Computers, robots, and wearable technologies are gaining the ability to sense, recognize, and respond intelligently to human emotion. This talk will highlight several important findings made at MIT, including surprises about the "true smile of happiness," new ways cameras (and your smartphone, even in your handbag) can compute your bio-signals without using any new sensors, and finding electrical signals on the wrist that reveal insight into deep brain activity, with implications for autism, anxiety, epilepsy, and more. What is the grand challenge we aim to solve next?