{"id":9271,"date":"2011-08-03T12:32:37","date_gmt":"2011-08-03T16:32:37","guid":{"rendered":"https:\/\/www.bu.edu\/chemistry\/?p=9271"},"modified":"2011-08-03T12:32:37","modified_gmt":"2011-08-03T16:32:37","slug":"drug-mechanism-of-action-using-bioinformatic-pathway-analysis","status":"publish","type":"post","link":"https:\/\/www.bu.edu\/chemistry\/2011\/08\/03\/drug-mechanism-of-action-using-bioinformatic-pathway-analysis\/","title":{"rendered":"Drug Mechanism of Action Using Bioinformatic Pathway Analysis"},"content":{"rendered":"<figure id=\"attachment_9319\" aria-describedby=\"caption-attachment-9319\" style=\"width: 144px\" class=\"wp-caption alignright\"><img loading=\"lazy\" class=\"size-medium wp-image-9319 \" title=\"Lisa Christadore\" src=\"\/chemistry\/files\/2011\/07\/lisa_christadore-275x300.jpg\" alt=\"Lisa Christadore\" width=\"134\" height=\"142\" \/><figcaption id=\"caption-attachment-9319\" class=\"wp-caption-text\">Lisa Christadore<\/figcaption><\/figure>\n<figure id=\"attachment_579\" aria-describedby=\"caption-attachment-579\" style=\"width: 151px\" class=\"wp-caption alignright\"><a href=\"https:\/\/www.bu.edu\/chemistry\/people\/faculty\/schaus\/\"><img loading=\"lazy\" class=\"size-full wp-image-579 \" title=\"Professor Scott Schaus\" src=\"\/chemistry\/files\/images\/scott.jpg\" alt=\"Professor Scott Schaus\" width=\"141\" height=\"140\" \/><\/a><figcaption id=\"caption-attachment-579\" class=\"wp-caption-text\">Professor Scott Schaus<\/figcaption><\/figure>\n<p><a href=\"https:\/\/www.bu.edu\/chemistry\/people\/faculty\/schaus\/\">Professor Scott Schaus<\/a> and <a href=\"https:\/\/www.bu.edu\/chemistry\/graduate\/\">Graduate Student<\/a> Lisa Christadore are co-authors of:<\/p>\n<blockquote><p><em><a href=\"http:\/\/www.pnas.org\/content\/early\/2011\/07\/20\/1100891108.abstract\" target=\"_blank\">Network-based prediction for sources of transcriptional dysregulation using latent pathway identification analysis<\/a><\/em><\/p><\/blockquote>\n<p>Published in <a href=\"http:\/\/www.pnas.org\/\" target=\"_blank\">PNAS<\/a> in July 2011, the paper represents their collaborative work with researchers in the <a href=\"http:\/\/www.bu.edu\/math\/\" target=\"_blank\">BU Department of Mathematics<\/a> and Statistics, <a href=\"http:\/\/www.bu.edu\/math\/people\/faculty\/probability-and-statistics\/kolaczyk\/\" target=\"_blank\">Professor Eric Kolaczyk<\/a> and Graduate Student Lisa Pham.<\/p>\n<p>It reports on the effectiveness of their novel method, latent pathway identification analysis (LPIA), in providing insights into systemic biological pathways and key cellular mechanisms that dictate disease states, drug response, and altered cellular function.  The work was supported by <a href=\"http:\/\/www.nih.gov\/\" target=\"_blank\">NIH<\/a>, <a href=\"http:\/\/www.nsf.gov\/\" target=\"_blank\">NSF<\/a>, and <a href=\"http:\/\/www.defense.gov\/\" target=\"_blank\">DOD<\/a>.<\/p>\n<figure id=\"attachment_9280\" aria-describedby=\"caption-attachment-9280\" style=\"width: 234px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/www.pnas.org\/content\/early\/2011\/07\/20\/1100891108.abstract\" target=\"_blank\"><img loading=\"lazy\" class=\"size-medium wp-image-9280 \" title=\"Professor Scott Schaus and Graduate Student Lisa Christadore are co-authors of &quot;Network-based prediction for sources of transcriptional dysegulation using latent pathway identification analysis.&quot;  Puublished in PNAS in July 2011.\" src=\"\/chemistry\/files\/2011\/07\/Screen-shot-2011-07-29-at-4.21.35-PM-224x300.png\" alt=\"Network-based prediction for sources of transcriptional dysregulation using latent pathway identification analysis.\" width=\"224\" height=\"300\" srcset=\"https:\/\/www.bu.edu\/chemistry\/files\/2011\/07\/Screen-shot-2011-07-29-at-4.21.35-PM-224x300.png 224w, https:\/\/www.bu.edu\/chemistry\/files\/2011\/07\/Screen-shot-2011-07-29-at-4.21.35-PM.png 425w\" sizes=\"(max-width: 224px) 100vw, 224px\" \/><\/a><figcaption id=\"caption-attachment-9280\" class=\"wp-caption-text\">Schematic illustration of the proposed LPIA method.<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Professor Scott Schaus and Graduate Student Lisa Christadore are co-authors of: Network-based prediction for sources of transcriptional dysregulation using latent pathway identification analysis Published in PNAS in July 2011, the paper represents their collaborative work with researchers in the BU Department of Mathematics and Statistics, Professor Eric Kolaczyk and Graduate Student Lisa Pham. It reports [&hellip;]<\/p>\n","protected":false},"author":1531,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[114,997,160,150,63,1503,65],"tags":[5284,5282,5280,5283,5285,5281,1353],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/posts\/9271"}],"collection":[{"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/users\/1531"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/comments?post=9271"}],"version-history":[{"count":63,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/posts\/9271\/revisions"}],"predecessor-version":[{"id":9462,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/posts\/9271\/revisions\/9462"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/media?parent=9271"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/categories?post=9271"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/tags?post=9271"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}