{"id":22,"date":"2016-02-19T16:09:06","date_gmt":"2016-02-19T21:09:06","guid":{"rendered":"https:\/\/www.bu.edu\/cmd\/?page_id=22"},"modified":"2023-12-18T16:31:56","modified_gmt":"2023-12-18T21:31:56","slug":"compound-libraries","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/cmd\/about-the-bu-cmd\/compound-libraries\/","title":{"rendered":"Our Compound Collection"},"content":{"rendered":"<p><a href=\"\/cmd\/files\/2021\/02\/vials.png\"><img loading=\"lazy\" src=\"\/cmd\/files\/2021\/02\/vials.png\" alt=\"\" width=\"522\" height=\"385\" class=\"alignnone size-full wp-image-1945\" \/><\/a><\/p>\n<h1><strong class=\"redtitle\"><span size=\"2\" style=\"font-size: small;\">BU-CMD SCREENING COLLECTION<\/span><\/strong><span><\/span><\/h1>\n<p>The BU-CMD inherited the CMLD-BU small molecule screening collection: an ever-growing set of structurally diverse compounds originally assembled during the 12-year span of the NIGMS CMLD Center Initiative. The collection also contains\u00a0more than 1,000 compounds obtained via \u201cDiversity Collections\u201d of synthetic targets and intermediates generated by our external colleagues.<\/p>\n<p><strong class=\"redtitle\">OUR APPROACH<\/strong><\/p>\n<p>Our center strives to create novel chemotypes that uniquely probe three-dimensional space by employing stereochemical and positional variation within the molecular framework as diversity elements in library design. Design of stereocontrolled chemical libraries at the CMLD-BU (and now the BU-CMD) is guided by several core strategies, including:<\/p>\n<ul>\n<li>Efficient, stereoselective generation of diverse scaffolds via rearrangements, annulations and cycloadditions<\/li>\n<li>Discovery of novel transformations and chemotypes using reaction screening<\/li>\n<li>Development of photochemical and microfluidic technologies for reaction discovery, methodology development and library synthesis<\/li>\n<li>Convergent synthesis of complex molecules through domain shuffling<\/li>\n<li>The use of stereochemically-well defined building blocks to generate novel scaffolds with positional and stereochemical diversity<\/li>\n<\/ul>\n<p><strong class=\"redtitle\">COLLECTION ANALYSIS<\/strong><\/p>\n<p>Click the following link to download a PDF of our 2012 Chemotype Summary, containing representative structures of chemotypes found in our screening collection with physical property analyses and pertinent literature references: [<a href=\"\/cmd\/files\/2016\/02\/CMLDchemotypes_Oct2012.pdf\" title=\"Chemotype Summary\" target=\"_blank\" rel=\"noopener noreferrer\">CMLDchemotypes_Oct2012<\/a>]<\/p>\n<p><strong class=\"redtitle\">SUBMISSION<\/strong><\/p>\n<p>If you are a synthetic organic chemist\u00a0and wish to contribute compounds to the BU-CMD screening collection, visit our <a href=\"https:\/\/www.bu.edu\/cmd\/contact-us\/submit\/\" title=\"Chemistry Outreach\" target=\"_blank\" rel=\"noopener noreferrer\">Diversity Collection<\/a> page for more information.<\/p>\n<p><strong class=\"redtitle\">SCREENING<\/strong><\/p>\n<p>If you are interested in obtaining a copy of our screening collection, please fill out our <a href=\"https:\/\/www.bu.edu\/cmd\/contact-us\/screen\/\">Questionnaire<\/a>\u00a0for more information. <a href=\"https:\/\/mlsmr.evotec.com\/MLSMR_HomePage\/\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>BU-CMD SCREENING COLLECTION The BU-CMD inherited the CMLD-BU small molecule screening collection: an ever-growing set of structurally diverse compounds originally assembled during the 12-year span of the NIGMS CMLD Center Initiative. The collection also contains\u00a0more than 1,000 compounds obtained via \u201cDiversity Collections\u201d of synthetic targets and intermediates generated by our external colleagues. OUR APPROACH Our [&hellip;]<\/p>\n","protected":false},"author":11615,"featured_media":0,"parent":1247,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/cmd\/wp-json\/wp\/v2\/pages\/22"}],"collection":[{"href":"https:\/\/www.bu.edu\/cmd\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/cmd\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cmd\/wp-json\/wp\/v2\/users\/11615"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cmd\/wp-json\/wp\/v2\/comments?post=22"}],"version-history":[{"count":12,"href":"https:\/\/www.bu.edu\/cmd\/wp-json\/wp\/v2\/pages\/22\/revisions"}],"predecessor-version":[{"id":2186,"href":"https:\/\/www.bu.edu\/cmd\/wp-json\/wp\/v2\/pages\/22\/revisions\/2186"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cmd\/wp-json\/wp\/v2\/pages\/1247"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/cmd\/wp-json\/wp\/v2\/media?parent=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}