\/figure>\t\t\t\t
\nTau Agent for the NeurodeGenerative Lesion of CTE (T.A.N.G.L.E.)<\/strong><\/h3>\n
![\"\"](\"\/cte\/files\/2023\/02\/TANGLE-flyer-2.6.2023-232x300.png\")
<\/p>\n\n\n\n\n\n\n\n\t\t\n\t\t\t\t\t\t\t\n
<\/figure>\t\t\t\t
\nHead Impact & Trauma Surveillance Study (HITSS)<\/strong><\/h3>\n
![\"\"](\"\/cte\/files\/2023\/02\/HITSS-Official-Flyer-232x300.jpeg\")
<\/p>\n\n\t\t\n\t\t\t\t\t\t\t\n
\nStunt Performance Research Neurological Trauma (SPRINT) Study<\/strong><\/h3>\n
![\"\"](\"\/cte\/files\/2024\/08\/SPRINT-Flyer-August-2024-232x300.png\")
<\/p>\n\n\n\n\n\n\n\n\n\n\n\t\t\n\t\t\t\t\t\t\t\n
![\"\"](\"\/cte\/files\/2023\/07\/Sophia-Nosek_Headshot-214x300.jpg\")
<\/figure>\t\t\t\t
\nProject S.A.V.E.<\/strong><\/h3>\n
![\"\"](\"\/cte\/files\/2023\/02\/SAVE-Flyer-233x300.png\")
<\/p>\n
\nFocused Imaging for the Neurodegenerative Disease Chronic Traumatic Encephalopathy (FIND-CTE)<\/strong><\/h3>\n
![\"\"](\"\/cte\/files\/2023\/02\/FIND-CTE-Flyer-232x300.png\")
<\/p>\n
\nDIAGNOSE CTE Research Project<\/strong><\/h3>\n
\n
\nLEGEND (Longitudinal Examination to Gather Evidence of Neurodegenerative Disease) Study<\/strong><\/h3>\n
\nDETECT (Diagnosing and Evaluating Traumatic Encephalopathy Using Clinical Tests) Study<\/strong><\/h3>\n
![\"\"](\"\/cte\/files\/2022\/06\/Sponsors-650x207.png\")
<\/p>\n