{"id":12949,"date":"2017-04-07T16:52:01","date_gmt":"2017-04-07T20:52:01","guid":{"rendered":"http:\/\/www.bu.edu\/csmet\/?post_type=profile&#038;p=12949"},"modified":"2019-08-12T13:57:04","modified_gmt":"2019-08-12T17:57:04","slug":"jonathan-s-duke-cohan","status":"publish","type":"profile","link":"https:\/\/www.bu.edu\/csmet\/profile\/jonathan-s-duke-cohan\/","title":{"rendered":"Jonathan S. Duke-Cohan"},"content":{"rendered":"<p>Dr. Duke-Cohan is a molecular and cellular biologist\/immunologist with a strong background in scientific computing \u2013 beginning in 1976 with programming in Fortran IV using IBM punched card decks on a DEC PDP-11 (!). Following an initial double major degree in Biochemistry\/Physiology and a PhD in Experimental Hematology from the University of London (UK), he undertook postdoctoral and junior faculty positions in Canada and Israel before coming to work at the Dana-Farber Cancer Institute in Boston in 1989, where he remains today, holding the position of Principal Research Scientist in addition to a Faculty position as Principal Associate in Medicine at Harvard Medical School. His research investigating the development, function and pathology of the immune system has been published in high profile scientific journals including Nature, Nature Genetics, Science, Science Signaling and Proceedings of the National Academies of Science (USA).<\/p>\n<p>He received a postgraduate certificate in Software Engineering from Harvard University (with a focus on C++ programming and logical analysis), he has served as reviewer and editor for several journals (currently Frontiers in Bioscience), and he has an ongoing position as Visiting Professor in the 1st Faculty of Medicine at the Charles University in Prague, Czech Republic, where he contributes to a Postgraduate course in the molecular mechanisms of etiology and the pathogenesis and therapy of diseases. Since 2012, he has been teaching in the Department of Computer Science at BU Metropolitan College.<\/p>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Courses<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<ul>\n<li><a href=\"https:\/\/www.bu.edu\/csmet\/cs570\/\">CS570 Biomedical Sciences and Health IT<\/a><\/li>\n<\/ul>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Research Interests<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\">\n<ul>\n<li><span>Molecular and cellular insights into diagnosis and therapy of autoimmune disease, infectious diseases and cancer.<\/span><\/li>\n<li><span>Summary at: <a href=\"http:\/\/www.dfhcc.harvard.edu\/insider\/member-detail\/member\/jonathan-s-duke-cohan-phd\/\">http:\/\/www.dfhcc.harvard.edu\/insider\/member-detail\/member\/jonathan-s-duke-cohan-phd\/<\/a><\/span><\/li>\n<li><span>Biomedical informatics<\/span><span> <\/div>\n<\/div>\n<\/span><\/li>\n<\/ul>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Scholarly Works<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\">\n<p>Recent works include:<\/p>\n<p>Mallis RJ, Brazin KN, Duke-Cohan JS, Hwang W, Wang JH, Wagner G, Arthanari H, Lang MJ, Reinherz EL, \u201cNMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology,\u201d J Biomol NMR. (February 2019). doi: 10.1007\/s10858-019-00234-8. [Epub ahead of print]<\/p>\n<p>Barrett RDH, Laurent S, Mallarino R, Pfeifer SP, Xu CCY, Foll M, Wakamatsu K, Duke-Cohan JS, Jensen JD, Hoekstra HE, \u201cLinking a mutation to survival in wild mice,\u201d Science 363 no.6426 (February 2019):499-504. doi: 10.1126\/science.aav3824.<\/p>\n<p>Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL, \u201cThe T Cell Antigen Receptor \u03b1 Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations,\u201d Immunity 49 no.5 (November 2018): 829-841.e6, doi: 10.1016\/j.immuni.2018.09.007.<\/p>\n<p>Duke-Cohan JS, Ishikawa Y, Yoshizawa A, Choi YI, Lee CN, Acuto O, Kissler S, Reinherz EL, \u201cRegulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity,\u201d Science Signaling 11 no. 534 (June 2018) pii: eaan8799. doi: 10.1126\/scisignal.aan8799.<\/p>\n<p><span><\/div>\n<\/div>\n<\/span><\/p>\n","protected":false},"author":13337,"template":"","_links":{"self":[{"href":"https:\/\/www.bu.edu\/csmet\/wp-json\/wp\/v2\/profile\/12949"}],"collection":[{"href":"https:\/\/www.bu.edu\/csmet\/wp-json\/wp\/v2\/profile"}],"about":[{"href":"https:\/\/www.bu.edu\/csmet\/wp-json\/wp\/v2\/types\/profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/csmet\/wp-json\/wp\/v2\/users\/13337"}],"version-history":[{"count":9,"href":"https:\/\/www.bu.edu\/csmet\/wp-json\/wp\/v2\/profile\/12949\/revisions"}],"predecessor-version":[{"id":22304,"href":"https:\/\/www.bu.edu\/csmet\/wp-json\/wp\/v2\/profile\/12949\/revisions\/22304"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/csmet\/wp-json\/wp\/v2\/media?parent=12949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}