{"id":25637,"date":"2026-01-20T12:30:50","date_gmt":"2026-01-20T17:30:50","guid":{"rendered":"https:\/\/www.bu.edu\/chemistry\/?p=25637"},"modified":"2026-01-20T16:38:56","modified_gmt":"2026-01-20T21:38:56","slug":"derosa-lab-publishes-recent-developments-in-shono-type-oxidation-strategies-for-modular-%ce%b1-csp3-h-functionalization-in-acs-publications","status":"publish","type":"post","link":"https:\/\/www.bu.edu\/chemistry\/2026\/01\/20\/derosa-lab-publishes-recent-developments-in-shono-type-oxidation-strategies-for-modular-%ce%b1-csp3-h-functionalization-in-acs-publications\/","title":{"rendered":"Derosa Lab Publishes &#8220;Recent Developments in Shono-Type Oxidation: Strategies for Modular \u03b1-C(sp3)\u2013H Functionalization&#8221; in ACS Electrochemistry"},"content":{"rendered":"<div class=\"article_abstract-title\" id=\"Abstract\" tabindex=\"0\">\n<h2>Abstract<\/h2>\n<\/div>\n<div class=\"article_abstract-content hlFld-Abstract\" id=\"abstractBox\" property=\"description\">\n<p class=\"articleBody_abstractText\">The Shono oxidation has served as a pillar in synthetic organic electrochemistry for over 50 years, demonstrating streamlined \u03b1-C(sp<sup>3<\/sup>)\u2013H functionalization of saturated azacycles via<span>\u00a0<\/span><i>N,O<\/i>-acetal intermediates that can be derivatized in subsequent chemical steps. These direct anodic oxidations, however, historically present challenges related to functional group tolerance and site-selectivity and can result in deleterious side reactivity. These obstacles have hampered general applications in complex molecule synthesis and late-stage functionalization, motivating new approaches to realize selective Shono-type functionalization reactions. Over the past decade, a variety of strategies building on this traditional platform have sought to expand reaction scope and selectivity. This Perspective highlights recent developments toward harnessing Shono oxidation for programmable \u03b1-C(sp<sup>3<\/sup>)\u2013H functionalization beyond canonical C\u2013O bond formation, focusing on improved two-step protocols, redox mediator approaches, and selective iminium ion formation.<\/p>\n<p>Click <a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acselectrochem.5c00443\">here<\/a> to read more.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Abstract The Shono oxidation has served as a pillar in synthetic organic electrochemistry for over 50 years, demonstrating streamlined \u03b1-C(sp3)\u2013H functionalization of saturated azacycles via\u00a0N,O-acetal intermediates that can be derivatized in subsequent chemical steps. These direct anodic oxidations, however, historically present challenges related to functional group tolerance and site-selectivity and can result in deleterious side [&hellip;]<\/p>\n","protected":false},"author":25585,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[118],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/posts\/25637"}],"collection":[{"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/users\/25585"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/comments?post=25637"}],"version-history":[{"count":2,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/posts\/25637\/revisions"}],"predecessor-version":[{"id":25645,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/posts\/25637\/revisions\/25645"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/media?parent=25637"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/categories?post=25637"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/tags?post=25637"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}